Can we apply the results of the Steroid Corneal Ulcer Trial to Nocardia infections of the cornea?

Expert Review of Ophthalmology

Volumn 8, Issue 1, 2013, Pages 41-44

  Garg, Prashant ^a   Vazirani, Jayesh ^a  

^a L V PRASAD EYE INSTITUTE   (India)

Author keywords

bacterial keratitis; corneal ulcer; corticosteroids; fluoroquinolones; in vitro antimicrobial susceptibility; Nocardia

Indexed keywords

AMIKACIN; CIPROFLOXACIN; CORTICOSTEROID; GENTAMICIN; LINEZOLID; MOXIFLOXACIN; PLACEBO; PREDNISOLONE SODIUM PHOSPHATE; QUINOLONE DERIVATIVE;

AGRICULTURAL WORKER; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BEST SPECTACLE CORRECTED VISUAL ACUITY; CLINICAL STUDY; CORNEA ULCER; CORTICOSTEROID THERAPY; DISEASE DURATION; DRUG EFFICACY; FINAL MEAN CORRECTED VISUAL ACUITY; HUMAN; INFECTION CONTROL; INJURY; KERATITIS; META ANALYSIS (TOPIC); NOCARDIA; NOCARDIA ASTEROIDES; NOCARDIA CYRIACIGEORGICA; NOCARDIA FARCINICA; NOCARDIA PNEUMONIAE; ONSET AGE; TREATMENT RESPONSE; VISUAL ACUITY;

EID: 84873381687     PISSN: 17469899     EISSN: 17469902     Source Type: Journal    
DOI: 10.1586/eop.12.72     Document Type: Article

References (20)

1. O'Day DM. Corticosteroids: An unresolved debate. Ophthalmology 98(6), 845-846 (1991).
2. Stern GA, Buttross M. Use of corticosteroids in combination with antimicrobial drugs in the treatment of infectious corneal disease. Ophthalmology 98(6), 847-853 (1991).
3. Carmichael TR, Gelfand Y, Welsh NH. Topical steroids in the treatment of central and paracentral corneal ulcers. Br. J. Ophthalmol. 74(9), 528-531 (1990). (Pubitemid 20265397)
4. Hindman HB, Patel SB, Jun AS. Rationale for adjunctive topical corticosteroids in bacterial keratitis. Arch. Ophthalmol. 127(1), 97-102 (2009).
5. Badenoch PR, Hay GJ, McDonald PJ, Coster DJ. A rat model of bacterial keratitis. Effect of antibiotics and corticosteroid. Arch. Ophthalmol. 103(5), 718-722 (1985). (Pubitemid 15052413)
6. Ohadi C, Litwin KL, Moreira H et al. Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis. Cornea 11(5), 398-403 (1992).
7. Engel LS, Callegan MC, Hobden JA, Reidy JJ, Hill JM, O'Callaghan RJ. Effectiveness of specific antibiotic/steroid combinations for therapy of experimental Pseudomonas aeruginosa keratitis. Curr. Eye Res. 14(3), 229-234 (1995).
8. Leibowitz HM, Kupferman A. Topically administered corticosteroids: effect on antibiotic-treated bacterial keratitis. Arch. Ophthalmol. 98(7), 1287-1290 (1980). (Pubitemid 10033731)
9. Stern GA, Buttross M. Use of corticosteroids in combination with antimicrobial drugs in the treatment of infectious corneal disease. Ophthalmology 98(6), 847-853 (1991).
10. Wilhelmus KR. Indecision about corticosteroids for bacterial keratitis: An evidence-based update. Ophthalmology 109(5), 835-842; quiz 843 (2002). (Pubitemid 34465213)
11. Suwan-apichon O, Reyes JMG, Herretes S, Vedula SS, Chuck RS. Topical corticosteroids as adjunctive therapy for bacterial keratitis. Cochrane Database Syst. Rev. 4, CD005430 (2007).
12. American Academy of Ophthalmology Corneal External Disease Panel. Preferred Practice Pattern® Guidelines. Bacterial Keratitis. San Francisco, CA, USA (2011).
13. Srinivasan M, Mascarenhas J, Rajaraman R et al. The Steroids for Corneal Ulcers Trial: study design and baseline characteristics. Arch. Ophthalmol. 130, 143-150 (2012).
14. Srinivasan M, Mascarenhas J, Rajaraman R et al. Corticosteroids for bacterial keratitis: The Steroids for Corneal Ulcers Trial (SCUT). Arch. Ophthalmol. 130, 151-157 (2012).
15. Lalitha P, Srinivasan M, Rajaraman R et al. Nocardia keratitis: clinical course and effect of corticosteroids. Am. J. Ophthalmol. 154(6), 934.e1-939.e1 (2012).
16. DeCroos FC, Garg P, Reddy AK et al.; Hyderabad Endophthalmitis Research Group. Optimizing diagnosis and management of Nocardia keratitis, scleritis, and endophthalmitis: 11-year microbial and clinical overview. Ophthalmology 118(6), 1193-1200 (2011).
17. Gopinathan U, Sharma S, Garg P, Rao GN. Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade. Indian J. Ophthalmol. 57(4), 273-279 (2009).
18. Srinivasan M, Gonzales CA, George C et al. Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, south India. Br. J. Ophthalmol. 81(11), 965-971 (1997). (Pubitemid 27493983)
19. Sridhar MS, Gopinathan U, Garg P, Sharma S, Rao GN. Ocular Nocardia infections with special emphasis on the cornea. Surv. Ophthalmol. 45(5), 361-378 (2001). (Pubitemid 32239516)
20. Larruskain J, Idigoras P, Marimón JM, Pérez-Trallero E. Susceptibility of 186 Nocardia sp. isolates to 20 antimicrobial agents. Antimicrob. Agents Chemother. 55(6), 2995-2998 (2011).