Somatic mutations of PHF6 in patients with chronic myeloid leukemia in blast crisis

Leukemia and Lymphoma

Volumn 54, Issue 3, 2013, Pages 671-672

  Li, Xianmin ^a   Yao, Hong ^a   Chen, Zixing ^a   Wang, Qinrong ^a   Zhao, Yun ^a   Chen, Suning ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; IMATINIB;

ADULT; AGED; BLAST CELL CRISIS; CHRONIC MYELOID LEUKEMIA; DNA SEQUENCE; FEMALE; FRAMESHIFT MUTATION; GENE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; PHF6 GENE; PRIORITY JOURNAL; SOMATIC MUTATION;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; BASE SEQUENCE; BLAST CRISIS; CARRIER PROTEINS; CHILD; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MALE; MIDDLE AGED; MUTATION; YOUNG ADULT;

EID: 84873359541     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.725203     Document Type: Letter

References (11)

1. Baker LA, Allis CD, Wang GG. PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutat Res 2008;647: 3-12.
2. Gécz J, Turner G, Nelson J, et al. The Börjeson-Forssman- Lehman syndrome (BFLS, MIM #301900). Eur JHum Genet 2006;14: 1233-1237.
3. Van Vlierberghe P, Palomero T, Khiabanian H, et al. PHF6 mutations in T-cell acute lymphoblastic leukemia. Nat Genet 2010: 42: 338-342.
4. Wang Q, Qiu H, Jiang H, et al. Mutation of PHF6 is associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia. Haematologica 2011: 96: 1808-1814.
5. Van Vlierberghe P, Patel J, Abdel-Wahab O, et al. PHF6 mutations in adult acute myeloid leukemia. Leukemia 2011: 25: 130-134.
6. Patel JP, Gönen M, Figueroa ME, et al. Prognostic relevance of integrated genetic prof ling in acute myeloid leukemia. N Engl J Med 2012;366: 1079-1089.
7. Radich JP. The biology of CML blast crisis. Hematology Am Soc Hematol Educ Program 2007: 384-391.
8. Güran S, Bahçe M, Beyan C, et al. P53, p15INK4B, p16INK4A and p57KIP2 mutations during the progression of chronic myeloid leukemia. Haematologia (Budap) 1998: 29: 181-193.
9. Grossmann V Kohlmann A, Zenger M, et al. A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76. 9% of cases. Leukemia 2011: 25: 557-560.
10. Zhang SJ, Ma LY, Huang QH, et al. Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia. Proc Natl Acad Sci USA 2008;105: 2076-2081.
11. Makishima H, Jankowska AM, McDevitt MA, et al. CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia. Blood 2011;117: e198-e206.