메뉴 건너뛰기




Volumn 8, Issue 2, 2013, Pages 282-301

Stochastic profiling of transcriptional regulatory heterogeneities in tissues, tumors and cultured cells

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; TRANSCRIPTION FACTOR RUNX1;

EID: 84873355312     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2012.158     Document Type: Article
Times cited : (24)

References (92)
  • 1
    • 53549123008 scopus 로고    scopus 로고
    • Nature, nurture, or chance: Stochastic gene expression and its consequences
    • Raj, A. & van Oudenaarden, A. Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 135, 216-226 (2008).
    • (2008) Cell , vol.135 , pp. 216-226
    • Raj, A.1    Van Oudenaarden, A.2
  • 2
    • 77952474987 scopus 로고    scopus 로고
    • Cellular heterogeneity: Do differences make a difference?
    • Altschuler, S.J. & Wu, L.F. Cellular heterogeneity: do differences make a difference? Cell 141, 559-563 (2010).
    • (2010) Cell , vol.141 , pp. 559-563
    • Altschuler, S.J.1    Wu, L.F.2
  • 3
    • 78951470515 scopus 로고    scopus 로고
    • Origins of regulated cell-to-cell variability
    • Snijder, B. & Pelkmans, L. Origins of regulated cell-to-cell variability. Nat. Rev. Mol. Cell Biol. 12, 119-125 (2011).
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 119-125
    • Snijder, B.1    Pelkmans, L.2
  • 4
    • 41749107942 scopus 로고    scopus 로고
    • Stochasticity and cell fate
    • Losick, R. & Desplan, C. Stochasticity and cell fate. Science 320, 65-68 (2008).
    • (2008) Science , vol.320 , pp. 65-68
    • Losick, R.1    Desplan, C.2
  • 5
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • Elowitz, M.B., Levine, A.J., Siggia, E.D. & Swain, P.S. Stochastic gene expression in a single cell. Science 297, 1183-1186 (2002).
    • (2002) Science , vol.297 , pp. 1183-1186
    • Elowitz, M.B.1    Levine, A.J.2    Siggia, E.D.3    Swain, P.S.4
  • 6
    • 70349466529 scopus 로고    scopus 로고
    • Population context determines cell-to-cell variability in endocytosis and virus infection
    • Snijder, B. et al. Population context determines cell-to-cell variability in endocytosis and virus infection. Nature 461, 520-523 (2009).
    • (2009) Nature , vol.461 , pp. 520-523
    • Snijder, B.1
  • 7
    • 84860187343 scopus 로고    scopus 로고
    • Single-cell analysis of population context advances RNAi screening at multiple levels
    • Snijder, B. et al. Single-cell analysis of population context advances RNAi screening at multiple levels. Mol. Syst. Biol. 8, 579 (2012).
    • (2012) Mol. Syst. Biol. , vol.8 , pp. 579
    • Snijder, B.1
  • 8
    • 33645033645 scopus 로고    scopus 로고
    • Probing gene expression in live cells, one protein molecule at a time
    • Yu, J., Xiao, J., Ren, X., Lao, K. & Xie, X.S. Probing gene expression in live cells, one protein molecule at a time. Science 311, 1600-1603 (2006).
    • (2006) Science , vol.311 , pp. 1600-1603
    • Yu, J.1    Xiao, J.2    Ren, X.3    Lao, K.4    Xie, X.S.5
  • 9
    • 28944434119 scopus 로고    scopus 로고
    • Real-time kinetics of gene activity in individual bacteria
    • Golding, I., Paulsson, J., Zawilski, S.M. & Cox, E.C. Real-time kinetics of gene activity in individual bacteria. Cell 123, 1025-1036 (2005).
    • (2005) Cell , vol.123 , pp. 1025-1036
    • Golding, I.1    Paulsson, J.2    Zawilski, S.M.3    Cox, E.C.4
  • 11
    • 33645027986 scopus 로고    scopus 로고
    • Stochastic protein expression in individual cells at the single-molecule level
    • Cai, L., Friedman, N. & Xie, X.S. Stochastic protein expression in individual cells at the single-molecule level. Nature 440, 358-362 (2006).
    • (2006) Nature , vol.440 , pp. 358-362
    • Cai, L.1    Friedman, N.2    Xie, X.S.3
  • 12
    • 79251603722 scopus 로고    scopus 로고
    • Non-genetic heterogeneity from stochastic partitioning at cell division
    • Huh, D. & Paulsson, J. Non-genetic heterogeneity from stochastic partitioning at cell division. Nat. Genet. 43, 95-100 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 95-100
    • Huh, D.1    Paulsson, J.2
  • 14
    • 77956528790 scopus 로고    scopus 로고
    • Fundamental limits on the suppression of molecular fluctuations
    • Lestas, I., Vinnicombe, G. & Paulsson, J. Fundamental limits on the suppression of molecular fluctuations. Nature 467, 174-178 (2010).
    • (2010) Nature , vol.467 , pp. 174-178
    • Lestas, I.1    Vinnicombe, G.2    Paulsson, J.3
  • 15
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • Spencer, S.L., Gaudet, S., Albeck, J.G., Burke, J.M. & Sorger, P.K. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459, 428-432 (2009).
    • (2009) Nature , vol.459 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3    Burke, J.M.4    Sorger, P.K.5
  • 16
    • 44349162752 scopus 로고    scopus 로고
    • Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
    • Chang, H.H., Hemberg, M., Barahona, M., Ingber, D.E. & Huang, S. Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature 453, 544-547 (2008).
    • (2008) Nature , vol.453 , pp. 544-547
    • Chang, H.H.1    Hemberg, M.2    Barahona, M.3    Ingber, D.E.4    Huang, S.5
  • 17
    • 77950809059 scopus 로고    scopus 로고
    • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
    • Sharma, S.V. et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141, 69-80 (2010).
    • (2010) Cell , vol.141 , pp. 69-80
    • Sharma, S.V.1
  • 18
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta, P.B. et al. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146, 633-644 (2011).
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1
  • 19
    • 33645825831 scopus 로고    scopus 로고
    • Living cells as test tubes
    • Xie, X.S., Yu, J. & Yang, W.Y. Living cells as test tubes. Science 312, 228-230 (2006).
    • (2006) Science , vol.312 , pp. 228-230
    • Xie, X.S.1    Yu, J.2    Yang, W.Y.3
  • 20
    • 84860171972 scopus 로고    scopus 로고
    • Cell biology using cell-to-cell variability-A new era in molecular biology
    • Pelkmans, L. Cell Biology. Using cell-to-cell variability-a new era in molecular biology. Science 336, 425-426 (2012).
    • (2012) Science , vol.336 , pp. 425-426
    • Pelkmans, L.1
  • 21
    • 84859641038 scopus 로고    scopus 로고
    • Using gene expression noise to understand gene regulation
    • Munsky, B., Neuert, G. & van Oudenaarden, A. Using gene expression noise to understand gene regulation. Science 336, 183-187 (2012).
    • (2012) Science , vol.336 , pp. 183-187
    • Munsky, B.1    Neuert, G.2    Van Oudenaarden, A.3
  • 22
    • 77953121190 scopus 로고    scopus 로고
    • Single cell analysis: The new frontier in 'omics'
    • Wang, D. & Bodovitz, S. Single cell analysis: the new frontier in 'omics'. Trends Biotechnol. 28, 281-290 (2010).
    • (2010) Trends Biotechnol. , vol.28 , pp. 281-290
    • Wang, D.1    Bodovitz, S.2
  • 23
    • 79953766940 scopus 로고    scopus 로고
    • Tumour evolution inferred by single-cell sequencing
    • Navin, N. et al. Tumour evolution inferred by single-cell sequencing. Nature 472, 90-94 (2011).
    • (2011) Nature , vol.472 , pp. 90-94
    • Navin, N.1
  • 24
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger, M. et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366, 883-892 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 883-892
    • Gerlinger, M.1
  • 25
    • 84863229772 scopus 로고    scopus 로고
    • Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm
    • Hou, Y. et al. Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell 148, 873-885 (2012).
    • (2012) Cell , vol.148 , pp. 873-885
    • Hou, Y.1
  • 26
    • 84863230091 scopus 로고    scopus 로고
    • Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor
    • Xu, X. et al. Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell 148, 886-895 (2012).
    • (2012) Cell , vol.148 , pp. 886-895
    • Xu, X.1
  • 27
    • 78650034777 scopus 로고    scopus 로고
    • Towards a knowledge-based Human Protein Atlas
    • Uhlen, M. et al. Towards a knowledge-based Human Protein Atlas. Nat. Biotechnol. 28, 1248-1250 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1248-1250
    • Uhlen, M.1
  • 28
    • 79955750055 scopus 로고    scopus 로고
    • Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
    • Bendall, S.C. et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 332, 687-696 (2011).
    • (2011) Science , vol.332 , pp. 687-696
    • Bendall, S.C.1
  • 29
    • 84856004321 scopus 로고    scopus 로고
    • Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells
    • Shi, Q. et al. Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells. Proc. Natl. Acad. Sci. USA 109, 419-424 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 419-424
    • Shi, Q.1
  • 30
    • 57349097152 scopus 로고    scopus 로고
    • Dynamic proteomics of individual cancer cells in response to a drug
    • Cohen, A.A. et al. Dynamic proteomics of individual cancer cells in response to a drug. Science 322, 1511-1516 (2008).
    • (2008) Science , vol.322 , pp. 1511-1516
    • Cohen, A.A.1
  • 31
    • 0036713497 scopus 로고    scopus 로고
    • Representation is faithfully preserved in global cDNA amplified exponentially from sub-picogram quantities of mRNA
    • Iscove, N.N. et al. Representation is faithfully preserved in global cDNA amplified exponentially from sub-picogram quantities of mRNA. Nat. Biotechnol. 20, 940-943 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 940-943
    • Iscove, N.N.1
  • 32
    • 0038702458 scopus 로고    scopus 로고
    • Single-cell transcriptional analysis of neuronal progenitors
    • Tietjen, I. et al. Single-cell transcriptional analysis of neuronal progenitors. Neuron 38, 161-175 (2003).
    • (2003) Neuron , vol.38 , pp. 161-175
    • Tietjen, I.1
  • 33
    • 0037343917 scopus 로고    scopus 로고
    • Single-cell transcript analysis of pancreas development
    • Chiang, M.K. & Melton, D.A. Single-cell transcript analysis of pancreas development. Dev. Cell 4, 383-393 (2003).
    • (2003) Dev. Cell , vol.4 , pp. 383-393
    • Chiang, M.K.1    Melton, D.A.2
  • 34
    • 84859602728 scopus 로고    scopus 로고
    • Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns
    • Sanchez-Freire, V., Ebert, A.D., Kalisky, T., Quake, S.R. & Wu, J.C. Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns. Nat. Protoc. 7, 829-838 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 829-838
    • Sanchez-Freire, V.1    Ebert, A.D.2    Kalisky, T.3    Quake, S.R.4    Wu, J.C.5
  • 35
    • 84861115379 scopus 로고    scopus 로고
    • Comprehensive qPCR profiling of gene expression in single neuronal cells
    • Citri, A., Pang, Z.P., Sudhof, T.C., Wernig, M. & Malenka, R.C. Comprehensive qPCR profiling of gene expression in single neuronal cells. Nat. Protoc. 7, 118-127 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 118-127
    • Citri, A.1    Pang, Z.P.2    Sudhof, T.C.3    Wernig, M.4    Malenka, R.C.5
  • 36
    • 77749323185 scopus 로고    scopus 로고
    • RNA-Seq analysis to capture the transcriptome landscape of a single cell
    • Tang, F. et al. RNA-Seq analysis to capture the transcriptome landscape of a single cell. Nat. Protoc. 5, 516-535 (2010).
    • (2010) Nat. Protoc. , vol.5 , pp. 516-535
    • Tang, F.1
  • 37
    • 34248662082 scopus 로고    scopus 로고
    • Split single-cell RT-PCR analysis of Purkinje cells
    • Esumi, S., Kaneko, R., Kawamura, Y. & Yagi, T. Split single-cell RT-PCR analysis of Purkinje cells. Nat. Protoc. 1, 2143-2151 (2006).
    • (2006) Nat. Protoc. , vol.1 , pp. 2143-2151
    • Esumi, S.1    Kaneko, R.2    Kawamura, Y.3    Yagi, T.4
  • 38
    • 34347235153 scopus 로고    scopus 로고
    • Global single-cell cDNA amplification to provide a template for representative high-density oligonucleotide microarray analysis
    • Kurimoto, K., Yabuta, Y., Ohinata, Y. & Saitou, M. Global single-cell cDNA amplification to provide a template for representative high-density oligonucleotide microarray analysis. Nat. Protoc. 2, 739-752 (2007).
    • (2007) Nat. Protoc. , vol.2 , pp. 739-752
    • Kurimoto, K.1    Yabuta, Y.2    Ohinata, Y.3    Saitou, M.4
  • 39
    • 33947315326 scopus 로고    scopus 로고
    • 220-plex microRNA expression profile of a single cell
    • Tang, F. et al. 220-plex microRNA expression profile of a single cell. Nat. Protoc. 1, 1154-1159 (2006).
    • (2006) Nat. Protoc. , vol.1 , pp. 1154-1159
    • Tang, F.1
  • 40
    • 33845629055 scopus 로고    scopus 로고
    • Gene expression profiling of single cells on large-scale oligonucleotide arrays
    • Hartmann, C.H. & Klein, C.A. Gene expression profiling of single cells on large-scale oligonucleotide arrays. Nucleic Acids Res. 34, e143 (2006).
    • (2006) Nucleic Acids Res. , vol.34
    • Hartmann, C.H.1    Klein, C.A.2
  • 41
    • 83255177150 scopus 로고    scopus 로고
    • Single-cell dissection of transcriptional heterogeneity in human colon tumors
    • Dalerba, P. et al. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat. Biotechnol. 29, 1120-1127 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 1120-1127
    • Dalerba, P.1
  • 42
    • 18344382135 scopus 로고    scopus 로고
    • Combined transcriptome and genome analysis of single micrometastatic cells
    • Klein, C.A. et al. Combined transcriptome and genome analysis of single micrometastatic cells. Nat. Biotechnol. 20, 387-392 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 387-392
    • Klein, C.A.1
  • 44
    • 45449085696 scopus 로고    scopus 로고
    • Individual retinal progenitor cells display extensive heterogeneity of gene expression
    • Trimarchi, J.M., Stadler, M.B. & Cepko, C.L. Individual retinal progenitor cells display extensive heterogeneity of gene expression. PLoS ONE 3, e1588 (2008).
    • (2008) PLoS ONE , vol.3
    • Trimarchi, J.M.1    Stadler, M.B.2    Cepko, C.L.3
  • 45
    • 34249307504 scopus 로고    scopus 로고
    • Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling
    • Trimarchi, J.M. et al. Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling. J. Comp. Neurol. 502, 1047-1065 (2007).
    • (2007) J. Comp. Neurol. , vol.502 , pp. 1047-1065
    • Trimarchi, J.M.1
  • 46
    • 45349107280 scopus 로고    scopus 로고
    • Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice
    • Kurimoto, K. et al. Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice. Genes Dev. 22, 1617-1635 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 1617-1635
    • Kurimoto, K.1
  • 47
    • 67349146589 scopus 로고    scopus 로고
    • MRNA-seq whole-transcriptome analysis of a single cell
    • Tang, F. et al. mRNA-seq whole-transcriptome analysis of a single cell. Nat. Methods 6, 377-382 (2009).
    • (2009) Nat. Methods , vol.6 , pp. 377-382
    • Tang, F.1
  • 48
    • 33749444296 scopus 로고    scopus 로고
    • Evidence for diversity in transcriptional profiles of single hematopoietic stem cells
    • Ramos, C.A. et al. Evidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS Genet. 2, e159 (2006).
    • (2006) PLoS Genet. , vol.2
    • Ramos, C.A.1
  • 49
    • 33745532801 scopus 로고    scopus 로고
    • Increased cell-to-cell variation in gene expression in ageing mouse heart
    • Bahar, R. et al. Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 441, 1011-1014 (2006).
    • (2006) Nature , vol.441 , pp. 1011-1014
    • Bahar, R.1
  • 50
    • 67649586670 scopus 로고    scopus 로고
    • Quantitative analysis of gene expression in a single cell by qPCR
    • Taniguchi, K., Kajiyama, T. & Kambara, H. Quantitative analysis of gene expression in a single cell by qPCR. Nat. Methods 6, 503-506 (2009).
    • (2009) Nat. Methods , vol.6 , pp. 503-506
    • Taniguchi, K.1    Kajiyama, T.2    Kambara, H.3
  • 51
    • 80054089321 scopus 로고    scopus 로고
    • Quantification noise in single cell experiments
    • Reiter, M. et al. Quantification noise in single cell experiments. Nucleic Acids Res. 39, e124 (2011).
    • (2011) Nucleic Acids Res. , vol.39
    • Reiter, M.1
  • 52
    • 1542328972 scopus 로고    scopus 로고
    • Properties of the reverse transcription reaction in mRNA quantification
    • Stahlberg, A., Hakansson, J., Xian, X., Semb, H. & Kubista, M. Properties of the reverse transcription reaction in mRNA quantification. Clin. Chem. 50, 509-515 (2004).
    • (2004) Clin. Chem. , vol.50 , pp. 509-515
    • Stahlberg, A.1    Hakansson, J.2    Xian, X.3    Semb, H.4    Kubista, M.5
  • 53
    • 84855326431 scopus 로고    scopus 로고
    • Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
    • Zhao, B. et al. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev. 26, 54-68 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 54-68
    • Zhao, B.1
  • 54
    • 0035035136 scopus 로고    scopus 로고
    • FGFR1, signaling, and AP-1 expression after retinal detachment: Reactive Muller and RPE cells
    • Geller, S.F., Lewis, G.P. & Fisher, S.K. FGFR1, signaling, and AP-1 expression after retinal detachment: reactive Muller and RPE cells. Invest. Ophthalmol. Vis. Sci. 42, 1363-1369 (2001).
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 1363-1369
    • Geller, S.F.1    Lewis, G.P.2    Fisher, S.K.3
  • 55
    • 0030058668 scopus 로고    scopus 로고
    • Cellular detachment and deformation induce IL-8 gene expression in human bronchial epithelial cells
    • Shibata, Y., Nakamura, H., Kato, S. & Tomoike, H. Cellular detachment and deformation induce IL-8 gene expression in human bronchial epithelial cells. J. Immunol. 156, 772-777 (1996).
    • (1996) J. Immunol. , vol.156 , pp. 772-777
    • Shibata, Y.1    Nakamura, H.2    Kato, S.3    Tomoike, H.4
  • 56
    • 77951643590 scopus 로고    scopus 로고
    • Identifying single-cell molecular programs by stochastic profiling
    • Janes, K.A., Wang, C.C., Holmberg, K.J., Cabral, K. & Brugge, J.S. Identifying single-cell molecular programs by stochastic profiling. Nat. Methods 7, 311-317 (2010).
    • (2010) Nat. Methods , vol.7 , pp. 311-317
    • Janes, K.A.1    Wang, C.C.2    Holmberg, K.J.3    Cabral, K.4    Brugge, J.S.5
  • 57
    • 67650319009 scopus 로고    scopus 로고
    • Single-molecule approaches to stochastic gene expression
    • Raj, A. & van Oudenaarden, A. Single-molecule approaches to stochastic gene expression. Annu. Rev. Biophys. 38, 255-270 (2009).
    • (2009) Annu. Rev. Biophys. , vol.38 , pp. 255-270
    • Raj, A.1    Van Oudenaarden, A.2
  • 58
    • 0030575911 scopus 로고    scopus 로고
    • Laser capture microdissection
    • Emmert-Buck, M.R. et al. Laser capture microdissection. Science 274, 998-1001 (1996).
    • (1996) Science , vol.274 , pp. 998-1001
    • Emmert-Buck, M.R.1
  • 59
    • 25844433114 scopus 로고    scopus 로고
    • Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels
    • Bengtsson, M., Stahlberg, A., Rorsman, P. & Kubista, M. Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels. Genome Res. 15, 1388-1392 (2005).
    • (2005) Genome Res. , vol.15 , pp. 1388-1392
    • Bengtsson, M.1    Stahlberg, A.2    Rorsman, P.3    Kubista, M.4
  • 60
    • 0034978467 scopus 로고    scopus 로고
    • Log-normal distributions across the sciences: Keys and clues
    • Limpert, E., Stahel, W.A. & Abbt, M. Log-normal distributions across the sciences: keys and clues. Bioscience 51, 341-352 (2001).
    • (2001) Bioscience , vol.51 , pp. 341-352
    • Limpert, E.1    Stahel, W.A.2    Abbt, M.3
  • 61
    • 0037868952 scopus 로고    scopus 로고
    • Single-cell microarray analysis in hippocampus CA1: Demonstration and validation of cellular heterogeneity
    • Kamme, F. et al. Single-cell microarray analysis in hippocampus CA1: demonstration and validation of cellular heterogeneity. J. Neurosci. 23, 3607-3615 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 3607-3615
    • Kamme, F.1
  • 62
    • 80053645783 scopus 로고    scopus 로고
    • Intersection of FOXO-and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression
    • Wang, L., Brugge, J.S. & Janes, K.A. Intersection of FOXO-and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proc. Natl. Acad. Sci. USA 108, E803-812 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108
    • Wang, L.1    Brugge, J.S.2    Janes, K.A.3
  • 63
    • 80055108192 scopus 로고    scopus 로고
    • RUNX1 and its understudied role in breast cancer
    • Janes, K.A. RUNX1 and its understudied role in breast cancer. Cell Cycle 10, 3461-3465 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 3461-3465
    • Janes, K.A.1
  • 64
    • 80055122188 scopus 로고    scopus 로고
    • Normal morphogenesis of epithelial tissues and progression of epithelial tumors
    • Wang, C.C., Jamal, L. & Janes, K.A. Normal morphogenesis of epithelial tissues and progression of epithelial tumors. Wiley Interdiscip. Rev. Syst. Biol. Med. 4, 51-78 (2012).
    • (2012) Wiley Interdiscip. Rev. Syst. Biol. Med. , vol.4 , pp. 51-78
    • Wang, C.C.1    Jamal, L.2    Janes, K.A.3
  • 65
    • 0028685490 scopus 로고
    • Fitting a mixture model by expectation maximization to discover motifs in biopolymers
    • Bailey, T.L. & Elkan, C. Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc. Int. Conf. Intell. Syst. Mol. Biol. 2, 28-36 (1994).
    • (1994) Proc. Int. Conf. Intell. Syst. Mol. Biol. , vol.2 , pp. 28-36
    • Bailey, T.L.1    Elkan, C.2
  • 67
    • 84862523863 scopus 로고    scopus 로고
    • Sequence analysis of mutations and translocations across breast cancer subtypes
    • Banerji, S. et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 486, 405-409 (2012).
    • (2012) Nature , vol.486 , pp. 405-409
    • Banerji, S.1
  • 68
    • 84862584058 scopus 로고    scopus 로고
    • Whole-genome analysis informs breast cancer response to aromatase inhibition
    • Ellis, M.J. et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature 486, 353-360 (2012).
    • (2012) Nature , vol.486 , pp. 353-360
    • Ellis, M.J.1
  • 70
    • 77249114260 scopus 로고    scopus 로고
    • Variability in gene expression underlies incomplete penetrance
    • Raj, A., Rifkin, S.A., Andersen, E. & van Oudenaarden, A. Variability in gene expression underlies incomplete penetrance. Nature 463, 913-918 (2010).
    • (2010) Nature , vol.463 , pp. 913-918
    • Raj, A.1    Rifkin, S.A.2    Andersen, E.3    Van Oudenaarden, A.4
  • 71
    • 67749117790 scopus 로고    scopus 로고
    • Partial penetrance facilitates developmental evolution in bacteria
    • Eldar, A. et al. Partial penetrance facilitates developmental evolution in bacteria. Nature 460, 510-514 (2009).
    • (2009) Nature , vol.460 , pp. 510-514
    • Eldar, A.1
  • 72
    • 33750868447 scopus 로고    scopus 로고
    • Isoelectric focusing technology quantifies protein signaling in 25 cells
    • O'Neill, R.A. et al. Isoelectric focusing technology quantifies protein signaling in 25 cells. Proc. Natl. Acad. Sci. USA 103, 16153-16158 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 16153-16158
    • O'neill, R.A.1
  • 73
    • 79957590332 scopus 로고    scopus 로고
    • Probing cellular protein complexes using single-molecule pull-down
    • Jain, A. et al. Probing cellular protein complexes using single-molecule pull-down. Nature 473, 484-488 (2011).
    • (2011) Nature , vol.473 , pp. 484-488
    • Jain, A.1
  • 74
    • 34250892135 scopus 로고    scopus 로고
    • The needle in the haystack: Application of breast fine-needle aspirate samples to quantitative protein microarray technology
    • Rapkiewicz, A. et al. The needle in the haystack: application of breast fine-needle aspirate samples to quantitative protein microarray technology. Cancer 111, 173-184 (2007).
    • (2007) Cancer , vol.111 , pp. 173-184
    • Rapkiewicz, A.1
  • 75
    • 80053388216 scopus 로고    scopus 로고
    • Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq
    • Adli, M. & Bernstein, B.E. Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq. Nat. Protoc. 6, 1656-1668 (2011).
    • (2011) Nat. Protoc. , vol.6 , pp. 1656-1668
    • Adli, M.1    Bernstein, B.E.2
  • 76
    • 65649130015 scopus 로고    scopus 로고
    • Automated microfluidic chromatin immunoprecipitation from 2,000 cells
    • Wu, A.R. et al. Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab Chip 9, 1365-1370 (2009).
    • (2009) Lab Chip , vol.9 , pp. 1365-1370
    • Wu, A.R.1
  • 77
    • 34548707114 scopus 로고    scopus 로고
    • Laser-capture microdissection
    • Espina, V. et al. Laser-capture microdissection. Nat. Protoc. 1, 586-603 (2006).
    • (2006) Nat. Protoc. , vol.1 , pp. 586-603
    • Espina, V.1
  • 78
    • 0043065383 scopus 로고    scopus 로고
    • High quality RNA retrieved from samples obtained by using LMPC (laser microdissection and pressure catapulting) technology
    • Burgemeister, R., Gangnus, R., Haar, B., Schutze, K. & Sauer, U. High quality RNA retrieved from samples obtained by using LMPC (laser microdissection and pressure catapulting) technology. Pathol. Res. Pract. 199, 431-436 (2003).
    • (2003) Pathol. Res. Pract. , vol.199 , pp. 431-436
    • Burgemeister, R.1    Gangnus, R.2    Haar, B.3    Schutze, K.4    Sauer, U.5
  • 79
    • 33746368013 scopus 로고    scopus 로고
    • Histological staining methods preparatory to laser capture microdissection significantly affect the integrity of the cellular RNA
    • Wang, H. et al. Histological staining methods preparatory to laser capture microdissection significantly affect the integrity of the cellular RNA. BMC Genomics 7, 97 (2006).
    • (2006) BMC Genomics , vol.7 , pp. 97
    • Wang, H.1
  • 80
    • 0027383628 scopus 로고
    • Construction of cDNA libraries from single cells
    • Brady, G. & Iscove, N.N. Construction of cDNA libraries from single cells. Methods Enzymol. 225, 611-623 (1993).
    • (1993) Methods Enzymol. , vol.225 , pp. 611-623
    • Brady, G.1    Iscove, N.N.2
  • 81
    • 34547623194 scopus 로고    scopus 로고
    • Common effector processing mediates cell-specific responses to stimuli
    • Miller-Jensen, K., Janes, K.A., Brugge, J.S. & Lauffenburger, D.A. Common effector processing mediates cell-specific responses to stimuli. Nature 448, 604-608 (2007).
    • (2007) Nature , vol.448 , pp. 604-608
    • Miller-Jensen, K.1    Janes, K.A.2    Brugge, J.S.3    Lauffenburger, D.A.4
  • 82
    • 11844288400 scopus 로고    scopus 로고
    • Real-time polymerase chain reaction-based exponential sample amplification for microarray gene expression profiling
    • Nagy, Z.B. et al. Real-time polymerase chain reaction-based exponential sample amplification for microarray gene expression profiling. Anal. Biochem. 337, 76-83 (2005).
    • (2005) Anal. Biochem. , vol.337 , pp. 76-83
    • Nagy, Z.B.1
  • 83
    • 33645544764 scopus 로고    scopus 로고
    • An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis
    • Kurimoto, K. et al. An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis. Nucleic Acids Res. 34, e42 (2006).
    • (2006) Nucleic Acids Res. , vol.34
    • Kurimoto, K.1
  • 84
    • 3242732932 scopus 로고    scopus 로고
    • Possible sources of dye-related signal correlation bias in two-color DNA microarray assays
    • Cox, W.G., Beaudet, M.P., Agnew, J.Y. & Ruth, J.L. Possible sources of dye-related signal correlation bias in two-color DNA microarray assays. Anal. Biochem. 331, 243-254 (2004).
    • (2004) Anal. Biochem. , vol.331 , pp. 243-254
    • Cox, W.G.1    Beaudet, M.P.2    Agnew, J.Y.3    Ruth, J.L.4
  • 85
    • 33748491517 scopus 로고    scopus 로고
    • The MicroArray Quality Control (MAQC) project shows inter-and intraplatform reproducibility of gene expression measurements
    • Shi, L. et al. The MicroArray Quality Control (MAQC) project shows inter-and intraplatform reproducibility of gene expression measurements. Nat. Biotechnol. 24, 1151-1161 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1151-1161
    • Shi, L.1
  • 86
    • 33845218548 scopus 로고    scopus 로고
    • Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR
    • Warren, L., Bryder, D., Weissman, I.L. & Quake, S.R. Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc. Natl. Acad. Sci. USA 103, 17807-17812 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17807-17812
    • Warren, L.1    Bryder, D.2    Weissman, I.L.3    Quake, S.R.4
  • 87
    • 0008710076 scopus 로고
    • Distribution of the coefficient of variation and the extended 't' distribution
    • McKay, A.T. Distribution of the coefficient of variation and the extended 't' distribution. J. Roy. Stat. Soc. 95, 695-698 (1932).
    • (1932) J. Roy. Stat. Soc. , vol.95 , pp. 695-698
    • McKay, A.T.1
  • 91
    • 0032926691 scopus 로고    scopus 로고
    • Immuno-LCM: Laser capture microdissection of immunostained frozen sections for mRNA analysis
    • Fend, F. et al. Immuno-LCM: laser capture microdissection of immunostained frozen sections for mRNA analysis. Am. J. Pathol. 154, 61-66 (1999).
    • (1999) Am. J. Pathol. , vol.154 , pp. 61-66
    • Fend, F.1
  • 92
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH
    • Vandesompele, J. et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3, RESEARCH0034 (2002).
    • (2002) Genome Biol. , vol.3 , pp. 0034
    • Vandesompele, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.