-
1
-
-
0017094798
-
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
-
Moncada S, Gryglewski R, Bunting S, et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976; 263:663-665.
-
(1976)
Nature
, vol.263
, pp. 663-665
-
-
Moncada, S.1
Gryglewski, R.2
Bunting, S.3
-
2
-
-
0018398906
-
Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls
-
Moncada S, Vane JR. Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N Engl J Med 1979; 300:1142-1147.
-
(1979)
N Engl J Med
, vol.300
, pp. 1142-1147
-
-
Moncada, S.1
Vane, J.R.2
-
3
-
-
0036007307
-
Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery
-
Clapp LH, Finney P, Turcato S, et al. Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am J Respir Cell Mol Biol 2002; 26:194-201.
-
(2002)
Am J Respir Cell Mol Biol
, vol.26
, pp. 194-201
-
-
Clapp, L.H.1
Finney, P.2
Turcato, S.3
-
4
-
-
0026628265
-
An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
-
Christman BW, McPherson CD, Newman JH, et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 1992; 327:70-75.
-
(1992)
N Engl J Med
, vol.327
, pp. 70-75
-
-
Christman, B.W.1
McPherson, C.D.2
Newman, J.H.3
-
5
-
-
0033032949
-
Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
-
Tuder RM, Cool CD, Geraci MW, et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 1999; 159:1925-1932.
-
(1999)
Am J Respir Crit Care Med
, vol.159
, pp. 1925-1932
-
-
Tuder, R.M.1
Cool, C.D.2
Geraci, M.W.3
-
6
-
-
0019985926
-
Prostacyclin-induced acute pulmonary vasodilation in primary pulmonary hypertension
-
Rubin LJ, Groves BM, Reeves JT, et al. Prostacyclin-induced acute pulmonary vasodilation in primary pulmonary hypertension. Circulation 1982; 66:334-338.
-
(1982)
Circulation
, vol.66
, pp. 334-338
-
-
Rubin, L.J.1
Groves, B.M.2
Reeves, J.T.3
-
7
-
-
0021367046
-
Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin)
-
Higenbottam T, Wheeldon D, Wells F, et al. Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin). Lancet 1984; 1:1046-1047.
-
(1984)
Lancet
, vol.1
, pp. 1046-1047
-
-
Higenbottam, T.1
Wheeldon, D.2
Wells, F.3
-
8
-
-
0025356811
-
Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial
-
Rubin LJ, Mendoza J, Hood M, et al. Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial. Ann Intern Med 1990; 112:485-191.
-
(1990)
Ann Intern Med
, vol.112
, pp. 485-191
-
-
Rubin, L.J.1
Mendoza, J.2
Hood, M.3
-
9
-
-
0030031888
-
A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension
-
Barst RJ, Rubin LJ, Long WA, et al. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med 1996; 334:296-301.
-
(1996)
N Engl J Med
, vol.334
, pp. 296-301
-
-
Barst, R.J.1
Rubin, L.J.2
Long, W.A.3
-
10
-
-
17144452827
-
Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease
-
Badesch DB, Tapson VF, McGoon MD, et al. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. Ann Intern Med 2000; 132:425-434.
-
(2000)
Ann Intern Med
, vol.132
, pp. 425-434
-
-
Badesch, D.B.1
Tapson, V.F.2
McGoon, M.D.3
-
11
-
-
0037126044
-
Survival in primary pulmonary hypertension: The impact of epoprostenol therapy
-
McLaughlin VV, Shillington A, Rich S. Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation 2002; 106:1477-1482.
-
(2002)
Circulation
, vol.106
, pp. 1477-1482
-
-
McLaughlin, V.V.1
Shillington, A.2
Rich, S.3
-
12
-
-
0037151645
-
Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: Prognostic factors and survival
-
Sitbon O, Humbert M, Nunes H, et al. Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J Am Coll Cardiol 2002; 40:780-788.
-
(2002)
J Am Coll Cardiol
, vol.40
, pp. 780-788
-
-
Sitbon, O.1
Humbert, M.2
Nunes, H.3
-
13
-
-
0033213243
-
The effects of chronic prostacyclin therapy on cardiac output and symptoms in primary pulmonary hypertension
-
Rich S, McLaughlin VV. The effects of chronic prostacyclin therapy on cardiac output and symptoms in primary pulmonary hypertension. J Am Coll Cardiol 1999; 34:1184-1187.
-
(1999)
J Am Coll Cardiol
, vol.34
, pp. 1184-1187
-
-
Rich, S.1
McLaughlin, V.V.2
-
14
-
-
12244251412
-
Efficacy and safety of treprostinil: An epoprostenol analogue for primary pulmonary hypertension
-
McLaughlin VV, Gaine SP, Barst RJ, et al. Efficacy and safety of treprostinil: an epoprostenol analogue for primary pulmonary hypertension. J Cardiovasc Pharmacol 2003; 41:293-299.
-
(2003)
J Cardiovasc Pharmacol
, vol.41
, pp. 293-299
-
-
McLaughlin, V.V.1
Gaine, S.P.2
Barst, R.J.3
-
15
-
-
0037086133
-
Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension
-
Simonneau G, Barst RJ, Galie N, et al. Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension. Am J Respir Crit Care Med 2002; 165:800-804.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, pp. 800-804
-
-
Simonneau, G.1
Barst, R.J.2
Galie, N.3
-
16
-
-
35448992075
-
Transition from IV epoprostenol to subcutaneous treprostinil in pulmonary arterial hypertension: A controlled trial
-
Rubenfire M, McLaughlin VV, Allen RP, et al. Transition from IV epoprostenol to subcutaneous treprostinil in pulmonary arterial hypertension: a controlled trial. Chest 2007; 132:757-763.
-
(2007)
Chest
, vol.132
, pp. 757-763
-
-
Rubenfire, M.1
McLaughlin, V.V.2
Allen, R.P.3
-
17
-
-
33646255654
-
Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil
-
Barst R, Galie N, Naeije R, et al. Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil. Eur Respir J 2006; 47:2049-2056.
-
(2006)
Eur Respir J
, vol.47
, pp. 2049-2056
-
-
Barst, R.1
Galie, N.2
Naeije, R.3
-
18
-
-
33745172176
-
Efficacy of long-term subcutaneous treprostinil sodium therapy in pulmonary hypertension
-
Lang I, Gomez-Sanchez M, Kneussl M, et al. Efficacy of long-term subcutaneous treprostinil sodium therapy in pulmonary hypertension. Chest 2006; 129:1636-1643.
-
(2006)
Chest
, vol.129
, pp. 1636-1643
-
-
Lang, I.1
Gomez-Sanchez, M.2
Kneussl, M.3
-
19
-
-
37349045123
-
Dose proportionality of treprostinil sodium administered by continuous subcutaneous and intravenous infusion
-
McSwain CS, Benza R, Shapiro S, et al. Dose proportionality of treprostinil sodium administered by continuous subcutaneous and intravenous infusion. J Clin Pharmacol 2008; 48:19-25.
-
(2008)
J Clin Pharmacol
, vol.48
, pp. 19-25
-
-
McSwain, C.S.1
Benza, R.2
Shapiro, S.3
-
20
-
-
33645119109
-
Safety and efficacy of IV tre-prostinil for pulmonary arterial hypertension: A prospective, multicenter, open-label, 12-week trial
-
Tapson VF, Gomberg-Maitland M, McLaughlin VV, et al. Safety and efficacy of IV tre-prostinil for pulmonary arterial hypertension: a prospective, multicenter, open-label, 12-week trial. Chest 2006; 129:683-688.
-
(2006)
Chest
, vol.129
, pp. 683-688
-
-
Tapson, V.F.1
Gomberg-Maitland, M.2
McLaughlin, V.V.3
-
21
-
-
30444458863
-
Transition from intravenous epopros-tenol to intravenous treprostinil in pulmonary hypertension
-
Gomberg-Maitland M, Tapson VF, Benza RL, et al. Transition from intravenous epopros-tenol to intravenous treprostinil in pulmonary hypertension. Am J Respir Crit Care Med 2005; 172:1586-1589.
-
(2005)
Am J Respir Crit Care Med
, vol.172
, pp. 1586-1589
-
-
Gomberg-Maitland, M.1
Tapson, V.F.2
Benza, R.L.3
-
22
-
-
40949101444
-
Bloodstream infections in patients given treatment with intravenous prostanoids
-
Kallen AJ, Lederman E, Balaji A, et al. Bloodstream infections in patients given treatment with intravenous prostanoids. Infect Control Hosp Epidemiol 2008; 29:342-349.
-
(2008)
Infect Control Hosp Epidemiol
, vol.29
, pp. 342-349
-
-
Kallen, A.J.1
Lederman, E.2
Balaji, A.3
-
23
-
-
0036682273
-
Inhaled iloprost for severe pulmonary hypertension
-
Olschewski H, Simonneau G, Galie N, et al. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 2002; 347:322-329.
-
(2002)
N Engl J Med
, vol.347
, pp. 322-329
-
-
Olschewski, H.1
Simonneau, G.2
Galie, N.3
-
24
-
-
0034702248
-
Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue
-
Hoeper MM, Schwarze M, Ehlerding S, et al. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 2000; 342:1866-1870.
-
(2000)
N Engl J Med
, vol.342
, pp. 1866-1870
-
-
Hoeper, M.M.1
Schwarze, M.2
Ehlerding, S.3
-
25
-
-
21544449424
-
Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension
-
Opitz CF, Wensel R, Winkler J, et al. Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension. Eur Heart J 2005; 26:1895-1902.
-
(2005)
Eur Heart J
, vol.26
, pp. 1895-1902
-
-
Opitz, C.F.1
Wensel, R.2
Winkler, J.3
-
26
-
-
33845526777
-
Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension
-
McLaughlin VV, Oudiz RJ, Adaani F, et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am J Respir Crit Care Med 2006; 174:1257-1263.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 1257-1263
-
-
McLaughlin, V.V.1
Oudiz, R.J.2
Adaani, F.3
-
27
-
-
33847368988
-
Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension
-
Hoeper MM, Leuchte H, Halank M, et al. Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur Respir J 2006; 28:691-694.
-
(2006)
Eur Respir J
, vol.28
, pp. 691-694
-
-
Hoeper, M.M.1
Leuchte, H.2
Halank, M.3
-
28
-
-
0022344228
-
Effect of a stable prostacyclin analogue on platelet function and experimentally-induced thrombosis in the microcirculation
-
Sim AK, McCraw AP, Cleland ME, et al. Effect of a stable prostacyclin analogue on platelet function and experimentally-induced thrombosis in the microcirculation. Arzneimittelfor-schung 1985; 35:1816-1818.
-
(1985)
Arzneimittelfor-schung
, vol.35
, pp. 1816-1818
-
-
Sim, A.K.1
McCraw, A.P.2
Cleland, M.E.3
-
29
-
-
0024408947
-
General pharmacology of beraprost sodium. 2nd communication: Effect on the autonomic, cardiovascular and gastrointestinal systems, and other effects
-
Murata T, Murai T, Kanai T, et al. General pharmacology of beraprost sodium. 2nd communication: effect on the autonomic, cardiovascular and gastrointestinal systems, and other effects. Arzneimittelforschung 1989; 39:867-876.
-
(1989)
Arzneimittelforschung
, vol.39
, pp. 867-876
-
-
Murata, T.1
Murai, T.2
Kanai, T.3
-
30
-
-
0036569119
-
Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: A randomized, double-blind, placebo-controlled trial
-
Galie N, Humbert M, Vachiery J, et al. Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol 2002; 39:1496-1502.
-
(2002)
J Am Coll Cardiol
, vol.39
, pp. 1496-1502
-
-
Galie, N.1
Humbert, M.2
Vachiery, J.3
-
31
-
-
0038037766
-
Beraprost therapy for pulmonary arterial hypertension
-
Barst RJ, McGoon MD, McLaughlin VV, et al. Beraprost therapy for pulmonary arterial hypertension. J Am Coll Cardiol 2003; 41:2119-2125.
-
(2003)
J Am Coll Cardiol
, vol.41
, pp. 2119-2125
-
-
Barst, R.J.1
McGoon, M.D.2
McLaughlin, V.V.3
|