메뉴 건너뛰기




Volumn 5, Issue 2, 2013, Pages 180-190

MicroRNAs in age-related diseases

Author keywords

Cardiac; MicroRNA; Neurodegeneration; Senescence; Vascular

Indexed keywords

MICRORNA; MICRORNA 107; MICRORNA 122; MICRORNA 146; MICRORNA 17; MICRORNA 18; MICRORNA 181; MICRORNA 181B; MICRORNA 19; MICRORNA 20; MICRORNA 216; MICRORNA 217; MICRORNA 22; MICRORNA 223; MICRORNA 238; MICRORNA 239; MICRORNA 24; MICRORNA 246; MICRORNA 29; MICRORNA 29A; MICRORNA 29B; MICRORNA 29C; MICRORNA 31B; MICRORNA 33B; MICRORNA 34; MICRORNA 34A; MICRORNA 71; MICRORNA 92A; RNA; RNA POLYMERASE II; UNCLASSIFIED DRUG;

EID: 84873298811     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201201986     Document Type: Review
Times cited : (155)

References (99)
  • 1
    • 79958718254 scopus 로고    scopus 로고
    • Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect
    • Bano D, Agostini M, Melino G, Nicotera P (2011) Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect. Mol Neurobiol 43: 124-130.
    • (2011) Mol Neurobiol , vol.43 , pp. 124-130
    • Bano, D.1    Agostini, M.2    Melino, G.3    Nicotera, P.4
  • 2
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 3
    • 79961095592 scopus 로고    scopus 로고
    • Biogenesis and regulation of cardiovascular microRNAs
    • Bauersachs J, Thum T (2011) Biogenesis and regulation of cardiovascular microRNAs. Circ Res 109: 334-347.
    • (2011) Circ Res , vol.109 , pp. 334-347
    • Bauersachs, J.1    Thum, T.2
  • 7
    • 84864809893 scopus 로고    scopus 로고
    • Telomerase gene therapy: a novel approach to combat aging
    • Boccardi V, Herbig U (2012) Telomerase gene therapy: a novel approach to combat aging. EMBO Mol Med 4: 685-687.
    • (2012) EMBO Mol Med , vol.4 , pp. 685-687
    • Boccardi, V.1    Herbig, U.2
  • 8
    • 29344467120 scopus 로고    scopus 로고
    • A developmental timing microRNA and its target regulate life span in C
    • Boehm M, Slack F (2005) A developmental timing microRNA and its target regulate life span in C. elegans. Science 310: 1954-1957.
    • (2005) elegans. Science , vol.310 , pp. 1954-1957
    • Boehm, M.1    Slack, F.2
  • 18
    • 44949181955 scopus 로고    scopus 로고
    • Aging and disease as modifiers of efficacy of cell therapy
    • Dimmeler S, Leri A (2008) Aging and disease as modifiers of efficacy of cell therapy. Circ Res 102: 1319-1330.
    • (2008) Circ Res , vol.102 , pp. 1319-1330
    • Dimmeler, S.1    Leri, A.2
  • 21
    • 84862202857 scopus 로고    scopus 로고
    • Cause or effect: misregulation of microRNA pathways in neurodegeneration
    • Gascon E, Gao FB (2012) Cause or effect: misregulation of microRNA pathways in neurodegeneration. Front Neurosci 6: 48.
    • (2012) Front Neurosci , vol.6 , pp. 48
    • Gascon, E.1    Gao, F.B.2
  • 24
    • 63349094897 scopus 로고    scopus 로고
    • Alterations of the microRNA network cause neurodegenerative disease
    • Hébert SS, De Strooper B (2009) Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci 32: 199-206.
    • (2009) Trends Neurosci , vol.32 , pp. 199-206
    • Hébert, S.S.1    De Strooper, B.2
  • 27
    • 78449293102 scopus 로고    scopus 로고
    • The miR-17 92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence
    • Hong L, Lai M, Chen M, Xie C, Liao R, Kang YJ, Xiao C, Hu WY, Han J, Sun P (2010) The miR-17 92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res 70: 8547-8557.
    • (2010) Cancer Res , vol.70 , pp. 8547-8557
    • Hong, L.1    Lai, M.2    Chen, M.3    Xie, C.4    Liao, R.5    Kang, Y.J.6    Xiao, C.7    Hu, W.Y.8    Han, J.9    Sun, P.10
  • 28
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu AL, Murphy CT, Kenyon C (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300: 1142-1145.
    • (2003) Science , vol.300 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 29
    • 80053921573 scopus 로고    scopus 로고
    • A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice
    • Hughes BG, Hekimi S (2011) A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice. PLoS One 6: e26116.
    • (2011) PLoS One , vol.6
    • Hughes, B.G.1    Hekimi, S.2
  • 31
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos D, Hirsch HA, Struhl K (2009) An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139: 693-706.
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 32
    • 84858126071 scopus 로고    scopus 로고
    • MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics
    • Iorio MV, Croce CM (2012) MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 4: 143-159.
    • (2012) A comprehensive review. EMBO Mol Med , vol.4 , pp. 143-159
    • Iorio, M.V.1    Croce, C.M.2
  • 33
    • 77955417245 scopus 로고    scopus 로고
    • MicroRNA-34a regulation of endothelial senescence
    • Ito T, Yagi S, Yamakuchi M (2010) MicroRNA-34a regulation of endothelial senescence. Biochem Biophys Res Commun 398: 735-740.
    • (2010) Biochem Biophys Res Commun , vol.398 , pp. 735-740
    • Ito, T.1    Yagi, S.2    Yamakuchi, M.3
  • 35
    • 77956270128 scopus 로고    scopus 로고
    • MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia
    • Jiao J, Herl LD, Farese RV, Gao FB (2010) MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia. PLoS One, 5, e10551.
    • (2010) PLoS One , vol.5
    • Jiao, J.1    Herl, L.D.2    Farese, R.V.3    Gao, F.B.4
  • 36
    • 80053210307 scopus 로고    scopus 로고
    • Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C
    • Kato M, Chen X, Inukai S, Zhao H, Slack FJ (2011) Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA 17: 1804-1820.
    • (2011) elegans. RNA , vol.17 , pp. 1804-1820
    • Kato, M.1    Chen, X.2    Inukai, S.3    Zhao, H.4    Slack, F.J.5
  • 37
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ (2010) The genetics of ageing. Nature 464: 504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 38
    • 80051604377 scopus 로고    scopus 로고
    • Gain of survival signaling by downregulation of three key miRNAs in brain of calorierestricted mice
    • Khanna A, Muthusamy S, Liang R, Sarojini H, Wang E (2011) Gain of survival signaling by downregulation of three key miRNAs in brain of calorierestricted mice. Aging (Albany NY) 3: 223-236.
    • (2011) Aging (Albany NY) , vol.3 , pp. 223-236
    • Khanna, A.1    Muthusamy, S.2    Liang, R.3    Sarojini, H.4    Wang, E.5
  • 39
    • 77953627194 scopus 로고    scopus 로고
    • Somatic mitochondrial DNA mutations in mammalian aging
    • Larsson NG (2010) Somatic mitochondrial DNA mutations in mammalian aging. Annu Rev Biochem 79: 683-706.
    • (2010) Annu Rev Biochem , vol.79 , pp. 683-706
    • Larsson, N.G.1
  • 40
    • 84859748623 scopus 로고    scopus 로고
    • An activityregulated microRNA, miR-188, controls dendritic plasticity and synaptic transmission by downregulating neuropilin-2
    • Lee K, Kim JH, Kwon OB, An K, Ryu J, Cho K, Suh YH, Kim HS (2012) An activityregulated microRNA, miR-188, controls dendritic plasticity and synaptic transmission by downregulating neuropilin-2. J Neurosci 32: 5678-5687.
    • (2012) J Neurosci , vol.32 , pp. 5678-5687
    • Lee, K.1    Kim, J.H.2    Kwon, O.B.3    An, K.4    Ryu, J.5    Cho, K.6    Suh, Y.H.7    Kim, H.S.8
  • 42
    • 79954592065 scopus 로고    scopus 로고
    • Upregulation of key microRNAs, and inverse downregulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain
    • Li N, Bates DJ, An J, Terry DA, Wang E (2011a) Upregulation of key microRNAs, and inverse downregulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain. Neurobiol Aging 32: 944-955.
    • (2011) Neurobiol Aging , vol.32 , pp. 944-955
    • Li, N.1    Bates, D.J.2    An, J.3    Terry, D.A.4    Wang, E.5
  • 43
    • 80855165230 scopus 로고    scopus 로고
    • Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging
    • Li X, Khanna A, Li N, Wang E (2011b) Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging. Aging (Albany NY) 3: 985-1002.
    • (2011) Aging (Albany NY) , vol.3 , pp. 985-1002
    • Li, X.1    Khanna, A.2    Li, N.3    Wang, E.4
  • 44
    • 10944269186 scopus 로고    scopus 로고
    • The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    • Li Z, Okamoto K, Hayashi Y, Sheng M (2004) The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 119: 873-887.
    • (2004) Cell , vol.119 , pp. 873-887
    • Li, Z.1    Okamoto, K.2    Hayashi, Y.3    Sheng, M.4
  • 45
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • Lin K, Hsin H, Libina N, Kenyon C (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet 28: 139-145.
    • (2001) Nat Genet , vol.28 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 46
    • 84869120708 scopus 로고    scopus 로고
    • Discovering the first microRNA-targeted drug
    • Lindow M, Kauppinen S (2012) Discovering the first microRNA-targeted drug. J Cell Biol 199: 407-412.
    • (2012) J Cell Biol , vol.199 , pp. 407-412
    • Lindow, M.1    Kauppinen, S.2
  • 50
    • 33847203593 scopus 로고    scopus 로고
    • Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
    • Lukiw WJ (2007) Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport 18: 297-300.
    • (2007) Neuroreport , vol.18 , pp. 297-300
    • Lukiw, W.J.1
  • 54
    • 79952017845 scopus 로고    scopus 로고
    • Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
    • Martinez P, Blasco MA (2011) Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 11: 161-176.
    • (2011) Nat Rev Cancer , vol.11 , pp. 161-176
    • Martinez, P.1    Blasco, M.A.2
  • 58
    • 0030698871 scopus 로고    scopus 로고
    • Life and death of neurons in the aging brain
    • Morrison JH, Hof PR (1997) Life and death of neurons in the aging brain. Science 278: 412-419.
    • (1997) Science , vol.278 , pp. 412-419
    • Morrison, J.H.1    Hof, P.R.2
  • 59
    • 84860751699 scopus 로고    scopus 로고
    • Telomeres and mitochondria in the aging heart
    • Moslehi J, DePinho RA, Sahin E (2012) Telomeres and mitochondria in the aging heart. Circ Res 110: 1226-1237.
    • (2012) Circ Res , vol.110 , pp. 1226-1237
    • Moslehi, J.1    DePinho, R.A.2    Sahin, E.3
  • 60
    • 77954996105 scopus 로고    scopus 로고
    • MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study
    • Nelson PT, Wang WX (2010) MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. J Alzheimers Dis 21: 75-79.
    • (2010) J Alzheimers Dis , vol.21 , pp. 75-79
    • Nelson, P.T.1    Wang, W.X.2
  • 61
    • 53749098061 scopus 로고    scopus 로고
    • Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression
    • Nishino J, Kim I, Chada K, Morrison SJ (2008) Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell 135: 227-239.
    • (2008) Cell , vol.135 , pp. 227-239
    • Nishino, J.1    Kim, I.2    Chada, K.3    Morrison, S.J.4
  • 62
    • 40149088267 scopus 로고    scopus 로고
    • The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans
    • Niwa R, Zhou F, Li C, Slack FJ (2008) The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Dev Biol 315: 418-425.
    • (2008) Dev Biol , vol.315 , pp. 418-425
    • Niwa, R.1    Zhou, F.2    Li, C.3    Slack, F.J.4
  • 64
    • 84859882975 scopus 로고    scopus 로고
    • The intersection between aging and cardiovascular disease
    • North BJ, Sinclair DA (2012) The intersection between aging and cardiovascular disease. Circ Res 110: 1097-1108.
    • (2012) Circ Res , vol.110 , pp. 1097-1108
    • North, B.J.1    Sinclair, D.A.2
  • 67
    • 63649097932 scopus 로고    scopus 로고
    • Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans
    • Pierce GL, Lesniewski LA, Lawson BR, Beske SD, Seals DR (2009) Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation 119: 1284-1292.
    • (2009) Circulation , vol.119 , pp. 1284-1292
    • Pierce, G.L.1    Lesniewski, L.A.2    Lawson, B.R.3    Beske, S.D.4    Seals, D.R.5
  • 69
    • 79951912532 scopus 로고    scopus 로고
    • Four faces of cellular senescence
    • Rodier F, Campisi J (2011) Four faces of cellular senescence. J Cell Biol 192: 547-556.
    • (2011) J Cell Biol , vol.192 , pp. 547-556
    • Rodier, F.1    Campisi, J.2
  • 70
    • 84861461464 scopus 로고    scopus 로고
    • Axis of ageing: telomeres, p53 and mitochondria
    • Sahin E, DePinho RA (2012) Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol 13: 397-404.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 397-404
    • Sahin, E.1    DePinho, R.A.2
  • 71
    • 79961170994 scopus 로고    scopus 로고
    • A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
    • Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP (2011) A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 146: 353-358.
    • (2011) Cell , vol.146 , pp. 353-358
    • Salmena, L.1    Poliseno, L.2    Tay, Y.3    Kats, L.4    Pandolfi, P.P.5
  • 73
    • 65749093295 scopus 로고    scopus 로고
    • Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex
    • Sethi P, Lukiw WJ (2009) Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci Lett 459: 100-104.
    • (2009) Neurosci Lett , vol.459 , pp. 100-104
    • Sethi, P.1    Lukiw, W.J.2
  • 74
    • 77956275374 scopus 로고    scopus 로고
    • MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
    • Somel M, Guo S, Fu N, Yan Z, Hu HY, Xu Y, Yuan Y, Ning Z, Hu Y, Menzel C, et al (2010) MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res 20: 1207-1218.
    • (2010) Genome Res , vol.20 , pp. 1207-1218
    • Somel, M.1    Guo, S.2    Fu, N.3    Yan, Z.4    Hu, H.Y.5    Xu, Y.6    Yuan, Y.7    Ning, Z.8    Hu, Y.9    Menzel, C.10
  • 75
    • 82955249843 scopus 로고    scopus 로고
    • Aging-associated cardiovascular changes and their relationship to heart failure
    • Strait JB, Lakatta EG (2012) Aging-associated cardiovascular changes and their relationship to heart failure. Heart Fail Clin 8: 143-164.
    • (2012) Heart Fail Clin , vol.8 , pp. 143-164
    • Strait, J.B.1    Lakatta, E.G.2
  • 76
    • 84861567114 scopus 로고    scopus 로고
    • MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
    • Tabuchi T, Satoh M, Itoh T, Nakamura M (2012) MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression. Clin Sci (Lond) 123: 161-171.
    • (2012) Clin Sci (Lond) , vol.123 , pp. 161-171
    • Tabuchi, T.1    Satoh, M.2    Itoh, T.3    Nakamura, M.4
  • 77
    • 84873287124 scopus 로고    scopus 로고
    • Reduction of type IV collagen by upregulated miR-29 in normal elderly mouse and klothodeficient, senescence-model mouse
    • Takahashi M, Eda A, Fukushima T, Hohjoh H (2012) Reduction of type IV collagen by upregulated miR-29 in normal elderly mouse and klothodeficient, senescence-model mouse. PLoS One 7: e48974.
    • (2012) PLoS One , vol.7
    • Takahashi, M.1    Eda, A.2    Fukushima, T.3    Hohjoh, H.4
  • 78
    • 34250868124 scopus 로고    scopus 로고
    • Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest
    • Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A, Menssen A, Meister G, Hermeking H (2007) Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6: 1586-1593.
    • (2007) Cell Cycle , vol.6 , pp. 1586-1593
    • Tarasov, V.1    Jung, P.2    Verdoodt, B.3    Lodygin, D.4    Epanchintsev, A.5    Menssen, A.6    Meister, G.7    Hermeking, H.8
  • 79
    • 84855244103 scopus 로고    scopus 로고
    • MicroRNA therapeutics in cardiovascular medicine
    • Thum T (2012) MicroRNA therapeutics in cardiovascular medicine. EMBO Mol Med 4: 3-14.
    • (2012) EMBO Mol Med , vol.4 , pp. 3-14
    • Thum, T.1
  • 81
    • 84863762192 scopus 로고    scopus 로고
    • The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche
    • Toledano H, D'Alterio C, Czech B, Levine E, Jones DL (2012) The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche. Nature 485: 605-610.
    • (2012) Nature , vol.485 , pp. 605-610
    • Toledano, H.1    D'Alterio, C.2    Czech, B.3    Levine, E.4    Jones, D.L.5
  • 82
    • 54949146881 scopus 로고    scopus 로고
    • Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging
    • Tzatsos A, Bardeesy N (2008) Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging. Cell Stem Cell 3: 469-470.
    • (2008) Cell Stem Cell , vol.3 , pp. 469-470
    • Tzatsos, A.1    Bardeesy, N.2
  • 83
    • 80053018047 scopus 로고    scopus 로고
    • Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells
    • Tzatsos A, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N (2011) Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells. J Biol Chem 286: 33061-33069.
    • (2011) J Biol Chem , vol.286 , pp. 33061-33069
    • Tzatsos, A.1    Paskaleva, P.2    Lymperi, S.3    Contino, G.4    Stoykova, S.5    Chen, Z.6    Wong, K.K.7    Bardeesy, N.8
  • 86
    • 55449100829 scopus 로고    scopus 로고
    • Toward microRNA-based therapeutics for heart disease: the sense in antisense
    • van Rooij E, Marshall WS, Olson EN (2008) Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ Res 103: 919-928.
    • (2008) Circ Res , vol.103 , pp. 919-928
    • van Rooij, E.1    Marshall, W.S.2    Olson, E.N.3
  • 89
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I, Nelson PT (2008) The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 28: 1213-1223.
    • (2008) J Neurosci , vol.28 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6    Rigoutsos, I.7    Nelson, P.T.8
  • 95
    • 84859942977 scopus 로고    scopus 로고
    • The expression of microRNA and microRNA clusters in the aging heart
    • Zhang X, Azhar G, Wei JY (2012b) The expression of microRNA and microRNA clusters in the aging heart. PLoS One 7: e34688.
    • (2012) PLoS One , vol.7
    • Zhang, X.1    Azhar, G.2    Wei, J.Y.3
  • 96
    • 77953457652 scopus 로고    scopus 로고
    • MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1
    • Zhao T, Li J, Chen AF (2010) MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am J Physiol Endocrinol Metab 299: E110-E116.
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Zhao, T.1    Li, J.2    Chen, A.F.3
  • 98
    • 84863005508 scopus 로고    scopus 로고
    • Autoregulation of microRNA biogenesis by let-7 and Argonaute
    • Zisoulis DG, Kai ZS, Chang RK, Pasquinelli AE (2012) Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature 486: 541-544.
    • (2012) Nature , vol.486 , pp. 541-544
    • Zisoulis, D.G.1    Kai, Z.S.2    Chang, R.K.3    Pasquinelli, A.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.