Less is more - How to avoid polypharmacy?;Weniger ist mehr - Wie Polypharmazie vermeiden?

Praxis

Volumn 102, Issue 1, 2013, Pages 21-27

  Neuner Jehle, S ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Inappropriate medication; Interactions; Less is more; Polypharmacy; Quarternary prevention

Indexed keywords

POLYPHARMACY; REVIEW;

ADVERSE DRUG REACTION REPORTING SYSTEMS; AGED; ALGORITHMS; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; GERIATRICS; HUMANS; INAPPROPRIATE PRESCRIBING; PATIENT ADMISSION;

EID: 84873295418     PISSN: 16618157     EISSN: 16618165     Source Type: Journal    
DOI: 10.1024/1661-8157/a001161     Document Type: Review

References (34)

1. Redberg RL: Less is more. Editorial. Arch Intern Med 2010; 170: 584.
2. Moynihan R, Doust J, Henry D: Preventing overdiagnosis: how to stop harming the healthy. BMJ 2012; 344: e3502.
3. Kuehlein T, et al.: Quartäre Prävention, eine Aufgabe für Hausärzte. PrimaryCare 2010; 10: 350-354.
4. Haefeli W: Polypharmazie. Swiss Med Forum 2011; 47: 847-852.
5. Viktil K, Blix HS, Moger TA, Reikvam A: Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems. Br J Clin Pharmacology 2006; 63: 187-194.
6. Chmiel C, Bhend H, Senn O, Zoller M, Rosemann Th, the FIRE study group: The Fire Project. A milestone for research in primary care in Switzerland. Swiss Med Wkly 2011; 140: w13142.
7. Kaufmann DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA: Recent patterns of medication use in the ambulatory adult populatotion of the United States: The Slone Survey. JAMA 2002; 287: 337-344 and annual report 2006 from the Slone Epidemiology Center at Boston University (www.bu.edu/slone/ slonesurvey/annualrpt/slonesurvey/webreport2006.pdf) (Pubitemid 34251967)
8. Frazier SC: Health outcomes and polypharmacy in elderly individuals: An integrated literature review. J Gerontol Nurs 2005; 31: 4-11.
9. Budnitz DS, Lovegrove MC, Shehab N, Richards CL: Emergency hospitalizations for adverse drug events in older americans. N Engl J Med 2011; 365: 2002-2012.
10. Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW: Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA 2005; 294: 716-724. (Pubitemid 41159291)
11. Tinetti ME, Bogardus ST Jr, Agostini JV: Potential pitfalls of diseasespecific guidelines for patients with multiple conditions. N Engl J Med 2004; 35: 2870-2874.
12. Kraehenbuehl S: Polypharmazie im Alter. Der Informierte Arzt 2012; 4: 34-37.
13. Haefeli WE, Facklam M: Kombinationstherapien und Arzneimittelwechselwirkungen. In Haefeli WE, Seibert-Grafe M, Gleiter CH (Hrsg.). Arzneimittel-Kombinationstherapie (p. 1-12). Sankt Augustin Kommissionsverlag Michael Itschert: 2002. 1-12.
14. Vonbach P, Dubied A, Krähenbühl S, Beer JH: Evaluation of frequently used drug interaction screening programs. Pharm World Sci 2008; 30: 367-374.
15. Schuler J, Dückelmann C, Beindl W, Prinz E, Michalski T, Pichler M: Polypharmacy and inappropriate prescribing in elderly internal-medicine patients in Austria. Wien Klin Wochenschr 2008; 120: 733-741.
16. Kuijpers MA, van Marum RJ, Egberts AC, Jansen PA, OLDY (Old people drugs and dysregulation) study group: Relationship between polypharmacy and underpre scribing. Br J Clin Pharmacology 2008; 65: 130-133.
17. Fick DM, Cooper JW, Wade W, Waller JL, Maclean JR, Beers: Updating the Beers criteria for potentially inappropriate medication use in older adults - results of a US consensus panel of experts. Archives Intern Med 2003; 163: 2716-2724. (Pubitemid 37517412)
18. Holt S, Schmiedl S, Thürmann PA: Potentiell inadäquate Medikation für altere Menschen: Die PRISCUS-Liste. Dtsch Ärztebl Int 2010; 107: 543-551. (Ausführliche Liste unter www.priscus.net einsehbar)
19. Müller CA, Wilm S, Thürmann PA, et al.: Die RIME-Studie - eine clusterrandomisierte kontrollierte Studie zur Reduktion von potentiell inadäquater Medikation in der Hausarztpraxis - Studienprotokoll. In 45. Kongress für Allgemeinmedizin und Familienmedizin, Forum Medizin 21, Salzburg 2011. www.egms.de/dynamic/de/meetings/fom2011; Symposium IIIb anwählen.
20. Sönnichsen A, Mann E, Flamm M, et al.: Polypharmacy: reduction of inappropriate medication and adverse drug events in older patients: a randomized controlled trial - study protocol of the PRIMA-study. In 45. Kongress für Allgemeinmedizin und Familienmedizin, Forum Medizin 21, Salzburg 2011. www.egms.de/dynamic/de/meetings/fom2011; Symposium IIIb anwählen.
21. Barry PJ, Gallagher P, Ryan C, O'mahony D: START (screening tool to alert doctors to the right treatment) - an evidence-based screening tool to detect prescribing omissions in elderly patients. Age Ageing 2007; 36: 632-638 (Pubitemid 350258972)
22. Gallagher P, Ryan C, Byrne S, Kennedy J, O'mahony D: STOPP (Screening tool of older person's prescriptions) and START (screening tool to alert doctors to right treatment). Consensus validation. Int J Clin Pharm Therapy 2008; 46: 72-83. (Pubitemid 351233792)
23. Hanlon JT, Weinberger M, Samsa GP, et al.: A randomised, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy. Am J Med 1996; 100: 428-437. (Pubitemid 26115198)
24. Garfinkel D, Mangin D: Feasability study of a systematic approach for discontinuation of multiple medications in older adults. Arch Intern Med 2010; 170: 1648-1654.
25. Patterson SM, Hughes C, Kerse N, Cardwell CR, Bradley MC: Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev 2012; 5: CD008165.
26. Bergman A, Olsson J, Carlsten A, Waern M, Fastbom J: Evaluation of the quality of drug therapy among elderly patients in nursing homes. Scand J Prim Health Care 2007; 25: 9-14.
27. Tamblyn RM, McLeod PJ, Abrahamowicz M, Laprise R: Do too many cooks spoil the broth? Multiple physician involvement in medical managment of elderly patients with potentially inappropriate drug combinations. CMAJ 1996; 154: 1177-1184. (Pubitemid 26143694)
28. Laroche ML, Charmes JP, Nouaille Y, Picard N, Merle L: Is inappropriate medication use a major cause of adverse drug reactions in the elderly? Br J Clin Pharmacol 2007; 63: 177-186. (Pubitemid 46072104)
29. Holland R, Desborough J, Goodyer L, Hall S, Wright D, Loke YK: Does pharmacist-led medication review help to reduce hospital admissions and deaths in older people? A systematic review and metaanalysis. Brit J Clin Pharmacology 2007; 65: 303-316. (Pubitemid 351316922)
30. Schmader KE, Hanlon JT, Pieper CF, et al.: Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am J Med 2004; 116: 394-401. (Pubitemid 38299484)
31. Spinewine A, Schmader KE, Barber N, et al.: Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet 2007; 370: 173-184. (Pubitemid 47049724)
32. Schulin J, Gebben H, Veehof LJ, Haaijer-Ruskamp FM: Deprescribing medication in very elderly patients with multimorbidity: the view of Dutch GPs. A qualitative study. BMC Fam Pract 2012; 13: 56.
33. Holmes HM, Hayley DC, Alexander GC, Sachs GA: Reconsidering medication appropriateness for patients late in life. Arch Intern Med 2006; 166: 605-609.
34. Fried TR, Tinetti ME, Agostini J, Iannone L, Towle V: Health outcome priorization to elicit preference of older persons with multiple health conditions. Patient Educ Couns 2011; 83: 278-282.