Enhanced expression of sulfatide, a sulfated glycolipid, in well-differentiated endometrial adenocarcinoma

International Journal of Gynecological Cancer

Volumn 22, Issue 7, 2012, Pages 1192-1197

  Sugiyama, Taro ^a   Miyazawa, Masaki ^a   Mikami, Mikio ^a   Goto, Yumiko ^a   Nishijima, Yoshihiro ^a   Ikeda, Masae ^a   Hirasawa, Takeshi ^a   Muramatsu, Toshinari ^a   Takekoshi, Susumu ^a   Iwamori, Masao ^b  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY   (Japan)

Author keywords

Carbohydrate sulfation; Endometrioid adenocarcinoma; Glandular differentiation; Sulfatide; Tumor grade

Indexed keywords

CERAMIDE; CHOLESTEROL; CHOLESTEROL ESTER; CHOLESTEROL SULFATE; GALACTOSYLCERAMIDE; GANGLIOSIDE GM3; GLYCOLIPID; GLYCOSYLTRANSFERASE; MESSENGER RNA; PHOSPHOLIPID; SULFATIDE; GALACTOSYLCERAMIDE SULFOTRANSFERASE; SULFOTRANSFERASE;

CLINICAL ARTICLE; CONFERENCE PAPER; ENDOMETRIUM CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPID COMPOSITION; LIPOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THIN LAYER CHROMATOGRAPHY; ADENOCARCINOMA; ARTICLE; CANCER GRADING; CELL DIFFERENTIATION; ENDOMETRIUM TUMOR; ENZYME IMMUNOASSAY; GENETICS; METABOLISM; PATHOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION;

ADENOCARCINOMA; CELL DIFFERENTIATION; CHROMATOGRAPHY, THIN LAYER; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; NEOPLASM GRADING; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFOGLYCOSPHINGOLIPIDS; SULFOTRANSFERASES;

EID: 84873261679     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e31825f639f     Document Type: Conference Paper

References (11)

1. Honke K, Hirahara Y, Dupree J, et al. Paranodal junction formation and spermatogenesis require sulfoglycolipids. Proc Natl Acad Sci U S A. 2002;99:4227-4232.
2. Ishibashi T, Dupree JL, Ikenaka K, et al. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J Neurosci. 2002;22:6507-6514.
3. Kubushiro K, Kojima K, Mikami M, et al. Menstrual cycle-associated alteration of sulfogalactosylceramide in human uterine endometrium: possible induction of glycolipid sulfation by sex steroid hormones. Arch Biochem Biophys. 1989;268:129-136.
4. Kiguchi K, Takamastu K, Tanaka J, et al. Glycosphingoplipids of various human ovarian tumors: a significantly high expression of I 3 SO3 GalCer and Lewis antigen in mucinous cyst adenocarcinoma. Cancer Res. 1992;52:416-421.
5. Kubushiro K, Tsukazaki K, Tanaka J, et al. Human uterine endometrial adenocarcinoma: characteristic acquirement of synthetic potentials for II 3 SO3-LacCer and Ganglio series sulfoglycosphingolipids after transfer of the cancer cells to culture. Cancer Res. 1992;52:803-809.
6. Mikami M, Harasawa M, Sugiyama T, et al. Induction of the differentiation of cultured endometrial carcinoma cells by type I collagen: relevance of sulfolipids. Oncol Lett. 2010;1:113-117.
7. Kiguchi K, Iwamori Y, Suzuki N. Characteristic expression of globotriaosyl ceramide in human ovarian carcinoma-derived cells with anticancer drug resistance. Cancer Sci. 2006;97:1321-1326.
8. Takehara K, Kubushiro K, Kiguchi K, et al. Expression of glycolipids bearing Lewis phenotypes in tissues and cultured cells of human gynecological cancers. Jpn J Cancer Res. 2002;93:1129-1137.
9. 3GalCer and Lewis antigen in mucinous cystadenocarcinoma. Cancer Res. 1992;52:416-421.
10. Osawa H, Sugano K, Igari T, et al. Immunohistochemical study of sulfatide expression in gastric carcinoma: alteration of sulfatide expression. J Clin Gastroenterol. 1997;25:S135-S140.
11. Ushijima K, Yahata H, Yoshikawa H, et al. Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol. 2007;25:2798-2803