Toxic response of zinc oxide nanoparticles in human epidermal keratinocyte HaCaT cells

Toxicology and Environmental Health Sciences

Volumn 4, Issue 1, 2012, Pages 14-18

  Lee, Seung Ho ^a,b   Lee, Hee Ra ^a   Kim, Yu Ri ^a,b   Kim, Meyoung Kon ^a,b  

^a Korea University College of Medicine   (South Korea)

^b The Environmental Health Center for Asthma   (United States)

Author keywords

Cytotoxicity; Oxidative stress; Reactive oxygen species; Zinc oxide nanoparticle

Indexed keywords

NANOPARTICLE; REACTIVE OXYGEN METABOLITE; ZINC OXIDE;

ARTICLE; CELL CULTURE; CELL DAMAGE; CELL MEMBRANE; CELL STRUCTURE; CELL VIABILITY; CYTOTOXICITY; HUMAN; HUMAN CELL; KERATINOCYTE; LIGHT SCATTERING; LIPID PEROXIDATION; MITOCHONDRION; OXIDATIVE STRESS; PARTICLE SIZE; TOXICOLOGY; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84873256743     PISSN: 20059752     EISSN: 22337784     Source Type: Journal    
DOI: 10.1007/s13530-012-0112-y     Document Type: Article

References (22)

1. Yousaf, A. S. & Ali, S. Why Nanoscience and nanotechnology? What is there for us? J. of Faculty of Eng. & Technol. 5, 11-20 (2008).
2. Burnett, M. E. & Wang, S. Q. Current sunscreen controversies: a critical review. Photodermatol. Photoimmunol. Photomed. 27, 58-67 (2011).
3. Nohynek, G. J., Dufour, E. K. & Roberts. M. S. Nanotechnology, cosmetics and the skin: is there a health risk? Skin Pharmacol. Physiol. 21, 136-149 (2008).
4. Nohynek, G. J. et al. Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety. Crit. Rev. Toxicol. 37, 251-277 (2007).
5. Brian, G. et al. Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin. Toxicol. Sciences118, 140-149 (2010).
6. Yang, H., Liu, C., Yang, D., Zhang, H. & Xi, Z. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J. Appl. Toxicol. 29, 69-78 (2009).
7. Huang, Z. et al. Toxicological effect of ZnO nanoparticles based on bacteria. Langmuir24, 4140-4144 (2008).
8. 2 to a freshwater microalga (Pseudokirchneriella subcapitata): the importance of particle solubility. Environ. Sci. Technol. 41, 8484-8490 (2007).
9. Zhu, X. et al. Comparative toxicity of several metal oxide nanoparticle aqueous suspensions to Zebrafish (Danio rerio) early developmental stage. J. Environ. Sci. Health A Toxicol. 43, 278-284 (2008).
10. Barbara, D. B. et al. Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells. Toxicol. Appl. Pharmacol. 246, 116-127 (2010).
11. Xiaoyong, D. et al. Nanosized zinc oxide particles induce neural stem cell apoptosis. Nanotechnology20, 111-118 (2009).
12. Maqusood, A. et al. ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress. Nanomedicine7, 904-917 (2011).
13. Wang, F. et al. Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells. Toxicol. In Vitro23, 808-815 (2009).
14. Akhtar, M. J. et al. The primary role of iron-mediated lipid peroxidation in the differential cytotoxicity caused by two varieties of talc nanoparticles on A549 cells and lipid peroxidation inhibitory effect exerted by ascorbic acid. Toxicol. In Vitro24, 1139-1147 (2010).
15. Yu, L. P., Fang, T., Xiong, D. W., Zhu, W. T. & Sima, X. F. Comparative toxicity of nano-ZnO and bulk ZnO suspensions to zebrafish and the effects of sedimentation, ·OH production and particle dissolution in distilled water. Epub. 13, 1975-1982 (2011).
16. Peter, B. et al. Optimized dispersion of nanoparticles for biological in vitro and in vivo studies. Particle and Fibre Toxicol. 5, 111-114 (2008).
17. Ludwig, K. et al. Oxide nanoparticle uptake in human lung fibroblasts: Effects of particles size, agglomeration, and diffusion at low concentrations. Environ. Sci. 39, 9370-9376 (2005).
18. Saito, H., Koyasu, J., Shigeoka, T. & Tomita, I. Cytotoxicity of chlorophenols to goldfish GFS cells with the MTT and LDH assays. Toxicol. In Vitro8, 1107-1112 (1994).
19. Ozben, T. Oxidative stress and apoptosis. J. Pharm. Sci. 96, 2181-2196 (2007).
20. Xia, T. et al. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano2, 2121-2134 (2008).
21. Akhtar, M. J. et al. Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells. Toxicology276, 95-102 (2010).
22. Berardis, B. D. et al. Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells. Toxicol. Appl. Pharmacol. 246, 116-127 (2010).