Skin absorption potential of ZnO nanoparticles

Toxicology and Environmental Health Sciences

Volumn 3, Issue 4, 2011, Pages 258-261

  Kim, Sun Yae ^a   Jeong, Sang Hoon ^a   Lee, Eun Young ^a   Park, Yoon Hee ^a   Bae, Hyun Cheol ^a   Jang, Yeon Sue ^a   Maeng, Eun Ho ^b   Kim, Meyoung Kon ^a   Son, Sang Wook ^a  

^a Korea University College of Medicine   (South Korea)

^b Korea Testing and Research Institute   (South Korea)

Author keywords

3D EpiDerm model (EPI 200); Absorption; Skin; ZnO

Indexed keywords

NANOPARTICLE; ZINC OXIDE;

ARTICLE; DRUG EXPOSURE; DRUG PENETRATION; EXPERIMENTAL MODEL; HUMAN; HUMAN SKIN EQUIVALENT MODEL; HUMAN TISSUE; IN VITRO STUDY; NANOTECHNOLOGY; PARTICLE SIZE; SKIN ABSORPTION; SURFACE CHARGE; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84873248248     PISSN: 20059752     EISSN: 22337784     Source Type: Journal    
DOI: 10.1007/s13530-011-0100-7     Document Type: Article

References (14)

1. Liu, W. T. Nanoparticles and their biological and environmental applications. J. Biosci. Bioeng. 102, 1-7 (2006).
2. Jain, T. K., Morales, M. A., Sahoo, S. K., Leslie-Pelecky, D. L. & Labhasetwar, V. Iron oxide nanoparticles for sustained delivery of anticancer agents. Mol. Pharm. 2, 194-205 (2005).
3. Nohynek, G. J., Dufour, E. K. & Roberts, M. S. Nanotechnology, cosmetics and the skin: is there a health risk? Skin Pharmacol. Physiol. 21, 136-149 (2008).
4. Nohynek, G. J., Lademann, J., Ribaud, C. & Roberts, M. S. Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety. Crit. Rev. Toxicol. 37, 251-277 (2007).
5. Cross, S. E. et al. Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol. Physiol. 20, 148-154 (2007).
6. Hu, T. et al. Xenobiotic metabolism gene expression in the EpiDerm in vitro 3D human epidermis model compared to human skin. Toxicol. In Vitro. http://www. ncbi. nlm. nih. gov/pubmed/20350595 (2010).
7. Park, Y. H. et al. Assessment of dermal toxicity of nanosilica using cultured keratinocytes, a human skin equivalent model and an in vivo model. Toxicology267, 178-181 (2009).
8. Cross, S. E. et al. Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol. Physiol. 20, 148-154 (2007).
9. Kim, S. et al. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 22, 93-97 (2004).
10. Peters, K., Unger, R. E., Kirkpatrick, C. J., Gatti, A. M. & Monari, E. Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation and inflammation. J. Mater. Sci. Mater. Med. 15, 321-325 (2004).
11. Hu, X., Cook, S., Wang, P. & Hwang, H. M. In vitro evaluation of cytotoxicity of engineered metal oxide nanoparticles. Sci. Total Environ. 407, 3070-3072 (2009).
12. Chen, L., McCrate, J. M., Lee, J. C. & Li, H. The role of surface charge on the uptake andbiocompatibility of hydroxyapatite nanoparticles with osteoblast cells. Nanotechnology22, 105708.
13. Newman, M. D., Stotland, M. & Ellis, J. I. The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens. J. Am. Acad. Dermatol. 61, 685-692, doi: S0190-9622 (09)00539-8 [pii]10. 1016/j. jaad. 2009. 02. 051 (2009).
14. 2 and ZnO nanoparticle percutaneous absorption. Skin Pharmacol. Physiol. 22, 266-275, doi: 000235554 [pii] 10. 1159/000235554 (2009).