Clinicopathologic characteristics and mucin expression in Brunner's gland proliferating lesions

Digestive Diseases and Sciences

Volumn 58, Issue 1, 2013, Pages 194-201

  Kim, Kyungeun ^a   Jang, Se Jin ^b   Song, Ho June ^c   Yu, Eunsil ^b  

^a School of Medicine   (South Korea)

^b University of Ulsan   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

Adenoma; Brunner's glands; Hamartoma; Hyperplasia; Mucins

Indexed keywords

MUCIN; MUCIN 1; MUCIN 2; MUCIN 5AC; MUCIN 6;

ADULT; AGED; ARTICLE; BRUNNER GLAND; BRUNNER GLAND HAMARTOMA; BRUNNER GLAND HYPERPLASIA; BRUNNER GLAND PROLIFERATING LESION; CANCER SUSCEPTIBILITY; CLINICAL ARTICLE; CLINICAL FEATURE; DUODENUM; DUODENUM POLYP; FEMALE; HAMARTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERPLASIA; LESIONS AND DEFECTS; MALE; METAPLASIA; MORPHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; BRUNNER GLANDS; FEMALE; GENE EXPRESSION REGULATION; HAMARTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL NEOPLASMS; MALE; MIDDLE AGED; MUCINS; YOUNG ADULT;

EID: 84873209706     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2320-3     Document Type: Article

References (30)

1. Mills SE. Histology for Pathologists. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2007.
2. Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN, Lantz PE, Isaacson PG. Gastrointestinal Pathology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008.
3. Botsford TW, Crowe P, Crocker DW. Tumors of the small intestine. A review of experience with 115 cases including a report of a rare case of malignant hemangio-endothelioma. Am J Surg. 1962;103:358-365.
4. Osborne R, Toffler R, Lowman RM. Brunner's gland adenoma of the duodenum. Am J Dig Dis. 1973;18:689-694.
5. Levine JA, Burgart LJ, Batts KP, Wang KK. Brunner's gland hamartomas: clinical presentation and pathological features of 27 cases. Am J Gastroenterol. 1995;90:290-294.
6. Chen YY, Su WW, Soon MS, Yen HH. Hemoclip-assisted polypectomy of large duodenal Brunner's gland hamartoma. Dig Dis Sci. 2006;51:1670-1672.
7. Ohba R, Otaka M, Jin M, et al. Large Brunner's gland hyperplasia treated with modified endoscopic submucosal dissection. Dig Dis Sci. 2007;52:170-172.
8. Akino K, Kondo Y, Ueno A, et al. Carcinoma of duodenum arising from Brunner's gland. J Gastroenterol. 2002;37:293-296.
9. Itsuno M, Makiyama K, Omagari K, et al. Carcinoma of duodenal bulb arising from the Brunner's gland. Gastroenterol Jpn. 1993;28:118-125.
10. Kushima R, Stolte M, Dirks K, et al. Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands. Virchows Arch. 2002;440:655-659.
11. Shimizu N, Tanaka S, Morikawa J, et al. Early duodenal cancer of the bulb - report of a case. Gan No Rinsho. 1989;35:100-106.
12. Suzuki T, Ito A, Takayasu H, et al. A case of duodenal Brunner's gland hyperplasia associated with in situ carcinoma. Nippon Shokakibyo Gakkai Zasshi. 1995;92:1189-1193.
13. Patel ND, Levy AD, Mehrotra AK, Sobin LH. Brunner's gland hyperplasia and hamartoma: imaging features with clinicopathologic correlation. AJR Am J Roentgenol. 2006;187:715-722.
14. Giorgadze TA, Peterman H, Baloch ZW, et al. Diagnostic utility of mucin profile in fine-needle aspiration specimens of the pancreas: an immunohistochemical study with surgical pathology correlation. Cancer. 2006;108:186-197.
15. Ho SB, Shekels LL, Toribara NW, et al. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res. 1995;55:2681-2690.
16. Tamada S, Goto M, Nomoto M, et al. Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: its relationship with tumor progression and prognosis. Pathol Int. 2002;52:713-723.
17. Ando H, Aihara R, Ohno T, Ogata K, Mochiki E, Kuwano H. Prognostic significance of the expression of MUC1 and collagen type IV in advanced gastric carcinoma. Br J Surg. 2009;96:901-909.
18. Baldus SE, Monig SP, Huxel S, et al. MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis. Clin Cancer Res. 2004;10:2790-2796.
19. Park SY, Roh SJ, Kim YN, et al. Expression of MUC1, MUC2, MUC5AC and MUC6 in cholangiocarcinoma: prognostic impact. Oncol Rep. 2009;22:649-657.
20. Brookes MJ, Manjunatha S, Allen CA, Cox M. Malignant potential in a Brunner's gland hamartoma. Postgrad Med J. 2003;79:416-417.
21. Faller G, Kirchner T. Low-grade intraepithelial neoplasia of Brunner's gland. Histopathology. 2005;47:118-119.
22. Fujimaki E, Nakamura S, Sugai T, Takeda Y. Brunner's gland adenoma with a focus of p53-positive atypical glands. J Gastroenterol. 2000;35:155-158.
23. Sakurai T, Sakashita H, Honjo G, Kasyu I, Manabe T. Gastric foveolar metaplasia with dysplastic changes in Brunner gland hyperplasia: possible precursor lesions for Brunner gland adenocarcinoma. Am J Surg Pathol. 2005;29:1442-1448.
24. Zanetti G, Casadei G. Brunner's gland hamartoma with incipient ductal malignancy. Report of a case. Tumori. 1981;67:75-78.
25. Fisher JK. Mucocele of a Brunner gland. Radiology. 1980;136:320.
26. Golan J, Dollberg L, Dollberg M, Farkash T, Rivkin L. Cystic hamartoma of Brunner's glands. Int Surg. 1978;63:173-175.
27. Powers M, Sayuk GS, Wang HL. Brunner gland cyst: report of three cases. Int J Clin Exp Pathol. 2008;1:536-538.
28. Taura M, Taura S, Kummerow FA, Noritomi S, Iwanaga S. An ultrastructural study of the Brunner's cyst. Gastroenterol Jpn. 1977;12:241-244.
29. Wolk DP, Knapper WH, Farr GH. Brunner's gland cystadenoma of the duodenum. Am J Surg. 1973;126:439-440.
30. Chang MS, Kim WH, Kim YI. Brunner's gland hamartoma. A clinicopathologic analysis of six cases. Korean J Gastrointest Endosc. 1994;14:19-23.