Pathophysiological model of chronic heart failure complicated with renal failure caused by three-quarter nephrectomy and subcutaneous injection of isoprenaline

Experimental and Therapeutic Medicine

Volumn 5, Issue 3, 2013, Pages 835-839

  Peng, Ding Feng ^a   Tang, Shao Yong ^a   Hu, Yong Jun ^a   Chen, Jiao ^a   Yang, Li ^a  

^a Puai Hospital   (China)

Author keywords

Heart failure; Isoprenaline; Renal failure; Sprague Dawley rats

Indexed keywords

ANGIOTENSIN II; BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CREATININE; FRUCTOSE BISPHOSPHATE ALDOLASE; ISOPRENALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIORENAL SYNDROME; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE MODEL; HEART FAILURE; HEART HEMODYNAMICS; HEART LEFT VENTRICLE FUNCTION; KIDNEY FAILURE; NEPHRECTOMY; NONHUMAN; PROTEIN DETERMINATION; PROTEIN URINE LEVEL; RAT; SYSTOLIC BLOOD PRESSURE; UREA NITROGEN BLOOD LEVEL;

EID: 84873189479     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.865     Document Type: Article

References (20)

1. Balakumar P, Singh AP and Singh M: Rodent models of heart failure. J Pharmacol Toxicol Methods 56: 1-10, 2007.
2. Patten RD and Hall-Porter MR: Small animal models of heart failure: development of novel therapies, past and present. Circ Heart Fail 2: 138-144, 2009.
3. Yang HC, Zuo Y and Fogo AB: Models of chronic kidney disease. Drug Discov Today Dis Models 7: 13-19, 2010.
4. Takeshita D, Shimizu J, Kitagawa Y, et al: Isoproterenol-induced hypertrophied rat hearts: does short-term treatment correspond to long-term treatment? J Physiol Sci 58: 179-188, 2008.
5. Van Dokkum RP, Eijkelkamp WB, Kluppel AC, et al: Myocardial infarction enhances progressive renal damage in an experimental model for cardio-renal interaction. J Am Soc Nephrol 15: 3103-3110, 2004.
6. Dikow R, Schmidt U, Kihm LP, et al: Uremia aggravates left ventricular remodeling after myocardial infarction. Am J Nephrol 32: 13-22, 2010.
7. Windt WA, Henning RH, Kluppel AC, Xu Y, de Zeeuw D and vanDokkum RP: Myocardial infarction does not further impair renal damage in 5/6 nephrectomized rats. Nephrol Dial Transplant 23: 3103-3110, 2008.
8. Amann K, Wiest G, Zimmer G, Gretz N, Ritz E and Mall G: Reduced capillary density in the myocardium of uremic rats-a stereological study. Kidney Int 42: 1079-1085, 1992.
9. Amann K, Tyralla K, Gross ML, et al: Cardiomyocyte loss in experimental renal failure: prevention by ramipril. Kidney Int 63: 1708-1713, 2003.
10. Mall G, Rambausek M, Neumeister A, Kollmar S, Vetterlein F and Ritz E: Myocardial interstitial fibrosis in experimental uremia-implications for cardiac compliance. Kidney Int 33: 804-811, 1988.
11. Tsuruoka S, Nishiki K, Wakaumi M, et al: Chronopharmacology of oxacalcitriol in 5/6 nephrectomized rats. Life Sci 75: 809-822, 2004.
12. Go AS, Chertow GM, Fan D, McCulloch CE and Hsu CY: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351: 1296-1305, 2004.
13. Sarnak MJ, Levey AS, Schoolwerth AC, et al: Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Hypertension 42: 1050-1065, 2003.
14. Wali RK, Wang GS, Gottlieb SS, et al: Effect of kidney transplantation on left ventricular systolic dysfunction and congestive heart failure in patients with end-stage renal disease. J Am Coll Cardiol 45: 1051-1060, 2005.
15. Butler J, Geisberg C, Howser R, et al: Relationship between renal function and left ventricular assist device use. Ann Thorac Surg81: 1745-1751, 2006.
16. Weinfeld MS, Chertow GM and Stevenson LW: Aggravated renal dysfunction during intensive therapy for advanced chronic heart failure. Am Heart J 138: 285-290, 1999.
17. Bongartz LG, Cramer MJ, Doevendans PA, Joles JA and BraamB: The severe cardiorenal syndrome: 'Guyton revisited'. Eur Heart J 26: 11-17, 2005.
18. Ronco C, Haapio M, House AA, Anavekar N and Bellomo R: Cardiorenal syndrome. J Am Coll Cardiol 52: 1527-1539, 2008.
19. Bongartz LG, Braam B, Verhaar MC, et al: Transient nitric oxide reduction induces permanent cardiac systolic dysfunction and worsens kidney damage in rats with chronic kidney disease. Am J Physiol Regul Integr Comp Physiol 298: R815-R823, 2010.
20. Rajaram V and Joseph J: Role of adenosine antagonism in the cardio-renal syndrome: pathophysiology and therapeutic potential. Curr Heart Fail Rep 4: 153-157, 2007.