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Volumn 58, Issue 1, 2013, Pages 275-281

Clinical and virological characteristics post HBsAg seroclearance in hepatitis B virus carriers with hepatic steatosis versus those without

Author keywords

Body mass index, BMI; HBsAg carriers; HBsAg seroclearance; HBV viremia; Hepatic steatosis; Liver cirrhosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN;

EID: 84873183024     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2343-9     Document Type: Article
Times cited : (62)

References (34)
  • 1
    • 59749096640 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • 19217993 10.1016/S0140-6736(09)60207-5 1:CAS:528:DC%2BD1MXhvFGltLk%3D
    • Liaw YF, Chu CM. Hepatitis B virus infection. Lancet. 2009;373:582-592.
    • (2009) Lancet , vol.373 , pp. 582-592
    • Liaw, Y.F.1    Chu, C.M.2
  • 2
    • 0036614299 scopus 로고    scopus 로고
    • Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B
    • 12029639 10.1053/jhep.2002.33638
    • Hsu YS, Chien RN, Yeh CT, et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology. 2002;35:1522-1527.
    • (2002) Hepatology , vol.35 , pp. 1522-1527
    • Hsu, Y.S.1    Chien, R.N.2    Yeh, C.T.3
  • 3
    • 2642580655 scopus 로고    scopus 로고
    • Natural history of hepatitis be antigen to antibody seroconversion in patients with normal serum aminotransferase levels
    • 15178498 10.1016/j.amjmed.2003.12.040 1:CAS:528:DC%2BD2cXkslWltLs%3D
    • Chu CM, Hung SJ, Lin J, Tai DI, Liaw YF. Natural history of hepatitis be antigen to antibody seroconversion in patients with normal serum aminotransferase levels. Am J Med. 2004;116:829-834.
    • (2004) Am J Med , vol.116 , pp. 829-834
    • Chu, C.M.1    Hung, S.J.2    Lin, J.3    Tai, D.I.4    Liaw, Y.F.5
  • 4
    • 0025753470 scopus 로고
    • Incidence, determinants and significance of delayed clearance of serum HBsAg in chronic hepatitis B virus infection: A prospective study
    • 2010157 10.1002/hep.1840130403 1:STN:280:DyaK3M7osVOisA%3D%3D
    • Liaw YF, Sheen IS, Chen TJ, Chu CM, Pao CC. Incidence, determinants and significance of delayed clearance of serum HBsAg in chronic hepatitis B virus infection: a prospective study. Hepatology. 1991;13:627-631.
    • (1991) Hepatology , vol.13 , pp. 627-631
    • Liaw, Y.F.1    Sheen, I.S.2    Chen, T.J.3    Chu, C.M.4    Pao, C.C.5
  • 5
    • 34248679355 scopus 로고    scopus 로고
    • HBsAg seroclearance in asymptomatic carriers of high endemic areas: Appreciably high rates during a long-term follow-up
    • 17465003 10.1002/hep.21612
    • Chu CM, Liaw YF. HBsAg seroclearance in asymptomatic carriers of high endemic areas: appreciably high rates during a long-term follow-up. Hepatology. 2007;45:1187-1192.
    • (2007) Hepatology , vol.45 , pp. 1187-1192
    • Chu, C.M.1    Liaw, Y.F.2
  • 6
    • 77950684115 scopus 로고    scopus 로고
    • Hepatitis B surface antigen seroclearance during chronic HBV infection
    • 20386068 10.3851/IMP1497
    • Chu CM, Liaw YF. Hepatitis B surface antigen seroclearance during chronic HBV infection. Antivir Ther. 2010;15:133-143.
    • (2010) Antivir Ther , vol.15 , pp. 133-143
    • Chu, C.M.1    Liaw, Y.F.2
  • 7
    • 34247521476 scopus 로고    scopus 로고
    • Does increased body mass index with hepatic steatosis contribute to seroclearance of hepatitis B virus (HBV) surface antigen in chronic HBV infection?
    • Chu CM, Lin DY, Liaw YF. Does increased body mass index with hepatic steatosis contribute to seroclearance of hepatitis B virus (HBV) surface antigen in chronic HBV infection? Int J Obes (Lond). 2007;31:871-875.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 871-875
    • Chu, C.M.1    Lin, D.Y.2    Liaw, Y.F.3
  • 8
    • 77955483993 scopus 로고    scopus 로고
    • Incidence and determinants of spontaneous Hepatitis B surface antigen seroclearance: A community-based follow-up study
    • 20434450 10.1053/j.gastro.2010.04.048
    • Liu J, Yang HI, Lee MH, et al. Incidence and determinants of spontaneous Hepatitis B surface antigen seroclearance: a community-based follow-up study. Gastroenterology. 2010;139:474-482.
    • (2010) Gastroenterology , vol.139 , pp. 474-482
    • Liu, J.1    Yang, H.I.2    Lee, M.H.3
  • 9
    • 80052386721 scopus 로고    scopus 로고
    • Hepatic steatosis in hepatitis B virus infected patients: Meta-analysis of risk factors and comparison with hepatitis C infected patients
    • 21649726
    • Machado MV, Oliveira AG, Cortez-Pinto H. Hepatic steatosis in hepatitis B virus infected patients: meta-analysis of risk factors and comparison with hepatitis C infected patients. J Gastroenterol Hepatol. 2011;26:1361-1367.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 1361-1367
    • MacHado, M.V.1    Oliveira, A.G.2    Cortez-Pinto, H.3
  • 10
    • 0036789020 scopus 로고    scopus 로고
    • Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection
    • 12360470 10.1053/gast.2002.36026
    • Chen YC, Sheen IS, Chu CM, Liaw YF. Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection. Gastroenterology. 2002;123:1084-1089.
    • (2002) Gastroenterology , vol.123 , pp. 1084-1089
    • Chen, Y.C.1    Sheen, I.S.2    Chu, C.M.3    Liaw, Y.F.4
  • 11
    • 11144305028 scopus 로고    scopus 로고
    • NASH: A hidden and silent fibroser finally revealed
    • 10.1016/j.jhep.2004.11.027
    • Ratziu V, Poynard T. NASH: a hidden and silent fibroser finally revealed. J Hepatol. 2005;42:132-138.
    • (2005) J Hepatol , vol.42 , pp. 132-138
    • Ratziu, V.1    Poynard, T.2
  • 12
    • 0012525113 scopus 로고
    • Clinical significance of ultrasonographical fatty live in asymptomatics: Analysis of 1040 check-up subjects
    • Lin DY, Sheen IS, Chiu CT, Lin SM, Kuo YC, Liaw YF. Clinical significance of ultrasonographical fatty live in asymptomatics: analysis of 1040 check-up subjects. J Med Ultrasound. 1993;1:165-171.
    • (1993) J Med Ultrasound , vol.1 , pp. 165-171
    • Lin, D.Y.1    Sheen, I.S.2    Chiu, C.T.3    Lin, S.M.4    Kuo, Y.C.5    Liaw, Y.F.6
  • 13
    • 0022645750 scopus 로고
    • Ultrasound scanning in the detection of hepatic fibrosis and steatosis
    • 10.1136/bmj.292.6512.13
    • Saverymittu SH, Joseph AEA, Maewell MD. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. BMJ. 1986;292:13-15.
    • (1986) BMJ , vol.292 , pp. 13-15
    • Saverymittu, S.H.1    Joseph, A.E.A.2    Maewell, M.D.3
  • 14
    • 0027173707 scopus 로고
    • Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: A longitudinal study
    • 8514896 10.1002/jcu.1870210502 1:STN:280:DyaK3s3psVSgtg%3D%3D
    • Lin DY, Sheen IS, Chiu CT, Lin SM, Kuo YC, Liaw YF. Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: a longitudinal study. J Clin Ultrasound. 1993;21:303-308.
    • (1993) J Clin Ultrasound , vol.21 , pp. 303-308
    • Lin, D.Y.1    Sheen, I.S.2    Chiu, C.T.3    Lin, S.M.4    Kuo, Y.C.5    Liaw, Y.F.6
  • 15
    • 33644637514 scopus 로고    scopus 로고
    • Fully automated quantitation of hepatitis B virus (HBV) DNA in human plasma by the COBAS AmpliPrep/COBAS TaqMan System
    • 16461000 10.1016/j.jcv.2006.01.003 1:CAS:528:DC%2BD28XitVGitb4%3D
    • Hochberger S, Althof D, de Schrott G, Nachbaur N, Rock H, Leying H. Fully automated quantitation of hepatitis B virus (HBV) DNA in human plasma by the COBAS AmpliPrep/COBAS TaqMan System. J Clin Virol. 2006;35:373-380.
    • (2006) J Clin Virol , vol.35 , pp. 373-380
    • Hochberger, S.1    Althof, D.2    De Schrott, G.3    Nachbaur, N.4    Rock, H.5    Leying, H.6
  • 16
    • 0021075388 scopus 로고
    • Sex difference in chronic hepatitis B virus infection: An appraisal based on the status of hepatitis B e antigen and antibody
    • 6313507 10.1002/hep.1840030611 1:STN:280:DyaL2c%2FjtVCrtg%3D%3D
    • Chu CM, Liaw YF, Sheen IS, Kin DY, Huang MJ. Sex difference in chronic hepatitis B virus infection: an appraisal based on the status of hepatitis B e antigen and antibody. Hepatology. 1983;3:947-950.
    • (1983) Hepatology , vol.3 , pp. 947-950
    • Chu, C.M.1    Liaw, Y.F.2    Sheen, I.S.3    Kin, D.Y.4    Huang, M.J.5
  • 17
    • 0027245407 scopus 로고
    • Sex difference in chronic hepatitis B virus infection: Studies of serum HBeAg and alanine aminotransferase levels in 10,431 asymptomatic Chinese HBsAg carriers
    • 8507764 10.1093/clind/16.5.709 1:STN:280:DyaK3s3otlGlsg%3D%3D
    • Chu CM, Sheen IS, Lin SM, Liaw YF. Sex difference in chronic hepatitis B virus infection: studies of serum HBeAg and alanine aminotransferase levels in 10,431 asymptomatic Chinese HBsAg carriers. Clin Infect Dis. 1993;16:709-713.
    • (1993) Clin Infect Dis , vol.16 , pp. 709-713
    • Chu, C.M.1    Sheen, I.S.2    Lin, S.M.3    Liaw, Y.F.4
  • 18
    • 33748502537 scopus 로고    scopus 로고
    • Prevalence of obesity and metabolic syndrome in Taiwan
    • 16935763 10.1016/S0929-6646(09)60161-3
    • Hwang LC, Bai CH, Chen CJ. Prevalence of obesity and metabolic syndrome in Taiwan. J Formos Med Assoc. 2006;105:626-635.
    • (2006) J Formos Med Assoc , vol.105 , pp. 626-635
    • Hwang, L.C.1    Bai, C.H.2    Chen, C.J.3
  • 19
    • 42449096428 scopus 로고    scopus 로고
    • Obesity and its related diseases in Taiwan
    • 18307696 10.1111/j.1467-789X.2007.00435.x
    • Huang KC. Obesity and its related diseases in Taiwan. Obes Rev. 2008;9:32-34.
    • (2008) Obes Rev , vol.9 , pp. 32-34
    • Huang, K.C.1
  • 20
    • 79956057442 scopus 로고    scopus 로고
    • Risk factors and predictors of non-alcoholic fatty liver disease in Taiwan
    • 21502673
    • Lin YC, Chou SC, Huang PT, Chiou HY. Risk factors and predictors of non-alcoholic fatty liver disease in Taiwan. Ann Hepatol. 2011;10:125-132.
    • (2011) Ann Hepatol , vol.10 , pp. 125-132
    • Lin, Y.C.1    Chou, S.C.2    Huang, P.T.3    Chiou, H.Y.4
  • 21
    • 43949084684 scopus 로고    scopus 로고
    • The "metabolovirus" model of hepatitis B virus nutritional therapy as an effective anti-viral weapon
    • 10.1016/j.mehy.2007.08.032
    • Shlomai A, Shaul Y. The "metabolovirus" model of hepatitis B virus nutritional therapy as an effective anti-viral weapon. Med Hypothesis. 2008;71:53-57.
    • (2008) Med Hypothesis , vol.71 , pp. 53-57
    • Shlomai, A.1    Shaul, Y.2
  • 22
    • 79551569966 scopus 로고    scopus 로고
    • Hepatocyte metabolic signaling pathways and regulation of hepatitis B virus expression
    • 10.1111/j.1478-3231.2010.02423.x
    • Bar-Yishay I, Shaul Y, Shlomai A. Hepatocyte metabolic signaling pathways and regulation of hepatitis B virus expression. Liver Int. 2011;31:285-290.
    • (2011) Liver Int , vol.31 , pp. 285-290
    • Bar-Yishay, I.1    Shaul, Y.2    Shlomai, A.3
  • 23
    • 73349125811 scopus 로고    scopus 로고
    • Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion
    • 19733654 10.1016/j.bbadis.2009.08.015 1:CAS:528:DC%2BD1MXht1ylur3L
    • Pettinelli P, Del Pozo T, Araya J, et al. Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion. Biochim Biophys Acta. 2009;1792:1080-1086.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 1080-1086
    • Pettinelli, P.1    Del Pozo, T.2    Araya, J.3
  • 24
    • 0032944066 scopus 로고    scopus 로고
    • Hepatitis B surface antigen disappearance and hepatitis B surface antigen subtype: A prospective, long-term, follow-up study of Japanese residents of Okinawa, Japan with chronic hepatitis B virus infection
    • 10348237 1:STN:280:DyaK1M3nsF2qsQ%3D%3D
    • Furusyo N, Hayashi J, Sawayama Y, Kishihara Y, Kashiwagi S. Hepatitis B surface antigen disappearance and hepatitis B surface antigen subtype: a prospective, long-term, follow-up study of Japanese residents of Okinawa, Japan with chronic hepatitis B virus infection. Am J Trop Med Hyg. 1999;60:616-622.
    • (1999) Am J Trop Med Hyg , vol.60 , pp. 616-622
    • Furusyo, N.1    Hayashi, J.2    Sawayama, Y.3    Kishihara, Y.4    Kashiwagi, S.5
  • 25
    • 4444251430 scopus 로고    scopus 로고
    • Natural history of chronic HBV carriers in northern Italy: Morbidity and mortality after 30 years
    • 15362032 10.1053/j.gastro.2004.06.021
    • Manno M, Cammà C, Schepis F, et al. Natural history of chronic HBV carriers in northern Italy: morbidity and mortality after 30 years. Gastroenterology. 2004;127:756-763.
    • (2004) Gastroenterology , vol.127 , pp. 756-763
    • Manno, M.1    Cammà, C.2    Schepis, F.3
  • 26
    • 19944434258 scopus 로고    scopus 로고
    • Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance
    • 15664243 10.1016/j.jhep.2004.10.026 1:CAS:528:DC%2BD2MXmvFSqtQ%3D%3D
    • Ahn SH, Park YN, Park JY, Chang HY, et al. Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance. J Hepatol. 2005;42:188-194.
    • (2005) J Hepatol , vol.42 , pp. 188-194
    • Ahn, S.H.1    Park, Y.N.2    Park, J.Y.3    Chang, H.Y.4
  • 27
    • 53049107213 scopus 로고    scopus 로고
    • HBsAg Seroclearance in chronic hepatitis B in Asian patients: Replicative level and risk of hepatocellular carcinoma
    • 18722377 10.1053/j.gastro.2008.07.008 1:CAS:528:DC%2BD1cXht12lurrP
    • Yuen MF, Wong DK, Fung J, et al. HBsAg Seroclearance in chronic hepatitis B in Asian patients: replicative level and risk of hepatocellular carcinoma. Gastroenterology. 2008;135:1192-1199.
    • (2008) Gastroenterology , vol.135 , pp. 1192-1199
    • Yuen, M.F.1    Wong, D.K.2    Fung, J.3
  • 28
    • 0030858894 scopus 로고    scopus 로고
    • Persistence of hepatitis B virus DNA in serum and liver from patients with chronic hepatitis B after loss of HBsAg
    • 9288597 10.1016/S0168-8278(97)80168-7 1:CAS:528:DyaK2sXlvFars7k%3D
    • Loriot MA, Marcellin P, Walker F, et al. Persistence of hepatitis B virus DNA in serum and liver from patients with chronic hepatitis B after loss of HBsAg. J Hepatol. 1997;27:251-258.
    • (1997) J Hepatol , vol.27 , pp. 251-258
    • Loriot, M.A.1    Marcellin, P.2    Walker, F.3
  • 29
    • 30944449596 scopus 로고    scopus 로고
    • Long-term outcome after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B
    • 10.1016/j.amjmed.2005.02.033
    • Arase Y, Ikeda K, Suzuki F, et al. Long-term outcome after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B. Am J Med. 2006;119:71.e9-71.e16.
    • (2006) Am J Med , vol.119
    • Arase, Y.1    Ikeda, K.2    Suzuki, F.3
  • 30
    • 34247173078 scopus 로고    scopus 로고
    • Long-term presence of HBV in the sera of chronic hepatitis B patients with HBsAg seroclearance
    • 17259734 10.1159/000098958 1:CAS:528:DC%2BD2sXktFOntbw%3D
    • Arase Y, Suzuki F, Suzuki Y, et al. Long-term presence of HBV in the sera of chronic hepatitis B patients with HBsAg seroclearance. Intervirology. 2007;50:161-165.
    • (2007) Intervirology , vol.50 , pp. 161-165
    • Arase, Y.1    Suzuki, F.2    Suzuki, Y.3
  • 31
    • 84555209282 scopus 로고    scopus 로고
    • Prevalence of and risk factor for hepatitis B viremia after spontaneous hepatitis B surface antigen seroclearance in hepatitis B carriers
    • 22052888 10.1093/cid/cir755 1:CAS:528:DC%2BC3MXhs12gsrzN
    • Chu CM, Liaw YF. Prevalence of and risk factor for hepatitis B viremia after spontaneous hepatitis B surface antigen seroclearance in hepatitis B carriers. Clin Infect Dis. 2012;54:88-90.
    • (2012) Clin Infect Dis , vol.54 , pp. 88-90
    • Chu, C.M.1    Liaw, Y.F.2
  • 32
    • 58249083392 scopus 로고    scopus 로고
    • Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B
    • 18832522 10.1136/gut.2008.157735
    • Wong GL, Wong VW, Choi PC, et al. Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B. Gut. 2009;58:111-117.
    • (2009) Gut , vol.58 , pp. 111-117
    • Wong, G.L.1    Wong, V.W.2    Choi, P.C.3
  • 33
    • 57149086471 scopus 로고    scopus 로고
    • Body-mass index and progression of hepatitis B: A population-based cohort study in men
    • 18955457 10.1200/JCO.2008.16.1075
    • Yu MW, Shih WL, Lin CL, et al. Body-mass index and progression of hepatitis B: a population-based cohort study in men. J Clin Oncol. 2008;26:5576-5582.
    • (2008) J Clin Oncol , vol.26 , pp. 5576-5582
    • Yu, M.W.1    Shih, W.L.2    Lin, C.L.3
  • 34
    • 42949107039 scopus 로고    scopus 로고
    • Virologic and histogic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT
    • 18471514 10.1053/j.gastro.2008.02.075
    • Kumar M, Sarin SK, Hissar S, et al. Virologic and histogic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT. Gastroenterology. 2008;134:1376-1384.
    • (2008) Gastroenterology , vol.134 , pp. 1376-1384
    • Kumar, M.1    Sarin, S.K.2    Hissar, S.3


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