Celecoxib downregulates CD133 expression through inhibition of the Wnt signaling pathway in colon cancer cells

Cancer Investigation

Volumn 31, Issue 2, 2013, Pages 97-102

  Deng, Yanhong ^a   Su, Qiao ^a   Mo, Jianwen ^a   Fu, Xinhui ^a   Zhang, Yan ^a   Lin, Edward H ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

CD133; Celecoxib; Colon cancer; Wnt

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 5; CD133 ANTIGEN; CELECOXIB; CHEMOKINE RECEPTOR CXCR4; CYCLIN DEPENDENT KINASE 2; GROWTH DIFFERENTIATION FACTOR; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; UNCLASSIFIED DRUG; WNT PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; CANCER INHIBITION; CELL DIFFERENTIATION; COLON CANCER; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN ISOLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANTIGENS, CD; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HT29 CELLS; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; PYRAZOLES; RNA, MESSENGER; SULFONAMIDES; WNT SIGNALING PATHWAY;

EID: 84873181649     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357907.2012.754458     Document Type: Article

References (16)

1. O'Brien CA, Pollett A,Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficientmice. Nature 2007;445(7123):106-110. (Pubitemid 46067310)
2. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R. Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445(7123):111-115. (Pubitemid 46067311)
3. Yanhong Deng, Meijing Huang, Jianping Wang, Tongyu Lin, Jian Xiao, Yonghua Cai, EdwardHLin. 5-Fluorouracil up regulates the stemness markerCD133 expression in colon cancer cells. Chinese J Pathophysiol 2009;25(11):2187-2191.
4. Fevr T, Robine S, Louvard D, Huelsken J.Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol 2007;27(21):7551-7559. (Pubitemid 350033660)
5. Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008;8(5):387-398. (Pubitemid 351589714)
6. Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 2009;457(7229):603-607.
7. Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, Su LK, Levin B. The effect of celecoxib, a cyclooxygenase- 2 inhibitor, in familial adenomatouspolyposis. N Engl J Med 2000;342(26):1946-1952.
8. Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, AndersonWF, Zauber A, Hawk E, BertagnolliM. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. 2005;352:1071-1080.
9. Gr?osch S,Maier TJ, Schiffmann S,Geisslinger G. Cyclooxygenase- 2(COX-2)-independent anticarcinogenic effects of selective COX- 2 inhibitors. 2006;98:736-747.
10. Deng YH, Pu XX, Huang MJ, Xiao Jian, Zhou Jiaming, Tongyu Lin, Edward H Lin. 5-Fluorouracil upregulates the activity ofWnt signaling pathway inCD133-positive colon cancer stem-like cells. Chin J Cancer 2010;29(9):810-815.
11. Sunayama J, Sato A, Matsuda K, Tachibana K,Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C. FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity. Stem Cells 2011;29(9):1327-1337.
12. Sgambato A, Puglisi MA, Errico F, Rafanelli F, Boninsegna A, Rettino A, Genovese G, Coco C, Gasbarrini A, Cittadini A. Post-translational modulation of CD133 expression during sodium butyrate-induced differentiation of HT29 human colon cancer cells: implications for its detection. J Cell Physiol 2010;224(1):234-241.
13. Haraguchi N, Ohkuma M, Sakashita H. CD133+CD44+ population efficiently enriches colon cancer initiating cells. Ann Surg Oncol 2008;15(10):2927-2933.
14. Lonnroth C, Andersson M, Nordgren S, Lundholm K. Downregulation of prominin 1/CD133 expression in colorectal cancer by NSAIDs following short-term preoperative treatment. Int J Oncol 2012;41(1):15-23.
15. Tuynman JB, Vermeulen L, Boon EM, Kemper K, Zwinderman AH, Peppelenbosch MP, Richel DJ. Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. Cancer Res 2008;68(4):1213-1220. (Pubitemid 351272241)
16. Qi L, Sun B, Liu Z, Li H, Gao J, Leng X. Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression. Cancer Sci 2012;103(4):828-835.