The effect of pimecrolimus on innate immunity in subjects with atopic dermatitis: A double-blind, randomized, vehicle-controlled study

British Journal of Dermatology

Volumn 168, Issue 2, 2013, Pages 426-428

  Afshar, M ^a   Kotol, P ^a   Miller, J ^a   Gallo, R ^a   Hata, T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 3; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 13; PIMECROLIMUS;

ANTIINFLAMMATORY ACTIVITY; ATOPIC DERMATITIS; DRUG EFFECT; HUMAN; INNATE IMMUNITY; LETTER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

DERMATITIS, ATOPIC; DERMATOLOGIC AGENTS; DOUBLE-BLIND METHOD; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-13; RNA, MESSENGER; TACROLIMUS;

EID: 84873158028     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2012.11052.x     Document Type: Letter

References (10)

1. Leung DYM,. Infection in atopic dermatitis. Curr Opin Pediatr 2003; 15: 399-404.
2. Nomura I, Goleva E, Howell MD, et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 2003; 171: 3262-9.
3. Ong PY, Ohtake T, Brandt C, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002; 347: 1151-60.
4. Gupta AK, Chow M,. Pimecrolimus: a review. J Eur Acad Dermatol Venereol 2003; 17: 493-503.
5. Buchau AS, Schauber J, Hultsch T, et al. Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes. J Invest Dermatol 2008; 128: 2646-54.
6. Harder J, Dressel S, Wittersheim M, et al. Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury. J Invest Dermatol 2010; 130: 1355-64.
7. Aberg KM, Radek KA, Choi E-H, et al. Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest 2007; 117: 3339-49.
8. Jensen J-M, Ahrens K, Meingassner J, et al. Differential suppression of epidermal antimicrobial protein expression in atopic dermatitis and in EFAD mice by pimecrolimus compared to corticosteroids. Exp Dermatol 2011; 20: 783-8.
9. Morsi HM, Azam MH, Elardy A, et al. The effect of topical betamethasone valerate cream 0·1% and pimecrolimus cream 1% on serum levels of IL-4 and IL-13 in moderately severe atopic dermatitis. A comparative study. Egyptian Dermatol Online J 2005; 1: 1-10.
10. Simon D, Vassina E, Yousefi S, et al. Inflammatory cell numbers and cytokine expression in atopic dermatitis after topical pimecrolimus treatment. Allergy 2005; 60: 944-51.