Antibodies recognizing specific Mycobacterium avium subsp. paratuberculosis's MAP3738c protein in type 1 diabetes mellitus children are associated with serum Th1 (CXCL10) chemokine

Cytokine

Volumn 61, Issue 2, 2013, Pages 337-339

  Cossu, Andrea ^a   Ferrannini, Ele ^b   Fallahi, Poupak ^b   Antonelli, Alessandro ^b   Sechi, Leonardo A ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

CCL2; CXCL10; Mycobacterium avium subsp. paratuberculosis; Type 1 diabetes mellitus

Indexed keywords

ANTIBODY; BACTERIAL PROTEIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN MAP3738C; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; BACTERIUM DETECTION; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM PARATUBERCULOSIS; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SCHOOL CHILD; TH1 CELL; TH2 CELL;

ADOLESCENT; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; BACTERIAL PROTEINS; CASE-CONTROL STUDIES; CHEMOKINE CXCL10; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; MALE; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS;

EID: 84873150719     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.11.008     Document Type: Article

References (12)

1. Hirschhorn J.N. Genetic epidemiology of type 1 diabetes. Pediatr Diabetes 2003, 4:87-100.
2. Brown C.T., Davis-Richardson A.G., Giongo A., Gano K.A., Crabb D.B., Mukherjee N., et al. Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One 2011, 6:e25792.
3. Cossu A., Rosu V., Paccagnini D., Cossu D., Pacifico A., Sechi L.A. MAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus. Clin Immunol 2011, 141:49-57.
4. Antonelli A., Fallahi P., Ferrari S.M., Pupilli C., d'Annunzio G., Lorini R., et al. Serum Th1 (CXCL10) and Th2 (CCL2) chemokine levels in children with newly diagnosed Type 1 diabetes: a longitudinal study. Diabet Med 2008, 25:1349-1353.
5. Ito R., Shin-Ya M., Kishida T., Urano A., Takada R., Sakagami J., et al. Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice. Clin Exp Immunol 2006, 146:330-338.
6. Cole A.M., Ganz T., Liese A.M., Burdick M.D., Liu L., Strieter R.M. Cutting edge: IFN-inducible ELR-CXC chemokines display defensin-like antimicrobial activity. J Immunol 2001, 167:623-627.
7. Graves D.T., Naguib G., Lu H., Leone C., Hsue H., Krall E. Inflammation is more persistent in type 1 diabetic mice. J Dent Res 2005, 84:324-328.
8. Naguib G., Al-Mashat H., Desta T., Graves D.T. Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation. J Invest Dermatol 2004, 123:87-92.
9. Olsen I., Tollefsen S., Aagaard C., Reitan L.J., Bannantine J.P., Andersen P., et al. Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients. PLoS One 2009, 4:e5641.
10. Chen M.C., Proost P., Gysemans C., Mathieu C., Eizirik D.L. Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 betaexposed human and rat islet cells. Diabetologia 2001, 44:325-332.
11. Begg D.J., de Silva K., Carter N., Plain K.M., Purdie A., Whittington R.J. Does a Th1 over Th2 dominancy really exist in the early stages of Mycobacterium avium subspecies paratuberculosis infections?. Immunobiology 2011, 216:840-846.
12. Futagami S., Hiratsuka T., Tatsuguchi A., Suzuki K., Kusunoki M., Shinji Y., et al. Monocyte chemoattractant protein 1 (MCP-1) released from Helicobacter pylori stimulated gastric epithelial cells induces cyclooxygenase 2 expression and activation in T cells. Gut 2003, 52:1257-1264.