Inappropriate surgical chemoprophylaxis and surgical site infection rate at a tertiary care teaching hospital

Brazilian Journal of Infectious Diseases

Volumn 17, Issue 1, 2013, Pages 48-53

  Rana, Devang Ashwinkumar ^a   Malhotra, Supriya Deepak ^a   Patel, Varsha Jitendra ^a  

^a B J MEDICAL COLLEGE   (India)

Author keywords

Kunin's criteria; Rationality; Surgical chemoprophylaxis; Surgical site infection (SSI)

Indexed keywords

AMIKACIN; AMPICILLIN PLUS CLOXACILLIN; ANTIINFECTIVE AGENT; CEFIXIME; CEFIXIME PLUS CLAVULANIC ACID; CEFOPERAZONE; CEFTRIAXONE; CEFUROXIME; CLAVULANIC ACID; GENTAMICIN; LEVOFLOXACIN; LINEZOLID; MEROPENEM; METRONIDAZOLE; PIPERACILLIN PLUS TAZOBACTAM; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; APPENDECTOMY; ARTICLE; CHEMOPROPHYLAXIS; CRITERION VARIABLE; DISEASE CONTROL; DRUG EFFICACY; FEMALE; GENERAL ANESTHESIA; HERNIORRHAPHY; HOSPITALIZATION; HUMAN; LAPAROSCOPY; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PRACTICE GUIDELINE; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; SURGICAL INFECTION; SURGICAL TECHNIQUE; TEACHING HOSPITAL; TERTIARY HEALTH CARE; TREATMENT RESPONSE;

ADOLESCENT; ADULT; AGED; ANTI-BACTERIAL AGENTS; FEMALE; HOSPITALS, TEACHING; HUMANS; INAPPROPRIATE PRESCRIBING; LENGTH OF STAY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SURGICAL WOUND INFECTION; TERTIARY HEALTHCARE; YOUNG ADULT;

EID: 84873147019     PISSN: 14138670     EISSN: 16784391     Source Type: Journal    
DOI: 10.1016/j.bjid.2012.09.003     Document Type: Article

References (29)

1. Fleming A. Penicillin. Nobel lecture. 1945. Available at [accessed 01.08.12]. http://www.nobelprize.%20org/medicine/laureates/1945/fleming-lecture.pdf.06.
2. Mangram A.J., Horan T.C., Pearson M.L., Silver L.C., Jarvis W.R. Guideline for prevention of surgical site infection 1999, Available at http://www.cdc.gov/hicpac/SSI/001_SSI.html [accessed 01.08.12].
3. Rehospitalizations After Treatment for SSI Add $10 Million to $65 Million to Healthcare Costs. Available at [accessed 01.08.12]. http://www.infectioncontroltoday.com/news/2012/06/rehospitalizations-after-treatment-for-ssi-add-10-to-65-million-to-healthcare-costs.aspx.
4. Perencevich E.N., Sands K.E., Cosgrove S.E., et al. Health and economic impact of surgical site infections diagnosed after hospital discharge. Emerg Infect Dis 2003, 9:196-203.
5. Mangram A.J., Horan T.C., Pearson M.L., Silver L.C., Jarvis W.R. Guideline for prevention for of surgical site infection 1999, Available at http://www.cdc.gov/hicpac/pdf/guidelines/SSI_1999.pdf [accessed 01.08.12].
6. Antibiotic prophylaxis in surgery. A national clinical guideline 2000, Royal College of Physicians, Scottish Intercollegiate Guidelines Network, Edinburgh, 2008 update available: www.sign.ac.uk/guidelines/fulltext/45/index.html [accessed 01.08.12].
7. National Collaborating Centre for Women's and Children's Health, Commissioned by the National Institute for Health and Clinical Excellence. Surgical site infection: prevention and treatment of surgical site infection. Available at [accessed 01.08.12]. http://www.nice.org.uk/nicemedia/pdf/CG74NICEGuideline.pdf.
8. American Society of Health System Pharmacist guidelines. Available at [accessed 01.08.12]. http://www.ashp.org/s_ashp/docs/files/BP07/TG_Surgical.pdf.
9. Rosario M.O., Peña A.C., Ampil I.D.E. Adherence to surgical antimicrobial prophylaxis guidelines in a tertiary private medical center. Phil J Microbiol Infect Dis 2010, 39:51-58.
10. van Kasteren M.E.E., Kullberg B.J., de Boer A.S., Mintjes-de Groot J., Gyssens I.C. Adherence to local hospital guidelines for surgical antimicrobial prophylaxis: a multicentre audit in Dutch hospitals. J Antimicrob Chemother 2003, 51:1389-1396.
11. Kunin C.M., Tupasi T., Craig W.A. Use of antimicrobials. A brief exposition of the problem and some tentative solutions. Ann Intern Med 1973, 79:555-560.
12. Bibi S., Channa A.G., Siddiqui T.R., Ahmed W. Frequency and risk factors of surgical site infections in general surgery ward of a tertiary care hospital of Karachi, Pakistan. Int J Infect Control 2011, 7:1-5. Available at http://www.ijic.info/article/view/6093/6140 [accessed 01.08.12].
13. Anvikar A.R., Deshmukh A.B., Karyakarte R.P., et al. One year prospective study of 3280 surgical wounds. Indian J Med Microbiol 1999, 17:129-132.
14. Patel D.A., Patel K.B., Bhatt S.K., Shah H.S. Surveillance of hospital acquired infection in surgical wards in tertiary care centre Ahmedabad, Gujarat. Natl J Commun Med 2011, 2:340-345.
15. Jawien M., Wojkowska-Mach J., Rozanska A., Bulanda M., Heczko P.B. Surgical site infection following cholecystectomy: comparison of procedures performed with and without a laparoscope. Int J Infect Control 2008, 4:1-5.
16. Rehan H.S., Kakkar A.K., Goel S. Pattern of surgical antibiotic prophylaxis in a tertiary care teaching hospital in India. Int J Infect Control 2010, 6:1-5.
17. Razavi S.M., Ibrahimpur M., Kashani A.S., Jafarian A. Abdominal surgical site infections: incidence and risk factors at an Iranian teaching hospital. BMC Surg 2005, 5:1-5.
18. Berard F., Gandon J. Postoperative wound infections: the influence of ultraviolet irradiation of the operating room and of various other factors. Ann Surg 1964, 160(Suppl. 1):1-192.
19. Patel S.M., Patel M.H., Patel S.D., Soni S.T., Kinariwala D.M., Vegad M.M. Surgical site infections: incidence and risk factors in a tertiary care hospital, western India. Natl J Commun Med 2012, 3:193-196.
20. Sanabria A., Domínguez L.C., Valdivieso E., Gómez G. Prophylactic antibiotics for mesh inguinal hernioplasty: a meta-analysis. Ann Surg 2007, 245:392-396.
21. Askarian M., Moravveji A.R., Mirkhani H., Namazi S., Weed H. Adherence to American Society of Health-System Pharmacists surgical antimicrobial prophylaxis guidelines in Iran. Infect Control Hosp Epidemiol 2006, 27:876-878.
22. Suchitra Joyce B., Lakshmidevi N. Surgical site infections: assessing risk factors, outcomes and antimicrobial sensitivity patterns. Afr J Microbiol Res 2009, 3:175-179.
23. Lee J.S., Hayanga A.J., Kubus J.J., Makepeace H., Hutton M., Campbell D.A. Local anesthesia: a strategy for reducing surgical site infections?. World J Surg 2011, 35:2596-2602.
24. DiPiro J.T., Martindale R.G., Bakst A., Vacani P.F., Watson P., Miller M.T. Infection in surgical patients: effects on mortality, hospitalization, and postdischarge care. Am J Health Syst Pharm 1998, 55:777-781.
25. Van Deer Meer J.W.M., Van Kasteren M. Improving prescribing in surgical prophylaxis. Antibiotic policies: theory and practice 2005, 185-226. Springer, New York, USA. 1st ed. I.M. Gould, J.W.M. van der Meer (Eds.).
26. Malik A., Malik S. Indian Drug Review Compendium 2011, Mediworld Publications, India. 1st ed.
27. Dettenkofer M., Forster D.H., Ebner W., et al. The practice of perioperative antimicrobial prophylaxis in eight German hospitals. Infection 2002, 30:164-167.
28. Willemsen I., Groenhuijzen A., Bogaers D., Stuurman A., van Keulen P., Kluytmans J. Appropriateness of antimicrobial therapy measured by repeated prevalence surveys. Antimicrob Agents Chemother 2007, 51:864-867.
29. Van Kasteren M.E.E., Mannien J., Kullberg B.J., et al. Quality improvement of surgical prophylaxis in Dutch hospitals: evaluation of a multi-site intervention by time series analysis. J Antimicrob Chemother 2005, 56:1094-1102.