-
1
-
-
49649122302
-
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
-
Andrews, Z.B., et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454 (2008), 846–851.
-
(2008)
Nature
, vol.454
, pp. 846-851
-
-
Andrews, Z.B.1
-
2
-
-
0038030760
-
Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels
-
Barkan, A.L., et al. Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. J. Clin. Endocrinol. Metabol. 88 (2003), 2180–2184.
-
(2003)
J. Clin. Endocrinol. Metabol.
, vol.88
, pp. 2180-2184
-
-
Barkan, A.L.1
-
3
-
-
78650304822
-
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor
-
Barnett, B.P., et al. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science 330 (2010), 1689–1692.
-
(2010)
Science
, vol.330
, pp. 1689-1692
-
-
Barnett, B.P.1
-
4
-
-
0034676324
-
Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
-
Bednarek, M.A., et al. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J. Med. Chem. 43 (2000), 4370–4376.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 4370-4376
-
-
Bednarek, M.A.1
-
5
-
-
37849189554
-
Protein tyrosine kinase-substrate interactions
-
Bose, R., et al. Protein tyrosine kinase-substrate interactions. Curr. Opin. Struct. Biol. 16 (2006), 668–675.
-
(2006)
Curr. Opin. Struct. Biol.
, vol.16
, pp. 668-675
-
-
Bose, R.1
-
6
-
-
78649855297
-
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice
-
Bricambert, J., et al. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J. Clin. Invest. 120 (2010), 4316–4331.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 4316-4331
-
-
Bricambert, J.1
-
7
-
-
51949097274
-
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
-
Buglino, J.A., Resh, M.D., Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J. Biol. Chem. 283 (2008), 22076–22088.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 22076-22088
-
-
Buglino, J.A.1
Resh, M.D.2
-
8
-
-
77955293319
-
Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog
-
Buglino, J.A., Resh, M.D., Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. PLoS One, 5, 2010, e11195.
-
(2010)
PLoS One
, vol.5
, pp. e11195
-
-
Buglino, J.A.1
Resh, M.D.2
-
9
-
-
0036930643
-
Ghrelin increases anxiety-like behavior and memory retention in rats
-
Carlini, V.P., et al. Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem. Biophys. Res. Commun. 299 (2002), 739–743.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, pp. 739-743
-
-
Carlini, V.P.1
-
10
-
-
72449192299
-
Ghrelin in the regulation of body weight and metabolism
-
Castaneda, T.R., et al. Ghrelin in the regulation of body weight and metabolism. Front. Neuroendocrinol. 31 (2010), 44–60.
-
(2010)
Front. Neuroendocrinol.
, vol.31
, pp. 44-60
-
-
Castaneda, T.R.1
-
11
-
-
78649826886
-
BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy
-
Cerchietti, L.C., et al. BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. J. Clin. Invest. 120 (2010), 4569–4582.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 4569-4582
-
-
Cerchietti, L.C.1
-
12
-
-
0035860538
-
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
-
Chamoun, Z., et al. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293 (2001), 2080–2084.
-
(2001)
Science
, vol.293
, pp. 2080-2084
-
-
Chamoun, Z.1
-
13
-
-
2542475178
-
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
-
Chen, H.Y., et al. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145 (2004), 2607–2612.
-
(2004)
Endocrinology
, vol.145
, pp. 2607-2612
-
-
Chen, H.Y.1
-
14
-
-
33747359918
-
The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition
-
Cheng, K.Y., et al. The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. J. Biol. Chem. 281 (2006), 23167–23179.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 23167-23179
-
-
Cheng, K.Y.1
-
15
-
-
24744471838
-
p300/CBP-associated factor drives DEK into interchromatin granule clusters
-
Cleary, J., et al. p300/CBP-associated factor drives DEK into interchromatin granule clusters. J. Biol. Chem. 280 (2005), 31760–31767.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31760-31767
-
-
Cleary, J.1
-
16
-
-
33746808398
-
Wnt/beta-catenin signaling in development and disease
-
Clevers, H., Wnt/beta-catenin signaling in development and disease. Cell 127 (2006), 469–480.
-
(2006)
Cell
, vol.127
, pp. 469-480
-
-
Clevers, H.1
-
17
-
-
0037456519
-
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
-
Cowley, M.A., et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37 (2003), 649–661.
-
(2003)
Neuron
, vol.37
, pp. 649-661
-
-
Cowley, M.A.1
-
18
-
-
0033679897
-
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
-
Date, Y., et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141 (2000), 4255–4261.
-
(2000)
Endocrinology
, vol.141
, pp. 4255-4261
-
-
Date, Y.1
-
19
-
-
2642565900
-
Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells
-
de la Cour Dornonville, C., et al. Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells. Regul. Pept. 120 (2004), 23–32.
-
(2004)
Regul. Pept.
, vol.120
, pp. 23-32
-
-
de la Cour Dornonville, C.1
-
20
-
-
14244255852
-
Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation
-
De Vriese, C., et al. Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation. Endocrinology 146 (2005), 1514–1522.
-
(2005)
Endocrinology
, vol.146
, pp. 1514-1522
-
-
De Vriese, C.1
-
21
-
-
43049170316
-
Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
-
Dezaki, K., et al. Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis. Pharmacol. Ther. 118 (2008), 239–249.
-
(2008)
Pharmacol. Ther.
, vol.118
, pp. 239-249
-
-
Dezaki, K.1
-
22
-
-
33344479006
-
Ghrelin controls hippocampal spine synapse density and memory performance
-
Diano, S., et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9 (2006), 381–388.
-
(2006)
Nat. Neurosci.
, vol.9
, pp. 381-388
-
-
Diano, S.1
-
23
-
-
78650080859
-
cat-ELCCA: a robust method to monitor the fatty acid acyltransferase activity of ghrelin O-acyltransferase (GOAT)
-
Garner, A.L., Janda, K.D., cat-ELCCA: a robust method to monitor the fatty acid acyltransferase activity of ghrelin O-acyltransferase (GOAT). Angew. Chem. Int. Ed Engl. 49 (2010), 9630–9634.
-
(2010)
Angew. Chem. Int. Ed Engl.
, vol.49
, pp. 9630-9634
-
-
Garner, A.L.1
Janda, K.D.2
-
24
-
-
79959433505
-
A small molecule antagonist of ghrelin O-acyltransferase (GOAT)
-
Garner, A.L., Janda, K.D., A small molecule antagonist of ghrelin O-acyltransferase (GOAT). Chem. Commun. (Camb.) 47 (2011), 7512–7514.
-
(2011)
Chem. Commun. (Camb.)
, vol.47
, pp. 7512-7514
-
-
Garner, A.L.1
Janda, K.D.2
-
25
-
-
0742287004
-
Evaluation of the comparability of commercial ghrelin assays
-
Groschl, M., et al. Evaluation of the comparability of commercial ghrelin assays. Clin. Chem. 50 (2004), 457–458.
-
(2004)
Clin. Chem.
, vol.50
, pp. 457-458
-
-
Groschl, M.1
-
26
-
-
0030762351
-
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
-
Guan, X.M., et al. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res. Mol. Brain Res. 48 (1997), 23–29.
-
(1997)
Brain Res. Mol. Brain Res.
, vol.48
, pp. 23-29
-
-
Guan, X.M.1
-
27
-
-
20744456118
-
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein
-
Guidez, F., et al. Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol. Cell. Biol. 25 (2005), 5552–5566.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5552-5566
-
-
Guidez, F.1
-
28
-
-
27844475676
-
The active site His-460 of human acyl-coenzyme A: cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain
-
Guo, Z.Y., et al. The active site His-460 of human acyl-coenzyme A: cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain. J. Biol. Chem. 280 (2005), 37814–37826.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 37814-37826
-
-
Guo, Z.Y.1
-
29
-
-
44049094269
-
Ghrelin octanoylation mediated by an orphan lipid transferase
-
Gutierrez, J.A., et al. Ghrelin octanoylation mediated by an orphan lipid transferase. Proc. Natl. Acad. Sci. USA 105 (2008), 6320–6325.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 6320-6325
-
-
Gutierrez, J.A.1
-
30
-
-
25844456544
-
Genetic determinants of pancreatic epsilon-cell development
-
Heller, R.S., et al. Genetic determinants of pancreatic epsilon-cell development. Dev. Biol. 286 (2005), 217–224.
-
(2005)
Dev. Biol.
, vol.286
, pp. 217-224
-
-
Heller, R.S.1
-
31
-
-
2342592115
-
Design, synthesis, and characterization of an ATP-peptide conjugate inhibitor of protein kinase A
-
Hines, A.C., Cole, P.A., Design, synthesis, and characterization of an ATP-peptide conjugate inhibitor of protein kinase A. Bioorg. Med. Chem. Lett. 14 (2004), 2951–2954.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 2951-2954
-
-
Hines, A.C.1
Cole, P.A.2
-
32
-
-
21844470994
-
Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design
-
Hines, A.C., et al. Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design. Bioorg. Chem. 33 (2005), 285–297.
-
(2005)
Bioorg. Chem.
, vol.33
, pp. 285-297
-
-
Hines, A.C.1
-
33
-
-
0034161499
-
A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
-
Hofmann, K., A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Trends Biochem. Sci. 25 (2000), 111–112.
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 111-112
-
-
Hofmann, K.1
-
34
-
-
9444246501
-
A receptor in pituitary and hypothalamus that functions in growth hormone release
-
Howard, A.D., et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273 (1996), 974–977.
-
(1996)
Science
, vol.273
, pp. 974-977
-
-
Howard, A.D.1
-
35
-
-
77954501905
-
Establishment of a novel ghrelin-producing cell line
-
Iwakura, H., et al. Establishment of a novel ghrelin-producing cell line. Endocrinology 151 (2010), 2940–2945.
-
(2010)
Endocrinology
, vol.151
, pp. 2940-2945
-
-
Iwakura, H.1
-
36
-
-
0019407381
-
On the attribution and additivity of binding energies
-
Jencks, W.P., On the attribution and additivity of binding energies. Proc. Natl. Acad. Sci. USA 78 (1981), 4046–4050.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 4046-4050
-
-
Jencks, W.P.1
-
37
-
-
0036829870
-
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet
-
Joseph, J.W., et al. Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 51 (2002), 3211–3219.
-
(2002)
Diabetes
, vol.51
, pp. 3211-3219
-
-
Joseph, J.W.1
-
38
-
-
0030450052
-
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
-
Kadowaki, T., et al. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 10 (1996), 3116–3128.
-
(1996)
Genes Dev.
, vol.10
, pp. 3116-3128
-
-
Kadowaki, T.1
-
39
-
-
0035513696
-
Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
-
Kamegai, J., et al. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes 50 (2001), 2438–2443.
-
(2001)
Diabetes
, vol.50
, pp. 2438-2443
-
-
Kamegai, J.1
-
40
-
-
17944364737
-
Substantial production of ghrelin by a human medullary thyroid carcinoma cell line
-
Kanamoto, N., et al. Substantial production of ghrelin by a human medullary thyroid carcinoma cell line. J. Clin. Endocrinol. Metabol. 86 (2001), 4984–4990.
-
(2001)
J. Clin. Endocrinol. Metabol.
, vol.86
, pp. 4984-4990
-
-
Kanamoto, N.1
-
41
-
-
67650423944
-
GOAT links dietary lipids with the endocrine control of energy balance
-
Kirchner, H., et al. GOAT links dietary lipids with the endocrine control of energy balance. Nat. Med. 15 (2009), 741–745.
-
(2009)
Nat. Med.
, vol.15
, pp. 741-745
-
-
Kirchner, H.1
-
42
-
-
0033540056
-
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
-
Kojima, M., et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999), 656–660.
-
(1999)
Nature
, vol.402
, pp. 656-660
-
-
Kojima, M.1
-
43
-
-
0033019208
-
The growth hormone secretagogue receptor
-
Korbonits, M., et al. The growth hormone secretagogue receptor. Growth Horm. IGF Res. 9 (1999), 93–99.
-
(1999)
Growth Horm. IGF Res.
, vol.9
, pp. 93-99
-
-
Korbonits, M.1
-
44
-
-
0033714888
-
HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF
-
Lau, O.D., et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol. Cell 5 (2000), 589–595.
-
(2000)
Mol. Cell
, vol.5
, pp. 589-595
-
-
Lau, O.D.1
-
45
-
-
33646755174
-
A Src-like inactive conformation in the abl tyrosine kinase domain
-
Levinson, N.M., et al. A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol., 4, 2006, e144.
-
(2006)
PLoS Biol.
, vol.4
, pp. e144
-
-
Levinson, N.M.1
-
46
-
-
43249089526
-
Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men
-
Liu, J., et al. Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men. J. Clin. Endocrinol. Metabol. 93 (2008), 1980–1987.
-
(2008)
J. Clin. Endocrinol. Metabol.
, vol.93
, pp. 1980-1987
-
-
Liu, J.1
-
47
-
-
39149109887
-
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
-
Liu, X., et al. The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature 451 (2008), 846–850.
-
(2008)
Nature
, vol.451
, pp. 846-850
-
-
Liu, X.1
-
48
-
-
56249100986
-
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
-
Liu, Y., et al. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456 (2008), 269–273.
-
(2008)
Nature
, vol.456
, pp. 269-273
-
-
Liu, Y.1
-
49
-
-
79956300886
-
Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300
-
Marek, R., et al. Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. J. Neurosci. 31 (2011), 7486–7491.
-
(2011)
J. Neurosci.
, vol.31
, pp. 7486-7491
-
-
Marek, R.1
-
50
-
-
0028131963
-
Solid-phase synthesis of adenosine phosphopeptides as potential bisubstrate inhibitors of protein-kinases
-
Medzihradszky, D., et al. Solid-phase synthesis of adenosine phosphopeptides as potential bisubstrate inhibitors of protein-kinases. J. Am. Chem. Soc. 116 (1994), 9413–9419.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 9413-9419
-
-
Medzihradszky, D.1
-
52
-
-
20244366719
-
Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin
-
Nishi, Y., et al. Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. Endocrinology 146 (2005), 2255–2264.
-
(2005)
Endocrinology
, vol.146
, pp. 2255-2264
-
-
Nishi, Y.1
-
53
-
-
0023630019
-
Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia
-
Nussbaum, S.R., et al. Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. Clin. Chem. 33 (1987), 1364–1367.
-
(1987)
Clin. Chem.
, vol.33
, pp. 1364-1367
-
-
Nussbaum, S.R.1
-
54
-
-
79953115619
-
Ghrelin: a gut hormonal basis of motility regulation and functional dyspepsia
-
Ogiso, K., et al. Ghrelin: a gut hormonal basis of motility regulation and functional dyspepsia. J. Gastroenterol. Hepatol. 26 (2011), 67–72.
-
(2011)
J. Gastroenterol. Hepatol.
, vol.26
, pp. 67-72
-
-
Ogiso, K.1
-
55
-
-
69949139699
-
Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation
-
Oussaief, L., et al. Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation. J. Biol. Chem. 284 (2009), 23912–23924.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 23912-23924
-
-
Oussaief, L.1
-
56
-
-
80054685861
-
Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae
-
Pagac, M., et al. Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae. J. Biol. Chem. 286 (2011), 36438–36447.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 36438-36447
-
-
Pagac, M.1
-
57
-
-
0035165210
-
Mechanism-based design of a protein kinase inhibitor
-
Parang, K., et al. Mechanism-based design of a protein kinase inhibitor. Nat. Struct. Biol. 8 (2001), 37–41.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 37-41
-
-
Parang, K.1
-
58
-
-
0345059765
-
Hedgehog signalling in cancer formation and maintenance
-
Pasca di Magliano, M., Hebrok, M., Hedgehog signalling in cancer formation and maintenance. Nat. Rev. Cancer 3 (2003), 903–911.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 903-911
-
-
Pasca di Magliano, M.1
Hebrok, M.2
-
59
-
-
0348010364
-
Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells
-
Potocky, T.B., et al. Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells. J. Biol. Chem. 278 (2003), 50188–50194.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 50188-50194
-
-
Potocky, T.B.1
-
60
-
-
1542267814
-
Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development
-
Prado, C.L., et al. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc. Natl. Acad. Sci. USA 101 (2004), 2924–2929.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 2924-2929
-
-
Prado, C.L.1
-
61
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
Reya, T., Clevers, H., Wnt signalling in stem cells and cancer. Nature 434 (2005), 843–850.
-
(2005)
Nature
, vol.434
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
62
-
-
2542421889
-
Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors
-
Sagar, V., et al. Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors. Bioorg. Med. Chem. 12 (2004), 3383–3390.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 3383-3390
-
-
Sagar, V.1
-
63
-
-
77957266562
-
Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium
-
Satou, M., et al. Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium. Endocrinology 151 (2010), 4765–4775.
-
(2010)
Endocrinology
, vol.151
, pp. 4765-4775
-
-
Satou, M.1
-
64
-
-
0033520487
-
In vivo protein transduction: delivery of a biologically active protein into the mouse
-
Schwarze, S.R., et al. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285 (1999), 1569–1572.
-
(1999)
Science
, vol.285
, pp. 1569-1572
-
-
Schwarze, S.R.1
-
65
-
-
0346434146
-
Conversion of a tyrosine kinase protein substrate to a high affinity ligand by ATP linkage
-
Shen, K., Cole, P.A., Conversion of a tyrosine kinase protein substrate to a high affinity ligand by ATP linkage. J. Am. Chem. Soc. 125 (2003), 16172–16173.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 16172-16173
-
-
Shen, K.1
Cole, P.A.2
-
66
-
-
78650791278
-
Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300
-
Spin, J.M., et al. Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300. PLoS One, 5, 2010, e14301.
-
(2010)
PLoS One
, vol.5
, pp. e14301
-
-
Spin, J.M.1
-
67
-
-
33646141847
-
Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
-
Sun, Y., et al. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab. 3 (2006), 379–386.
-
(2006)
Cell Metab.
, vol.3
, pp. 379-386
-
-
Sun, Y.1
-
68
-
-
38549133092
-
Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
-
Sun, Y., et al. Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology 149 (2008), 843–850.
-
(2008)
Endocrinology
, vol.149
, pp. 843-850
-
-
Sun, Y.1
-
69
-
-
33751318469
-
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion
-
Takada, R., et al. Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev. Cell 11 (2006), 791–801.
-
(2006)
Dev. Cell
, vol.11
, pp. 791-801
-
-
Takada, R.1
-
70
-
-
70449632792
-
Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid
-
Takahashi, T., et al. Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid. J. Biochem. 146 (2009), 675–682.
-
(2009)
J. Biochem.
, vol.146
, pp. 675-682
-
-
Takahashi, T.1
-
71
-
-
77956357163
-
Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans
-
Tong, J., et al. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes 59 (2010), 2145–2151.
-
(2010)
Diabetes
, vol.59
, pp. 2145-2151
-
-
Tong, J.1
-
72
-
-
80051470522
-
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation
-
Wang, L., et al. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science 333 (2011), 765–769.
-
(2011)
Science
, vol.333
, pp. 765-769
-
-
Wang, L.1
-
73
-
-
0037098974
-
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
-
Wierup, N., et al. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul. Pept. 107 (2002), 63–69.
-
(2002)
Regul. Pept.
, vol.107
, pp. 63-69
-
-
Wierup, N.1
-
74
-
-
0032744366
-
Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
-
Willesen, M.G., et al. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70 (1999), 306–316.
-
(1999)
Neuroendocrinology
, vol.70
, pp. 306-316
-
-
Willesen, M.G.1
-
75
-
-
38849090670
-
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
-
Yang, J., et al. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132 (2008), 387–396.
-
(2008)
Cell
, vol.132
, pp. 387-396
-
-
Yang, J.1
-
76
-
-
49449085708
-
Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides
-
Yang, J., et al. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc. Natl. Acad. Sci. USA 105 (2008), 10750–10755.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 10750-10755
-
-
Yang, J.1
-
77
-
-
84857375127
-
The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction
-
Yi, C.X., et al. The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. PLoS One, 7, 2012, e32100.
-
(2012)
PLoS One
, vol.7
, pp. e32100
-
-
Yi, C.X.1
-
78
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang, J.H., et al. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4 (1999), 67–73.
-
(1999)
J. Biomol. Screen.
, vol.4
, pp. 67-73
-
-
Zhang, J.H.1
-
79
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang, C.Y., et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105 (2001), 745–755.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
-
80
-
-
64749091867
-
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
Zhao, C., et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 458 (2009), 776–779.
-
(2009)
Nature
, vol.458
, pp. 776-779
-
-
Zhao, C.1
-
81
-
-
77952165770
-
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
-
Zhao, T.J., et al. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc. Natl. Acad. Sci. USA 107 (2010), 7467–7472.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 7467-7472
-
-
Zhao, T.J.1
-
82
-
-
77957668161
-
Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice
-
Zhao, T.J., et al. Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc. Natl. Acad. Sci. USA 107 (2010), 15868–15873.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 15868-15873
-
-
Zhao, T.J.1
-
83
-
-
29044440879
-
Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor
-
Zheng, Y., et al. Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor. J. Am. Chem. Soc. 127 (2005), 17182–17183.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 17182-17183
-
-
Zheng, Y.1
-
84
-
-
0033597852
-
Proteolytic processing in the secretory pathway
-
Zhou, A., et al. Proteolytic processing in the secretory pathway. J. Biol. Chem. 274 (1999), 20745–20748.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20745-20748
-
-
Zhou, A.1
-
85
-
-
33846024377
-
On the processing of proghrelin to ghrelin
-
Zhu, X., et al. On the processing of proghrelin to ghrelin. J. Biol. Chem. 281 (2006), 38867–38870.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 38867-38870
-
-
Zhu, X.1
|