Syndromes of orthostatic intolerance: A hidden danger

Journal of Internal Medicine

Volumn 273, Issue 4, 2013, Pages 322-335

  Fedorowski, A ^a,b   Melander, O ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cardiovascular disease; Mortality; Orthostatic hypotension; Syncope

Indexed keywords

BISOPROLOL; CALCIUM CHANNEL BLOCKING AGENT; DESMOPRESSIN; EPHEDRINE; FLUDROCORTISONE; IVABRADINE; LOOP DIURETIC AGENT; MIDODRINE; PSEUDOEPHEDRINE; PYRIDOSTIGMINE; THREO 3,4 DIHYDROXYPHENYLSERINE;

AGING; BODY MASS; CARDIOVASCULAR MORTALITY; CEREBROVASCULAR ACCIDENT; CIRCULATION; COMPRESSION STOCKING; ENVIRONMENTAL TEMPERATURE; FAINTNESS; FALLING; GENETIC PREDISPOSITION; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART INFARCTION; HEMODYNAMIC MONITORING; HOSPITALIZATION; HUMAN; HUMIDITY; KIDNEY FAILURE; MORBIDITY; ORTHOSTATIC INTOLERANCE; PACEMAKER; PATIENT EDUCATION; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SITTING; SMOKING; SUPINE POSITION;

HUMANS; ORTHOSTATIC INTOLERANCE; POSTURE; PREVALENCE; RISK FACTORS; SYNCOPE; SYNDROME; WORLD HEALTH;

EID: 84873139005     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/joim.12021     Document Type: Review

References (115)

1. Smith JJ, Porth CM, Erickson M. Hemodynamic response to the upright posture. J Clin Pharmacol 1994; 34: 375-86.
2. Low PA, Singer W. Management of neurogenic orthostatic hypotension: an update. Lancet Neurol 2008; 7: 451-8.
3. Maarsingh OR, Dros J, Schellevis FG et al. Causes of persistent dizziness in elderly patients in primary care. Ann Fam Med 2010; 8: 196-205.
4. van Dijk JG, Thijs RD, Benditt DG, Wieling W. A guide to disorders causing transient loss of consciousness: focus on syncope. Nat Rev Neurol 2009; 5: 438-48.
5. Van Lieshout JJ, Wieling W, Karemaker JM, Secher NH. Syncope, cerebral perfusion, and oxygenation. J Appl Physiol 2003; 94: 833-48.
6. Vaddadi G, Lambert E, Corcoran SJ, Esler MD. Postural syncope: mechanisms and management. Med J Aust 2007; 187: 299-304.
7. Gates S, Fisher JD, Cooke MW, Carter YH, Lamb SE. Multifactorial assessment and targeted intervention for preventing falls and injuries among older people in community and emergency care settings: systematic review and meta-analysis. BMJ 2008; 336: 130-3.
8. Hajjar I. Postural blood pressure changes and orthostatic hypotension in the elderly patient: impact of antihypertensive medications. Drugs Aging 2005; 22: 55-68.
9. Weber MA, Wenger NK, Scheidt S. A focus on heart failure and other age-related cardiovascular conditions. Am J Geriatr Cardiol 2005; 14: 221-3.
10. Bradbury S, Eggleston C. Postural hypotension: a report of three cases. Am Heart J 1925; 1: 73-86.
11. Bjure A, Laurell H. Abnormal static circulatory phenomena and their symptoms: arterial orthostatic anemia as neglected clinical picture. Upsala Läkaref Förh 1927; 33: 1-23.
12. Laubry C, Doumer E. L'hypotension orthostatique. Presse Méd 1932; 40: 17-20.
13. Korns HM, Randall WL. Orthostatic hypotension treated with benzedrine: report of case. Am Heart J 1937; 13: 114-8.
14. Gillespie DL, Barker NW. Orthostatic hypotension: report of two cases in which the patients were children. J Pediatrics 1938; 12: 772-7.
15. Farmer HE. Case report of orthostatic hypotension. J Natl Med Assoc 1941; 33: 126-9.
16. MacLean AR, Allen EV. Orthostatic hypotension and orthostatic tachycardia - treatment with the "head-up" bed. J Am Med Assoc 1940; 115: 2162-7.
17. Braunwald E, Wagner HN Jr. The pressor effect of the antidiuretic principle of the posterior pituitary in orthostatic hypotension. J Clin Invest 1956; 35: 1412-8.
18. Shy GM, Drager GA. A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study. Arch Neurol 1960; 2: 511-27.
19. Hughes RC, Cartlidge NE, Millac P. Primary neurogenic orthostatic hypotension. J Neurol Neurosurg Psychiatry 1970; 33: 363-71.
20. Nanda RN, Johnson RH, Keogh HJ. Treatment of neurogenic orthostatic hypotension with a monoamine oxidase inhibitor and tyramine. Lancet 1976; 2: 1164-7.
21. Thomas JE, Schirger A, Fealey RD, Sheps SG. Orthostatic hypotension. Mayo Clin Proc 1981; 56: 117-25.
22. Schatz IJ. Orthostatic hypotension. I. Functional and neurogenic causes. Arch Intern Med 1984a; 144: 773-7.
23. Schatz IJ. Orthostatic hypotension. II. Clinical diagnosis, testing, and treatment. Arch Intern Med 1984b; 144: 1037-41.
24. Goldstein DS, Polinsky RJ, Garty M et al. Patterns of plasma levels of catechols in neurogenic orthostatic hypotension. Ann Neurol 1989; 26: 558-63.
25. Onrot J, Goldberg MR, Hollister AS, Biaggioni I, Robertson RM, Robertson D. Management of chronic orthostatic hypotension. Am J Med 1986; 80: 454-64.
26. Dorlas JC, Nijboer JA, Butijn WT, van der Hoeven GM, Settels JJ, Wesseling KH. Effects of peripheral vasoconstriction on the blood pressure in the finger, measured continuously by a new noninvasive method (the Finapres). Anesthesiology 1985; 62: 342-5.
27. Wieling W, Shepherd JT. Initial and delayed circulatory responses to orthostatic stress in normal humans and in subjects with orthostatic intolerance. Int Angiol 1992; 11: 69-82.
28. Hollister AS. Orthostatic hypotension. Causes, evaluation, and management. West J Med 1992; 157: 652-7.
29. Taylor AA. Autonomic control of cardiovascular function: clinical evaluation in health and disease. J Clin Pharmacol 1994; 34: 363-74.
30. Low PA, Opfer-Gehrking TL, Textor SC et al. Postural tachycardia syndrome (POTS). Neurology 1995; 45: S19-25.
31. Jacob G, Robertson D. Orthostatic hypotension: epidemiology, pathophysiology and management. Curr Opin Nephrol Hypertens 1995; 4: 452-4.
32. Mathias CJ. Orthostatic hypotension: causes, mechanisms, and influencing factors. Neurology 1995; 45: S6-11.
33. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 1996; 46: 1470.
34. Rutan GH, Hermanson B, Bild DE, Kittner SJ, LaBaw F, Tell GS. Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. Hypertension 1992; 19: 508-19.
35. Masaki KH, Schatz IJ, Burchfiel CM et al. Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program. Circulation 1998; 98: 2290-5.
36. Luukinen H, Koski K, Laippala P, Kivela SL. Prognosis of diastolic and systolic orthostatic hypotension in older persons. Arch Intern Med 1999; 159: 273-80.
37. Viramo P, Luukinen H, Koski K, Laippala P, Sulkava R, Kivela SL. Orthostatic hypotension and cognitive decline in older people. J Am Geriatr Soc 1999; 47: 600-4.
38. Rose KM, Tyroler HA, Nardo CJ et al. Orthostatic hypotension and the incidence of coronary heart disease: the Atherosclerosis Risk in Communities study. Am J Hypertens 2000; 13: 571-8.
39. Eigenbrodt ML, Rose KM, Couper DJ, Arnett DK, Smith R, Jones D. Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke 2000; 31: 2307-13.
40. Rose KM, Holme I, Light KC, Sharrett AR, Tyroler HA, Heiss G. Association between the blood pressure response to a change in posture and the 6-year incidence of hypertension: prospective findings from the ARIC study. J Hum Hypertens 2002; 16: 771-7.
41. Grubb BP, Karas B. Clinical disorders of the autonomic nervous system associated with orthostatic intolerance: an overview of classification, clinical evaluation, and management. Pacing Clin Electrophysiol 1999; 22: 798-810.
42. Mathias CJ, Kimber JR. Postural hypotension: causes, clinical features, investigation, and management. Annu Rev Med 1999; 50: 317-36.
43. Smit AA, Halliwill JR, Low PA, Wieling W. Pathophysiological basis of orthostatic hypotension in autonomic failure. J Physiol 1999; 1: 1-10.
44. Harms MP, Colier WN, Wieling W, Lenders JW, Secher NH, van Lieshout JJ. Orthostatic tolerance, cerebral oxygenation, and blood velocity in humans with sympathetic failure. Stroke 2000; 31: 1608-14.
45. Goldstein DS, Robertson D, Esler M, Straus SE, Eisenhofer G. Dysautonomias: clinical disorders of the autonomic nervous system. Ann Intern Med 2002; 137: 753-63.
46. Maule S, Papotti G, Naso D, Magnino C, Testa E, Veglio F. Orthostatic hypotension: evaluation and treatment. Cardiovasc Hematol Disord Drug Targets 2007; 7: 63-70.
47. Low PA. Prevalence of orthostatic hypotension. Clin Auton Res 2008; 18(Suppl. 1): 8-13.
48. Wieling W, Krediet CT, van Dijk N, Linzer M, Tschakovsky ME. Initial orthostatic hypotension: review of a forgotten condition. Clin Sci 2007; 112: 157-65.
49. Gibbons CH, Freeman R. Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance. Neurology 2006; 67: 28-32.
50. Moya A, Sutton R, Ammirati F et al. Guidelines for the diagnosis and management of syncope (version 2009): the Task Force for the Diagnosis and Management of Syncope of the European Society of Cardiology (ESC). Eur Heart J 2009; 30: 2631-71.
51. Brignole M, Menozzi C, Del Rosso A et al. New classification of haemodynamics of vasovagal syncope: beyond the VASIS classification. Analysis of the pre-syncopal phase of the tilt test without and with nitroglycerin challenge. Vasovagal Syncope International Study. Europace 2000; 2: 66-76.
52. Fedorowski A, Burri P, Melander O. Orthostatic hypotension in genetically related hypertensive and normotensive individuals. J Hypertens 2009; 27: 976-82.
53. Wieling W, Schatz IJ. The consensus statement on the definition of orthostatic hypotension: a revisit after 13 years. J Hypertens 2009; 27: 935-8.
54. Freeman R. Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med 2008; 358: 615-24.
55. Goldstein DS, Sharabi Y. Neurogenic orthostatic hypotension: a pathophysiological approach. Circulation 2009; 119: 139-46.
56. Freeman R, Wieling W, Axelrod FB et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 2011; 21: 69-72.
57. Rose KM, Eigenbrodt ML, Biga RL et al. Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) Study. Circulation 2006; 114: 630-6.
58. Fedorowski A, Stavenow L, Hedblad B, Berglund G, Nilsson PM, Melander O. Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project). Eur Heart J 2010a; 31: 85-91.
59. Franceschini N, Rose KM, Astor BC, Couper D, Vupputuri S. Orthostatic hypotension and incident chronic kidney disease: the atherosclerosis risk in communities study. Hypertension 2010; 56: 1054-9.
60. Fedorowski A, Stavenow L, Hedblad B, Berglund G, Nilsson PM, Melander O. Consequences of orthostatic blood pressure variability in middle-aged men (The Malmo Preventive Project). J Hypertens 2010b; 28: 551-9.
61. Benvenuto LJ, Krakoff LR. Morbidity and mortality of orthostatic hypotension: implications for management of cardiovascular disease. Am J Hypertens 2011; 24: 135-44.
62. Fedorowski A, Hedblad B, Melander O. Early postural blood pressure response and cause-specific mortality among middle-aged adults. Eur J Epidemiol 2011; 26: 537-46.
63. Harms MP, Wesseling KH, Pott F et al. Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress. Clin Sci 1999; 97: 291-301.
64. Grubb BP. Neurocardiogenic syncope and related disorders of orthostatic intolerance. Circulation 2005; 111: 2997-3006.
65. Vinik AI, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation 2007; 115: 387-97.
66. Mandl T, Wollmer P, Manthorpe R, Jacobsson LT. Autonomic and orthostatic dysfunction in primary Sjogren's syndrome. J Rheumatol 2007; 34: 1869-74.
67. Goldstein DS, Tack C. Noninvasive detection of sympathetic neurocirculatory failure. Clin Auton Res 2000; 10: 285-91.
68. Vogel ER, Sandroni P, Low PA. Blood pressure recovery from Valsalva maneuver in patients with autonomic failure. Neurology 2005; 65: 1533-7.
69. Robertson D. The pathophysiology and diagnosis of orthostatic hypotension. Clin Auton Res 2008; 18(Suppl. 1): 2-7.
70. Robertson D, Robertson RM. Causes of chronic orthostatic hypotension. Arch Intern Med 1994; 154: 1620-4.
71. Tabara Y, Kohara K, Miki T. Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension. J Hypertens 2002; 20: 651-6.
72. North KE, Rose KM, Borecki IB et al. Evidence for a gene on chromosome 13 influencing postural systolic blood pressure change and body mass index. Hypertension 2004; 43: 780-4.
73. Pankow JS, Dunn DM, Hunt SC et al. Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study. Am J Hypertens 2005; 18: 672-8.
74. Fedorowski A, Franceschini N, Brody J et al. Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium. Eur Heart J 2012; 33: 2331-41.
75. Senard JM, Rai S, Lapeyre-Mestre M et al. Prevalence of orthostatic hypotension in Parkinson's disease. J Neurol Neurosurg Psychiatry 1997; 63: 584-9.
76. Allcock LM, Ullyart K, Kenny RA, Burn DJ. Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 2004; 75: 1470-1.
77. Matinolli M, Korpelainen JT, Korpelainen R, Sotaniemi KA, Myllyla VV. Orthostatic hypotension, balance and falls in Parkinson's disease. Mov Disord 2009; 24: 745-51.
78. Wu JS, Yang YC, Lu FH, Wu CH, Chang CJ. Population-based study on the prevalence and correlates of orthostatic hypotension/hypertension and orthostatic dizziness. Hypertens Res 2008; 31: 897-904.
79. Wu JS, Yang YC, Lu FH, Wu CH, Wang RH, Chang CJ. Population-based study on the prevalence and risk factors of orthostatic hypotension in subjects with pre-diabetes and diabetes. Diabetes Care 2009; 32: 69-74.
80. Sasaki O, Nakahama H, Nakamura S et al. Orthostatic hypotension at the introductory phase of haemodialysis predicts all-cause mortality. Nephrol Dial Transplant 2005; 20: 377-81.
81. Brignole M, Ungar A, Casagranda I et al. Prospective multicentre systematic guideline-based management of patients referred to the Syncope Units of general hospitals. Europace 2010; 12: 109-18.
82. Baron-Esquivias G, Martinez-Alday J, Martin A et al. Epidemiological characteristics and diagnostic approach in patients admitted to the emergency room for transient loss of consciousness: Group for Syncope Study in the Emergency Room (GESINUR) study. Europace 2010; 12: 869-76.
83. Marrison VK, Fletcher A, Parry SW. The older patient with syncope: practicalities and controversies. Int J Cardiol 2012; 155: 9-13.
84. Fedorowski A, Burri P, Juul-Moller S, Melander O. A dedicated investigation unit improves management of syncopal attacks (Syncope Study of Unselected Population in Malmo-SYSTEMA I). Europace 2010c; 12: 1322-8.
85. Kenny RA, Ingram A, Bayliss J, Sutton R. Head-up tilt: a useful test for investigating unexplained syncope. Lancet 1986; 1: 1352-5.
86. Tan MP, Newton JL, Chadwick TJ, Parry SW. The relationship between carotid sinus hypersensitivity, orthostatic hypotension, and vasovagal syncope: a case-control study. Europace 2008; 10: 1400-5.
87. Shaw FE, Kenny RA. The overlap between syncope and falls in the elderly. Postgrad Med J 1997; 73: 635-9.
88. O'Dwyer C, Bennett K, Langan Y, Fan CW, Kenny RA. Amnesia for loss of consciousness is common in vasovagal syncope. Europace 2011; 13: 1040-5.
89. Mathias CJ, Low DA, Iodice V, Owens AP, Kirbis M, Grahame R. Postural tachycardia syndrome-current experience and concepts. Nat Rev Neurol 2012; 8: 22-34.
90. Wieling W, Van Lieshout JJ, Hainsworth R. Extracellular fluid volume expansion in patients with posturally related syncope. Clin Auton Res 2002; 12: 242-9.
91. Kaufmann H. L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US experience. Clin Auton Res 2008; 18(Suppl. 1): 19-24.
92. Ungar A, Morrione A, Rafanelli M et al. The management of syncope in older adults. Minerva Med 2009; 100: 247-58.
93. Parry SW, Tan MP. An approach to the evaluation and management of syncope in adults. BMJ 2010; 340: c880.
94. Mansoor GA. Orthostatic hypotension due to autonomic disorders in the hypertension clinic. Am J Hypertens 2006; 19: 319-26.
95. Takeda A, Toda T, Fujii T, Matsui N. Bedtime administration of long-acting antihypertensive drugs restores normal nocturnal blood pressure fall in nondippers with essential hypertension. Clin Exp Nephrol 2009; 13: 467-72.
96. Vij R, Peixoto AJ. Management of nocturnal hypertension. Expert Rev Cardiovasc Ther 2009; 7: 607-18.
97. Ejaz AA, Kazory A, Heinig ME. 24-hour blood pressure monitoring in the evaluation of supine hypertension and orthostatic hypotension. J Clin Hypertens (Greenwich) 2007; 9: 952-5.
98. van der Velde N, Stricker BH, Pols HA, van der Cammen TJ. Risk of falls after withdrawal of fall-risk-increasing drugs: a prospective cohort study. Br J Clin Pharmacol 2007; 63: 232-7.
99. Shibao C, Grijalva CG, Raj SR, Biaggioni I, Griffin MR. Orthostatic hypotension-related hospitalizations in the United States. Am J Med 2007; 120: 975-80.
100. Rubenstein LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing 2006; 35(Suppl. 2): ii37-41.
101. Gangavati A, Hajjar I, Quach L et al. Hypertension, orthostatic hypotension, and the risk of falls in a community-dwelling elderly population: the maintenance of balance, independent living, intellect, and zest in the elderly of Boston study. J Am Geriatr Soc 2011; 59: 383-9.
102. Verwoert GC, Mattace-Raso FU, Hofman A et al. Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam study. J Am Geriatr Soc 2008; 56: 1816-20.
103. Yatsuya H, Folsom AR, Alonso A, Gottesman RF, Rose KM. Postural changes in blood pressure and incidence of ischemic stroke subtypes: the ARIC study. Hypertension 2011; 57: 167-73.
104. Kario K, Eguchi K, Hoshide S et al. U-curve relationship between orthostatic blood pressure change and silent cerebrovascular disease in elderly hypertensives: orthostatic hypertension as a new cardiovascular risk factor. J Am Coll Cardiol 2002; 40: 133-41.
105. Fedorowski A, Engstrom G, Hedblad B, Melander O. Orthostatic hypotension predicts incidence of heart failure: the Malmo preventive project. Am J Hypertens 2010d; 23: 1209-15.
106. Jones CD, Loehr L, Franceschini N et al. Orthostatic hypotension as a risk factor for incident heart failure: the atherosclerosis risk in communities study. Hypertension 2012; 59: 913-8.
107. Fedorowski A, Hedblad B, Engstrom G, Gustav Smith J, Melander O. Orthostatic hypotension and long-term incidence of atrial fibrillation: the Malmo Preventive Project. J Intern Med 2010e; 268: 383-9.
108. Lakatta EG. Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons. Heart Fail Rev 2002; 7: 29-49.
109. Okamoto LE, Gamboa A, Shibao C et al. Nocturnal blood pressure dipping in the hypertension of autonomic failure. Hypertension 2009; 53: 363-9.
110. Fagard RH, Celis H, Thijs L et al. Daytime and nighttime blood pressure as predictors of death and cause-specific cardiovascular events in hypertension. Hypertension 2008; 51: 55-61.
111. Mattace-Raso FU, van der Cammen TJ, Knetsch AM et al. Arterial stiffness as the candidate underlying mechanism for postural blood pressure changes and orthostatic hypotension in older adults: the Rotterdam Study. J Hypertens 2006; 24: 339-44.
112. Fan XH, Wang Y, Sun K et al. Disorders of orthostatic blood pressure response are associated with cardiovascular disease and target organ damage in hypertensive patients. Am J Hypertens 2010; 23: 829-37.
113. Maule S, Milan A, Grosso T, Veglio F. Left ventricular hypertrophy in patients with autonomic failure. Am J Hypertens 2006; 19: 1049-54.
114. Sato Y, Ichihashi K, Kikuchi Y, Shiraishi H, Momoi MY. Autonomic function in adolescents with orthostatic dysregulation measured by heart rate variability. Hypertens Res 2007; 30: 601-5.
115. Fedorowski A, Ostling G, Persson M et al. Orthostatic blood pressure response, carotid intima-media thickness, and plasma fibrinogen in older nondiabetic adults. J Hypertens 2012b; 30: 522-9.