Leukaemia relapse after allogeneic transplants for acute myeloid leukaemia: Predictive role of WT1 expression

British Journal of Haematology

Volumn 160, Issue 4, 2013, Pages 503-509

  Pozzi, Sarah ^a   Geroldi, Simona ^a   Tedone, Elisabetta ^a   Luchetti, Silvia ^a   Grasso, Raffaella ^a   Colombo, Nicoletta ^a   Di Grazia, Carmen ^a   Lamparelli, Teresa ^a   Gualandi, Francesca ^a   Ibatici, Adalberto ^a   Bregante, Stefania ^a   Van Lint, Maria Teresa ^a   Raiola, Anna Maria ^a   Dominietto, Alida ^a   Varaldo, Riccardo ^a   Signori, Alessio ^b   Bacigalupo, Andrea ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Acute Myeloid Leukaemia; Allogeneic stem cell transplantation; WT1

Indexed keywords

CYCLOSPORIN A; STEROID; WT1 PROTEIN;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DONOR LYMPHOCYTE INFUSION; FEMALE; GENE EXPRESSION; GENE FUNCTION; GRAFT VERSUS LEUKEMIA EFFECT; HUMAN; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; MAJOR CLINICAL STUDY; MALE; MYELOABLATIVE CONDITIONING; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTIVE VALUE; PRIORITY JOURNAL; RISK ASSESSMENT; SURVIVAL PREDICTION; SURVIVAL RATE; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKEMIA, MYELOID, ACUTE; LYMPHOCYTE TRANSFUSION; MALE; MIDDLE AGED; NEOPLASM PROTEINS; POSTOPERATIVE CARE; PREOPERATIVE CARE; RECURRENCE; SURVIVAL RATE; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; WT1 PROTEINS; YOUNG ADULT;

EID: 84873083071     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12181     Document Type: Article

References (24)

1. Arellano, M.L., Langston, A., Winton, E., Flowers, C.R. & Waller, E.K. (2007) Treatment of relapsed acute leukemia after allogeneic transplantation: a single center experience. Biology of Blood and Marrow Transplantation, 13, 116-123.
2. Bosi, A., Laszlo, D., Labopin, M., Reffeirs, J., Michallet, M., Gluckman, E., Alessandrino, P.E., Locatelli, F., Vernant, J.P., Sierra, J., Jouet, J.P. & Frassoni, F., Acute Leukemia Working Party of the European Blood and Marrow Transplant Group. (2001) Second allogeneic bone marrow transplantation in acute leukemia: results of a survey by the European Cooperative Group for Blood and Marrow Transplantation. Journal of Clinical Oncology, 19, 3675-3684.
3. Candoni, A., Tiribelli, M., Toffoletti, E., Cilloni, D., Chiarvesio, A., Michelutti, A., Simeone, E., Pipan, C., Saglio, G. & Fanin, R. (2009) Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid leukemia. European Journal of Haematology, 82, 61-68.
4. Cilloni, D. & Saglio, G. (2004) WT1 as a universal marker for minimal residual disease detection and quantification in myeloid leukemias and in myelodysplastic syndrome. Acta Haematologica, 112, 79-84.
5. Cilloni, D., Gottardi, E., De Micheli, D., Serra, A., Volpe, G., Messa, F., Rege-Cambrin, G., Guerrasio, A., Divona, M., Lo Coco, F. & Saglio, G. (2002) Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukaemia patients. Leukemia, 16, 2115-2121.
6. Cilloni, D., Gottardi, E., Messa, F., Fava, M., Scaravaglio, P., Bertini, M., Girotto, M., Marinone, C., Ferrero, D., Gallamini, A., Levis, A. & Saglio, G., Piedmont Study Group on Myleodysplastic Syndromes. (2003) Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System Score in patients with myelodysplastic syndromes. Journal of Clinical Oncology, 21, 1988-1895.
7. Cilloni, D., Messa, F., Arruga, F., Defilippi, I., Gottardi, E., Fava, M., Carturan, S., Catalano, R., Bracco, E., Messa, E., Nicoli, P., Diverio, D., Sanz, M.A., Martinelli, G., Lo-Coco, F. & Saglio, G. (2008) Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy. Haematologica, 93, 921-924.
8. Cilloni, D., Renneville, A., Hermitte, F., Hills, R.K., Daly, S., Jovanovic, J.V., Gottardi, E., Fava, M., Schnittger, S., Weiss, T., Izzo, B., Nomdedeu, J., van der Heijden, A., van der Reijden, B.A., Jansen, J.H., van der Velden, V.H., Ommen, H., Preudhomme, C., Saglio, G. & Grimwade, D. (2009) Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European Leukemia Net study. Journal of Clinical Oncology, 27, 5195-5201.
9. Dominietto, A., Pozzi, S., Miglino, M., Albarracin, F., Piaggio, G., Bertolotti, F., Grasso, R., Zupo, S., Raiola, A.M., Gobbi, M., Frassoni, F. & Bacigalupo, A. (2007) Donor lymphocyte infusions for the treatment of minimal residual disease in acute leukemia. Blood, 109, 5063-5064.
10. Gratwohl, A., Hermans, J., Goldman, J.M., Arcese, W., Carreras, E., Devergie, A., Frassoni, F., Gahrton, G., Kolb, H.J., Niederwieser, D., Ruutu, T., Vernant, J.P., de Witte, T. & Apperley, J. (1998) Risk assessment for patients with chronic myeloid leukaemia before allogeneic blood or marrow transplantation. Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Lancet, 352, 1087-1092.
11. Inoue, K., Ogawa, H., Yamagami, T., Soma, T., Tani, Y., Tatekawa, T., Oji, Y., Tamaki, H., Kyo, T., Dohy, H., Hiraoka, A., Masaoka, T., Kishimoto, T. & Sugiyama, H. (1996) Long-term follow-up of minimal residual disease in leukemia patients by monitoring WT1 (Wilms tumor gene) expression levels. Blood, 88, 2267-2278.
12. Jacobsohn, D.A., Tse, W.T., Chaleff, S., Rademaker, A., Duerst, R., Olszewski, M., Huang, W., Chou, P.M. & Kletzel, M. (2009) High WT1 gene expression before haematopoietic stem cell transplant in children with acute myeloid leukaemia predicts poor event-free survival. British Journal of Haematology, 146, 669-7419650884.
13. Keiding, N., Klein, J.P. & Horowitz, M.M. (2001) Multi-state models and outcome prediction in bone marrow transplantation. Statistics in Medicine, 20, 1871-1885.
14. Keilholz, U., Menssen, H.D., Gaiger, A., Menke, A., Oji, Y., Oka, Y., Scheibenbogen, C., Stauss, H., Thiel, E. & Sugiyama, H. (2005) Wilms' tumour gene 1 (WT1) in human neoplasia. Leukemia, 19, 1318-1323.
15. Kolb, H.J., Schattenberg, A., Goldman, J.M., Hertenstein, B., Jacobsen, N., Arcese, W., Ljungman, P., Ferrant, A., Verdonck, L., Niederwieser, D., van Rhee, F., Mittermueller, J., de Witte, T., Holler, E. & Ansari, H., European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. (1995) Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood, 86, 2041-2050.
16. Ogawa, H., Tamaki, H., Ikegame, K., Soma, T., Kawakami, M., Tsuboi, A., Kim, E.H., Hosen, N., Murakami, M., Fujioka, T., Masuda, T., Taniguchi, Y., Nishida, S., Oji, Y., Oka, Y. & Sugiyama, H. (2003) The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia. Blood, 101, 1698-1704.
17. Ogawa, H., Ikegame, K., Kawakami, M. & Tamaki, H. (2004) WT1 gene transcript assay for relapse in acute leukemia after transplantation. Leukaemia & Lymphoma, 45, 1747-1753.
18. Passweg, J.R., Tiberghien, P., Cahn, J.Y., Vowels, M.R., Camitta, B.M., Gale, R.P., Herzig, R.H., Hoelzer, D., Horowitz, M.M., Ifrah, N., Klein, J.P., Marks, D.I., Ramsay, N.K., Rowlings, P.A., Weisdorf, D.J., Zhang, M.J. & Barrett, A.J. (1998) Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia. Bone Marrow Transplantation, 21, 153-158.
19. Sullivan, K.M., Weiden, P.L., Storb, R., Witherspoon, R.P., Fefer, A., Fisher, L., Buckner, C.D., Anasetti, C., Appelbaum, F.R. & Badger, C. (1989) Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. Blood, 73, 1720-1728.
20. Tamura, K., Kanazawa, T., Suzuki, M., Koitabashi, M., Ogawa, C. & Morikawa, A. (2006) Successful rapid discontinuation of immunosuppressive therapy at molecular relapse after allogeneic bone marrow transplantation in a pediatric patient with myelodysplastic syndrome. American Journal of Hematology, 81, 139-141.
21. Weiden, P.L., Sullivan, K.M., Flournoy, N., Storb, R. & Thomas, E.D. (1981) Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation. New England Journal of Medicine, 304, 1529-1533.
22. Weisser, M., Kern, W., Rauhut, S., Schoch, C., Hiddemann, W. & Haferlach, T. (2005) Prognostic impact of RT-PCR based quantification of WT1 gene expression during MRD monitoring of acute myeloid leukaemia. Leukemia, 8, 1416-1423.
23. Wheatley, K., Burnett, A.K., Goldstone, A.H., Gray, R.G., Hann, I.M., Harrison, C.J., Rees, J.K., Stevens, R.F. & Walker, H. (1999) A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties. British Journal of Haematology, 107, 69-79.
24. Zikos, P., van Lint, M.T., Lamparelli, T., Gualandi, F., Occhini, D., Bregante, S., Berisso, G., Mordini, N., Incagliato, M., Fugazza, G., Sessarego, M. & Bacigalupo, A. (1998) Allogeneic hemopoietic stem cell transplantation for patients with high risk acute lymphoblastic leukemia: favorable impact of chronic graft-versus-host disease on survival and relapse. Haematologica, 83, 896-903.