IgG4-related disease: Why high IgG4 and fibrosis?

Arthritis Research and Therapy

Volumn 15, Issue 1, 2013, Pages

  Koike, Takao ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; APRIL PROTEIN; B CELL ACTIVATING FACTOR; CD40 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 21; INTERLEUKIN 4; MESSENGER RNA; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA; IMMUNOGLOBULIN G;

AUTOIMMUNE PANCREATITIS; B LYMPHOCYTE; CELL INFILTRATION; DACRYOCYSTITIS; EDITORIAL; FIBROSIS; HUMAN; HUMORAL IMMUNITY; HYPERIMMUNOGLOBULINEMIA; IMMUNOGLOBULIN G4 RELATED DISEASE; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE; MIKULICZ DISEASE; MONONUCLEAR CELL; PATHOGENESIS; PHLEBITIS; PLASMA CELL; REGULATORY T LYMPHOCYTE; SJOEGREN SYNDROME; TH1 CELL; TH2 CELL; BIOSYNTHESIS; BLOOD; FEMALE; GENE REARRANGEMENT; MALE; METABOLISM; PHYSIOLOGY;

FEMALE; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; LEUKOCYTES, MONONUCLEAR; MALE; SJOGREN'S SYNDROME;

EID: 84873057286     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4122     Document Type: Editorial

References (9)

1. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T, Mimori T, Tanaka Y, Tsubota K, Yoshino T, Kawa S, Suzuki R, Takegami T, Tomosugi N, Kurose N, Ishigaki Y, Azumi A, Kojima M, Nakamura S, Inoue D. A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol 2012, 22:1-14. 10.1007/s10165-011-0508-6, 3278618, 21881964.
2. Stone JS, Yoh Z, Vikram D. IgG4-related disease. N Engl J Med 2012, 366:539-551. 10.1056/NEJMra1104650, 22316447.
3. Aalverse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp Allergy 2009, 39:469-477. 10.1111/j.1365-2222.2009.03207.x, 19222496.
4. Nirula A, Glaser SM, Kalled SL, Taylar FR. What is IgG4? A review of the biology of a unique immunoglobulin subtype. Curr Opin Rheumatol 2011, 23:119-124. 10.1097/BOR.0b013e3283412fd4, 21124094.
5. Tsuboi H, Matsuo N, Iizuka M, Tsuzuki S, Kondo Y, Tanaka A, Moriyama M, Matsumoto I, Nakamura S, Sumida T. Analysis of IgG4 class switch-related molecules in IgG4-related disease. Arthritis Res Ther 2012, 14:R171. 10.1186/ar3924, 22824292.
6. Tanaka A, Moriyama M, Nakashima H, Miyake K, Hayashida JN, Maehara T, Shinozaki S, Kubo Y, Nakamura S. Th2 and regulatory immune reactions contributes to IgG4 production and the initiation of Mikulicz's disease. Arthritis Rheum 2012, 64:254-263. 10.1002/art.33320, 21898360.
7. Zen Y, Fujii T, Harada K, Kawano M, Yamada K, Takahira M, Nakanuma Y. Th2 and regulatory immune reaction are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis. Hepatology 2007, 45:1538-1546. 10.1002/hep.21697, 17518371.
8. Nakashima H, Miyake K, Moriyama M, Tanaka A, Watanabe M, Abe Y, Sato H, Nakamura S, Saito T. An amplification of IL-10 and TGF-beta in patients with IgG4-related tubulointerstitial nephritis. Clin Nephrol 2010, 73:385-391.
9. Miyoshi H, Uchida K, Taniguchi T, Yazumi S, Matsushita M, Takaoka M, Okazaki K. Circulating naïve and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis. Pancreas 2008, 36:133-140. 10.1097/MPA.0b013e3181577553, 18376303.