Early-in-life bladder inflammation alters U50,488H but not morphine-induced inhibition of visceromotor responses to urinary bladder distension

Neuroscience Letters

Volumn 534, Issue 1, 2013, Pages 150-154

  Shaffer, Amber D ^a   Ness, Timothy J ^b   Randich, Alan ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Animals; Inflammation; Newborn; Opioid; Painful bladder syndrome; Visceral pain

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; KAPPA OPIATE RECEPTOR; MORPHINE; U 50 488 H; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL EXPERIMENT; ARTICLE; BLADDER DISTENSION; CONTROLLED STUDY; DRUG EFFECT; ELECTROMYOGRAM; FEMALE; INTERSTITIAL CYSTITIS; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX; VISCERAL PAIN; VISCEROMOTOR REFLEX;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANESTHESIA; ANIMALS; CYSTITIS; DILATATION, PATHOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MORPHINE; RATS; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; REFLEX; TIME FACTORS; URINARY BLADDER; ZYMOSAN;

EID: 84873056098     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.11.035     Document Type: Article

References (20)

1. Chakrabarti S., Liu N.J., Gintzler A.R. Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:20115-20119.
2. Crain E.F., Gershel J.C. Urinary tract infections in febrile infants younger than 8 weeks of age. Pediatrics 1990, 86:363-367.
3. Danzebrink R.M., Green S.A., Gebhart G.F. Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat. Pain 1995, 63:39-47.
4. DeBerry J., Ness T.J., Robbins M.T., Randich A. Inflammation-induced enhancement of the visceromotor reflex to urinary bladder distension: modulation of endogenous opioids and the effects of early-in-life experience with bladder inflammation. Journal of Pain 2007, 8:914-923.
5. Fitzgerald M., Millard C., McIntosh N. Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anesthesia. Pain 1989, 39:31-36.
6. Holm S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics 1979, 6:65-70.
7. Joshi S.K., Lamb K., Bielefeldt K., Gebhart G.F. Arylacetamide kappa-opioid receptor agonists produce a tonic- and use-dependent block of tetrodotoxin-sensitive and -resistant sodium currents in colon sensory neurons. Journal of Pharmacology and Experimental Therapeutics 2003, 307:361-372.
8. Joshi S.K., Su X., Porreca F., Gebhart G.F. Kappa-opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. Journal of Neuroscience 2000, 20:5874-5879.
9. Knox R.J., Dickenson A.H. Effects of selective and non-selective kappa-opioid receptor agonists on cutaneous C-fibre-evoked responses of rat dorsal horn neurons. Brain Research 1987, 415:21-29.
10. Liu N.J., Chakrabarti S., Schnell S., Wessendorf M., Gintzler A.R. Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal morphine antinociception. Journal of Neuroscience 2011, 31:11836-11845.
11. Liu N.J., von Gizycki H., Gintzler A.R. Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine. Journal of Pharmacology and Experimental Therapeutics 2007, 322:654-660.
12. Peters K.M., Killinger K.A., Ibrahim I.A. Childhood symptoms and events in women with interstitial cystitis/painful bladder syndrome. Urology 2009, 73:258-262.
13. Randich A., Uzzell T., DeBerry J.J., Ness T.J. Neonatal urinary bladder inflammation produces adult bladder hypersensitivity. Journal of Pain 2006, 7:469-479.
14. Sengupta J.N., Su X., Gebhart G.F. Kappa, but not mu or delta, opioids attenuate responses to distension of afferent fibers innervating the rat colon. Gastroenterology 1996, 111:968-980.
15. Shaffer A.D., Ball C.L., Robbins M.T., Ness T.J., Randich A. Effects of acute adult and early-in-life bladder inflammation on bladder neuropeptides in adult female rats. BMC Urology 2011, 11:18-25.
16. A.D. Shaffer, T.J. Ness, M.T. Robbins, A. Randich, Early-in-life bladder inflammation alters opioid peptide content in the spinal cord and bladder of adult female rats, Journal of Urology, in press.
17. Su X., Joshi S.K., Kardos S., Gebhart G.F. Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral anti-nociceptive effects. Journal of Neurophysiology 2002, 87:1271-1279.
18. Su X., Riedel E.X., Leon L.A., Laping N.J. Pharmacologic evaluation of pressor and visceromotor reflex responses to bladder distension. Neurourology and Urodynamics 2008, 27:249-253.
19. Su X., Sengupta J.N., Gebhart G.F. Effects of opioids on mechanosensitive pelvic nerve afferent fibers innervating the urinary bladder of the rat. Journal of Neurophysiology 1997, 77:1566-1580.
20. Sullivan A.F., Dickenson A.H. Electrophysiologic studies on the spinal antinociceptive action of kappa opioid agonists in the adult and 21-day-old rat. Journal of Pharmacology and Experimental Therapeutics 1991, 256:1119-1125.