High incidence of pulmonary tuberculosis in children admitted with severe pneumonia in Uganda

BMC Pediatrics

Volumn 13, Issue 1, 2013, Pages

  Nantongo, Josephine M ^a   Wobudeya, Eric ^b,c   Mupere, Ezekiel ^a   Joloba, Moses ^a   Ssengooba, Willy ^a   Kisembo, Harriet N ^a   Lubega, Irene R ^a,c   Musoke, Philippa M ^a,c  

^a MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^b MULAGO NATIONAL REFERRAL HOSPITAL   (Uganda)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIUM CULTURE; BCG VACCINATION; BLOOD CULTURE; CHILD; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; PNEUMONIA; PRESCHOOL CHILD; THORAX RADIOGRAPHY; TUBERCULIN TEST; UGANDA;

CHILD; CHILD, PRESCHOOL; COST OF ILLNESS; CROSS-SECTIONAL STUDIES; HOSPITALIZATION; HUMANS; INCIDENCE; INFANT; LOGISTIC MODELS; MULTIVARIATE ANALYSIS; PNEUMONIA; SEVERITY OF ILLNESS INDEX; TUBERCULOSIS, PULMONARY; UGANDA;

EID: 84873035111     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/1471-2431-13-16     Document Type: Article

References (25)

1. WHO Report 2011: Global Tuberculosis Control 2011, In. Geneva: World Health Organisation.
2. Zar HJ, Hanslo D, Tannenbaum E, Klein M, Argent A, Eley B, Burgess J, Magnus K, Bateman ED, Hussey G. Aetiology and outcome of pneumonia in human immunodeficiency virus-infected children hospitalized in South Africa. Acta Paediatr 2001, 90(2):119-125. 10.1111/j.1651-2227.2001.tb00270.x, 11236037.
3. Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ 2008, 86(5):408-416. 10.2471/BLT.07.048769, 2647437, 18545744.
4. Country Health System Fact Sheet 2006 Uganda 2006, Geneva: World Health Organisation, accessed at http://www.afro.who.int/en/uganda/country-health-profile.html.
5. McNally LM, Jeena PM, Gajee K, Thula SA, Sturm AW, Cassol S, Tomkins AM, Coovadia HM, Goldblatt D. Effect of age, polymicrobial disease, and maternal HIV status on treatment response and cause of severe pneumonia in South African children: a prospective descriptive study. Lancet 2007, 369(9571):1440-1451. 10.1016/S0140-6736(07)60670-9, 17467514.
6. Nelson LJ, Wells CD. Global epidemiology of childhood tuberculosis. Int J Tuberc Lung Dis 2004, 8(5):636-647.
7. Global Tuberculosis Report 2012 2012, In. Geneva: World Health Organisation.
8. Jeena PM, Pillay P, Pillay T, Coovadia HM. Impact of HIV-1 co-infection on presentation and hospital-related mortality in children with culture proven pulmonary tuberculosis in Durban, South Africa. Int J Tuberc Lung Dis 2002, 6(8):672-678.
9. Craig SE, Bettinson H, Sabin CA, Gillespie SH, Lipman MC. Think TB! Is the diagnosis of pulmonary tuberculosis delayed by the use of antibiotics?. Int J Tuberc Lung Dis 2009, 13(2):208-213.
10. The stop TB strategy, vol. WHO/HTM/TB/2006.368 2006, Geneva: World Health Organisation.
11. Bahl R, Bhandari N, Bhan MK. Classification and treatment of pneumonia. Indian J Pediatr 1994, 61(6):605-618. 10.1007/BF02751964, 7721363.
12. MGIT Procedure Manual [http://www.finddiagnostics.org/export/sites/default/resource-centre/find_documentation/pdfs/mgit_manual_nov_2007.pdf].
13. Strong BE, Kubica GP. Isolation and identification of Mycobacterium tuberculosis: A Guide For The Level III laboratory 1981, Atlanta, Georgia: CDC.
14. Hirano K, Aono A, Takahashi M, Abe C. Mutations including IS6110 insertion in the gene encoding the MPB64 protein of Capilia TB-negative Mycobacterium tuberculosis isolates. J Clin Microbiol 2004, 42(1):390-392. 10.1128/JCM.42.1.390-392.2004, 321697, 14715787.
15. Graham SM, Ahmed T, Amanullah F, Browning R, Cardenas V, Casenghi M, Cuevas LE, Gale M, Gie RP, Grzemska M, et al. Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel. J Infect Dis 2012, 205(Suppl 2):S199-S208. 10.1093/infdis/jis008, 22448023.
16. Feng JY, Fang WF, Wu CL, Yu CJ, Lin MC, Ku SC, Chen YC, Chen CW, Tu CY, Su WJ, et al. Concomitant pulmonary tuberculosis in hospitalized healthcare-associated pneumonia in a tuberculosis endemic area: a multi-center retrospective study. PLoS One 2012, 7(5):e36832. 10.1371/journal.pone.0036832, 3358294, 22629334.
17. Iriso R, Mudido PM, Karamagi C, Whalen C. The diagnosis of childhood tuberculosis in an HIV-endemic setting and the use of induced sputum. Int J Tuberc Lung Dis 2005, 9(7):716-726.
18. Moore DP, Klugman KP, Madhi SA. Role of Streptococcus pneumoniae in hospitalization for acute community-acquired pneumonia associated with culture-confirmed Mycobacterium tuberculosis in children: a pneumococcal conjugate vaccine probe study. Pediatr Infect Dis J 2010, 29(12):1099-1104. 10.1097/INF.0b013e3181eaefff, 21155174.
19. Madhi SA, Petersen K, Madhi A, Khoosal M, Klugman KP. Increased disease burden and antibiotic resistance of bacteria causing severe community-acquired lower respiratory tract infections in human immunodeficiency virus type 1-infected children. Clin Infect Dis 2000, 31(1):170-176. 10.1086/313925, 10913417.
20. Marais BJ, Obihara CC, Gie RP, Schaaf HS, Hesseling AC, Lombard C, Enarson D, Bateman E, Beyers N. The prevalence of symptoms associated with pulmonary tuberculosis in randomly selected children from a high burden community. Arch Dis Child 2005, 90(11):1166-1170. 10.1136/adc.2004.060640, 1720178, 16243872.
21. Soeters M, de Vries AM, Kimpen JL, Donald PR, Schaaf HS. Clinical features and outcome in children admitted to a TB hospital in the Western Cape-the influence of HIV infection and drug resistance. S Afr Med J 2005, 95(8):602-606.
22. Houwert KA, Borggreven PA, Schaaf HS, Nel E, Donald PR, Stolk J. Prospective evaluation of World Health Organization criteria to assist diagnosis of tuberculosis in children. Eur Respir J 1998, 11(5):1116-1120. 10.1183/09031936.98.11051116, 9648965.
23. Styblo K. Surveillance of tuberculosis. Int J Epidemiol 1976, 5(1):63-68. 10.1093/ije/5.1.63, 1262116.
24. Blower SM, Daley CL. Problems and solutions for the Stop TB partnership. Lancet Infect Dis 2002, 2(6):374-376. 10.1016/S1473-3099(02)00292-X, 12144901.
25. Marais BJ, Gie RP, Schaaf HS, Beyers N, Donald PR, Starke JR. Childhood pulmonary tuberculosis: old wisdom and new challenges. Am J Respir Crit Care Med 2006, 173(10):1078-1090. 10.1164/rccm.200511-1809SO, 16484674.