Two cases of sepsis-like illness in infants caused by human parechovirus traced back to elder siblings with mild gastroenteritis and respiratory symptoms

Journal of Clinical Microbiology

Volumn 51, Issue 2, 2013, Pages 715-718

  Eis Hübinger, Anna M ^a   Eckerle, Isabella ^a   Helmer, Angelika ^a   Reber, Ulrike ^a   Dresbach, Till ^b   Buderus, Stephan ^c   Drosten, Christian ^a   Müller, Andreas ^b  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c ST MARIEN HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMPICILLIN; C REACTIVE PROTEIN; INTERLEUKIN 6; NUCLEOTIDE; PIPERACILLIN PLUS TAZOBACTAM; TOBRAMYCIN;

ARTICLE; CASE REPORT; ENTERIC VIRUS; ERYTHEMA; FECES ANALYSIS; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; HUMAN PARECHOVIRUS TYPE 3; INFANT; MALE; MUSCLE HYPERTONIA; NEWBORN; NEWBORN INTENSIVE CARE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARECHOVIRUS; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY VIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; SIBLING; TACHYCARDIA; THROMBOCYTE COUNT; URINALYSIS; VIRAL GASTROENTERITIS; VIRAL RESPIRATORY TRACT INFECTION; VIRUS DETECTION;

CHILD, PRESCHOOL; FEMALE; GASTROENTERITIS; HUMANS; INFANT; INFANT, NEWBORN; MALE; MOLECULAR SEQUENCE DATA; PARECHOVIRUS; PICORNAVIRIDAE INFECTIONS; RNA, VIRAL; SEPSIS; SEQUENCE ANALYSIS, DNA; SIBLINGS; VIRAL LOAD;

EID: 84873021148     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02731-12     Document Type: Article

References (27)

1. Baumgarte S, de Souza Luna LK, Grywna K, Panning M, Drexler JF, Karsten C, Huppertz HI, Drosten C. 2008. Prevalence, types, and RNA concentrations of human parechoviruses, including a sixth parechovirus type, in stool samples from patients with acute enteritis. J. Clin. Microbiol. 46:242-248.
2. Pham NT, Trinh QD, Khamrin P, Maneekarn N, Shimizu H, Okitsu S, Mizuguchi M, Ushijima H. 2010. Diversity of human parechoviruses isolated from stool samples collected from Thai children with acute gastroenteritis. J. Clin. Microbiol. 48:115-119.
3. Benschop KSM, Schinkel J, Minnaar RP, Pajkrt D, Spanjerberg L, Kraakman HC, Berkhout B, Zaaijer HL, Beld MG, Wolthers KC. 2006. Human parechovirus infections in Dutch children and the association between serotype and disease severity. Clin. Infect. Dis. 42:204 -210.
4. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, Jha P, Campbell H, Walker CF, Cibulskis R, Eisele T, Liu L, Mathers C, Child Health Epidemiology Reference Group of WHO and UNICEF. 2010. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 375:1969 -1987.
5. Boivin G, Abed Y, Boucher FD. 2005. Human parechovirus 3 and neonatal infections. Emerg. Infect. Dis. 11:103-107.
6. Wolthers KC, Benschop KS, Schinkel J, Molenkamp R, Bergevoet RM, Spijkerman IJ, Kraakman HC, Pajkrt D. 2008. Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children. Clin. Infect. Dis. 47:358 -363.
7. Harvala H, Robertson I, Chieochansin T, McWilliam Leitch EC, Templeton K, Simmonds P. 2009. Specific association of human parechovirus type 3 with sepsis and fever in young infants, as identified by direct typing of cerebrospinal fluid samples. J. Infect. Dis. 199:1753-1760.
8. Selvarangan R, Nzabi M, Selvaraju SB, Ketter P, Carpenter C, Harrison CJ. 2011. Human parechovirus 3 causing sepsis-like illness in children from midwestern United States. Pediatr. Infect. Dis. J. 30:238 -242.
9. Renaud C, Kuypers J, Ficken E, Cent A, Corey L, Englund JA. 2011. Introduction of a novel parechovirus RT-PCR clinical test in a regional medical center. J. Clin. Virol. 51:50 -53.
10. Walters B, Peñaranda S, Nix WA, Oberste MS, Todd KM, Katz BZ, Zheng X. 2011. Detection of human parechovirus (HPeV)-3 in spinal fluid specimens from pediatric patients in the Chicago area. J. Clin. Virol. 52:187-191.
11. Piralla A, Furione M, Rovida F, Marchi A, Stronati M, Gerna G, Baldanti F. 2012. Human parechovirus infections in patients admitted to hospital in Northern Italy, 2008-2010. J. Med. Virol. 84:686-690.
12. Schuffenecker I, Javouhey E, Gillet Y, Kugener B, Billaud G, Floret D, Lina B, Morfin F. 2012. Human parechovirus infections, Lyon, France, 2008-10: evidence for severe cases. J. Clin. Virol. 54:337-341.
13. Harvala H, Wolthers KC, Simmonds P. 2010. Parechoviruses in children: understanding a new infection. Curr. Opin. Infect. Dis. 23:224 -230.
14. Sedmak G, Nix WA, Jentzen J, Haupt TE, Davis JP, Bhattacharyya S, Pallansch MA, Oberste MS. 2010. Infant deaths associated with human parechovirus infection in Wisconsin. Clin. Infect. Dis. 50:357-361.
15. Al Maamari K, Docherty C, Aitken C. 2009. "Twin" viruses. J. Clin. Virol. 44:vi.
16. Calvert J, Chieochansin T, Benschop KS, McWilliam Leitch EC, Drexler JF, Grywna K, da Costa Ribeiro H Jr, Drosten C, Harvala H, Poovorawan Y, Wolthers KC, Simmonds P. 2010. Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates. J. Gen. Virol. 91:1229 -1238.
17. Westerhuis BM, Koen G, Wildenbeest JG, Pajkrt D, de Jong MD, Benschop KS, Wolthers KC. 2012. Specific cell tropism and neutralization of human parechovirus types 1 and 3: implications for pathogenesis and therapy development. J. Gen. Virol. 93:2363-2370.
18. Pallansch M, Roos R. 2007. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses, p 839-893. In Knipe DM, Howley PM (ed), Fields' virology, 5th edition. Lippincott Williams & Wilkins, Philadelphia, PA.
19. Verboon-Maciolek MA, Krediet TG, Gerards LJ, de Vries LS, Groenendaal F, van Loon AM. 2008. Severe neonatal parechovirus infection and similarity with enterovirus infection. Pediatr. Infect. Dis. J. 27:241-245.
20. Benschop K, Thomas X, Serpenti C, Molenkamp R, Wolthers K. 2008. High prevalence of human parechovirus (HPeV) genotypes in the Amsterdam region and identification of specific HPeV variants by direct genotyping of stool samples. J. Clin. Microbiol. 46:3965-3970.
21. Tapia G, Cinek O, Witsø E, Kulich M, Rasmussen T, Grinde B, Rønningen KS. 2008. Longitudinal observation of parechovirus in stool samples from Norwegian infants. J. Med. Virol. 80:1835-1842.
22. van der Sanden S, de Bruin E, Vennema H, Swanink C, Koopmans M, van der Avoort H. 2008. Prevalence of human parechovirus in the Netherlands in 2000 to 2007. J. Clin. Microbiol. 46:2884 -2889.
23. Ito M, Yamashita T, Tsuzuki H, Kabashima Y, Hasegawa A, Nagaya S, Kawaguchi M, Kobayashi S, Fujiura A, Sakae K, Minagawa H. 2010. Detection of human parechoviruses from clinical stool samples in Aichi, Japan. J. Clin. Microbiol. 48:2683-2688.
24. Benschop K, Minnaar R, Koen G, van Eijk H, Dijkman K, Westerhuis B, Molenkamp R, Wolthers K. 2010. Detection of human enterovirus and human parechovirus (HPeV) genotypes from clinical stool samples: polymerase chain reaction and direct molecular typing, culture characteristics, and serotyping. Diagn. Microbiol. Infect. Dis. 68:166 -173.
25. Sharp J, Bell J, Harrison CJ, Nix AW, Oberste MS, Selvarangan R. 2012. Human parechovirus in respiratory specimens from children in Kansas City, Missouri. J. Clin. Microbiol. 50:4111- 4113.
26. Harvala H, Robertson I, McWilliam Leitch EC, Benschop K, Wolthers KC, Templeton K, Simmonds P. 2008. Epidemiology and clinical associations of human parechovirus respiratory infections. J. Clin. Microbiol. 46:3446 -3453.
27. Zhong H, Lin Y, Sun J, Su L, Cao L, Yang Y, Xu J. 2011. Prevalence and genotypes of human parechovirus in stool samples from hospitalized children in Shanghai, China, 2008 and 2009. J. Med. Virol. 83: 1428 -1434.