Cardiac disease in adolescents with delayed diagnosis of vertically acquired HIV infection

Clinical Infectious Diseases

Volumn 56, Issue 4, 2013, Pages 576-582

  Miller, Robert F ^a,b   Kaski, Juan P ^a,c   Hakim, James ^e   Matenga, Jonathan ^e   Nathoo, Kusum ^e   Munyati, Shungu ^f   Desai, Sujal R ^d   Corbett, Elizabeth L ^b,f,g   Ferrand, Rashida A ^b,f  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF ZIMBABWE   (Zimbabwe)

^f BIOMEDICAL RESEARCH AND TRAINING INSTITUTE   (Zimbabwe)

^g UNIVERSITY OF MALAWI   (Malawi)

Author keywords

adolescent; Africa; cardiac disease; cardiomyopathy; vertically acquired HIV

Indexed keywords

ANTIRETROVIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; ZIDOVUDINE;

ADOLESCENT; ADOLESCENT DISEASE; ADULT; ANAMNESIS; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CHILD; CLINICAL EXAMINATION; DIASTOLIC DYSFUNCTION; DOPPLER ECHOCARDIOGRAPHY; DYSPNEA; FEMALE; HEART DISEASE; HEART LEFT VENTRICLE HYPERTROPHY; HEART PALPITATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LUNG ARTERY PRESSURE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SCHOOL CHILD; THORAX PAIN; VERTICAL TRANSMISSION;

ADOLESCENT; CHILD; DELAYED DIAGNOSIS; ECHOCARDIOGRAPHY; FEMALE; HEART VENTRICLES; HIV INFECTIONS; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; VENTRICULAR DYSFUNCTION, LEFT; YOUNG ADULT; ZIMBABWE;

EID: 84873019006     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cis911     Document Type: Article

References (40)

1. Joint United Nations Programme on HIV/AIDS. Global report annexes. Available at: http://www.unaids.org/documents/20101123-Global Report-Annexes1-em.pdf. Accessed 9 April 2012.
2. Marson M, Zaba B, Salomon JA, Brahmbhatt H, Bagenda D. Estimating the net effect of HIV on child mortality in African populations affected by generalized HIV epidemics. J Acquir Immune Defic Syndr 2005; 38:219-27.
3. Stover J, Walker N, Grassly NC, Marston M. Projecting the demographic impact of AIDS and the number of people in need of treatment: updates to the Spectrum projection package. Sex Trans Infect 2006; 82(Suppl 3):iii45-50.
4. Ferrand RA, Corbett EL, Wood R, et al. AIDS among older children and adolescents in Southern Africa: projecting the time course and magnitude of the epidemic. AIDS 2009; 23:2039-46.
5. Ferrand RA, Munaiwa L, Matsekete J, et al. Undiagnosed HIV infection among adolescents seeking primary care in Zimbabwe. Clin Infect Dis 2010; 51:844-51.
6. Ferrand RA, Desai SR, Hopkins C, et al. Chronic lung disease in adolescents with delayed diagnosis of vertically-acquired HIV infection. Clin Infect Dis 2012; 55:145-52.
7. Ferrand RA, Bandason T, Musivaire P, et al. Causes of acute hospitalization in adolescence: burden and spectrum of HIV-related morbidity in a country with an early-onset and severe HIV epidemic: a prospective survey. PLoS Med 2010; 7:e1000178.
8. Lipshultz SE, Easley KA, Orav EJ, et al. for the Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV infection (P2C2 HIV) Study Group. Left ventricular structure and function in children infected with human immunodeficiency virus. The prospective P2C2 HIV Multicenter Study. Circulation 1998; 97:1246-56.
9. Starc TJ, Lipshultz SE, Kaplan S, et al.; for the Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV infection (P2C2 HIV) Study Group. Cardiac complications in children with human immunodeficiency virus infection. Pediatrics 1999; 104:e14.
10. Lipshultz SE, Easley KA, Orav EJ, et al. Cardiac dysfunction and mortality in HIV-infected children: the prospective P2C2 HIV Multicenter Study. Circulation 2000; 102:1542-8.
11. Starc TJ, Lipshultz SE, Easley KA, et al.; for the Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV infection (P2C2 HIV) Study Group. Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: the prospective P2C2 HIV study. J Pediatr 2002; 141:327-35.
12. Fisher SD, Easley KA, Orav EJ, et al.; for the Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV infection (P2C2 HIV) Study Group. Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study. Am Heart J 2005; 150:439-47.
13. Brown SC, Schoeman CJ, Bester CJ. Cardiac findings in children admitted to a hospital general ward in South Africa: a comparison of HIV-infected and uninfected children. Cardiovasc J South Afr 2005; 16:206-10.
14. Lubega S, Zirembuzi GW, Lwabi P. Heart diseases among children with HIV/AIDS attending the pediatric infectious disease clinic at Mulago hospital. Afr Health Sci 2005; 5:219-26.
15. Okoromah CA, Ojo OO, Ogunkunle OO. Cardiovascular dysfunction in HIV-infected children in a sub-Saharan African country: comparative cross-sectional observational study. J Trop Pediatr 2012; 58:3-11.
16. Pongprot Y, Sittiwangkul R, Silvilairat S, Sirisanthana V. Cardiac manifestations in HIV-infected Thai children. Ann Trop Paediatr 2004; 24:153-9.
17. Ferrand RA, Luethy R, Bwakura F, Mujuru H, Miller RF, Corbett EL. HIV infection presenting in older children and adolescents: a case series from Harare, Zimbabwe. Clin Infect Dis 2007; 44:874-8.
18. World Health Organization. Interim WHO clinical staging of HIV/AIDS and HIV/AIDS case definitions for surveillance-African Region. Report No: WHO/HIV/2005.02. Geneva, Switzerland: World Health Organization, 2005.
19. Cole TJ. Growth monitoring with the British 1990 growth reference. Arch Dis Child 1997; 76:47-9.
20. Gottdiener JS, Bednarz J, Devereux R, et al. American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr 2004; 17:1086-119.
21. Henry WL, DeMaria A, Gramiak R, et al. Report of the American society of echocardiography committee on nomenclature and standards in two-dimensional echocardiography. Circulation 1980; 62:212-7.
22. Kircher BJ, Himelman RB, Schiller NB. Noninvasive estimation of right atrial pressure from the inspiratory collapse of the inferior vena cava. Am J Cardiol 1990; 66:493-6.
23. Foster BJ, Mackie AS, Mitsnefes M, Ali H, Mamber S, Colan SD. A novel method of expressing left ventricular mass relative to body size in children. Circulation 2008; 117:2769-75.
24. Kampmann C, Wiethoff CM, Wenzel A, et al. Normal values of M mode echocardiographic measurements of more than 2000 healthy infants and children in central Europe. Heart 2000; 83:667-72.
25. Bannerman C, Chitskie I. Cor pulmonale in children with human immunodeficiency virus infection. Ann Trop Paediatr 1995; 15: 129-35.
26. Kavanaugh-McHugh A, Ruff A, Rowe S, Holt E, Wilfert C, Modlin JF. Cardiac abnormalities in a multi-center interventional study of children with symptomatic HIV infection. The ACTG 043. Pediatr Res 1991; 29:176A (Abstract).
27. Herman DS, Lam L, Taylor MR, et al. Truncations of titin causing dilated cardiomyopathy. N Engl J Med 2012; 366:619-28.
28. Friedrich FW, Carrier L. Genetics of hypertrophic and dilated cardiomyopathy. Curr Pharm Biotechnol 2012 [Epub ahead of print].
29. Kindermann I, Barth C, Mahfoud F, et al. Update on myocarditis. J Am Coll Cardiol 2012; 59:779-92.
30. Twagirumukiza M, Nkeramihigo E, Seminega B, Gasakure E, Boccara F, Barbaro G. Prevalence of dilated cardiomyopathy in HIV-infected African patients not receiving HAART: a multicenter, observational, prospective, cohort study in Rwanda. Curr HIV Res 2007; 5:129-37.
31. Miller TL, Orav EJ, Colan SD, Lipshultz SE. Nutritional status and cardiac mass and function in children infected with the human immunodeficiency virus. Am J Clin Nutr 1997; 66:660-4.
32. Kan H, Xie Z, Finkel MS. P38 MAP kinase-mediated negative inotropic effect of HIV gp120 on cardiac myocytes. Am J Physiol Cell Physiol 2004; 286:C1-7.
33. Berzingi C, Chen F, Finkel MS. P38 MAP kinase inhibitor prevents diastolic dysfunction in rats following HIV gp120 injection in vivo. Cardiovasc Toxicol 2009; 9:142-50.
34. Liggett SB. β-adrenergic receptors in the failing heart: the good, the bad, and the unknown. J Clin Invest 2001; 107:947-8.
35. Kelly KM, Tarwater PM, Karper JM, et al. Diastolic dysfunction is associated with myocardial viral load in simian immunodeficiency virus-infected macaques. AIDS 2012; 26:815-23.
36. Chen F, Bhardwaj R, Finkel MS. Diastolic dysfunction following HIV infection. AIDS 2012; 26:885-6.
37. World Health Organization. Antiretroviral therapy for HIV infection in infants and children: towards universal access. Available at: http://www. who.int/hiv/pub/paediatric/paed-prelim-summary.pdf. Accessed 12 April 2012.
38. Luo L, Ye Y, Liu Z, et al. Assessment of cardiac diastolic dysfunction in HIV-infected people without cardiovascular symptoms in China. Int J STD & AIDS 2010; 21:814-8.
39. Meng Q, Lima JAC, Lai H, et al. Use of HIV protease inhibitors is associated with left ventricular morphologic changes and diastolic dysfunction. J Acquir Immune Defic Syndr 2002; 30:306-10.
40. Tukei VJ, Asiimwe A, Maganda A, et al. Safety and tolerability of antiretroviral therapy among HIV-infected children and adolescents in Uganda. J Acquir Immune Defic Syndr 2012; 59:274-80.