Hyperbaric oxygen therapy and delayed radiation injuries (soft tissue and bony necrosis): 2012 update

Undersea and Hyperbaric Medicine

Volumn 39, Issue 6, 2012, Pages 1121-1139

  Feldmeier, John J ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMEN; BONE NECROSIS; CONNECTIVE TISSUE; CYSTITIS; ENTERITIS; HUMAN; HYPERBARIC OXYGEN; LARYNX; LIMB; MANDIBLE; METHODOLOGY; NECROSIS; NERVOUS SYSTEM; PATHOLOGY; PELVIS; PROCTITIS; RADIATION EXPOSURE; RADIATION INJURY; REVIEW; THORAX WALL;

ABDOMEN; CONNECTIVE TISSUE; CYSTITIS; ENTERITIS; EXTREMITIES; HUMANS; HYPERBARIC OXYGENATION; LARYNX; MANDIBLE; NECROSIS; NERVOUS SYSTEM; OSTEORADIONECROSIS; PELVIS; PROCTITIS; RADIATION INJURIES; THORACIC WALL;

MLCS; MLOWN;

EID: 84872981802     PISSN: 10662936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (109)

1. Rubin P, Casarrett GW. Clinical Radiation Pathology, Vol I, pp 58-61, Philadelphia Pa: WB Saunders, 1968.
2. Dorr W, Hendry H. Consequential late effects in normal tissues. Radiotherapy and Oncology 2001;61:223-31. (Pubitemid 33127227)
3. Carl UM, Hartmann KA. Hyperbaric oxygen treatment for symptomatic breast edema after radiation therapy. Undersea Hyperb Med 1998;25;233-234. (Pubitemid 128456994)
4. Delanian S, Lefaix J. Current management for late normal tissue injury: radiation-induced fibrosis and necrosis. Semin Radiat Oncol 2007;17:99-107. (Pubitemid 46476864)
5. Fleckenstein K, Gauter-Fleckenstein B, Jackson IL, Rabbani Z, Anscher M, Vujaskovic Z. Using biological markers to predict risk of radiation injury. Semin Radiat Oncol 2007;17:89-98. (Pubitemid 46467379)
6. Marx RE. Radiation injury to tissue. In: Kindwall EP, ed. Hyperbaric Medicine Practice, Second Edition. Flagstaff, Best Publishing, 1999, pp 665-723.
7. Feldmeier JJ, Davolt DA, Court WS, Onoda JM, Alecu R. Histologic morphometry confirms a prophylactic effect for hyperbaric oxygen in the prevention of delayed radiation enteropathy. Undersea Hyper Med 1998;25(2):93-97. (Pubitemid 128456977)
8. Feldmeier JJ, Jelen I, Davolt DA, Valente PT, Meltz ML, Alecu R. Hyperbaric oxygen as a prophylaxis for radiation induced delayed enteropathy. Radiotherapy and Oncology 1995;35:138-144
9. Rubin P, Finkelstein J, Shapiro D. Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes. Int J Radiat Oncol Biol Phys 1992;24:93-101.
10. Trott KR. Chronic damage after radiation therapy: Challenge to radiation biology. Int J Radiat Oncol Biol Phys 1984;10:907-913. (Pubitemid 14094070)
11. Marx RE. Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg 1983;41:283-288 (Pubitemid 13061964)
12. Marx RE, Ehler WJ, Tayapongsak P, Pierce LW. Relationship of oxygen dose to angiogenesis induction in irradiated tissue. Am J Surg 1990;160:519-524. (Pubitemid 20375616)
13. Goldstein LJ, Gallagher KA, Bauer SM et al. Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxide. Stem Cells. 2006;24:2309-18. (Pubitemid 44527485)
14. Gallagher KA, Liu Z, Xiao M et al. Diabetic impairments in NO-mediated endothelial progenitor mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest. 2007;117:1249-59. (Pubitemid 46718413)
15. Bedwinek JM, Shukovsky LJ, Fletcher GH, Daly TE. Osteonecrosis in patients treated with definitive radiotherapy for squamous cell cancers of the oral cavity and naso-and oropharynx. Radiology 1976;119:665-667.
16. Emami B, Lyman J, Brown A, Coia L, Gottein M, Munzenrider JE, Shank B, Solin LJ, Wesson M. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991:21:109-122.
17. Gomez DR, Estilo L, Wolden SL, Zelefsky MJ, Kraus DH, Wong RJ, Shaha AR, Jatin JP, Mechalakos JG, Lee NY. Correlation of osteoradionecrosis and dental events with dosimetric parameters in intensity-modulated radiation therapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2011 Nov. 15;81(4):e207-13.
18. Parsons JT. The effect of radiation on normal tissues of the head and neck. In: Million RR, Cassisi NJ, eds. Management of head and neck cancer: A multi-disciplinary ppproach. Philadelphia: JB Lippincott, 1994:245-289.
19. Max RE. Osteoradionecrosis of the jaws: Review and update. HBO Review 1984;5(2):78-126.
20. Marx RE, Ames JR. The use of hyperbaric oxygen therapy in bony reconstruction of the irradiated and tissue deficient patient. J Oral Maxillofac Surg 1982;40:412-9.
21. Feldmeier JJ, Hampson NB. A systematic review of the literature reporting the application of hyperbaric oxygen prevention and treatment of delayed radiation injuries: an evidence based approach. UHM 2002;29:4-30.
22. Tobey RE, Kelly JF. Osteoradionecrosis of the jaws. Otolaryngol Clin North Am. 1979;12(1):183-186. (Pubitemid 9132512)
23. Maier A, Gaggl A, Klemen H, Santler G, Anegg U, Fell B, Karcher H, Smolle-Juttner FM, Friehs GB. Review of severe osteoradionecrosis treated by surgery alone or surgery with postoperative hyperbaric oxygenation. Br J Oral Maxillofac Surg 2000;38:173-6. (Pubitemid 30386601)
24. Annane D, Depondt J, Aubert P et al. Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized controlled, double-blind trial from ORN96 Study Group. J Clin Oncol 2004;22:4893-4900. (Pubitemid 46638613)
25. Feldmeier JJ, Heimbach RD, Davolt DA, Court WS, Stegmann BJ, Sheffield PJ. Hyperbaric oxygen as an adjunctive treatment for delayed radiation injury of the chest wall: a retrospective review of 23 cases. Undersea Hyperb Med 1995;22:383-393.
26. Moon RE, McGraw TA, Blakey G. Hyperbaric oxygen therapy for radiation necrosis of the jaw: comments on a randomized study. UHM 2005;32:145-6.
27. Laden G. Hyperbaric oxygen therapy for radionecrosis: clear evidence from confusing data (letter to the editor). J Clin Oncol 2005;23:4465. (Pubitemid 46207024)
28. Gal TJ, Yueh B, Futran ND. Influence of prior hyperbaric oxygen therapy in complications following microvascular reconstruction for advanced osteoradionecrosis. Arch Otolaryngol Head Neck Surg 2003;129:72-76 (Pubitemid 36074942)
29. Teng MS, Futran ND. Osteoradionecrosis of the mandible. Cur Opin Otolaryngol Head Neck Surg 2005;13:217-21. (Pubitemid 41003848)
30. Mendenhall WM. Mandibular Osteoradionecrosis (editorial) J Clin Oncol 2004;22:4867-8.
31. Hampson NB, Holm JR, Wreford-Brown CE, Feldmeier JJ. Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen for chronic radiation issue injury. Cancer 2012;118:3860-8.
32. Marx RE, Johnson RP, Kline SN. Prevention of osteoradionecrosis: A randomized prospective clinical trial of hyperbaric oxygen versus penicillin. J Am Dent Assoc 1985;11:49-54.
33. Vudiniabola S, Pirone C, Williamson J, Goss A N N. Hyperbaric oxygen in the prevention of osteoradionecrosis of the jaws. Australian Dental Journal 1999;44:243-247.
34. David LA, Sandor GK, Evans AW, Brown DH. Hyperbaric oxygen therapy and mandibular osteoradionecrosis: a retrospective study and analysis of treatment outcomes. J Can Dent Assoc 2001;67:384.
35. Chavez JA, Adkinson CD. Adjunctive hyperbaric oxygen in irradiated patients requiring dental extractions: outcomes and complications. J Oral Maxillofac Surg 2001;59:518-22. (Pubitemid 32391138)
36. Sulaiman F, Huryn JM, Ziotolow IM. Dental extractions in the irradiated head and neck patient: a retrospective analysis of Memorial Sloan-Kettering Cancer Center protocols, criteria, and end results. J Oral Maxillofac Surg 2003;61:1123-31. (Pubitemid 37193487)
37. Wahl MJ. Osteoradionecrosis prevention myths. Int J Radiation Oncology Biol Phys 2006;64:661-9. (Pubitemid 43183558)
38. Mendenhall WM, Amdur RJ, Palta JR. Intensity-modulated radiotherapy in the standard management of head and neck cancer: promises and pitfalls. J Clin Oncol. 2006 Jun. 10;24(17):2618-23. (Pubitemid 46622082)
39. Reuther T, Schuster T, Mende U, Kubler A. Osteoradionecrosis of the jaws as a side effect of radiotherapy of head and neck tumour patients - a report of a thirty year retrospective review. Int J Oral Maxillofac Surg. 2003 Jun: 32(3):289-95. (Pubitemid 36700738)
40. Kim JC, Elkin D, Hendrickson FR. Carcinoma of the vocal cords: results of treatment and time-dose relationships. Cancer 1978;42:1114-9. (Pubitemid 9054566)
41. Stell PM, Morrison ND. Radiation necrosis of the larynx: etiology and management. Arch Oto-rhin-laryngol 1973;98:111-3.
42. Flood LM, brightwell AP. Clinical assessment of the irradiated larynx. J Laryngol Otol 1984;98:493-8.
43. Chandler JR. Radiation fibrosis and necrosis of the larynx. Ann Otol Rhinol & Laryngol 1979;88:509-14. (Pubitemid 9255205)
44. Ferguson BJ, Hudson WR, Farmer JC. Hyperbaric oxygen for laryngeal radionecrosis. Ann Otol Laryngol 1987;96:1-6.
45. Feldmeier JJ, Heimbach RD, Davolt DA, Brakora MJ. Hyperbaric oxygen as an adjunctive treatment for severe laryngeal necrosis: A report of nine consecutive cases. Undersea Hyper Med 1993;20:329-335.
46. Filintisis GA, Moon RE, Kraft KL, Farmer JC, Scher RL, Piantadosi CA. Laryngeal radionecrosis and hyperbaric oxygen therapy: report of 18 cases and review of the literature. Ann Otol Rhinol Laryngol 2000;109:554-62. (Pubitemid 30429083)
47. Narzony W, Sicko Z, Kot J et al. Hyperbaric oxygen therapy in the treatment of complications of irradiation in the head and neck area. Undersea Hyperb Med 2005;32:103-10. (Pubitemid 40707776)
48. Hsu YC, Lee KW, Tsai KB et al. Treatment of laryngeal necrosis with hyperbaric oxygen therapy: a case report. Kaohsing Med 2005;21:88-92.
49. Davis JC, Dunn JM, Gates GA, Heimbach RD. Hyperbaric oxygen: a new adjunct in the management of radiation necrosis. Arch Otolaryngol 1979;105:58-61. (Pubitemid 9118158)
50. Neovius EB, Lind MG, Lind FG. Hyperbaric oxygen for wound complications after surgery in the irradiated head and neck: a review of the literature and a report of 15 consecutive cases. Head and Neck 1997;19:315-322. (Pubitemid 27273110)
51. Feldmeier JJ, Newman R, Davolt DA, Heimbach RD, Newman NK, Hernandez LC. Prophylactic hyperbaric oxygen for patients undergoing salvage for recurrent head and neck cancers following full course irradiation (abstract). Undersea Hyper Med 1998;25(Suppl):10.
52. Sassler AM, Esclamado RM, Wolf GT. Surgery after organ preservation therapy. Analysis of wound complications. Arch Otolaryngol Head Neck Surg. 1995 Feb; 121(2):162-5.
53. Agra IM, Carvalho AL, Pontes E, Campos OD, Ulbrich FS, Magrin J, Kowalski LP. Postoperative complications after en bloc salvage surgery for head and neck cancer. Arch Otolaryngol Head Neck Surg. 2003 Dec; 129(12):1317-21. (Pubitemid 37523106)
54. Hart GB, Manous EG. The treatment of radiation necrosis with hyperbaric oxygen (OHP). Cancer 1976;37:2580-5.
55. Vanderpuye V, Goldson A. Osteoradionecrosis of the mandible. J Natl Med Assoc. 2000 Dec; 92(12):579-84.
56. Carl UM, Hartmann KA. Hyperbaric oxygen treatment for symptomatic breast edema after radiation therapy. Undersea Hyperb Med 1998;25:233-4. (Pubitemid 128456994)
57. Carl UM, Feldmeier JJ, Schmitt G, Hartmann KA. Hyperbaric oxygen therapy for late sequelae in women receiving radiation after breast conserving surgery. Int J Radiat Oncol Biol Phys 2001;49:1029-31. (Pubitemid 32184609)
58. Bevers RF, Bakker DJ, Kurth KH. Hyperbaric oxygen treatment for haemorrhagic radiation cystitis. Lancet 1995;346:803-805.
59. Neheman A, Nativ O, Moskovitz B, Melamed Y, Stein A. hyperbaric oxygen therapy for radiation-induced haemorrhagic cystitis. BJU Int 2005;96:107-9. (Pubitemid 40942879)
60. Corman JM, McClure D, Pritchett R, Kozlowski P, Hampson NB. Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen. J Urol 2003;160:2200-2. (Pubitemid 36576750)
61. Chong KT, Hampson NB, Corman JM. Early hyperbaric oxygen improves outcome for radiation-induced hemorrhagic cystitis. Urology 2005;65:649-53. (Pubitemid 40522992)
62. Cheng C, Foo KT. Management of severe chronic radiation cystitis. Ann Acad Med Singapore 1992;21:368-71.
63. Li A, Sun J, Chao H. Late bladder complications following radiotherapy of carcinoma of the uterine cervix. Zhonghua Fu Chan Ke 1995;30:741-3.
64. Feldmeier JJ, Jelen I, Davolt DA, Valente PT, Meltz ML, Alecu R. Hyperbaric oxygen as a prophylaxis for radiation induced delayed enteropathy. Radiotherapy and Oncology 1995;35:138-144.
65. Feldmeier JJ, Davolt DA, Court WS, Onoda JM, Alecu R. Histologic morphometry confirms a prophylactic effect for hyperbaric oxygen in the prevention of delayed radiation enteropathy. Undersea Hyper Med 1998;25(2):93-97. (Pubitemid 128456977)
66. Bredfeldt JE, Hampson NB. Hyperbaric oxygen (HBO2) therapy for chronic radiation enteritis. Am J Gastroenterol 1998;93(9):1665.
67. Neurath MF, Branbrink A, Meyer zum Buschenfelde KH, Lohse AW. A new treatment for severe malabsorption due to radiation enteritis. Lancet 1996;347:1302. (Pubitemid 26137796)
68. Jones K, Evans AW, Bristow RG et al. Treatment of radiation proctitis with hyperbaric oxygen. Radiotherapy and Oncology 2006;78:91-4. (Pubitemid 43136540)
69. Girinius S, Ceronsky N, Gesell L et al. Treatment of refractory radiation-induced hemorrhagic proctitis with hyperbaric oxygen therapy. Am J Clin Oncol 2006;29:588-92. (Pubitemid 44915295)
70. Dall'Era MA, Hampson NB, His RA et al. Hyperbaric oxygen therapy for radiation induced proctopathy in men treated for prostate cancer. J Urol 2006;176:87-90. (Pubitemid 43833170)
71. Marshall GT, Thirlby RC, Bredfeldt JE, Hampson NB. Treatment of gastrointestinal radiation injury with hyperbaric oxygen Undersea Hyperb Med 2007;34:35-42.
72. Clarke RE, Tenorio L M C, Hussey JR et al. Hyperbaric oxygen treatment of chronic refractory radiation proctitis: a randomized and controlled double-blind crossover trial with long term follow-up.. Int J Radiat Oncol Biol Phys 2008;72(1):134-143
73. Farmer JC, Shelton DL, Bennett PD, Angelillo JD, Hudson MD. Treatment of radiation-induced injury by hyperbaric oxygen. Ann Otol 1978;87;707-15. (Pubitemid 9035785)
74. Williams J A A, Clarke D, Dennis W A A, Dennis E J J, Smith S T T. Treatment of pelvic soft tissue radiation necrosis with hyperbaric oxygen. Am J Obstet Gynecol 1992;167:415-416.
75. Feldmeier JJ, Heimbach RD, Davolt DA, Court WS, Stegmann BJ, Sheffield PJ. Hyperbaric oxygen as an adjunctive treatment for delayed radiation injuries of the abdomen and pelvis. Undersea Hyperb Med 1997;23(4):205-213.
76. Fink D, Chetty N, Lehm JP, Marsden DE, Hacker NF. Hyperbaric oxygen therapy for delayed radiation injuries in gynecological cancers. Int J Gynecol Cancer 2006;16:638-42.
77. Craighead P, Shea-Budgell MA, Nation J, Esmail R, Evans AW, Parliament M, Oliver TK, Hagen NA. Hyperbaric oxygen for late radiation tissue injury in gynecologic malignancies. Curr Oncol 2011;18(5):220-7.
78. Feldmeier JJ, Heimbach RD, Davolt DA, McDonough MJ, Stegmann BJ, Sheffield PJ. Hyperbaric oxygen in the treatment of delayed radiation injuries of the extremities Undersea Hyper Med 2000;27(1):15-19.
79. Marcus RB Jr, Million RR. The incidence of transverse myelitis after radiation of the cervical spinal cord. Int J Radiat Oncol Biol Phys 1990;19:3-8. (Pubitemid 20239777)
80. Glassburn JR, Brady LW. Treatment with hyperbaric oxygen for radiation myelitis. Proc. 6th Int Cong on Hyperbaric Medicine 1977:266-77.
81. Calabro F, Jinkins JR. MRI of radiation myelitis: a report of a case treated with hyperbaric oxygen. Eur Radiol 2000;10:1079-84. (Pubitemid 30450816)
82. Feldmeier JJ, Lange JD, Cox SD, Chou L, Ciaravino V. Hyperbaric oxygen as a prophylaxis or treatment for radiation myelitis. Undersea Hyper Med 1993;20(3):249-255.
83. Sminia P, Van der Kleij AJ, Carl UM, Feldmeier JJ, Hartmann KA. Prophylactic hyperbaric oxygen treatment and rat spinal cord re-irradiation. Cancer Lett 2003 Feb. 28;191(1):59-65. (Pubitemid 36254778)
84. Schulteiss TE, Stephen LC, Peters LJ. Survival in radiation myelopathy. Int J Radiat Oncol Biol Phys. 1986;12:1765-9. (Pubitemid 17182215)
85. Chuba PJ, Aronin P, Bhambhani K, Eichenhorn M, Zamarano L, Cianci P, Muhlbauer M, Porter AT, Fontanesi J. Hyperbaric oxygen therapy for radiation-induced brain injury in children. Cancer 1997;80:2005-2012. (Pubitemid 27479797)
86. Leber KA, Eder HG, Kovac H, Anegg U, Pendl G. Treatment of cerebral radionecrosis by hyperbaric oxygen therapy. Sterotact Funct Neurosurg 1998;70(Suppl 1):229-36.
87. Cirafisi C, Verderame F. Radiation-induced rhomboencephalopathy. Ital J Neurol Sci 1999;20:55-8.
88. Dear GdeL, Rose RE, Dunn R, Piantadosi CA, Stolp BW, Carraway MS, Thalmann ED, Kraft K, Rice JR, Friedman AH, Friedman HS, Moon RE. Treatment of neurological symptoms of radionecrosis of the brain with hyperbaric oxygen: a case series. Presented at the 35th Annual Undersea and Hyperbaric Medical Society Scientific Meeting. 28-30 June 2002, San Diego, CA.
89. Gesell LB, Warnick R, Breneman J, Albright R, Racadio J, Mink S. Effectiveness of hyperbaric oxygen for the treatment of soft tissue radionecrosis of the brain. Presented at the 35th Annual Undersea and Hyperbaric Medical Society Scientific Meeting. 28-30 June, 2002, San Diego, CA.
90. Guy J, Schatz N J J. Hyperbaric oxygen in the treatment of radiation-induced optic neuropathy. Ophthalmology 1986;93:1083-8. (Pubitemid 16012720)
91. Roden D, Bosley TM, Fowble B, Clark J, Savino PJ, Sergott RC, Schatz NJ. Delayed radiation injury to the retrobulbar optic nerves and chiasm. Clinical syndrome and treatment with hyperbaric oxygen and corticosteroids. Ophthalmolgy 1990;97:346-51. (Pubitemid 20087983)
92. Fontanesi J, Golden EB, Cianci PC, Heideman RL. Treatment of radiation-induced optic neuropathy in the pediatric population. Journal of Hyperbaric Medicine 1991;6(4):245-248.
93. Borruat F X X, Schatz N J J, Glaser J S S, Feun L G G, Matos L. Visual recovery from radiation-induced optic neuropathy. The role of hyperbaric oxygen therapy. J Clin Neuroophthalmol 1993;13:98-101. (Pubitemid 23182620)
94. Boschetti M, De Lucchi M, Giusti M, Spena C, Corallo G, Goglia U, Ceresola E, Resmini E, Vera L, Minuto F, Ferone D. Partial visual recovery from radiation-induced optic neuropathy after hyperbaric oxygen therapy in a patient with Cushing disease. Eur J Endocrinol-01-JUN-2006;154(6):813-8. (Pubitemid 43997719)
95. Videtic GM, Venkatesan VM. Hyperbaric oxygen corrects sacral plexopathy due to osteoradionecrosis appearing 15 years after pelvic irradiation. Clin Oncol (R Coll Radiol). 1999;11(3):198-9. (Pubitemid 29366596)
96. Pritchard J, Anand P, Broome J, Davis C, Gothard L, Hall E, Maher J, McKinna F, Millington J, Misra V P P, Pitkin A, Yarnold J R R. Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy. Radiother Oncol 2001;58:279-86. (Pubitemid 32181862)
97. Granstrom G, Jacobsson m, Tjellstrom A. Titanium implants in irradiated patients: benefits from hyperbaric oxygen. Int J Oral maxillofac Implants 1992;7:15-25.
98. Ueda M, Kaneda T, Takahashi H. Effect of hyperbaric oxygen therapy on osseointegration of titanium implants in irradiated bone: A preliminary report. Int J Oral Maxillofac Implants 1993;8:41-44.
99. Pomeroy BD, Keim LW, Taylor RJ. Preoperative hyperbaric oxygen therapy for radiation induced injuries. J Urol 1998;159:1630-1632. (Pubitemid 29117355)
100. Feldmeier JJ, Heimbach RD, Davolt DA, Brakora MJ, Sheffield PJ, Porter AT. Does hyperbaric oxygen have a cancer causing or promoting effect? A review of the pertinent literature. Undersea Hyper Med 1994;21:467-475.
101. Feldmeier JJ. Hyperbaric oxygen: does it have a cancer causing or growth enhancing effect. In: Proceedings of the Consensus Conference sponsored by the European Society for Therapeutic Radiology and Oncology and the European Committee for Hyperbaric Medicine. Portugal 2001:129-146.
102. Chong KT, Hampson NB, Bostwick DG, Vessella RL, Corman JM. Hyperbaric oxygen does not accelerate latent in vivo prostate cancer: implications for the treatment of radiation-induced haemorrhagic cystitis. BJU Int 2004;94(9):1275-8. (Pubitemid 40052092)
103. Stuhr LE, Iverson VV, Straume O, Maehle BO, Reed RK. Hyperbaric oxygen alone or combined with 5-FU attenuates growth of DMBA induced rat mammary tumors. Cancer Lett 2004;210(1):3540.
104. Sun TB, Chen RL, Hsu YH. The effect of hyperbaric oxygen on human oral cancer cells. Undersea Hyperb Med. 2004;31(2):251-60. (Pubitemid 39225045)
105. Shi Y, Lee CS, Wu J, Koch CJ, Thom SR, Maity A, Bernhard EJ. Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature. Head Neck. 2005 May; 27(5):362-9. (Pubitemid 40593889)
106. Granowitz EV, Tonomura N, Benson RM, Katz DM, Band V, Makari-Judson GP, Osborne BA. Hyperbaric oxygen inhibits benign and malignant human mammary epithelial cell proliferation. Anticancer Res. 2005;6B: 3833-42. (Pubitemid 41665152)
107. Daruwalla J, Christophi C. The effect of hyperbaric oxygen therapy on tumour growth in a mouse model of colorectal cancer liver metastases. Eur J Cancer. 2006 Dec; 42(18):3304-11. (Pubitemid 44869015)
108. Haroon AT, Patel M, Al-Mehdi AB. Lung metastatic load limitation with hyperbaric oxygen. Undersea Hyperb Med. 2007 Mar-Apr; 34(2):83-90.
109. Lin H, Ku C, Liu D, Chao H, Lin C, Jen Y. Hyperbaric oxygen for late radiation-associated tissue necroses: is it safe in patients with locoregionally recurrent and then successfully salvaged head-and-neck cancers? Int J Radiation Oncology Biol Phys 2009;74(4):1077-1082.