Budesonide/formoterol maintenance and reliever therapy via Turbuhaler versus fixed-dose budesonide/formoterol plus terbutaline in patients with asthma: Phase III study results

Respirology

Volumn 18, Issue 2, 2013, Pages 354-363

  Atienza, Tito ^a   Aquino, Teresita ^b   Fernández, Marcelo ^c   Boonsawat, Watchara ^d   Kawai, Mitsuru ^e   Kudo, Takahide ^f   Ekelund, Jan ^g   Ivanov, Stefan ^g   Carlsson, Lars Goran ^g  

^a Mary Mediatrix Medical Center Batangas   (Philippines)

^b Veterans Memorial Medical Centre   (Philippines)

^c Centro Respiratorio Quilmes   (Argentina)

^d KHON KAEN UNIVERSITY   (Thailand)

^e Kawai Chest Clinic   (Japan)

^f ASTRAZENECA   (United Kingdom)

^g ASTRAZENECA R AND D   (Sweden)

Author keywords

asthma; budesonide formoterol; budesonide formoterol as maintenance and reliever therapy; exacerbation

Indexed keywords

BUDESONIDE PLUS FORMOTEROL; TERBUTALINE;

ADULT; ARTICLE; ASTHMA; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG TOLERABILITY; EMERGENCY WARD; FEMALE; HOSPITALIZATION; HUMAN; INHALER; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TREATMENT DURATION; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADULT; ASTHMA; BRONCHODILATOR AGENTS; BUDESONIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ETHANOLAMINES; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LONGITUDINAL STUDIES; LUNG; MALE; MIDDLE AGED; TERBUTALINE; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 84872940337     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/resp.12009     Document Type: Article

References (20)

1. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. 2011. [updated 2011]. Available from URL: http://www.ginasthma.org
2. Greening AP, Ind PW, Northfield M, et al. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Lancet 1994; 344: 219-224. (Pubitemid 24229008)
3. O'Byrne PM, Barnes PJ, Rodriguez-Roisin R, et al. Low dose inhaled budesonide and formoterol in mild persistent asthma: OPTIMA randomized trial. Am. J. Respir. Crit. Care Med. 2001; 164: 1392-1397. (Pubitemid 33124016)
4. Pauwels RA, Lofdahl C-G, Postma DS, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. N. Engl. J. Med. 1997; 337: 1405-1411. (Pubitemid 27497887)
5. Woolcock A, Lundback B, Ringdal N, et al. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am. J. Respir. Crit. Care Med. 1996; 153: 1481-1488. (Pubitemid 26141329)
6. Humbert M, Andersson TLG, Buhl R,. Budesonide/formoterol for maintenance and reliever therapy in the management of moderate to severe asthma. Eur. J. Allergy Clin. Immunol. 2008; 63: 1567-1580.
7. Partridge MR, van der Molen T, Myrseth SE, et al. Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study. BMC Pulmon. Med. 2006; 6: 13.
8. Bousquet J, Boulet LP, Peters MJ, et al. Budesonide/formoterol formoterol for maintenance and relief in uncontrolled asthma vs. high-dose salmeterol/fluticasone. Respir. Med. 2007; 101: 2437-2446. (Pubitemid 350010579)
9. Kuna P, Peters MJ, Manjra AI, et al. Effect of budesonide/formoterol maintenance and reliever therapy on asthma exacerbations. Int. J. Clin. Pract. 2007; 61: 725-736. (Pubitemid 46587876)
10. O'Byrne PM, Bisgaard H, Godard PP, et al. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am. J. Respir. Crit. Care Med. 2005; 171: 129-136. (Pubitemid 40105411)
11. Rabe KF, Atienza T, Magyar P, et al. Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: A randomised controlled, double-blind study. Lancet 2006; 368: 744-753. (Pubitemid 44279053)
12. Rabe KF, Pizzichini E, Stallberg B, et al. Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: A randomized, double-blind trial. Chest 2006; 129: 246-256. (Pubitemid 43289841)
13. Scicchitano R, Aalbers R, Ukena D, et al. Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Curr. Med. Res. Opin. 2004; 20: 1403-1418. (Pubitemid 39361344)
14. Lundborg M, Wille S, Bjermer L, et al. Maintenance plus reliever budesonide/formoterol compared with a higher maintenance dose of budesonide/formoterol plus formoterol as reliever in asthma: an efficacy and cost-effectiveness study. Curr. Med. Res. Opin. 2006; 22: 809-821. (Pubitemid 43875550)
15. Sears MR, Boulet LP, Laviolette M, et al. Budesonide/formoterol maintenance and reliever therapy: impact on airway inflammation in asthma. Eur. Respir. J. 2008; 31: 982-989.
16. Vogelmeier C, D'Urzo A, Pauwels R, et al. Budesonide/formoterol maintenance and reliever therapy: an effective asthma treatment option? Eur. Respir. J. 2005; 26: 819-828. (Pubitemid 41632038)
17. Demoly P, Louis R, Soes-Petersen U, et al. Budesonide/formoterol maintenance and reliever therapy versus conventional best practice. Respir. Med. 2009; 103: 1623-1632.
18. Edwards SJ, von Maltzahn R, Naya IP, et al. Budesonide/formoterol for maintenance and reliever therapy o asthma: A meta analysis of randomised controlled trials. Int. J. Clin. Pract. 2010; 64: 619-627.
19. Braido F, Baiardino I, Compalati E, et al. Towards the Grade of Recommendations, Assessment, Development and Evaluation system: methods and results of budesonide/formoterol maintenance and reliever therapy research. Curr. Opin. Allergy Clin. Immunol. 2011; 11: 361-374.
20. Sears MR, Radner F,. Safety of budesonide/formoterol maintenance and reliever therapy in asthma trial. Respir. Med. 2009; 103: 1960-1968.