The design and analysis of parallel experiments to produce structurally identifiable models

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 40, Issue 1, 2013, Pages 93-100

  Cheung, S Y Amy ^a   Yates, James W T ^a   Aarons, Leon ^b  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Bioequivalence; Covariates; Parameter estimation; Parent metabolite models; Pharmacokinetic models; Structural identifiability

Indexed keywords

DEXTROMETHORPHAN; DEXTROMETHORPHAN PLUS QUINIDINE; QUINIDINE;

ARTICLE; COMPARTMENT MODEL; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; METHODOLOGY; PHARMACOKINETICS; PRIORITY JOURNAL; STRUCTURAL EQUATION MODELING; STRUCTURE ACTIVITY RELATION;

ABSORPTION; ADMINISTRATION, ORAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC EMPTYING; HUMANS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RESEARCH DESIGN;

EID: 84872922464     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-012-9291-z     Document Type: Article

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