Treatment of non-unions with bone defects: Which option and why?

Injury

Volumn 44, Issue SUPPL.1, 2013, Pages

  Ashman, O ^a   Phillips, A M ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Bone defects; Bone grafts; Bone shortening; Bone substitutes; Distraction osteogenesis; Gene therapy; Growth factors; Non union; Scaffolds; Stem cells

Indexed keywords

BIOMATERIAL; GROWTH FACTOR; OSTEOGENIC PROTEIN 1; POLY(METHYL METHACRYLATE); PROCOLLAGEN C PROTEINASE; TISSUE SCAFFOLD; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BONE ALLOGRAFT; BONE DEFECT; BONE DEVELOPMENT; BONE GRAFT; BONE MATRIX; BONE PROSTHESIS; CALLUS; CELLS; CEMENT SPACER; CHRONIC PAIN; DEBRIDEMENT; DISTRACTION OSTEOGENESIS; DONOR SITE; EXTERNAL FIXATOR; FIBULA GRAFT; FOREIGN BODY; FRACTURE HEALING; FRACTURE NONUNION; GENE THERAPY; HUMAN; JOINT CONTRACTURE; LEG LENGTHENING; MESENCHYMAL STEM CELL; MICROSURGERY; OSSIFICATION; OSTEOBLAST; OSTEOTOMY; PATIENT COMPLIANCE; PERONEUS NERVE; PRIORITY JOURNAL; PSEUDARTHROSIS; REAMER; SOFT TISSUE DEFECT; STEM CELL; STRESS FRACTURE; TISSUE ENGINEERING; TRABECULAR BONE; VASCULARIZATION;

AMPUTATION; BONE DISEASES; BONE LENGTHENING; BONE REGENERATION; BONE TRANSPLANTATION; FRACTURES, UNUNITED; GENETIC THERAPY; HUMANS; OSTEOGENESIS, DISTRACTION; PATIENT SELECTION; TISSUE ENGINEERING; TREATMENT OUTCOME;

EID: 84872876932     PISSN: 00201383     EISSN: 18790267     Source Type: Journal    
DOI: 10.1016/S0020-1383(13)70010-X     Document Type: Article

References (19)

1. M Sen, T Miclau Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions? Injury 2007 S75 S80
2. S Pneumaticos, G Triantafyllopoulos, E Basdra, A Papvassiliou Segmental bone defects: from cellular and molecular pathways to the development of novel biological treatments J Cell Mol Med 14 11 2010 2561 2569
3. T DeCoster, R Gehlert, E Mikola, M Pirela-Cruz Management of posttraumatic segmental bone defects J Am Acad Orthop Surg 12 2004 28 38
4. T Watson Distraction osteogenesis J Am Acad Orthop Surg 14 2006 S168 S174
5. J Aronson Current concepts review: limb-lengthening, skeletal reconstruction, and bone transport with the Ilizarov method J Bone Joint Surg 79-A 8 1997 1243 1258
6. A Kanellopoulos, P Soucacos Management of nonunion with distraction osteogenesis Injury 37 Suppl 1 2006 S51 S55
7. A Moroni, C Faldini, S Marchetti, M Manca, V Consoli, S Gianni Improvement of the bone-pin interface strength in osteoporotic bone with the use of hydroxyapatite-coated tapered external-fixation pins: A prospective randomized clinical study of wrist fractures J Bone Joint Surg Am 83 2001 717 721
8. D Bae, P Waters Free Vascularized Fibula Grafting: Principles, Techniques, and Application in Pediatric Orthopaedics. Orthop J Harvard Med Sch Online http://www.orthojournalhms.org/volume8/manuscripts/ms01.htm
9. K Malizos, C Zalavras, P Soucacos, A Beris, J Urbaniak Free vascularized fibular grafts for reconstruction of skeletal defects J Am Acad Orthop Surg 12 2004 360 369
10. M Wood Free vascularized fibular grafting-25 years' experience: tips, techniques, and pearls Orthop Clin North Am 38 2007 1 12
11. AJ Weiland Current concepts review: vascularized free bone transplants J Bone Joint Surg Am 63 1981 166 169
12. A Beris, M Lykissas, A Korompilias, M Vekris, G Mitsionis, K Malizos, P Soucacos Vascularized fibula transfer for lower limb reconstruction Microsurgery 31 2011 205 211
13. P Pelissier, AC Masquelet, R Bareille, SM Pelissier, J Amedee Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration J Orthop Res 22 1 2004 73 79
14. O Giannoudis, O Faour, T Goff, N Kanakaris, R Dimitriou Masquelet technique for the treatment of bone defects: tips-tricks and future directions Injury 42 2011 591 598
15. U Stock, J Vacanti Tissue engineering: current state and prospects Annu Rev Med 52 2001 443 451
16. R Dimitriou, E Jones, D McGonagle, P Giannoudis Bone regeneration: current concepts and future directions BMC Med 9 2011 66
17. M Urist Bone: formation by autoinduction Science 150 1965 893 899
18. P Giannoudis, C Tzioupis Clinical applications of BMP-7. The UK perspective Injury 36 Suppl 3 2005 S47 S50
19. G Friedlaender, C Perry, J Cole, S Cook, G Cierny, G Muschler, G Zych, J Calhoun, A LaForte, S Yin Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions J Bone Joint Surg Am 83-A 2001 S151 S158