Protein kinase CK2: An ugly duckling in the kinome pond

Cellular and Molecular Life Sciences

Volumn 66, Issue 11-12, 2009, Pages 1797-1799

  Pinna, L A ^a   Allende, J E ^b  

^a VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

Apoptosis; Cancer addiction; Casein kinase 2; Druggable kinases; Oncokinome; Protein kinase CK2; Protein phosphorylation

Indexed keywords

CASEIN KINASE II; ISOENZYME;

ANIMAL; DRUG ANTAGONISM; HUMAN; PHOSPHORYLATION; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CASEIN KINASE II; HUMANS; ISOENZYMES; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84872864632     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-9148-9     Document Type: Review

References (14)

1. Burnett, G. and Kennedy, E. P. (1954) The enzymatic phosphorylation of proteins J. Biol. Chem. 211, 969-980.
2. Manning, G., White, D. B., Martinez, T., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science 298, 1912-1934.
3. Krebs,E. G. and Fisher,E. H. (1956)The phosphorylase-b to -a converting enzyme of rabbit skeletal muscle. Biochim. Biophys. Acta 20, 150-157.
4. Cohen, P., Yellowlees, D., Aitken, A., Donella-Deana, A., Hemmings, B. A. and Parker, P. J. (1982) Separation and characterization of glycogen synthase kinase 3, glycogen synthase kinase 4 and glycogen synthase kinase 5 from rabbit skeletal muscle. Eur. J. Biochem. 124, 21-35.
5. Villar-Palasi, C. and Kumon, A. (1981) Purification and properties of a dog cardiac troponin-T kinase. J. Biol. Chem. 256, 7409-7415.
6. Pinna, L. A. (1994) A historical view of protein kinase CK2. Cell. Mol. Biol. Res. 40, 383-390.
7. Meggio, F. and Pinna, L. A. (2003) One thousand and one substrates of protein kinase CK2? FASEB J. 17, 349-368.
8. Salvi, M., Sarno, S., Cesaro, L., Nakamura, H. and Pinna, L. A. (2009) Extraordinary pleiotropy of protein kinase CK2 revealed by weblogo phosphoproteome analysis. Biochim. Biophys. Acta (2009) doi: 10.1016/j.bbamcr.2009.01.013
9. Raaf, J., Brunstein, E., Issinger, O.-G. and Niefind, K. (2008) The CK2alpha/CK2beta interface of human CK2 harbors a binding pocket for small molecules. Chem. Biol. 15, 111-117.
10. Jedlicki, A., Allende,C. C. and Allende, J. E. (2008) CK2alpha/CK1alpha chimeras are sensitive to regulation by the CK2beta subunit. Mol. Cell. Biochem. 316, 25-35.
11. Rodriguez, F. A., Contreras, C., Bolanos-Garcia, V. and Allende, J. E. (2008). Protein kinase CK2 as an ectokinase: the role of the regulatory CK2beta subunit. Proc. Natl. Acad. Sci. USA. 15;105, 5693-5698.
12. Guerra, B. and Issinger, O.-G. (2008) Protein kinase CK2 in human diseases. Curr. Med. Chem. 15, 1870-1886.
13. Sarno, S. and Pinna, L. A. (2008) Protein kinase CK2 as a druggable target. Mol. Biosyst. 4, 889-894.
14. Weinstein, I. B. (2002) Addiction to oncogenes - the Achilles heal of cancer. Science 297, 63-64.