Bone metabolism in 2012: Novel osteoporosis targets

Nature Reviews Endocrinology

Volumn 9, Issue 2, 2013, Pages 72-74

  Ohlsson, Claes ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; SCLEROSTIN; SEMAPHORIN 3A;

DRUG EFFICACY; DRUG SAFETY; DRUG TARGETING; GENE LOCUS; GENOME ANALYSIS; HUMAN; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; REVIEW;

ANIMALS; BONE DENSITY; DIGESTIVE SYSTEM; GENOME-WIDE ASSOCIATION STUDY; HUMANS; META-ANALYSIS AS TOPIC; OSTEOPOROSIS; SEMAPHORIN-3A;

EID: 84872846279     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2012.252     Document Type: Review

References (10)

1. Estrada, K. et al. Genome-wide meta-Analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat. Genet. 44, 491-501 (2012).
2. Zheng, H. F. et al. WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet. 8, e1002745 (2012).
3. Ralston, S. H. & Uitterlinden, A. G. Genetics of osteoporosis. Endocr. Rev. 31, 629-662 (2010).
4. Andrew, T., Antioniades, L., Scurrah, K. J., Macgregor, A. J. & Spector, T. D. Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD. J. Bone Miner. Res. 20, 67-74 (2005).
5. Hayashi, M. et al. Osteoprotection by semaphorin 3A. Nature 485, 69-74 (2012).
6. Zaidi, M. & Iqbal, J. Translational medicine: Double protection for weakened bones. Nature 485, 47-48 (2012).
7. Sjogren, K. et al. The gut microbiota regulates bone mass in mice. J. Bone Miner. Res. 27, 1357-1367 (2012).
8. Ley, R. E. et al. Evolution of mammals and their gut microbes. Science 320, 1647-1651 (2008).
9. Cho, I. et al. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 488, 621-626 (2012).
10. Boonen, S. et al. Fracture risk and zoledronic acid therapy in men with osteoporosis. N. Engl. J. Med. 367, 1714-1723 (2012).