The nonantibiotic small molecule cyslabdan enhances the potency of β-lactams against MRSA by inhibiting pentaglycine interpeptide bridge synthesis.

PloS one

Volumn 7, Issue 11, 2012, Pages

  Koyama, Nobuhiro ^a   Tokura, Yuriko ^b   Münch, Daniela ^b   Sahl, Hans Georg ^b   Schneider, Tanja ^b   Shibagaki, Yoshio ^b   Ikeda, Haruo ^b   Tomoda, Hiroshi ^b  

^a KITASATO UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BACTERIAL PROTEIN; BOCILLIN FL; BORON DERIVATIVE; CYSLABDAN; DITERPENE; DRUG DERIVATIVE; FEMA PROTEIN, BACTERIA; IMIPENEM; PENICILLIN DERIVATIVE; PEPTIDE; PEPTIDOGLYCAN; POLYGLYCINE; PRIMER DNA;

ANTIBIOTIC RESISTANCE; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; JAPAN; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; TANDEM MASS SPECTROMETRY; ULTRAVIOLET SPECTROPHOTOMETRY;

ACETYLCYSTEINE; BACTERIAL PROTEINS; BORON COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES; DNA PRIMERS; DRUG RESISTANCE, BACTERIAL; DRUG SYNERGISM; IMIPENEM; JAPAN; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PENICILLINS; PEPTIDES; PEPTIDOGLYCAN; SPECTROPHOTOMETRY, ULTRAVIOLET; TANDEM MASS SPECTROMETRY;

EID: 84872844174     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048981     Document Type: Article

References (0)