Sexual Desire and Hypoactive Sexual Desire Disorder in Women. Introduction and Overview. Standard Operating Procedure (SOP Part 1)

Journal of Sexual Medicine

Volumn 10, Issue 1, 2013, Pages 36-49

  Bitzer, Johannes ^a   Giraldi, Annamaria ^b   Pfaus, Jim ^c  

^a UNIVERSITY WOMEN S HOSPITAL   (Switzerland)

^b Rigshospitalet   (Denmark)

^c Concordia University ^*  (Canada)

Author keywords

Etiology and Pathogenesis; Hypoactive Sexual Desire Disorder; Treatment Options

Indexed keywords

ANDROGEN; ESTROGEN; GESTAGEN;

ANDROGEN DEFICIENCY; ANTICIPATION; ANXIETY; ARTHRITIS; ARTICLE; BODY IMAGE; CORONARY ARTERY DISEASE; COUNSELING; DEMENTIA; DIABETES MELLITUS; EMOTION; FEMALE SEXUAL DYSFUNCTION; HEALTH CARE PERSONNEL; HUMAN; HYPERPROLACTINEMIA; HYPERTENSION; HYPERTHYROIDISM; HYPOACTIVE SEXUAL DESIRE DISORDER; HYPOPHYSIS TUMOR; HYPOTHYROIDISM; LIFE EVENT; MAJOR DEPRESSION; MENOPAUSE; MULTIPLE SCLEROSIS; NEOPLASM; NEUROMUSCULAR DISEASE; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; PSYCHOTHERAPY; PUBERTY; PUERPERIUM; SCHIZOPHRENIA; SEXUAL ABUSE; SEXUAL BEHAVIOR; SPINAL CORD INJURY; URINE INCONTINENCE;

EID: 84872839341     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02818.x     Document Type: Article

References (107)

1. Segraves R, Woodard T. Female hypoactive sexual desire disorder: History and current status. J Sex Med 2006;3:408-18.
2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 2nd edition. Washington, DC: American Psychiatric Press; 1968.
3. Masters WH, Johnson VE. Human sexual inadequacy. Boston, MA: Little Brown; 1970.
4. Lief HI. Inhibited sexual desire. Med Aspects Hum Sex 1977;7:94-5.
5. Kaplan HS. Hypoactive sexual desire disorder. J Sex Marital Ther 1977;3:3-9.
6. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd edition. Washington, DC: American Psychiatric Press; 1980.
7. American Psychiatric Association. Diagnostic and statistical manuel of mental disorders. 3rd edition. Washington, DC: American Psychiatric Press; 1987.
8. American Psychiatric Association. Diagnostic and statistical manuel of mental disorders. 4th edition. text revision. Washington, DC: American Psychiatric Press; 2000.
9. Basson R, Leiblum S, Brotto L, Derogatis L, Fourcroy J, Fugl-Meyer K, Graziottin A, Heiman JR, Laan E, Meston C, Schover L, van Lankveld J, Weijmar Schultz W. Definitions of women's sexual dysfunction reconsidered: Advocating expansion and revision. J Psychosom Obstet Gynaecol 2003;24:221-9.
10. Giraldi A, Rellini A, Bitzer J, Pfaus JG, Laan E, Jannini E, Fugl-Meyer AR. Questionnaires for assessment of female sexual dysfunction: A review and proposal for a standardized screener. J Sex Med 2011;8:2681-94.
11. Levine S. Sexuality in mid-life. New York: Plenum; 1998.
12. Pfaff DW. Drive: Neurobiological and molecular mechanisms of motivation. Cambridge, MA: MIT Press; 1999.
13. Pfaus JG. Pathways of sexual desire. J Sex Med 2009;6:1506-33.
14. Basson R. Using a different model for female sexual response to address women's problematic low sexual desire. J Sex Marital Ther 2001;27:395-403.
15. Masters WH, Johnson VE. Human sexual response. New York: Bantam Books; 1966.
16. Pfaus JG. Revisiting the concept of sexual motivation. Annu Rev Sex Res 1999;10:120-56.
17. Laan E, Everaerd W, van der Velde J, Geer JH. Determinants of subjective experiences of sexual arousal in women: Feedback from genital arousal and erotic stimulus content. Psychophysiology 1995;32:444-51.
18. Bitzer J, Alder J. Sexualstörungen bei der Frau. Ther Umsch 2010;67:105-16.
19. Bancroft J, Graham CA, Janssen E, Sanders SA. The dual control model: Current status and future directions. J Sex Res 2009;46:121-42.
20. Basson R, Wiermann ME, van Lankveld J, Brotto L. Summary of the recommendations on sexual dysfunctions in women. J Sex Med 2010;7:314-26.
21. van der Geest S, Bitzer J. Personal communication.
22. Sand M, Fisher WA. Women's endorsement of models of female sexual response: The nurses' sexuality study. J Sex Med 2007;4:708-19.
23. Brotto LA, Bitzer J, Laan E, Leiblum S, Luria M. Women's sexual desire and arousal disorders. J Sex Med 2010;7:586-614.
24. Laumann EO, Paik A, Rosen R. Sexual dysfunction in the Unites States: Prevalence and predictors. JAMA 1999;281:537-44.
25. Fugl-Meyer AR, Sjogren Fugl-Meyer K. Sexual disabilities, problems and satisfaction in 18-74 years old Swedes. Scand J Sexol 1999;2:79-105.
26. Laumann EO, Nicolosi A, Glasser DB, Paik A, Gingell C, Moreira E, Wang T. Sexual problems among women and men aged 40-80 years: Pravalence and correlates identified in the Global Study of Sexual Attitudes and Behaviours. Int J Impot Res 2005;17:39-57.
27. Leiblum SR, Koochaki PE, Rodenberg CA, Barton IP, Rosen RC. Hypoactive sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS). Menopause 2006;13:46-56.
28. Dennerstein L, Koochaki P, Barton I, Graziottin A. Hypoactive sexual desire disorder in menopausal women: A survey of Western European women. J Sex Med 2006;3:212-22.
29. West SL, D'Aloisio AA, Agans RP, Kalsbeek WD, Borisov NN, Thorp JM. Prevalence of low sexual desire and hypoactive sexual desire disorder in a nationally respresentative sample of US women. Arch Intern Med 2008;168:1441-9.
30. Witting K, Santtila P, Varjonen M, Jern P, Johansson A, von der Pahlen B, Sandnabba K. Female sexual dysfunction, sexual distress and compatibility with partner. J Sex Med 2008;5:2587-99.
31. Hayes RD. Assessing female sexual dysfunction in epidemiological studies: Why is it necessary to measure both low sexual function and sexually-related distress? Sex Health 2008;5:215-8.
32. Shifren JL, Monz BU, Russo PA, Segreti A, Johannes CB. Sexual problems and distress in Unites States women: Prevalence and correlates. Obstet Gynecol 2008;112:970-8.
33. Salonia A, Lanzi R, Nappi RE, Gatti E, Moltoni G, Rigatti P, Lanzi R. Sexual dysfunction in dysthyroidal women. Int J Impot Res 2002;14(suppl 4):52-8.
34. Salonia A, Zanni G, Nappi RE, Briganti A, Deho F, Fabbri F, Colombo R, Guazzoni G, Di Giolamo V, Rigatti P, Montorsi F. Sexual dysfunction is common in women with lower urinary tract symptoms and urinary incontinence: Results of a cross-sectional study. Eur Urol 2004;45:642-8.
35. Shaw C. A systematic review of the literature on the prevalence of sexual impairment in women with urinary incontinence and the prevalence of urinary leakage during sexual activity. Eur Urol 2002;42:432-40.
36. Enzlin P, Mathieu C, Vanderschueren D, Demyttenaere K. Diabetes and female sexuality: A review of 25 years' research. Diabet Med 1998;15:809-15.
37. Schreiner-Engel P, Schiavi RC, Vietorisz D, Smith H. The differential impact of diabetes type on female sexuality. J Psychosom Res 1987;31:23-33.
38. Erol B, Tefekli A, Ozbery I, Salman F, Dincag N, Kadioglu A, Tellaloglu S. Sexual dysfunction in type II diabetic females: A comparative study. J Sex Marital Ther 2002;28(suppl 1):55-62.
39. Schiel R, Muller UA. Prevalence of sexual disorders in a selection-free diabetic population (JEVIN). Diabetes Res Clin Pract 1999;44:115-21.
40. Enzlin P, Matthieu C, Van den Bruel A, Bosteels J, Vanderschueren D, Demyttenaere K. Sexual dysfunction in women with type 1 diabetes. Diabetes Care 2002;25:672-7.
41. Enzlin P, Mathieu C, Van Den Bruel A, Vanderschueren D, Demyttenaere K. Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes. Diabetes Care 2003;26:409-14.
42. Salonia A, Briganti A, Montorsi P. Sexual dysfunction in women with coronary artery disease. Int J Impot Res 2002;14(suppl 4):80-92.
43. Okeahialam BM, Obeka NC. Sexual dysfunction in female hypertensives. J Natl Med Assoc 2006;98:638-40.
44. Burchardt M, Burchardt T, Anastasiadis AG, Kiss AJ, Baer L, Pawar RV, de la Taille A, Shabsigh A, Ghafar MA, Shabsigh R. Sexual dysfunction is common and overlooked in female patients with hypertension. J Sex Marital Ther 2002;28:17-26.
45. Panus RS, Mihailescu GD, Gomisiewicz MT, Sutaria SH, Wallace DJ. Sex and arthritis. Bull Rheum Dis 2000;49:1-4.
46. Sipski ML, Alexander CJ. Sexual activities, response and satisfaction in women pre- and post-spinal cord injury. Arch Phys Med Rehabil 1993;74:1025-9.
47. Hennessey A, Robertson NP, Swinger R, Compston DA. Urinary fecal and sexual dysfunction in patients with multiple sclerosis. J Neurol 1999;246:1027-32.
48. Yu M, Roane DM, Miner CR, Fleming M, Rogers JD. Dimensions of sexual dysfunction in Parkinson disease. Am J Geriatr Psychiatry 2004;12:221-6.
49. Dunn KM, Croft PR, Hackett GI. Association of sexual problems with social, psychological, and physical problems in men and in women: A cross sectional population survey. J Epidemiol Community Health 1999;53:144-8.
50. Hawton K, Gath D, Day A. Sexual function in a community sample of middle-aged women with partners: Effect of age, marital, socioeconomic, psychiatric, gynecological and menopausal factors. Arch Sex Behav 1994;23:375-95.
51. Baggaley M. Sexual dysfunction in schizophrenia: Focus on recent evidence. Hum Psychopharmacol 2008;23:201-9.
52. Hulter B, Lundberg PO. Sexual function in women with hypothalamo-pituitary disorders. Arch Sex Behav 1994;23:171-83.
53. Juraskova I, Butow P, Robertson R, Sharpe L, McLeod C, Hacker N. Post treatment sexual adjustement following cervical and endometrial cancer: A qualitative insight. Psychooncology 2003;12:267-79.
54. Bloom JL, Stewart SL, Chang S, Banks PJ. Then and now: Quality of life of young cancer survivors. Psychooncology 2004;13:147-60.
55. Graziottin A, Castoldi E. Sexuality and breast cancer. A review. In: Studd J, ed. The management of the menopause. The millennium review. New York: Parthenon; 2000:211-20.
56. Sheppard C, Whitely R. Psychosexual problems after gynaecological cancer. J Br Menopause Soc 2006;12:24-7.
57. Kornblith AB, Ligibel J. Psychosocial and sexual functioning of survivors of breast cancer. Semin Oncol 2003;30:799-813.
58. Jensen PT, Groenvold M, Klee MC, Thranov I, Petersen MA, Machin D. Early stage cervical carcinoma, radical hysterectomy and sexual function. A longitudinal study. Cancer 2004;100:97-106.
59. Butler-Manuel SA, Buttery LD, A'Hern RP, Polak JM, Barton DP. Pelvic nerve plexus trauma at radical hysterectomy and simple hysterectomy: The nerve content of the uterine supporting ligaments. Cancer 2000;89:834-41.
60. Cundiff GW, Fenner D. Evaluation and treatment of women with rectocele: Focus on associated defecatory and sexual dysfunction. Obstet Gynecol 2004;104:1403-21.
61. Fokdal L, Hoyer M, Meldgaard P, von der Masse H. Long-term bladder, colorectal, and sexual functions after radical radiotherapy for urinary bladder cancer. Radiother Oncol 2004;72:139-45.
62. Kennedy SH, Dickens SE, Eisfeld BS, Bagby RM. Sexual dysfunction before antidepressant therapy in major depression. J Affect Disord 1999;56:201-8.
63. Frohlich P, Meston C. Sexual functioning and self-reported depressive symptoms among college women. J Sex Res 2002;39:321-5.
64. Bartlik B, Kocsis JH, Legere R, Villaluz J, Kosoy A, Gelenberg AJ. Sexual dysfuncion secondary to depressive disorders. J Gend Specif Med 1999;2:52-60.
65. Meston CM, Heiman JR. Ephredine-activated physiological sexual arousal in women. Arch Gen Psychiatry 1998;55:652-6.
66. Trudel G, Landry L, Larose YC. Low sexual desire: The role of anxiety, depression and marital adjustment. Sex Marital Ther 1997;12:95-9.
67. Barlow DH. Causes of sexual dysfunction: The role of anxiety and cognitive interference. J Consult Clin Psychol 1986;54:140-8.
68. Segraves RT, Balon R. Sexual pharmacology. Fast facts. New York and London: WW Norton; 2003.
69. Krebs M, Leopold K, Hinzpeter A, Schäfer M. Current schizophrenia drugs: Efficacy and side effects. Expert Opin Pharmacother 2006;7:1005-16.
70. Gregorian RS, Golden KA, Bahce A, Goodman C, Kwong WJ, Khan ZM. Antidepressant-induced sexual dysfunction. Ann Pharmacother 2002;36:1577-89.
71. Clayton AH. Female sexual dysfunction related to depression and antidepressant medications. Curr Womens Health Rep 2002;2:182-7.
72. Davis SR, Guay AT, Shifren JL, Mazer NA. Endocrine aspects of female sexual dysfunction. J Sex Med 2004;1:82-6.
73. Stanislaw H, Rice FJ. Correlation between sexual desire and menstrual cycle characteristics. Arch Sex Behav 1988;17:499-508.
74. Giraldi A, Marson L, Nappi R, Pfaus J, Traish AM, Vardi Y, Goldstein I. Physiology of female sexual function: Animal models. J Sex Med 2004;1:237-53.
75. Vermeulen A, Verdonck L. Plasma androgen levels during the menstrual cycle. Am J Obstet Gynecol 1976;125:491-4.
76. Davis SR, Davison SL, Donath S, Bell RJ. Circulating androgen levels and self-reported sexual function in women. JAMA 2005;294:91-6.
77. Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: A prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985;47:339-51.
78. Dennerstein L, Dudley EC, Hopper JL, Burger H. Sexuality, hormones and the menopausal transition. Maturitas 1997;26:83-92.
79. Dennerstein L, Lehert P, Burger M. The relative effects of hormones and relationship factors on sexual function of women through the natural menopausal transition. Fertil Steril 2005;84:174-80.
80. Dennerstein L, Guthrie JR, Hayes RD, DeRogatis LR, Lehert P. Sexual function, dysfunction, and sexual distress in a prospective, population-based sample of mid-aged Australian-born women. J Sex Med 2008;5:2291-9.
81. Bitzer J, Alder J. Sexuality during pregnancy and the postpartum period. J Sex Educ Ther 2000;25:49-58.
82. Barbosa-Vargas E, Pfaus JG, Woodside B. Sexual behavior in lactating rats: Role of estrogen-induced progesterone receptors. Horm Behav 2009;56:246-53.
83. Miller KK, Biller BM, Beauregard C, Lipman JG, Jones J, Schoenfeld D, Sherman JC, Swearingen B, Loeffler J, Klibanski A. Effects of testosterone replacement in androgen-deficient women with hypopituitarism: A randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2006;91:1683-92.
84. Warnock JK, Clayton A, Croft H, Segraves R, Biggs FC. Comparison of androgens in women with hypoactive sexual desire disorder: Those on Combined Oral Contraceptives (COCs) vs. those not on COCs. J Sex Med 2006;3:878-82.
85. Bancroft J, Hammond G, Graham C. Do oral contraceptives produce irreversible effects on women's sexuality? J Sex Med 2006;3:567-72.
86. Wallwiener M, Wallwiener LM, Seeger H, Mueck AO, Zipfel S, Bitzer J, Wallwiener CW. Effects of sex hormones in oral contraceptives on the female sexual function score: A study in German female medical students. Contraception 2010;82:155-9.
87. Leonard LM, Follette VM. Sexual functioning in women reporting a history of child sexual abuse: Review of the empirical literature and clinical implications. Annu Rev Sex Res 2002;13:346-87.
88. Fergusson DM, Mullen PE. Childhood sexual abuse: An evidence based perspective. Thousand Oaks, CA: Sage; 1999.
89. Meston CM, Heiman JR. Sexual abuse and sexual function: Examination of sexually relevant cognitive processes. J Consult Clin Psychol 2000;68:399-406.
90. Oberg K, Fugl-Meyer K, Fugl-Meyer A. On sexual well-being in sexually abused Swedish women: Epidemiological aspects. Sex Relatsh Ther 2002;17:329-41.
91. Elmerstig E, Wijma B, Swahnberg K. Young Swedish women's experience of pain and discomfort during sexual intercourse. Acta Obstet Gynecol Scand 2009;88:98-103.
92. Cranston-Cuebas MA, Barlow DH. Cognitive and affective contributions to sexual functioning. Annu Rev Sex Res 1990;1:119-61.
93. Adams AE, Haynes SN, Brayer MA. Cognitive distraction in female sexual arousal. Psychophysiology 1985;22:689-96.
94. Dove NL, Wiedermann MW. Cognitive distraction and women's sexual functioning. J Sex Marital Ther 2000;26:67-78.
95. Kaplan HS. Anxiety and sexual dysfunction. J Clin Psychiatry 1988;49:21-5.
96. Wiedermann MW. Women's body image self-consciousness during physical intimacy with the partner. J Sex Res 2000;37:60-8.
97. Faith M, Schare M. The role of body image in sexually avoidant behaviour. Arch Sex Behav 1993;22:345-56.
98. Aubin S, Heiman JR. Sexual dysfunction from a relationship perspective. In: Harvey JH, Wenzel A, Sprecher S, eds. The handbook of sexuality in close relationships. Mahwah: Erlbaum; 2004:477-517.
99. Dean J, Rubio-Aurioles E, McCabe M, Eardley I, Speakman M, Buvat J, de Tejada IS, Fisher W. Integrating partners into erectile dysfunction treatment: Improving the sexual experience for the couple. Int J Clin Pract 2008;62:127-33.
100. Goldstein I, Fisher WA, Sand M, Rosen RC, Mollen M, Brock G, Karlin G, Pommerville P, Bangerter K, Bandel TJ, Derogatis LR, Vardenafil Study Group. Women's sexual function improves when partners are administered vardenafil for erectile dysfunction: A prospective, randomized, double-blind, placebo-controlled trial. J Sex Med 2005;2:819-32.
101. Klusmann D. Sexual motivation and the duration of partnership. Arch Sex Behav 2002;31:275-87.
102. Trudel G, Boulos L, Benoit M. Dyadic adjustment in couples with hypoactive sexual desire. J Sex Educ Ther 1993;19:31-6.
103. Banmen J, Vogel NA. The relationship between marital quality and interpersonal sexual communication. Fam Ther 1985;12:45-58.
104. Metz ME, Epstein N. Assessing the role of relationship conflict in sexual dysfunction. J Sex Marital Ther 2002;28:139-64.
105. Purnine DM, Carey MP. Interpersonal communication and sexual adjustment: The roles of understanding and agreement. J Consult Clin Psychol 1997;65:1017-25.
106. Zimmer D. Interaction patterns and communication skills in sexually distressed, maritally distressed, and normal couples: Two experimental studies. J Sex Marital Ther 1983;9:251-65.
107. Rust J, Golombock S, Collier J. Marital problems and sexual dysfunction: How are they related? Br J Psychiatry 1988;152:629-31.