N-acetylcysteine attenuates renal alterations induced by senescence in the rat

Experimental Gerontology

Volumn 48, Issue 2, 2013, Pages 298-303

  Shimizu, Maria Heloisa M ^a   Volpini, Rildo A ^a   de Bragança, Ana Carolina ^a   Campos, Renata ^a   Canale, Daniele ^a   Sanches, Talita R ^a   Andrade, Lúcia ^a   Seguro, Antonio C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aging kidneys; Klotho; N acetylcysteine; Oxidative stress; P53; Renal function

Indexed keywords

ACETYLCYSTEINE; AQUAPORIN 2; BIOLOGICAL MARKER; DRINKING WATER; INULIN; KLOTHO PROTEIN; PHOSPHATE; PROTEIN ED1; PROTEIN NKCC2; PROTEIN P53; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; UREA TRANSPORTER A1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREATININE CLEARANCE; DISEASE CONTROL; DRUG MECHANISM; FOLLOW UP; INULIN CLEARANCE; KIDNEY DYSFUNCTION; KIDNEY PARENCHYMA; LONG TERM CARE; MACROPHAGE; MALE; MONOCYTE; NEPHRITIS; NONHUMAN; OXIDATIVE STRESS; PHOSPHATE EXCRETION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; PROTEINURIA; RAT; SENESCENCE; TREATMENT DURATION; TREATMENT RESPONSE;

ACETYLCYSTEINE; AGE FACTORS; AGING; ANIMALS; ANTIOXIDANTS; AQUAPORIN 2; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL AGING; CHOLESTEROL; ECTODYSPLASINS; GLUCURONIDASE; IMMUNOHISTOCHEMISTRY; INULIN; KIDNEY; MALE; MEMBRANE TRANSPORT PROTEINS; OXIDATIVE STRESS; PHOSPHATES; RATS; RATS, WISTAR; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TUMOR SUPPRESSOR PROTEIN P53;

RATTUS; RATTUS NORVEGICUS;

EID: 84872818035     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2012.11.006     Document Type: Article

References (24)

1. Anderson S., Halter J.B., Hazzard W.R., Himmelfarb R.J., Horne F.M., Kaysen G.A., Kusek J.W., Nayfield S.G., Schmader K., Tian Y., Ashworth J.R., Clayton C.P., Parker R.P., Tarver E.D., Woolard N.F., High K.P., workshop participants Prediction, progression, and outcomes of chronic kidney disease in older adults. J. Am. Soc. Nephrol. 2009, 20:1199-1209.
2. Araujo M., Helou C.M.B., Seguro A.C. Renal potassium handling in aging rat. Kidney Blood Press. Res. 1998, 21:425-431.
3. Belmin J., Levy B.I., Michel J.B. Changes in the renin-angiotensin-aldosterone axis in later life. Drugs Aging 1994, 5:391-400.
4. Brudieux R., Ait Chaoui A., Rakotondrazafy J. Age-related decreases in plasma adrenocorticotropic hormone, corticosterone, and aldosterone responses to exogenous corticotropin-releasing hormone in the rat. Gerontology 1995, 41:308-314.
5. Choudhury D., Levi M. Kidney aging - inevitable or preventable. Nat. Rev. Nephrol. 2011, 7:706-711.
6. Cocco T.P., Sgobbo M., Clemente B., Lopriore I., Grattagliano M. Di, Paola G. Villanil Tissue-specific changes of mitochondrial functions in aged rats: effects of a long-term dietary treatment with N-acetylcysteine. Free Radic. Biol. Med. 2005, 38:796-805.
7. Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
8. Haruna Y., Kashihara N., Satoh M., Tomita N., Namikoshi T., Sasaki T., Fujimori T., Xie P., Kanwar Y.S. Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc. Natl. Acad. Sci. U. S. A. 2007, 2331-2336.
9. Korou L.M., Agrogiannis G., Pantopoulou A., Vlashos I.S., Iliopoulos D., Karatza T., Perrea D.N. Comparative antilipemic effect of N-acetylcysteine and sesame oil administration in diet-induced hypercholesterolemic mice. Lipids Health Dis. 2010, 9:23.
10. Kuro-o M. Klotho and aging. Biochim. Biophys. Acta 2009, 1790:1049-1058.
11. Kuro-o M., Matsumura Y., Izawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., Shiraki-Iida T., Nishikawa S., Nagai R., Nabeshima Y.I. Mutation of mouse Klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
12. Levi M., Jameson D.M., Van Der Meer B.W. Role of BBM lipid composition and fluidity in impaired renal Pi transport in aged rat. Am. J. Physiol. 1989, 256:F85-F94.
13. Madamanchi N.R., Runge M.S. Mitochondrial dysfunction in atherosclerosis. Circ. Res. 2007, 100:460-473.
14. Masuda H., Chikuda H., Suga T., Kawaguchi H., Kuro-o M. Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice. Mech. Ageing Dev. 2005, 126:1274-1283.
15. Mulroney S.E., Woda C., Haramati A. Changes in renal phosphate reabsorption in the aged rat. Proc. Soc. Exp. Biol. Med. 1998, 218:62-67.
16. Sands J.M. Urinary concentration and dilution in the aging kidney. Semin. Nephrol. 2009, 29:579-586.
17. Schalanger L.E., Bailey J.L., Sands J.M. Electrolyte in the aging. Adv. Chronic Kidney Dis. 2010, 17:308-319.
18. Shimizu M.H., Coimbra T.M., de Araujo M., Menezes L.F., Seguro A.C. N-acetylcysteine attenuates the progression of chronic renal failure. Kidney Int. 2005, 68:2208-2217.
19. Shimizu M.H.M., Danilovic A., Andrade L., Volpini R.A., Libório A.B., Sanches T.R.C., Seguro A.C. N-acetylcysteine protects against renal injury following bilateral ureteral obstruction. Nephrol. Dial. Transplant. 2008, 23:3067-3073.
20. Shimizu H., Bolati D., Adijiand A., Enomoto A., Nishijima F., Dateki M., Niwa T. Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate. Am. J. Physiol. Cell Physiol. 2010, 299:C1110-C1117.
21. Takahashi Y., Kuro-o M., Ishikawa F. Aging mechanisms. PNAS 2000, 97:12407-12408.
22. Yamamoto Y.M., Clark J.D., Pastor J.V., Gurnani P., Nandi A., Kurosu H., Miyoshi M., Ogawa Y., Castrillon D.H., Rosenblatt K.P., Kuro-o M. Regulation of oxidative stress by the anti-aging hormone Klotho. J. Biol. Chem. 2005, 280:38029-38034.
23. Yang H., Fogo A. Cell senescence in the aging kidney. J. Am. Soc. Nephrol. 2010, 21:1436-1439.
24. Zhou X.J., Rakheja D., Yu X., Saxena R., Vaziri N.D., Silva F.G. The aging kidney. Kidney Int. 2008, 9:1-8.