Metagenomic and metabolomic characterization of rabies encephalitis: New insights into the treatment of an ancient disease

Journal of Infectious Diseases

Volumn 207, Issue 9, 2013, Pages 1451-1456

  Reinke, Stacey N ^a   Resch, Lothar ^a   Maingat, Ferdinand ^a   Branton, William ^a   Jackson, Alan C ^b   Holt, Robert ^c   Slupsky, Carolyn ^a   Marrie, Thomas ^a   Sykes, Brian D ^a   Power, Christopher ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

deep sequencing; neuroinflammation; NMR; rabies virus

Indexed keywords

AMANTADINE; COMPLEMENTARY DNA; KETAMINE; MIDAZOLAM; PROPOFOL; RABIES IMMUNOGLOBULIN; RABIES VIRUS ANTIGEN; RIBAVIRIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ADULT; ARM PAIN; ARTICLE; ASSISTED VENTILATION; BASAL GANGLION; BAT; BITE; BRAIN ATROPHY; BRAIN CORTEX; BRAIN STEM; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; ENTEROVIRUS; HERPES SIMPLEX; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTENSIVE CARE UNIT; INTUBATION; LYMPHOCYTIC INFILTRATION; LYMPHOCYTOSIS; MALE; METABOLOMICS; METAGENOMICS; NERVOUS SYSTEM INFLAMMATION; NEUROIMAGING; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; RABIES; RABIES ENCEPHALITIS; REAL TIME POLYMERASE CHAIN REACTION; REPEAT PROCEDURE; SEQUENCE ANALYSIS; VIRUS DETECTION; VIRUS ENCEPHALITIS; VIRUS GENOME;

AGED; BRAIN; BRAIN CHEMISTRY; ENCEPHALITIS, VIRAL; GENE EXPRESSION PROFILING; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; METAGENOME; MIDDLE AGED; RABIES; RABIES VIRUS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84872809123     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis479     Document Type: Article

References (13)

1. Wunner WH, Briggs DJ. Rabies in the 21 century. PLoS Negl Trop Dis 2010; 4:e591.
2. Jackson AC. Rabies. Neurol Clin 2008; 26:717-26, ix. (Pubitemid 352020486)
3. Willoughby RE Jr, Tieves KS, Hoffman GM, et al. Survival after treatment of rabies with induction of coma. N Engl J Med 2005; 352:2508-14. (Pubitemid 41007866)
4. McDermid RC, Saxinger L, Lee B, et al. Human rabies encephalitis following bat exposure: failure of therapeutic coma. CMAJ 2008; 178:557-61. (Pubitemid 351413999)
5. Vergote D, Butler GS, Ooms M, et al. Proteolytic processing of SDF-1 alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration. Proc Natl Acad Sci USA 2006; 103:19182-7. (Pubitemid 350002847)
6. Freeman JD, Warren RL, Webb JR, Nelson BH, Holt RA. Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing. Genome Res 2009; 19:1817-24.
7. Reinke SN, Hu X, Sykes BD, Lemire BD. Caenorhabditis elegans diet significantly affects metabolic profile, mitochondrial DNA levels, lifespan and brood size. Mol Genet Metab 2010; 100:274-82.
8. Takahashi K, Ohyabu Y, Solodushko V, et al. Taurine renders the cell resistant to ischemia-induced injury in cultured neonatal rat cardiomyocytes. J Cardiovasc Pharmacol 2003; 41:726-33. (Pubitemid 36523175)
9. Johnson T, Nath A. Immune reconstitution inflammatory syndrome and the central nervous system. Curr Opin Neurol 2011; 24:284-90.
10. Wilson RD, Priano LL, Traber DL, Sakai H, Daniels JC, Ritzmann SE. An investigation of possible immunosuppression from ketamine and 100 percent oxygen in normal children. Anesth Analg 1971; 50:464-70.
11. Freire-Garabal M, Belmonte A, Balboa JL, Nunez MJ. Effects of midazolam on T-cell immunosuppressive response to surgical stress in mice. Pharmacol Biochem Behav 1992; 43:85-9.
12. Galley HF, Dubbels AM, Webster NR. The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes. Anesth Analg 1998; 86:1289-93. (Pubitemid 28249254)
13. Aramburo A, Willoughby RE, Bollen AW, et al. Failure of the Milwaukee protocol in a child with rabies. Clin Infect Dis 2011; 53: 572-4.