Strategies for Endogenous Spinal Cord Repair: HPMA Hydrogel to Recruit Migrating Endogenous Stem Cells

Advances in Experimental Medicine and Biology

Volumn 760, Issue , 2012, Pages 25-52

  Espinosa Jeffrey, Araceli ^a   Oregel, Karlos ^a   Wiggins, Laurent ^a   Valera, Remelyn ^a   Bosnoyan, Kathrin ^a   Agbo, Chioma ^a   Awosika, Oluwole ^a   Zhao, Paul M ^a   de Vellis, Jean ^a   Woerly, Stéphane ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Organogel   (Canada)

Author keywords

Myelin Basic Protein; Nestin Expression; Neural Stem Cell; Spinal Cord; Spinal Cord Injury

Indexed keywords

MYELIN; NESTIN; NEUROFILAMENT 160 PROTEIN; NEUROFILAMENT 200 PROTEIN; NEUROFILAMENT PROTEIN; POLY[N (2 HYDROXYPROPYL)METHACRYLAMIDE]; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; HYDROXYPROPYL METHACRYLATE; METHACRYLIC ACID DERIVATIVE; NERVE PROTEIN; TISSUE SCAFFOLD;

ASTROCYTE; AXON; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL SELF-RENEWAL; CELLULAR DISTRIBUTION; GLIOSIS; HUMAN; HYDROGEL; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECONSTRUCTIVE SURGERY; REGENERATIVE MEDICINE; SPINAL CORD REGENERATION; STEM CELL; STEM CELL NICHE; TISSUE ENGINEERING; TISSUE REPAIR; ANIMAL; ARTICLE; CAT; CELL MOTION; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; METABOLISM; METHODOLOGY; NERVE REGENERATION; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SPINAL CORD; SPINAL CORD INJURY;

ANIMALS; ASTROCYTES; BIOLOGICAL MARKERS; CATS; CELL MOVEMENT; DISEASE MODELS, ANIMAL; HUMANS; HYDROGEL; METHACRYLATES; NERVE REGENERATION; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; RATS; SPINAL CORD; SPINAL CORD INJURIES; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84872800944     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-1-4614-4090-1_3     Document Type: Chapter

References (58)

1. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian nervous system. Science 1992; 255(5052):1707-1710.
2. Dromard C, Guillon H, Rigau V et al. Adult human spinal cord harbors neural precursor cells that generate neurons and glial cells in vitro..J Neurosci Res 2008; 86(9): 1916-1926.
3. Gage FH. Mammalian neural stem cells. Science 2000; 287(5457):1433-1438.
4. Homer PJ, Power AE, Kempennann G et al. Proliferation and differentiation of progenitor cells throughout the intact adult spinal cord..I Neurosci 2000; 20:2218-2228.
5. Yamamoto S, Yamamoto N, Kitamura T et al. Proliferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord. Exp Neurol 2001; 172( I): 115-127.
6. Picard-Riera N, Nait-Dumesmar B, Baron-Van Evercoom A. Endogenous adult neural stem cells: Limits and potential to repair the injured central nervous system. J Neurosci Res 2004; 76:223-231.
7. Taupin P, Gage FH. Adult neurogenesis and neural stem cells of the central nervous system in mammals..I Neurosci Res 2002; 69(6):745-749.
8. Tamura A, Kirino T, Nakafuku M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 2002; II 0(4):429-441.
9. Yagita Y, Kitagawa K, Dhtsuki T et al. Neurogenesis by progenitor cells in the ischemic cerebral cortex and striatum. Stroke 2001; 32:1890-1896.
10. lin K, Sun Y, Xie L et al. Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol Cell Neurosci 2003; 24:171-189.
11. Imitola J, Raddassi K, In Park K et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1a/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci USA 2004; 101(52): 18117-18122.
12. Dkano H, Sakaguchi M, Dhki K et al. Regeneration ofthe central nervous system using endogenous repair mechanisms. JNeurochem 2007; 102(5):1459-1465.
13. Horky LL, Galimi F, Gage FH et al. Fate of endogenous stem/progenitor cells following spinal cord injury. J Comp Neurol 2006; 498(4):525-538.
14. Ke Y, Chi L, Xu R et al. Early response of endogenous adult neural progenitor cells to acute spinal cord injury in mice. Stem cells 2006; 24(4): 1011-1019.
15. Namiki.I, Tator CH. Cell proliferation and nestin expression in the ependyma of the adult rat spinal cord after injury. J Neuropathol Exp Neurol 1999; 58:489-498.
16. Peppas NA, Bures P, Leobandung W et al. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 2000; 50(1):27-46.
17. Subramanian A, Krishnan U, Sethuraman S. Development ofbiomaterial scaffold fornerve tissue engineering: Biomaterial mediated neural regeneration. J Biomed Sci 2009; 16(1):108-119.
18. Hoffinan AS. Hydrogel for biomedical applications. Adv Drug Del Rev 2002; 54( 1):3-12.
19. Woerly S, Pinet E, de Robertis L et al. Heterogeneous PHPMA hydrogels for tissue repair and axonal regeneration in the injured spinal cord. J Biomaterial Sci Polymer Ed 1998; 9(7):681-711.
20. Woerly S, Doan VD, Sosa N et al. Reconstruction of the double transected cat spinal cord after Neurogel implantation, axonal tracing, immunohistochemical and ultrastructural studies. lnt J Dev Neurosci 2001; 19(1):63-83.
21. Woerly S, Doan VD, Paramore CG et al. Spinal cord reconstruction and functional recovery using Neurogel after chronic injury. J Neurosci Res 2001; 66: 1187-1197.
22. Woerly S, Doan VD, Sosa N et al. Prevention of gliotic scar formation by Neurogel allows partial endogenous repair oftransected cat spinal cord. J Neurosci Res 2004; 7:262-272.
23. Woerly S, Awosika O, Zhao P et al. Expression of Heat Shock Protein (HSP)-25 and HSP-32 in rat spinal cord reconstructed with Neurogel. Neurochem Res 2005; 30:721-735.
24. Bradbury E, McMahon SB. Spinal cord repair strategies, why do they work? Nature Rev Neurosci 2006; 7(8):644-653.
25. Murray M, Fischer I. Transplantation and gene therapy, combined approaches forrepairofspinal cord injuriez. Neuroscientist 2001; 7:28-41.
26. Jones LL, Dudega M, Bunge MB et al. Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury..I Physiol2001; 533(1):83-89.
27. Lu P, Yang H, Jones LL et al. Combinatorial Therapy with Neurotrophins and cAMP Promotes Axonal Regeneration beyond Sites of Spinal Cord Injury..I Neurosci 2004; 24(28):6402-6409.
28. Xu Y, Kitada M, Yamaguchi M et al. Increase in bFGF-responsive neural progenitor population following contusion injury of the adult rodent spinal cord. Neurosci Lett 2006; 397(3): 174-179.
29. Profyis C, Cheema SS, Zang D et al. Degenerative and regenerative mechanisms governing spinal cord injury. Neurobiol Disease 2004; 15(3):415-436.
30. Nomura H, Tator CH, Shoichet MS. Bioengineered Strategies for Spinal Cord Repair. J Neurotrauma 2006; 23:496-507.
31. Samadikuchaksaraei A. An overview oftissue engineering approaches for management of spinal cord injuries. J NeuroEng Rehab 2007; 4:5-31.
32. Teixeira AI, Duckworth JK, Hermanson O. Getting the right stuff, controlling neural stem cell state and fate in vivo and in vitro with biomaterials. Cell Res 2007; 17(1):56-61.
33. Teng YD, Lavik EB, Qu X et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci USA 2002; 99(5):3024-3029.
34. Silva GA, Czeisler C, Niece KL et al. Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science 2004; 303: 1352-1355.
35. Silva NA, Salgado AJ, Sousa RA et al. Development and characterization of a novel hybrid tissue engineering-based scaffold for spinal cord injury. Tissue Eng 2010; 16(1):45-54.
36. Woerly S, Fort S, Pignot-Paintrand P et al. Development of a Sialic Acid-Containing Hydrogel of Poly[N-(2-hydroxypropyl) methacrylamide]: Characterization and Implantation Study. Biomacromol2008; 9(9):2329-2337.
37. Itoh T, Satou S, Hashimoto H et al. Isolation of neural stem cells from damaged rat cerebral cortex after traumatic brain injury. NeuroReport2005; 16(15):1687-1691.
38. Duggal NR, Schmidt-Kastner, Hakim AM. Nestin expression in reactive astrocytes following focal cerebral ischemia in rats. Brain Res 1997; 768(1-2):1-9.
39. Rice C, Khaldi A, Harvey HB et al. Proliferation and neuronal differentiation of mitotically active cells following traumatic brain injury. Exp NeuroI 2003; 183(2):406-417.
40. Cizkova D, Vanicky I et al. Response of ependymal progenitors to spinal cord injury or enhanced physical activity in adult rat. Cell Mol Neurobiol2009; 29:999-1013.
41. Salman H, Ghosh P, Kernie SG. Subventricular zone neural stem cells remodel the brain following traumatic injury in adult mice. J Neurotrauma 2004; 21:283-292.
42. Zai LJ, Yoo S, Wrathall JR. Increased growth factor expression and cell proliferation after contusive spinal cord injury. Brain Res 2005; 1052(2):147-155.
43. Shen Q, Goderie SK, Jin L et al. Endothelial cells stimulate self:renewal and expand neurogenesis of neural stem cells. Science 2004; 304: 1338-1340.
44. Stujkovic M, Sanchez-Puelles JM, Moreno-Manzano V et al. Activated spinal cord ependymal stem cells rescue neurological function. Stem Cell 2009; 27:733-743.
45. Roufosse CA, Direkze NC, Otto WR et al. Circulating mesenchymal stem cells. Int J Biochem Cell Bioly 2004; 36:585-597.
46. Kaya SA, Mahmood A, Li Y et al. Expression of nestin after traumatic brain injury in rat brain. Brain Research 1999; 840(1-2,4):153-157.
47. Foret A, Quertainmont R, Botman O et al. Stem cells in the adult rat spinal cord: plasticity after injury and treadmill training exercise. J Neurochem 2010; 112(3):762-772.
48. U da M, Ishido M, Kami K et al. Effects of chronic treadmill running on neurogenesis in the dentate gyrus of the hippocampus of adult rat. Brain Res 2006; 1104(1):64-72.
49. Lee SH, Kim YH, Kim YJ et al. Enforced physical training promotes neurogenesis in the subgranular zone after focal cerebral ischemia. J Neurol Sci 2008; 269:54-61.
50. Teng YD, Liao WL, Choi H et al. Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells. Regen Med 2006; 1(6):763-776.
51. Eidelberg E, Story JL, Walden JG et al. Anatomical correlates of return oflocomotor function after partial spinal cord lesions in cats. Exp Brain Res 1981; 42:81-88.
52. Blight AR. Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling. Neurosci 1983; 10:521-543.
53. Fehlings MG, Tator CH. The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury. Exp Neuro11995; 132(2):220-228.
54. Zhang Y, Klassen HJ, Tucker BA et al. CNS Progenitor cells cromote a cermissive Environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. J Neurosci 2007; 27(17):4499-4506.
55. Jones LL, Yamaguchi Y, Stallcup WB et al. NG2 Is a Major Chondroitin Sulfate Proteoglycan Produced after Spinal Cord Injury and Is Expressed by Macrophages and Oligodendrocyte Progenitors. J Neurosci 2002; 22(7):2792-3280.
56. Espinosa-Jeffrey A, Zhao P, Awosika A et al. Activation, proliferation and commitment of endogenous, stem! progenitor cells to the oligodendrocyte lineage by a combination of neurotrophic factors in a rat model of dysmyelination. Dev Neurosci 2006; 28(6):488-498.
57. Espinosa-Jeffrey A, Zhao Seiji HP, Awosika O et al. Prospects for the use of stem cells in myelin repair. J Neurosci Res 2011; 88 (8):1682-1694.
58. Krityakiarana W, Espinosa-Jeffrey A, Paul M et al. Combination oftrophic factors enhances nestin expressing progenitors and neuroprotection after spinal cord injury (Presented at the Society for Neuroscience 2 Annual meeting 2010).