A Potential Role for Plasma Uric Acid in the Endothelial Pathology of Plasmodium falciparum malaria

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Mita Mendoza, Neida K ^a,b   van de Hoef, Diana L ^c   Lopera Mesa, Tatiana M ^a   Doumbia, Saibou ^d   Konate, Drissa ^d   Doumbouya, Mory ^d   Gu, Wenjuan ^a   Anderson, Jennifer M ^a   Santos Argumedo, Leopoldo ^b   Rodriguez, Ana ^c   Fay, Michael P ^a   Diakite, Mahamadou ^d   Long, Carole A ^a   Fairhurst, Rick M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF BAMAKO   (Mali)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; THROMBOMODULIN; THROMBOPLASTIN; URIC ACID; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE DURATION; DISEASE MARKER; DISEASE SEVERITY; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MOLECULAR PATHOLOGY; NONHUMAN; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; PROGNOSIS; PROTEIN BLOOD LEVEL; URIC ACID URINE LEVEL;

E-SELECTIN; ENDOTHELIUM; ERYTHROCYTES; FIBRIN; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MALARIA, FALCIPARUM; MICROVESSELS; PLASMODIUM FALCIPARUM; PLATELET AGGREGATION; THROMBOMODULIN; URIC ACID; VASCULAR CELL ADHESION MOLECULE-1;

MALIA; PLASMODIUM FALCIPARUM;

EID: 84872795977     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054481     Document Type: Article

References (47)

1. Kim H, Higgins S, Liles WC, Kain KC, (2011) Endothelial activation and dysregulation in malaria: a potential target for novel therapeutics. Curr Opin Hematol 18: 177-185.
2. Turner GD, Ly VC, Nguyen TH, Tran TH, Nguyen HP, et al. (1998) Systemic endothelial activation occurs in both mild and severe malaria. Correlating dermal microvascular endothelial cell phenotype and soluble cell adhesion molecules with disease severity. Am J Pathol 152: 1477-1487.
3. Conroy AL, Phiri H, Hawkes M, Glover S, Mallewa M, et al. (2010) Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study. PLoS One 5: e15291.
4. Furuta T, Kimura M, Watanabe N, (2010) Elevated levels of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor (VEGFR)-2 in human malaria. Am J Trop Med Hyg 82: 136-139.
5. Jain V, Armah HB, Tongren JE, Ned RM, Wilson NO, et al. (2008) Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India. Malar J 7: 83.
6. Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, et al. (2008) Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. Proc Natl Acad Sci U S A 105: 17097-17102.
7. Tchinda VH, Tadem AD, Tako EA, Tene G, Fogako J, et al. (2007) Severe malaria in Cameroonian children: correlation between plasma levels of three soluble inducible adhesion molecules and TNF-alpha. Acta Trop 102: 20-28.
8. Jakobsen PH, Morris-Jones S, Ronn A, Hviid L, Theander TG, et al. (1994) Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium falciparum or P. vivax malaria and association with disease severity. Immunology 83: 665-669.
9. Francischetti IM, Seydel KB, Monteiro RQ, (2008) Blood coagulation, inflammation, and malaria. Microcirculation 15: 81-107.
10. Francischetti IM, Seydel KB, Monteiro RQ, Whitten RO, Erexson CR, et al. (2007) Plasmodium falciparum-infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation complexes. J Thromb Haemost 5: 155-165.
11. Anstey NM, Weinberg JB, Hassanali MY, Mwaikambo ED, Manyenga D, et al. (1996) Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med 184: 557-567.
12. Sobolewski P, Gramaglia I, Frangos J, Intaglietta M, van der Heyde HC, (2005) Nitric oxide bioavailability in malaria. Trends Parasitol 21: 415-422.
13. Prato M, D'Alessandro S, Van den Steen PE, Opdenakker G, Arese P, et al. (2011) Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium. Cell Microbiol 13: 1275-1285.
14. Krishnegowda G, Hajjar AM, Zhu J, Douglass EJ, Uematsu S, et al. (2005) Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J Biol Chem 280: 8606-8616.
15. Gillrie MR, Lee K, Gowda DC, Davis SP, Monestier M, et al. (2012) Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction. Am J Pathol 180: 1028-1039.
16. Orengo JM, Evans JE, Bettiol E, Leliwa-Sytek A, Day K, et al. (2008) Plasmodium-induced inflammation by uric acid. PLoS Pathog 4: e1000013.
17. Orengo JM, Leliwa-Sytek A, Evans JE, Evans B, van de Hoef D, et al. (2009) Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response. PLoS One 4: e5194.
18. So A, Thorens B, (2010) Uric acid transport and disease. J Clin Invest 120: 1791-1799.
19. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, et al. (2003) Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41: 1183-1190.
20. Ames BN, Cathcart R, Schwiers E, Hochstein P, (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A 78: 6858-6862.
21. Nakagawa T, Kang DH, Feig D, Sanchez-Lozada LG, Srinivas TR, et al. (2006) Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular disease. Kidney Int 69: 1722-1725.
22. Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, et al. (2005) Hyperuricemia induces endothelial dysfunction. Kidney Int 67: 1739-1742.
23. Kanellis J, Kang DH, (2005) Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol 25: 39-42.
24. Hong Q, Qi K, Feng Z, Huang Z, Cui S, et al. (2012) Hyperuricemia induces endothelial dysfunction via mitochondrial Na(+)/Ca(2+) exchanger-mediated mitochondrial calcium overload. Cell Calcium.
25. Price KL, Sautin YY, Long DA, Zhang L, Miyazaki H, et al. (2006) Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol 17: 1791-1795.
26. Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, et al. (2008) Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J Hypertens 26: 269-275.
27. Filiopoulos V, Hadjiyannakos D, Vlassopoulos D, (2012) New insights into uric acid effects on the progression and prognosis of chronic kidney disease. Ren Fail 34: 510-520.
28. Pasalic D, Marinkovic N, Feher-Turkovic L, (2012) Uric acid as one of the important factors in multifactorial disorders-facts and controversies. Biochem Med (Zagreb) 22: 63-75.
29. Puddu P, Puddu GM, Cravero E, Vizioli L, Muscari A (2012) The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: Molecular mechanisms and clinical implications. J Cardiol.
30. Tomiyama H, Higashi Y, Takase B, Node K, Sata M, et al. (2011) Relationships among hyperuricemia, metabolic syndrome, and endothelial function. Am J Hypertens 24: 770-774.
31. Gersch C, Palii SP, Kim KM, Angerhofer A, Johnson RJ, et al. (2008) Inactivation of nitric oxide by uric acid. Nucleosides Nucleotides Nucleic Acids 27: 967-978.
32. Feig DI, Kang DH, Nakagawa T, Mazzali M, Johnson RJ, (2006) Uric acid and hypertension. Curr Hypertens Rep 8: 111-115.
33. Strazzullo P, Puig JG, (2007) Uric acid and oxidative stress: relative impact on cardiovascular risk? Nutr Metab Cardiovasc Dis 17: 409-414.
34. Panoulas VF, Milionis HJ, Douglas KM, Nightingale P, Kita MD, et al. (2007) Association of serum uric acid with cardiovascular disease in rheumatoid arthritis. Rheumatology (Oxford) 46: 1466-1470.
35. Kawai T, Ohishi M, Takeya Y, Onishi M, Ito N, et al. (2012) Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients. Hypertens Res.
36. Lopera-Mesa TM, Mita-Mendoza NK, van de Hoef DL, Doumbia S, Konate D, et al. (2012) Plasma Uric Acid Levels Correlate with Inflammation and Disease Severity in Malian Children with Plasmodium falciparum Malaria. PLoS One 7: e46424.
37. Wright SP, (1992) Adjusted p-values for simultaneous inference. Biometrics 48: 1005-1013.
38. Barbier M, Faille D, Loriod B, Textoris J, Camus C, et al. (2011) Platelets alter gene expression profile in human brain endothelial cells in an in vitro model of cerebral malaria. PLoS One 6: e19651.
39. Wassmer SC, de Souza JB, Frere C, Candal FJ, Juhan-Vague I, et al. (2006) TGF-beta1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria. J Immunol 176: 1180-1184.
40. Combes V, Coltel N, Faille D, Wassmer SC, Grau GE, (2006) Cerebral malaria: role of microparticles and platelets in alterations of the blood-brain barrier. Int J Parasitol 36: 541-546.
41. Yeo TW, Lampah DA, Tjitra E, Gitawati R, Kenangalem E, et al. (2009) Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. J Infect Dis 200: 1522-1529.
42. Hsieh MS, Ho HC, Chou DT, Pan S, Liang YC, et al. (2003) Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages. J Cell Biochem 89: 791-799.
43. Fiore E, Fusco C, Romero P, Stamenkovic I, (2002) Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity. Oncogene 21: 5213-5223.
44. Wu HL, Lin CI, Huang YL, Chen PS, Kuo CH, et al. (2008) Lysophosphatidic acid stimulates thrombomodulin lectin-like domain shedding in human endothelial cells. Biochem Biophys Res Commun 367: 162-168.
45. Hintze J L, Nelson RD, (1998) Violin plots: a box plot-density trace synergism. The American Statistician 52(2): 181-184.
46. Atoh Y (2011) viopoints: 1-D Scatter Plots with Jitter Using Kernel Density Estimates. R package version 0.2-1. http://CRAN.R-project.org/package=viopoints.
47. W S Cleveland, E Grosse, WM Shyu (1992) Local regression models. Chapter 8, Statistical Models in S, Eds. J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.