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Volumn 3, Issue , 2011, Pages 61-70

In vitro human skin permeation of endoxifen: Potential for local transdermal therapy for primary prevention and carcinoma in situ of the breast

Author keywords

Breast cancer prevention; Endoxifen; Human skin; Oleic acid; Transdermal

Indexed keywords


EID: 84872769788     PISSN: None     EISSN: 11791314     Source Type: Journal    
DOI: 10.2147/BCTT.S20821     Document Type: Article
Times cited : (26)

References (28)
  • 1
    • 33845904405 scopus 로고    scopus 로고
    • Chemoprevention of breast cancer with selective oestrogenreceptor modulators
    • Jordan VC. Chemoprevention of breast cancer with selective oestrogenreceptor modulators. Nat Rev Cancer. 2007;7(1):46-53.
    • (2007) Nat Rev Cancer , vol.7 , Issue.1 , pp. 46-53
    • Jordan, V.C.1
  • 2
    • 0037464769 scopus 로고    scopus 로고
    • Overview of the main outcomes in breast-cancer prevention trials
    • Cuzick J, Powles T, Veronesi U, et al. Overview of the main outcomes in breast-cancer prevention trials. Lancet. 2003;361(9354):296-300.
    • (2003) Lancet , vol.361 , Issue.9354 , pp. 296-300
    • Cuzick, J.1    Powles, T.2    Veronesi, U.3
  • 3
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    • Goetz MP, Rae JM, Suman VJ, et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol. 2005;23(36):9312-9318.
    • (2005) J Clin Oncol , vol.23 , Issue.36 , pp. 9312-9318
    • Goetz, M.P.1    Rae, J.M.2    Suman, V.J.3
  • 4
    • 33847034287 scopus 로고    scopus 로고
    • The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
    • Goetz MP, Knox SK, Suman VJ, et al. The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat. 2007;101(1):113-121.
    • (2007) Breast Cancer Res Treat , vol.101 , Issue.1 , pp. 113-121
    • Goetz, M.P.1    Knox, S.K.2    Suman, V.J.3
  • 5
    • 62449153701 scopus 로고    scopus 로고
    • The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells
    • Wu X, Hawse JR, Subramaniam M, Goetz MP, Ingle JN, Spelsberg TC. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res. 2009;69(5):1722-1727.
    • (2009) Cancer Res , vol.69 , Issue.5 , pp. 1722-1727
    • Wu, X.1    Hawse, J.R.2    Subramaniam, M.3    Goetz, M.P.4    Ingle, J.N.5    Spelsberg, T.C.6
  • 6
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998;90(18): 1371-1388.
    • (1998) J Natl Cancer Inst , vol.90 , Issue.18 , pp. 1371-1388
    • Fisher, B.1    Costantino, J.P.2    Wickerham, D.L.3
  • 7
    • 0022549944 scopus 로고
    • Trans- 4-Hydroxytamoxifen concentration and metabolism after local percutaneous administration to human breast
    • Mauvais-Javis P, Baudot N, Castaigne D, Banzet P, Kuttenn F. trans- 4-Hydroxytamoxifen concentration and metabolism after local percutaneous administration to human breast. Cancer Res. 1986;46(3): 1521-1525.
    • (1986) Cancer Res , vol.46 , Issue.3 , pp. 1521-1525
    • Mauvais-Javis, P.1    Baudot, N.2    Castaigne, D.3    Banzet, P.4    Kuttenn, F.5
  • 8
    • 0029160910 scopus 로고
    • Phase I study of percutaneous 4-hydroxy-tamoxifen with analyses of 4-hydroxy-tamoxifen concentrations in breast cancer and normal breast tissue
    • Pujol H, Girault J, Rouanet P, et al. Phase I study of percutaneous 4-hydroxy-tamoxifen with analyses of 4-hydroxy-tamoxifen concentrations in breast cancer and normal breast tissue. Cancer Chemother Pharmacol. 1995;36(6):493-498.
    • (1995) Cancer Chemother Pharmacol , vol.36 , Issue.6 , pp. 493-498
    • Pujol, H.1    Girault, J.2    Rouanet, P.3
  • 9
    • 21144447743 scopus 로고    scopus 로고
    • Neoadjuvant percutaneous 4-hydroxytamoxifen decreases breast tumoral cell proliferation: A prospective controlled randomized study comparing three doses of 4-hydroxytamoxifen gel to oral tamoxifen
    • Rouanet P, Linares-Cruz G, Dravet F, et al. Neoadjuvant percutaneous 4-hydroxytamoxifen decreases breast tumoral cell proliferation: a prospective controlled randomized study comparing three doses of 4-hydroxytamoxifen gel to oral tamoxifen. J Clin Oncol. 2005;23(13): 2980-2987.
    • (2005) J Clin Oncol , vol.23 , Issue.13 , pp. 2980-2987
    • Rouanet, P.1    Linares-Cruz, G.2    Dravet, F.3
  • 10
    • 0022447075 scopus 로고
    • Methods for in vitro percutaneous absorption studies. VI: Preparation of the barrier layer
    • Bronaugh RL, Stewart RF. Methods for in vitro percutaneous absorption studies. VI: preparation of the barrier layer. J Pharm Sci. 1986;75(5): 487-491.
    • (1986) J Pharm Sci , vol.75 , Issue.5 , pp. 487-491
    • Bronaugh, R.L.1    Stewart, R.F.2
  • 11
    • 35648988473 scopus 로고    scopus 로고
    • A phase II trial of Afimoxifene (4-hydroxytamoxifen gel) for cyclical mastalgia in premenopausal women
    • Mansel R, Goyal A, Nestour EL, Masini-Eteve V, O'Connell K. A phase II trial of Afimoxifene (4-hydroxytamoxifen gel) for cyclical mastalgia in premenopausal women. Breast Cancer Res Treat. 2007; 106(3):389-397.
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.3 , pp. 389-397
    • Mansel, R.1    Goyal, A.2    Nestour, E.L.3    Masini-Eteve, V.4    O'Connell, K.5
  • 12
    • 17644387537 scopus 로고    scopus 로고
    • Endoxifen (4-hydroxy- N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
    • Lim YC, Desta Z, Flockhart DA, Skaar TC. Endoxifen (4-hydroxy- N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. Cancer Chemother Pharmacol. 2005;55(5):471-478.
    • (2005) Cancer Chemother Pharmacol , vol.55 , Issue.5 , pp. 471-478
    • Lim, Y.C.1    Desta, Z.2    Flockhart, D.A.3    Skaar, T.C.4
  • 13
    • 33745939124 scopus 로고    scopus 로고
    • Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells
    • Lim YC, Li L, Desta Z, et al. Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J Pharmacol Exp Ther. 2006;318(2):503-512.
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.2 , pp. 503-512
    • Lim, Y.C.1    Li, L.2    Desta, Z.3
  • 15
    • 0029844908 scopus 로고    scopus 로고
    • Mutual hairless rat skin permeationenhancing effect of ethanol/water system and oleic acid
    • Kim DD, Kim JL, Chien YW. Mutual hairless rat skin permeationenhancing effect of ethanol/water system and oleic acid. J Pharm Sci. 1996;85(11):1191-1195.
    • (1996) J Pharm Sci , vol.85 , Issue.11 , pp. 1191-1195
    • Kim, D.D.1    Kim, J.L.2    Chien, Y.W.3
  • 16
    • 49549104910 scopus 로고    scopus 로고
    • Skin permeation enhancement of diclofenac by fatty acids
    • Kim MJ, Doh HJ, Choi MK, et al. Skin permeation enhancement of diclofenac by fatty acids. Drug Deliv. 2008;15(6):373-379.
    • (2008) Drug Deliv , vol.15 , Issue.6 , pp. 373-379
    • Kim, M.J.1    Doh, H.J.2    Choi, M.K.3
  • 17
    • 0023680522 scopus 로고
    • Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique
    • Goodman M, Barry BW. Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique. J Invest Dermatol. 1988;91(4):323-327.
    • (1988) J Invest Dermatol , vol.91 , Issue.4 , pp. 323-327
    • Goodman, M.1    Barry, B.W.2
  • 18
    • 0037448407 scopus 로고    scopus 로고
    • Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels
    • Fang JY, Hwang TL, Leu YL. Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels. Int J Pharm. 2003;250(2):313-325.
    • (2003) Int J Pharm , vol.250 , Issue.2 , pp. 313-325
    • Fang, J.Y.1    Hwang, T.L.2    Leu, Y.L.3
  • 19
    • 0034945113 scopus 로고    scopus 로고
    • In vitro visualization and quantification of oleic acid induced changes in transdermal transport using two-photon fluorescence microscopy
    • Yu B, Dong CY, So PT, Blankschtein D, Langer R. In vitro visualization and quantification of oleic acid induced changes in transdermal transport using two-photon fluorescence microscopy. J Invest Dermatol. 2001;117(1):16-25.
    • (2001) J Invest Dermatol , vol.117 , Issue.1 , pp. 16-25
    • Yu, B.1    Dong, C.Y.2    So, P.T.3    Blankschtein, D.4    Langer, R.5
  • 20
    • 0028822489 scopus 로고
    • Percutaneous penetration of fluorescein isothiocyanate-dextrans and the mechanism for enhancement effect of enhancers on the intercellular penetration
    • Ogiso T, Paku T, Iwaki M, Tanino T. Percutaneous penetration of fluorescein isothiocyanate-dextrans and the mechanism for enhancement effect of enhancers on the intercellular penetration. Biol Pharm Bull. 1995;18(11):1566-1571.
    • (1995) Biol Pharm Bull , vol.18 , Issue.11 , pp. 1566-1571
    • Ogiso, T.1    Paku, T.2    Iwaki, M.3    Tanino, T.4
  • 21
    • 17444368310 scopus 로고    scopus 로고
    • Short-term effects of estrogen, tamoxifen and raloxifene on hemostasis: A randomizedcontrolled study and review of the literature
    • Cosman F, Baz-Hecht M, Cushman M, et al. Short-term effects of estrogen, tamoxifen and raloxifene on hemostasis: a randomizedcontrolled study and review of the literature. Thromb Res. 2005;116(1): 1-13.
    • (2005) Thromb Res , vol.116 , Issue.1 , pp. 1-13
    • Cosman, F.1    Baz-Hecht, M.2    Cushman, M.3
  • 22
    • 80052059849 scopus 로고    scopus 로고
    • First results from the International Breast Cancer Intervention Study (IBIS-I): A randomised prevention trial
    • Cuzick J, Forbes J, Edwards R, et al. First results from the International Breast Cancer Intervention Study (IBIS-I): a randomised prevention trial. Lancet. 2002;360(9336):817-824.
    • (2002) Lancet , vol.360 , Issue.9336 , pp. 817-824
    • Cuzick, J.1    Forbes, J.2    Edwards, R.3
  • 23
    • 0032491774 scopus 로고    scopus 로고
    • Estrogen receptor expression in benign breast epithelium and breast cancer risk [see comments]
    • Khan SA, Rogers MA, Khurana KK, Meguid MM, Numann PJ. Estrogen receptor expression in benign breast epithelium and breast cancer risk [see comments]. J Natl Cancer Inst. 1998;90(1):37-42.
    • (1998) J Natl Cancer Inst , vol.90 , Issue.1 , pp. 37-42
    • Khan, S.A.1    Rogers, M.A.2    Khurana, K.K.3    Meguid, M.M.4    Numann, P.J.5
  • 24
    • 0025908152 scopus 로고
    • Estrogen and progesterone receptors in the normal female breast
    • Ricketts D, Turnbull L, Ryall G, et al. Estrogen and progesterone receptors in the normal female breast. Cancer Res. 1991;51: 1817-1822.
    • (1991) Cancer Res , vol.51 , pp. 1817-1822
    • Ricketts, D.1    Turnbull, L.2    Ryall, G.3
  • 25
    • 34147168298 scopus 로고    scopus 로고
    • Contrary view: The breast is not an organ per se, but a distinctive region of skin and subcutaneous tissue
    • Ackerman AB, Kessler G, Gyorfi T, Tsou HC, Gottlieb GJ. Contrary view: the breast is not an organ per se, but a distinctive region of skin and subcutaneous tissue. Am J Dermatopathol. 2007;29(2): 211-218.
    • (2007) Am J Dermatopathol , vol.29 , Issue.2 , pp. 211-218
    • Ackerman, A.B.1    Kessler, G.2    Gyorfi, T.3    Tsou, H.C.4    Gottlieb, G.J.5
  • 26
    • 33751020280 scopus 로고    scopus 로고
    • Prospective randomized trial comparing intradermal, intraparenchymal, and subareolar injection routes for sentinel lymph node mapping and biopsy in breast cancer
    • Povoski SP, Olsen JO, Young DC, et al. Prospective randomized trial comparing intradermal, intraparenchymal, and subareolar injection routes for sentinel lymph node mapping and biopsy in breast cancer. Ann Surg Oncol. 2006;13(2):10-11.
    • (2006) Ann Surg Oncol , vol.13 , Issue.2 , pp. 10-11
    • Povoski, S.P.1    Olsen, J.O.2    Young, D.C.3
  • 27
    • 0033510722 scopus 로고    scopus 로고
    • Subareolar versus peritumoral injection for location of the sentinel lymph node
    • Klimberg VS, Rubio IT, Henry R, Cowan C, Colvert M, Korourian S. Subareolar versus peritumoral injection for location of the sentinel lymph node. Ann Surg. 1999;229(6):860-864.
    • (1999) Ann Surg , vol.229 , Issue.6 , pp. 860-864
    • Klimberg, V.S.1    Rubio, I.T.2    Henry, R.3    Cowan, C.4    Colvert, M.5    Korourian, S.6
  • 28
    • 0026425653 scopus 로고
    • Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment
    • Lien EA, Solheim E, Ueland PM. Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment. Cancer Res. 1991;51(18):4837-4844.
    • (1991) Cancer Res , vol.51 , Issue.18 , pp. 4837-4844
    • Lien, E.A.1    Solheim, E.2    Ueland, P.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.