Paget′s disease of the breast

Journal of Carcinogenesis

Volumn 10, Issue , 2011, Pages

  Karakas, Cansu ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Breast; nipple; Paget s disease

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 10; CYTOKERATIN 12; CYTOKERATIN 14; CYTOKERATIN 20; CYTOKERATIN 7; EPITHELIAL MEMBRANE ANTIGEN; MUCIN;

ANTIGEN EXPRESSION; ARTICLE; CANCER DIAGNOSIS; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; HISTOGENESIS; HUMAN; MAMMOGRAPHY; MASTECTOMY; NUCLEAR MAGNETIC RESONANCE IMAGING; PAGET NIPPLE DISEASE;

EID: 84872740061     PISSN: 09746773     EISSN: 14773163     Source Type: Journal    
DOI: 10.4103/1477-3163.90676     Document Type: Article

References (78)

1. Paget J. On the disease of the mammary areola preceding cancer of the mammary gland. St Bartholomews Hosp Rep 1874;10:87-9.
2. Tavassoli FA. Pathology of the breast. Norwalk, Connecticut: AppletonandLange; 1999. p. 731-60.
3. Sakorafas GH, Blanchard K, Sarr MG, Farley DR. Paget's disease of the breast. Cancer Treat Rev 2001;27:9-18. (Pubitemid 32229682)
4. Kanitakis J. Mammary and extramammary Paget's disease. J Eur Acad Dermatol Venereol 2007;21:581-90. (Pubitemid 46916755)
5. Martin VG, Pellettiere EV, Gress D, Miller AW. Paget's disease in an adolescent arising in a supernumerary nipple. J Cutan Pathol 1994;21:283-6. (Pubitemid 24213246)
6. Ascensao AC, Marques MS, Capitao-Mor M. Paget's disease of the nipple. Clinical and pathological review of 109 female patients. Dermatologica 1985;170:170-9. (Pubitemid 15111943)
7. Rosen PP. Paget's disease of the nipple. Rosen's breast pathology. 2 nd ed. Philadelphia: Lippincott-Raven: 2001. p. 565-80.
8. Franceschini G, Masetti R, D'Ugo D, Palumbo F, D'Alba P, Mul A, et al. Synchronous bilateral Paget's disease of the nipple associated with bilateral breast carcinoma. Breast J 2005;11:355-6. (Pubitemid 41726041)
9. Kao GF, Graham JH, Helwig EB. Paget's disease of the ectopic breast with an underlying intraductal carcinoma: Report of a case. J Cutan Pathol 1986;13:59-66. (Pubitemid 16166494)
10. Suster S, Ronnen M, Huszar M, J Bubis JJ. Paget's disease of the breast with underlying carcinoma arising in systemic scleroderma. J Dermatol Surg Oncol 1988;14:648-50.
11. Kothari AS, Beechey-Newman N, Hamed H, Fentiman IS, D'Arrigo C, Hanby AM, et al. Paget disease of the nipple: A multifocal manifestation of higher-risk disease. Cancer 2002;95:1-7. (Pubitemid 34743474)
12. Kollmorgen DR, Varanasi JS, Edge SB, Carson WE 3rd. Paget's disease of the breast: a 33-year experience. J Am Coll Surg 1998;187:171-7. (Pubitemid 28392274)
13. Yim JH, Wick MR, Philpott GW, Norton JA, Doherty GM. Underlying pathology in mammary Paget's disease. Ann Surg Oncol 1997;4:287-92. (Pubitemid 127725230)
14. Chaudary MA, Millis RR, Lane EB, Miller NA. Paget's disease of the nipple: a 10-year review including clinical, pathological and immunohistochemical findings. Breast Cancer Res Treat 1986;8:139-46. (Pubitemid 17011492)
15. Lancer HA, Moschella SL. Paget's disease of the male breast. J Am Acad Dermatol 1982;7:393-6. (Pubitemid 12051524)
16. O'Sullivan ST, McGreal GT, Lyons A, Burke L, Geoghegan JG, Brady MP. Paget's disease of the breast in a man without underlying breast carcinoma. J Clin Pathol 1994;47:851-2.
17. Ho TC, Jacques M, Schopflocher P. Pigmented Paget's disease of the male breast. J Am Acad Dermatol 1990;23:338-41. (Pubitemid 20250674)
18. Deasai DC, Brennan EJ, Carp NZ. Paget's disease of the male breast. Am Surg 1996;62:1068-72. (Pubitemid 26394276)
19. Ikeda DM, Helvie MA, Frank TS, Chapel KL, Andersson IT. Paget disease of the nipple: radiologic-pathologic correlation. Radiology 1993;189:89-94. (Pubitemid 23292928)
20. Gunhan-Bilgen I, Oktay A. Paget's disease of the breast: clinical, mammographic, sonographic and pathologic findings in 52 cases. Eur J Radiol 2006;60:256-63. (Pubitemid 44635044)
21. Morrough M, Morris EA, Liberman L, Van Zee K, Cody HS 3rd, King TA. MRI indentifies otherwise occult disease in select patients with Paget disease of the nipple. J Am Coll Surg 2008;206:316-21.
22. Sawyer RH, Asbury DL. Mammographic appearances in Paget's disease of the breast. Clin Radiol 1994;49:185-8. (Pubitemid 24087091)
23. Burke ET, Brauning MP, McLelland R, Pisan ED, Cooper LL. Paget disease of the breast: a pictorial assay. Radiographics 1998;18:1459-64. (Pubitemid 128467070)
24. Yang WT, King W, Metreweli C. Clinically and mammographically occult invasive ductal carcinoma diagnosed by ultra-sound: the focally dilated duct. Australas Radiol 1997;41:73-5. (Pubitemid 27146336)
25. Morrogh M, Morris EA, Liberman L, Borgen PI, King TA. The predictive value of ductography and magnetic resonance imaging in the management of nipple discharge. Ann Surg Oncol 2007;14:3369-77. (Pubitemid 350160109)
26. Amano G, Yajima M, Moroboshi Y, Kuriya Y, Ohuchi N. MRI accurately depicts underlying DCIS in a patient with Paget's disease of the breast without palpable mass and mammography findings. Jpn J Clin Oncol 2005;35:149-53. (Pubitemid 40514544)
27. Frei KA, Bonel HM, Pelte MF, Hylton NM, Kinkel K. Paget disease of the breast: findings at magnetic resonance imaging and histopathologic correlation. Invest Radiol 2005;40:363-7. (Pubitemid 40734565)
28. Smith KJ, Tuur S, Corvette D, Lupton GP, Skelton HG. Cytokeratin 7 staining in mammary and extramammary Paget's disease. Mod Pathol 1997;11:1069-74. (Pubitemid 27521282)
29. Yao DX, Hoda SA, Chiu A, Ring L, Rosen PP. Intraepidermal cytokeratin 7 immunoreactive cells in the non-neoplastic nipple may represent interepithelial extension of lactiferous duct cells. Histopathology 2002;40:230-6. (Pubitemid 34227113)
30. Kanitakis J. Solid cutaneous tumours. In: Kanitakis J, Vassileva S, Woodley D, editors. Diagnostic Immunohistochemistry of the Skin. An Illustrated Text. London: Chapman and Hall Medical; 1998.p. 279-99.
31. Mori O, Hachisuka H, Nakano S, Sasai Y, Shiku H. Expression of ras p21 in mammary and extramammary Paget's disease. Arch Pathol Lab Med 1990;114:858-61. (Pubitemid 20233225)
32. Kanitakis J, Thivolet J, Claudy A. p53 protein expression in mammary and extramammary Paget's disease. Anticancer Res 1993;13:2429-33. (Pubitemid 24103287)
33. Ellis PE, Fong LF, Rolfe KJ, Crow JC, Reid WM, Davidson T, et al. The role of p53 and Ki67 in Paget's disease of the vulva and the breast. Gynecol Oncol 2002;86:150-6. (Pubitemid 34953497)
34. Fu W, Lobocki CA, Silberberg BK, Chelladurai M, Young SC. Molecular markers in Paget disease of the breast. J Surg Oncol 2001;77:171-8. (Pubitemid 32645771)
35. Ellis PE, MacLean AB, Crow JC, Wong Te Fong LF, Rolfe KJ, Perrett CW. Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 cases. Histopathology 2009;55:709-15.
36. Liegl B, Horn L, Moinfar F. Androgen receptors are frequently expressed in mammary and extramammary Paget's disease. Mod Pathol 2005;18:1283-8. (Pubitemid 41348646)
37. Sek P, Zawrocki A, Biernat W, Piekarski JH. HER2 molecular subtype is a dominant subtype of mammary Paget's cells. An immunohistochemical study. Histopathology 2010;57:564-71.
38. Wolber RA, Dupuis BA, Wick MR. Expression of C-erbB-2 oncoprotein in mammary and extramammary Paget's disease. Am J Clin Pathol 1991;96:243-7.
39. Giger O, Caduff R, O'Meara A, Diener PA, Knuth A, Jager D, et al. Frequent expression of the breast differentiation antigen NY-BR-1 in mammary and extramammary Paget's disease. Pathol Int 2010;60:726-34.
40. Muir R. The pathogenesis of Paget's disease of the nipple and associated lesions. Br J Surg 1935;22:728-37.
41. Muir R. Further observations on Paget's disease of the nipple and associated lesions. J Pathol 1939;49:299-312.
42. Ashikari R, Park K, Huvos AG, Urban JA. Paget's disease of the breast. Cancer 1970;26:680-85.
43. Cohen C, Guarner J, DeRose PB. Mammary Paget's disease and associated carcinoma. An immunohistochemical study. Arch Pathol Lab Med 1993;117:291-4. (Pubitemid 23077493)
44. Schelfhout VR, Coene ED, Delaey B, Thys S, Page DL, De Potter CR. Pathogenesis of Paget's disease: epidermal heregulin-alpha, motility factor, and the HER receptor family. J Natl Cancer Inst 2000;92:622-8. (Pubitemid 30321304)
45. Sagami S. Electron microscopic studies in Paget's disease. Med J Osaka Univ 1963;14:173-88.
46. Sagebiel RW. Ultrastructural observations on epidermal cells in Paget's disease of the breast. Am J Pathol 1969;57:49-64.
47. Lagios MD, Westdahl PR, Rose MR, Concannon S. Paget's disease of the nipple. Alternative management in cases without or with minimal extent of underlying breast carcinoma. Cancer 1984;54:545-51. (Pubitemid 14087886)
48. Jahn H, Osther PJ, Nielsen EH, Rasmussen G, Andersen J. An electron microscopic study of clinical Paget's disease of the nipple. APMIS 1995;103:628-34.
49. Lucarotti ME, Dumm JM, Webb AJ. Scrape cytology in the diagnosis of Paget's disease of the breast. Cytopathology 1994;5:301-5. (Pubitemid 24301548)
50. Samarasinghe D, Frost F, Sterrett G, Whitaker D, Ingram D, Shiner H. Cytological diagnosis of Paget's disease of the nipple by scrape smears: a report of five cases. Diagn Cytopathol 1993;9:291-5. (Pubitemid 23155810)
51. Hitchcock A, Topham S, Bell J, Gullick W, Elston CW, Ellis IO. Routine diagnosis of mammary Paget's disease. A modern approach. Am J Surg Pathol 1992;16:58-61.
52. van der Putte SC, Toonstra J, Hennipman A. Mammary Paget's disease confined to the areola and associated with multifocal Toker cell hyperplasia. Am J Dermatopathol 1995;17:487-93.
53. Miller L, Tyler W, Maroon M, Miller OF 3rd. Erosive adenomatosis of the nipple: a benign imitator of malignant breast disease. Cutis 1997;59:91-2. (Pubitemid 27082144)
54. Lundquist K, Kohler S, Rouse RV. Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Am J Surg Pathol 1999;23:212-9. (Pubitemid 29075163)
55. Mitchell S, Lachica R, Randall MB, Beech DJ. Paget's disease of the breast areola mimicking cutaneous melanoma. Breast J 2006;12:233-6.
56. Lloyd J, Flanagan AM. Mammary and extramammary Paget's disease. J Clin Pathol 2000;53:742-9.
57. Reed W, Oppedal BR, Eeg Larsen T. Immunohistology is valuable in distinguishing between Paget's disease, Bowen's disease and superficial spreading malignant melanoma. Histopathology 1990;16:583-8. (Pubitemid 20183007)
58. Toker C: Clear cells of nipple epidermis. Cancer 1970, 25:601-10.
59. Mai KT, Yazdi HM, Perkins DG. Mammary Paget's disease: evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of the lactiferous duct and a discontinuous pattern of tumor spread. Pathol Int 1999;49:956-61. (Pubitemid 30043134)
60. Zeng Z, Melamed J, Symmans PJ, Cangiarella JF, Shapiro RL, Peralta H, et al. Benign proliferative nipple duct lesions frequently contain CAM 5.2 and anti-cytokeratin 7 immunoreactive cells in the overlying epidermis. Am J Surg Pathol 1999;23:1349-55. (Pubitemid 29517328)
61. Park S, Suh YL. Useful immunohistochemical markers for distinguishing Paget cells from Toker cells. Pathology 2009;41:640-4.
62. Kohler S, Rouse RV, Smoller BR. The differential diagnosis of pagetoid cells in the epidermis. Mod Pathol 1998;11:79-92. (Pubitemid 28177368)
63. Willman JH, Golitz LE, Fitzpatrick JE. Clear cells of Toker in accessory nipples. J Cutan Pathol 2003;30:256-60. (Pubitemid 36555133)
64. Keatings L, Sinclair J, Wright C, Corbett IP, Watchorn C, Hennessy C, et al: C-erbB-2 oncoprotein expression in mammary and extramammary Paget's disease: an immunohistochemical study. Histopathology 1990;17:243-7. (Pubitemid 20275967)
65. Di Tommaso L, Franchi G, Destro A, Broglia F, Minuti F, Rahal D, et al. Toker cells of the breast. Morphological and immunohistochemical characterization of 40 cases. Hum Pathol 2008;39:1295-300.
66. Kawase K, Dimaio DJ, Tucker SL, Buchholz TA, Ross MI, Feig BW, et al. Paget's disease of the breast: there is a role for breast-conserving therapy. Ann Surg Oncol 2005;12:391-7.
67. Paone JF, Baker RR. Pathogenesis and treatment of Paget's disease of the breast. Cancer 1981;48:825-9. (Pubitemid 11075241)
68. Dixon AR, Galea MH, Ellis IO, Elston CW, Blamey RW. Paget's disease of the nipple. Br J Surg 1991;78:722-3.
69. Polgar C, Orosz Z, Kovacs T, Fodor J. Breast-conserving therapy for Paget disease of the nipple: a prospective European Organization for Research and Treatment of Cancer Study of 61 patients. Cancer 2002;94:1904-5. (Pubitemid 34241132)
70. Bijker N, Rutgers E, Duchateau L, Peterse JL, Julien JP, Cataliotti L. Breast-conserving therapy for Paget disease of the nipple: a prospective European organization for Research and Treatment of Cancer study of 61 patients. Cancer 2001;91:472-7. (Pubitemid 32105691)
71. Bulens P, Vanuytsel L, Rijnders A, van der chueren E. Breast conserving treatment of Paget's disease. Radiother Oncol 1990;17:305-9. (Pubitemid 20130039)
72. Stockdale AD, Brierley JD, White WF, Folkes A, Rostom AY. Radiotherapy for Paget's disease of the nipple: a conservative alternative. Lancet 1989;2:664-6. (Pubitemid 19220235)
73. van Dongen JA, Voogd AC, Fentiman IS, Legrand C, Sylvester RJ, Tong D, et al. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2000;92:1143-50.
74. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347:1227-32. (Pubitemid 35176241)
75. Fisher B, Anderson S, Bryant J, Margolese RG, Deutch M, Fisher ER, et al. Twenty-year follow up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347:1233-41. (Pubitemid 35176242)
76. El-Sharkawi A, Waters JS. The place for conservative treatment in the management of Paget's disease of the nipple. Eur J Surg Oncol 1992. 18. 301-3.
77. Fourquet A, Campana F, Vielh P, Schlinger P, Jullien D, Vilcoq JR. Paget's disease of the nipple without detectable breast tumor: conservative management with radiation therapy. Int J Radiat Oncol Biol Phys 1987;13:1463-5. (Pubitemid 17164166)
78. Stotter AT, McNeese M, Oswald MJ, Ames FC, Romsdahl MM. The role of limited surgery with irradiation in primary treatment of ductal in-situ breast cancer. Int J Radiat Oncol Biol Phys 1990;18:283-7. (Pubitemid 20097520)