Relationship of RhoA signaling activity with ezrin expression and its significance in the prognosis for breast cancer patients

Chinese Medical Journal

Volumn 126, Issue 2, 2013, Pages 242-247

  Ma, Li ^a   Liu, Yue Ping ^a   Zhang, Xiang Hong ^a   Geng, Cui Zhi ^a   Li, Zeng Huai ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Breast neoplasm; Ezrin; Prognosis; RhoA

Indexed keywords

EZRIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER INVASION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETROSPECTIVE STUDY; SIGNAL TRANSDUCTION; SURVIVAL RATE; UPREGULATION;

ADULT; AGED; BREAST NEOPLASMS; CYTOSKELETAL PROTEINS; FEMALE; HUMANS; MIDDLE AGED; PHOSPHORYLATION; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SURVIVAL RATE;

EID: 84872718739     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20110738     Document Type: Article

References (17)

1. Kamai T, Yamanishi T, Shirataki H, Takagi K, Asami H, Ito Y, et al. Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res 2004; 10: 4799-4805.
2. Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY, et al. Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Proc Natl Acad Sci USA 2005; 102: 15207-15212.
3. Sahai E, Marshall CJ. Rho-GTPases and cancer. Nat Rev Cancer 2002; 2: 133-42.
4. Ma L, Liu YP, Zhang XH, Xing LX, Wang JL, Geng CZ. Effect of RhoA signaling transduction on expression of ezrin in breast cancer cell lines. Chin J Canc (Chin) 2009; 28: 108-111.
5. Tavassoli FA, Devillee P. World Health Organization classification of tumours: pathology and genetics of tumours of the breast and female genital organs. Lyon: IARC press; 2003: 10.
6. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer: I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991; 19: 403-410.
7. Lloveras B, Edgerton S, Thor AD. Evaluation of in vitro bromodeoxyuridine labeling of breast carcinomas with the use of a commercial kit. Am J Clin Pathol 1991; 95: 41-47.
8. Koerner FC, Goldberg DE, Edgerton SM, Schwartz LH. pS2 protein and steroid hormone receptors in invasive breast carcinomas. Int J Cancer 1992; 52: 183-188.
9. Ma L, Zhang XH, Xing LX, Li YH, Wang XL, Wang YJ. Relationship of ezrin protein expression to the carcinogenesis and prognosis of infitrating breast ductal carcinoma. Chin J Oncol (Chin) 2008; 30: 279-283.
10. Kakinuma N, Roy BC, Zhu Y, Wang Y, Kiyama R. Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling. J Cell Biol 2008; 181: 537-549.
11. Matsui T, Yonemura S, Tsukita S, Tsukita S. Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases. Curr Biol 1999; 9: 1259-1262.
12. Lim S, Ryu J, Shin JA, Shin MJ, Ahn YK, Kim JJ, et al. Tumor necrosis factor-α potentiates RhoA-mediated monocyte transmigratory activity in vivo at a picomolar level. Arterioscler Thromb Vasc Biol 2009; 29: 2138-2145.
13. Granes F, Urena JM, Rocamora N, Vilaro S. Ezrin links syndecan-2 to the cytoskeleton. J Cell Sci 2000; 113: 1267-1276.
14. Schmieder S, Nagai M, Orlando RA, Takeda T, Farquhar MG. Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and ezrin in MDCK cells. J Am Soc Nephrol 2004; 15: 2289-2298.
15. Sawada N, Itoh H, Miyashita K, Tsujimoto H, Sone M, Yamahara K, et al. Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro-and antifibrotic signals in blood vessels. Mol Cell Biol 2009; 29: 6018-6032.
16. Knezevic N, Roy A, Timblin B, Konstantoulaki M, Sharma T, Malik AB, et al. GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability. Mol Cell Biol 2007; 27: 6323-6333.
17. Nagao T, Qin C, Grosheva I, Maxfield FR, Pierini LM. Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting RhoA regulation. Arterioscler Thromb Vasc Biol. 2007; 27: 1596-1602.