Quantification of intact carboplatin in human plasma ultrafitrates using hydrophilic interaction liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 917-918, Issue , 2013, Pages 18-23

  Ito, Hajime ^a   Yamaguchi, Hiroaki ^a   Fujikawa, Asuka ^a   Shiida, Narumi ^a   Tanaka, Nobuaki ^a   Ogura, Jiro ^a   Kobayashi, Masaki ^a   Yamada, Takehiro ^b   Mano, Nariyasu ^c   Iseki, Ken ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^c TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Carboplatin; Hydrophilic interaction liquid chromatography tandem mass spectrometry; Plasma ultrafiltrates

Indexed keywords

ANALYTICAL METHOD; CANCER PATIENTS; CARBOPLATIN; CHROMATOGRAPHIC SEPARATIONS; CLINICAL PHARMACOKINETICS; HUMAN PLASMAS; HYDROPHILIC INTERACTION; INTERNAL STANDARDS; LINEARITY RANGE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOW ENERGY COLLISIONS; LOWER LIMIT OF QUANTIFICATIONS; MOBILE PHASE; NON SMALL CELL LUNG CANCER; OVARIAN CANCERS; PHARMACOKINETIC STUDIES; SCAN MODE; SELECTED REACTION MONITORING; TRIPLE QUADRUPOLE;

ACETIC ACID; ACETONITRILE; DISEASES; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; PLASMA (HUMAN); PLATINUM;

MASS SPECTROMETRY;

CARBOPLATIN; OXALIPLATIN;

ARTICLE; BIOLOGICAL MONITORING; CANCER PATIENT; CHEMICAL INTERACTION; COLLISIONALLY ACTIVATED DISSOCIATION; DRUG BLOOD LEVEL; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; FREEZE THAWING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SELECTED REACTION MONITORING; SIGNAL NOISE RATIO; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION;

CARBOPLATIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION;

EID: 84872715733     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.11.024     Document Type: Article

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