The mechanisms of insulin secretion and calcium signaling in pancreatic β-cells exposed to fluoroquinolones

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 1, 2013, Pages 31-35

  Bito, Motoki ^a,c   Tomita, Takashi ^a,b   Komori, Mika ^a,d   Taogoshi, Takanori ^a,b   Kimura, Yasuhiro ^a,b   Kihira, Kenji ^a,b  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

^c Saiseikai Imabari Hospital   (Japan)

^d KURUME UNIVERSITY HOSPITAL   (Japan)

Author keywords

Calcium signaling; Fluoroquinolone; Hypoglycemia; Insulin; Pancreatic cell

Indexed keywords

CALCIUM ION; DANTROLENE; GATIFLOXACIN; GLYCYLPHENYLALANINE; GLYCYLPHENYLALANINE 2 NAPHTYLAMIDE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; LEVOFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RYANODINE RECEPTOR; THAPSIGARGIN; TOLBUTAMIDE; UNCLASSIFIED DRUG; XESTOSPONGIN C;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EXTRACELLULAR CALCIUM; INSULIN RELEASE; LYSOSOME; NONHUMAN; PANCREAS ISLET BETA CELL; RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; CALCIUM SIGNALING; CELL LINE; CRICETINAE; FLUOROQUINOLONES; INSULIN; INSULIN-SECRETING CELLS; OFLOXACIN; TOLBUTAMIDE;

EID: 84872707848     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00425     Document Type: Article

References (15)

1. Rouveix B. Antibiotic safety assessment. Int. J. Antimicrob. Agents, 21, 215-221 (2003).
2. Bolon MK. The newer fluoroquinolones. Infect. Dis. Clin. North Am., 23, 1027-1051 (2009).
3. Kendall C, Wooltorton E. People with diabetes should avoid antibiotic gatifloxacin. CMAJ, 174, 1089-1090 (2006).
4. Mehlhorn AJ, Brown DA. Safety concerns with fluoroquinolones. Ann. Pharmacother., 41, 1859-1866 (2007).
5. Maeda N, Tamagawa T, Niki I, Miura H, Ozawa K, Watanabe G, Nonogaki K, Uemura K, Iguchi A. Increase in insulin release from rat pancreatic islets by quinolone antibiotics. Br. J. Pharmacol., 117, 372-376 (1996).
6. + channels. Eur. J. Pharmacol., 497, 111-117 (2004).
7. Tomita T, Onishi M, Sato E, Kimura Y, Kihira K. Gatifloxacin induces augmented insulin release and intracellular insulin depletion of pancreatic islet cells. Biol. Pharm. Bull., 30, 644-647 (2007).
8. Ghaly H, Kriete C, Sahin S, Pflöger A, Holzgrabe U, Zünkler BJ, Rustenbeck I. The insulinotropic effect of fluoroquinolones. Biochem. Pharmacol., 77, 1040-1052 (2009).
9. + channels. Life Sci., 73, 429-435 (2003).
10. + channels. Toxicology, 228, 239-248 (2006).
11. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951).
12. Akita M, Ogawa Y, Yagi Y, Hiratsuka K, Kurosawa T, Suda T. Effects of fluoroquinolone antibiotics on the insulin release and the serum glucose concentration in rats. Pharmacol. Ther. Jpn., 35, 1061-1068 (2007).
13. Zhang CL, Katoh M, Shibasaki T, Minami K, Sunaga Y, Takahashi H, Yokoi N, Iwasaki M, Miki T, Seino S. The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science, 325, 607-610 (2009).
14. 2+ signal that is essential for insulin secretion in mouse pancreatic islets. Diabetes, 57, 868-878 (2008).
15. 2+ release from insulin-containing vesicles in living pancreatic β-cells (MIN6). J. Biol. Chem., 278, 11057-11064 (2003).