The influence of RAMP1 overexpression on CGRP-induced osteogenic differentiation in MG-63 cells in vitro: An experimental study

Journal of Cellular Biochemistry

Volumn 114, Issue 2, 2013, Pages 314-322

  Zhao, Zhiliang ^a   Fu, Xiaobing ^b   Zhang, Gang ^a   Li, Yan ^c   Wu, Meng ^b   Tan, Yinghui ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

CGRP; CRLR; MG 63 cells; Osteogenic differentiation; RAMP1

Indexed keywords

ALIZARIN RED S; ALKALINE PHOSPHATASE; CALCITONIN GENE RELATED PEPTIDE; CALCIUM; COLLAGEN TYPE 1; MESSENGER RNA; RECEPTOR ACTIVITY MODIFYING PROTEIN 1;

ARTICLE; BIOLOGICAL MONITORING; BONE DEVELOPMENT; BONE MATRIX; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL LINE; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

CALCITONIN GENE-RELATED PEPTIDE; CALCITONIN RECEPTOR-LIKE PROTEIN; CELL DIFFERENTIATION; CELL LINE; CELL MEMBRANE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; OSTEOGENESIS; RECEPTOR ACTIVITY-MODIFYING PROTEIN 1;

EUKARYOTA;

EID: 84872690794     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24375     Document Type: Article

References (21)

1. Costa-Rodrigues J, Fernandes A, Fernandes MH. 2011. Reciprocal osteoblastic and osteoclastic Modulation in co-cultured MG-63 osteosarcoma cells and human osteoclast precursors. J Cell Biochem 112(12):3704-3713.
2. Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM. 2005. Pharmacological discrimination of calcitonin receptor: Receptor activity-modifying protein complexes. Mol Pharmacol 67(5):1655-1665.
3. Hay DL, Poyner DR, Sexton PM. 2006. GPCR modulation by RAMPs. Pharmacol Ther 109(1-2):173-197.
4. Irie K, Hara-Irie F, Ozawa H, Yajima T. 2002. Calcitonin gene-related peptide (CGRP)-containing nerve fibers in bone tissue and their involvement in bone remodeling. Microsc Res Tech 58:85-90.
5. Kawase T, Okuda K, Burns DM. 2005. Immature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that respond differently to [Cys(Acm)2,7] calcitonin gene-related peptide and CGRP8-37. Am J Physiol Cell Physiol 289:C811-C818.
6. Kim JY, Choi JY, Jeong JH, Jang ES, Kim AS, Kim SG, Kweon HY, Jo YY, Yeo JH. 2010. Low molecular weight silk fibroin increases alkaline phosphatase and type I collagen expression in MG63 cells. BMB Rep 43:52-56.
7. Kristiansen KA, Edvinsson L. 2010. Expressional change in calcitonin gene-related peptide, receptor activity modifying protein 1 (RAMP1) and bradykinin 1 receptor after experimental inflammation in rat trigeminal ganglia. Curr Neurobiol 1:82-88.
8. Lagerström MC, Schiöth HB. 2008. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 7(4):339-357.
9. Lerner UH, Persson E. 2008. Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. J Musculoskelet Neuronal Interact 8(2):154-165.
10. Li Y, Tan YH, Zhang G, Yang B, Zhang J. 2009. Effects of calcitonin gene-related peptide on the expression and activity of nitric oxide synthase during mandibular bone healing in rabbits: An experimental study. J Oral Maxillofac Surg 67(2):273-279.
11. Li Y, Tan YH, Yang B, Zhang G, Xiao X, Lu Z. 2011. Effect of calcitonin gene-related peptide on nitric oxide production in osteoblasts: An experimental study. Cell Biol Int 35(8):757-765.
12. Lindemann RK, Newbold A, Whitecross KF, Cluse LA, Frew AJ, Ellis L, Williams S, Wiegmans AP, Dear AE, Scott CL. 2007. Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc Natl Acad Sci 104(19):8071.
13. Mao X, Peng H, Ling J, Friis T, Whittaker AK, Crawford R, Xiao Y. 2009. Enhanced human bone marrow stromal cell affinity for modified poly (L-lactide) surfaces by the upregulation of adhesion molecular genes. Biomaterials 30(36):6903-6911.
14. Matsuo K, Irie N. 2008. Osteoclast-osteoblast communication. Arch Biochem Biophys 473:201-209.
15. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. 1998. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393(6683):333-341.
16. Naot D, Cornish J. 2008. The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism. Bone 43(5):813-818.
17. Recober A, Goadsby PJ. 2010. Calcitonin gene-related peptide (CGRP): A molecular link between obesity and migraine? Drug News Perspect 23(2):112.
18. Saracino S, Mozzati M, Martinasso G, Pol R, Canuto RA, Muzio G. 2009. Superpulsed laser irradiation increases osteoblast activity via modulation of bone morphogenetic factors. Lasers Surg Med 41(4):298-304.
19. Wang L, Shi X, Zhao R, Halloran BP, Clark DJ, Jacobs CR, Kingery WS. 2010. Calcitonin-gene-related peptide stimulates stromal cell osteogenic differentiation and inhibits RANKL induced NF-κB activation, osteoclastogenesis and bone resorption. Bone 46(5):1369-1379.
20. Wu M, Li Y, Zhang JY, Sun S, Deng ZH, Tan YH. 2010. Differential protein expression of osteoblasts under the CGRP treatment. J Pract Stomatol 26(006):705-710.
21. Xu L, Tan YH, He HT. 2005. The influence of calcitonin gene related peptide on the expression of OPG/RANKL mRNA in rabbit osteoblasts. J Pract Stomatol 21(003):396-399.