Leucine accelerates blood ethanol oxidation by enhancing the activity of ethanol metabolic enzymes in the livers of SHRSP rats

Amino Acids

Volumn 43, Issue 6, 2012, Pages 2545-2551

  Murakami, Hitoshi ^a,b   Ito, Michiko ^a   Furukawa, Yuji ^a   Komai, Michio ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

Author keywords

Alcohol metabolic enzymes; Ethanol oxidation; Leucine

Indexed keywords

2 OXOISOCAPROIC ACID; ALANINE; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; BRANCHED CHAIN AMINO ACID; ETHANOL METABOLIC ENZYME; ISOLEUCINE; LEUCINE; LIVER ENZYME; UNCLASSIFIED DRUG; VALINE;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ALCOHOL OXIDATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; LIVER; LIVER CELL; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT;

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ANIMALS; ETHANOL; LEUCINE; LIVER; OXIDATION-REDUCTION; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; TIME FACTORS;

RATTUS;

EID: 84872685404     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1406-8     Document Type: Article

References (41)

1. Beauge F, Mangeney M, Nordmann J, Nordmann R (1980) Comparative study of the effect of amino acids on ethanol oxidation in isolated hepatocytes from starved and fed rats. Adv Exp Med Biol 132:393-402
2. Bernal CA, Vazquez JA, Adibi SA (1993) Leucine metabolism during chronic ethanol consumption. Metabolism 42(9):1084-1086 (Pubitemid 23292680)
3. Cronholm T (1993) Ethanol metabolism in isolated hepatocytes. Effects of methylene blue, cyanamide and penicillamine on the redox state of the bound coenzyme and on the substrate exchange at alcohol dehydrogenase. Biochem Pharmacol 45(3): 553-558 (Pubitemid 23064558)
4. Cunningham CC, Preedy VR, Paice AG, Hesketh JE, Peters TJ, Patel VB, Volpi E, Mawatari K, Masaki H, Mori M, Torii K (2001) Ethanol and protein metabolism. Alcohol Clin Exp Res 25(5)Suppl ISBRA):262S-268S
5. Deaciuc IV, D'Souza NB, Lang CH, Spitzer JJ (1992) Effects of acute alcohol intoxication on gluconeogenesis and its hormonal responsiveness in isolated, perfused rat liver. Biochem Pharmacol 44(8):1617-1624
6. Deitrich RA, Petersen D, Vasiliou V (2007) Removal of acetaldehyde from the body. Novartis Found Symp 285:23-40 discussion 40-51, 198-199
7. Ehrig T, Bosron WF, Li TK (1990) Alcohol and aldehyde dehydrogenase. Alcohol Alcohol 25(2-3):105-116
8. Holecek M, Tilser I, Skopec F, Sprongl L (1996) Leucine metabolism in rats with cirrhosis. J Hepatol 24(2):209-216 (Pubitemid 26057956)
9. Holt S (1981) Observations on the relation between alcohol absorption and the rate of gastric emptying. Can Med Assoc J 124(3):267-277, 297
10. Kajiwara K, Okuno M, Kobayashi T, Honma N, Maki T, Kato M, Ohnishi H, Muto Y, Moriwaki H (1998) Oral supplementation with branched-chain amino acids improves survival rate of rats with carbon tetrachloride-induced liver cirrhosis. Dig Dis Sci 43(7):1572-1579 (Pubitemid 28357280)
11. Kimura S, Kim CH, Ohtomo IM, Yokomukai Y, Komai M, Morimatsu F (1991) Nutritional studies of the roles of dietary protein levels and umami in the preference response to sodium chloride for experimental animals. Physiol Behav 49(5): 997-1002
12. Koch OR, Pani G, Borrello S, Colavitti R, Cravero A, Farre S, Galeotti T (2004) Oxidative stress and antioxidant defenses in ethanol-induced cell injury. Mol Aspects Med 25(1-2):191-198. doi:10.1016/j.mam.2004.02.019 (Pubitemid 38401941)
13. Koivisto T, Eriksson CJ (1994) Hepatic aldehyde and alcohol dehydrogenases in alcohol-preferring and alcohol-Avoiding rat lines. Biochem Pharmacol 48(8):1551-1558 (Pubitemid 24336780)
14. Lakshman MR, Chambers LL, Chirtel SJ, Ekarohita N (1988) Roles of hormonal and nutritional factors in the regulation of rat liver alcohol dehydrogenase activity and ethanol elimination rate in vivo. Alcohol Clin Exp Res 12(3):407-411
15. Lardeux BR, Mortimore GE (1987) Amino acid and hormonal control of macromolecular turnover in perfused rat liver. Evidence for selective autophagy. J Biol Chem 262(30):14514-14519
16. Leevy CM, Moroianu SA (2005) Nutritional aspects of alcoholic liver disease. Clin Liver Dis 9(1):67-81. doi:10.1016/j.cld.2004. 11.003 (Pubitemid 40341947)
17. Lieber CS, Gentry RT, Baraona E (1994) First pass metabolism of ethanol. Alcohol Alcohol Suppl 2:163-169
18. Liu WH, Liu TC, Yin MC (2008) Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury. Food Chem Toxicol 46(5):1503-1509. doi:10.1016/j.fct.2007.12.013
19. Matsumura T, Morinaga Y, Fujitani S, Takehana K, Nishitani S, Sonaka I (2005) Oral administration of branched-chain amino acids activates the mTOR signal in cirrhotic rat liver. Hepatol Res 33(1):27-32. doi:10.1016/j.hepres. 2005.07.001 (Pubitemid 41447880)
20. Matsuzaki S, Gordon E, Lieber CS (1981) Increased alcohol dehydrogenase independent ethanol oxidation at high ethanol concentrations in isolated rat hepatocytes: the effect of chronic ethanol feeding. J Pharmacol Exp Ther 217(1):133-137 (Pubitemid 11103834)
21. Mezey E, Potter JJ, Rhodes DL (1986) Effect of growth hormone on alcohol dehydrogenase activity in hepatocyte culture. Hepatology 6(6):1386-1390 (Pubitemid 17210572)
22. Mezey E, Potter JJ, Mishra L, Sharma S, Janicot M (1990) Effect of insulin-like growth factor I on rat alcohol dehydrogenase in primary hepatocyte culture. Arch Biochem Biophys 280(2):390-396 (Pubitemid 20221981)
23. Milner RD (1969) Stimulation of insulin secretion in vitro by essential aminoacids. Lancet 1(7605):1075-1076
24. Morgan MY, Marshall AW, Milsom JP, Sherlock S (1982) Plasma amino-Acid patterns in liver disease. Gut 23(5):362-370 (Pubitemid 12155272)
25. Oh SI, Lee MS, Kim CI, Song KY, Park SC (2002) Aspartate modulates the ethanol-induced oxidative stress and glutathione utilizing enzymes in rat testes. Exp Mol Med 34(1):47-52 (Pubitemid 34408205)
26. Oneta CM, Simanowski UA, Martinez M, Allali-Hassani A, Pares X, Homann N, Conradt C, Waldherr R, Fiehn W, Coutelle C, Seitz HK (1998) First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying. Gut 43(5):612-619 (Pubitemid 28520093)
27. Peng HC, Chen YL, Chen JR, Yang SS, Huang KH, Wu YC, Lin YH, Yang SC (2011) Effects of glutamine administration on inflammatory responses in chronic ethanol-fed rats. J Nutr Biochem 22(3):282-288. doi:10.1016/j.jnutbio.2010.02. 006
28. Siegel FL, Roach MK, Pomeroy LR (1964) Plasma amino acid patterns in alcoholism: the effects of ethanol loading. Proc Natl Acad Sci USA 51:605-611
29. Singh SP, Patel DG, Snyder AK (1980) Ethanol inhibition of insulin secretion by perfused rat islets. Acta Endocrinol 93(1):61-66 (Pubitemid 10217285)
30. Sugano T, Handler JA, Yoshihara H, Kizaki Z, Thurman RG (1990) Acute and chronic ethanol treatment in vivo increases malateaspartate shuttle capacity in perfused rat liver. J Biol Chem 265(35):21549-21553 (Pubitemid 120014195)
31. Tanaka T, Ando M, Yamashita T, Toda T, Monna T, Nishiguchi S, Matsui T, Kuroki T, Otani S, Maezono K et al (1993) Effects of alanine and glutamine administration on the inhibition of liver regeneration by acute ethanol treatment. Alcohol Alcohol Suppl 1B:41-45 (Pubitemid 24082964)
32. Tanaka T, Imano M, Yamashita T, Monna T, Nishiguchi S, Kuroki T, Otani S, Maezono K, Mawatari K (1994) Effect of combined alanine and glutamine administration on the inhibition of liver regeneration caused by long-term administration of alcohol. Alcohol Alcohol Suppl 29(1):125-132
33. Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M, Fujiwara K (2007) Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway. Biochem Biophys Res Commun 358(1): 176-180. doi:10.1016/j.bbrc.2007.04.093 (Pubitemid 46719099)
34. Torii K (1997) A new pharmacological and physiological aspects of L-Amino acids. Nihon Yakurigaku Zasshi 110(Suppl 1):28P-32P (Pubitemid 27490512)
35. Vary TC, Deiter G, Goodman SA (2005) Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling. Am J Phys Heart Circ Phys 288(1):H121-H128. doi:10.1152/ajpheart.00440.2004 (Pubitemid 40023838)
36. Venerando R, Miotto G, Kadowaki M, Siliprandi N, Mortimore GE (1994) Multiphasic control of proteolysis by leucine and alanine in the isolated rat hepatocyte. Am J Phys 266(2 Pt 1):C455-C461
37. Wands JR, Carter EA, Bucher NL, Isselbacher KJ (1979) Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication. Gastroenterology 77(3):528-531 (Pubitemid 9234351)
38. Xu X, Ingram RL, Sonntag WE (1995) Ethanol suppresses growth hormone-mediated cellular responses in liver slices. Alcohol Clin Exp Res 19(5):1246-1251
39. Yang SC, Ito M, Morimatsu F, Furukawa Y, Kimura S (1993) Effects of amino acids on alcohol intake in stroke-prone spontaneously hypertensive rats. J Nutr Sci Vitaminol 39(1):55-61
40. Yang SC, Ito M, Furukawa Y, Kimura S (1994) Comparative study of alcohol metabolism in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats fed normal or low levels of dietary protein. J Nutr Sci Vitaminol 40(6):547-555
41. Yin SJ (1994) Alcohol dehydrogenase: enzymology and metabolism. Alcohol Alcohol Suppl 2:113-119