Thyroid hormone abnormalities in hemodialyzed patients: Low triiodothyronine as well as high reverse triiodothyronine are associated with increased mortality

Physiological Research

Volumn 61, Issue 5, 2012, Pages 495-501

  Horacek J ^a   Dusilova Sulkova S ^a   Kubisova M ^a   Safranek R ^a   Malirova E ^a   Kalousova M ^b   Svilias, I ^a   Maly J ^a   Sobotka, L ^a   Zak P ^a  

^a UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Hemodialysis; Reverse triiodothyronine; Survival; Thyroid; Triiodothyronine

Indexed keywords

BIOLOGICAL MARKER; LIOTHYRONINE;

AGED; ARTICLE; BLOOD; CHRONIC KIDNEY FAILURE; CZECH REPUBLIC; FEMALE; HUMAN; MALE; MIDDLE AGED; MORTALITY; PREVALENCE; PROGNOSIS; RENAL REPLACEMENT THERAPY; REPRODUCIBILITY; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SURVIVAL; SURVIVAL RATE;

AGED; BIOLOGICAL MARKERS; CZECH REPUBLIC; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PREVALENCE; PROGNOSIS; RENAL DIALYSIS; REPRODUCIBILITY OF RESULTS; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; SURVIVAL RATE; TRIIODOTHYRONINE;

EID: 84872659178     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. ADLER SM, WARTOFSKY L: The nonthyroidal illness syndrome. Endocrinol Metab Clin North Am 36: 657-672, 2007.
2. CARRERO JJ, QURESHI AR, AXELSSON J, YILMAZ MI, REHNMARK S, WITT MR, BÁRÁNY P, HEIMBÜRGER O, SULIMAN ME, ALVESTRAND A, LINDHOLM B, STENVINKEL P: Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease. J Intern Med 262: 690-701, 2007.
3. CAVALLI A, DEL VECCHIO L, MANZONI C, LOCATELLI F: Hemodialysis: yesterday, today and tomorrow. Minerva Urol Nefrol 62: 1-11, 2010.
4. DOCTER R, KRENNING EP, DE JONG M, HENNEMANN G: The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism. Clin Endocrinol 39: 499-518, 1993.
5. ENIA G, PANUCCIO V, CUTRUPI S, PIZZINI P, TRIPEPI G, MALLAMACI F, ZOCCALI C: Subclinical hypothyroidism is linked to micro-inflammation and predicts death in continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant 22: 538-544, 2007.
6. FABER J, HEAF J, KIRKEGAARD C, LUMHOLTZ IB, SIERSBAEK-NIELSEN K, KØLENDORF K, FRIIS T: Simultaneous turnover studies of thyroxine, 3,5,3' and 3,3',5'-triiodothyronine, 3,5-, 3,3', and 3'5'-diiodothyronine, and 3'-monoiodothyronine in chronic renal failure. J Clin Endocrinol Metab 56: 211-217, 1983.
7. GO AS, CHERTOW GM, FAN D, MCCULLOCH CE, HSU CY: Chronic kidney disease and the risk of death, cardiovascular events and hospitalization. N Engl J Med 351: 1296-1305, 2004.
8. HOLLOWELL JG, STAEHLING NW, FLANDERS WD, HANNON WH, GUNTER EW, SPENCER CA, BRAVERMAN LE: Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87: 489-499, 2002.
9. HORACEK J, SPITALNIKOVA S, DLABALOVA B, MALIROVA E, VIZDA J, SVILIAS I, CEPKOVA J, MC GRATH C, MALY J: Universal screening detects two-times more thyroid disorders in early pregnancy than targeted high-risk case finding. Eur J Endocrinol 163: 645-650, 2010.
10. IGLESIAS P, DIEZ JJ: Thyroid dysfunction and kidney disease. Eur J Endocrinol 160: 503-515, 2009.
11. JAMESON JL, WEETMAN AP: Disorders of the thyroid gland. In: Harrison's Principles of Internal Medicine (17th ed.). AS FAUCI, E BRAUNWALD, DL KASPER, SL HAUSER, DL LONGO, JL JAMESON, J LOSCALZO (eds), McGraw-Hill Companies Inc, New York, 2008, pp 2224-2247.
12. KAPTEIN EM: Thyroid hormone metabolism and thyroid diseases in chronic renal failure. Endocrine Rev 17: 45-63, 1996.
13. KAPTEIN EM, FEINSTEIN EI, NICOLOFF JT, MASSRY GD: Serum reverse triiodothyronine and thyroxine kinetics in patients with chronic renal failure. J Clin Endocrinol Metab 57: 181-189, 1983a
14. KAPTEIN EM, FEINSTEIN EI, NICOLOFF JT, MASSRY GD: Alterations of serum reverse triiodothyronine and thyroxine kinetics in chronic renal failure: Role of nutritional status, chronic illness, uremia, and hemodialysis. Kidney Int 24 (Suppl 16): S180-S186, 1983b.
15. LAMEIRE N, VAN BIESEN W, VANHOLDER R: Did 20 years of technological innovations in hemodialysis contribute to better patient outcomes? Clin J Am Soc Nephrol 4 (Suppl 1): S30-S40, 2009
16. LIM VS: Thyroid function in patients with chronic renal failure. Am J Kidney Dis 38: S80-S84, 2001.
17. LIM VS, FANG VS, KATZ AI, REFETOFF S: Thyroid dysfunction in chronic renal failure. J Clin Invest 60: 522-534, 1977.
18. LO JC, CHERTOW GM, GO AS, HSU CY: Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease. Kidney Int 67: 1047-1052, 2005.
19. MAIA AL, GOEMANN IM, MEYER ELS, WAJNER SM: Type 1 iodothyronine deiodinase in human physiology and disease. J Endocrinol 209: 283-297, 2011.
20. NATIONAL KIDNEY FOUNDATION, HEMODIALYSIS ADEQUACY 2006 WORK GROUP: Clinical practice guidelines for hemodialysis adequacy, update 2006. Am J Kidney Dis 48 (Suppl 1): S2-S90, 2006.
21. PEETERS RP, WOUTERS PJ, VAN TOOR H, KAPTEIN E, VISSER TJ, VAN DEN BERGHE G: Serum 3,3',5'-triiodothyronine (rT3) and 3,5,3'-triiodothyronine/rT3 are prognostic markers in critically ill patients and are associated with postmortem tissue deiodinase activities. J Clin Endocrinol Metab 90: 4559-4565, 2005.
22. ROTONDI M, NETTI GS, ROSATI A, MAZZINGHI B, MAGRI F, RONCONI E, BECHERUCCI F, PRADELLA F, SALVADORI M, SERIO M, ROMAGNANI P, CHIOVATO L: Pretransplant serum FT3 levels in kidney graft recipients are useful for identifying patients with higher risk for graft failure. Clin Endocrinol 68: 220-225, 2008.
23. VAN DEN BELD AW, VISSER TJ, FEELDERS RA, GROBBEE DE, LAMBERTS SWJ: Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab 90: 6403-6409, 2005.
24. WILLIAMS GR, BASSETT JHD: Local control of thyroid hormone action: role of type 2 deiodinase. J Endocrinol 209: 261-272, 2011.
25. WITZKE O, WIEMANN J, PATSCHAN D, WU K, PHILIPP T, SALLER B, MANN K, REINHARDT W: Differential T4 degradation pathways in young patients with preterminal and terminal renal failure. Horm Metab Res 39: 355-358, 2007.
26. ZOCCALI C, MALLAMACI F, TRIPEPI G, CUTRUPI S, PIZZINI P: Low triiodothyronine and survival in end-stage renal disease. Kidney Int 70: 523-528, 2006.