Adipose stromal cell and sarpogrelate orchestrate the recovery of inflammation-induced angiogenesis in aged hindlimb ischemic mice

Aging Cell

Volumn 12, Issue 1, 2013, Pages 32-41

  Fan, Weiwei ^a,b   Li, Chengxiang ^a   Qin, Xing ^a   Wang, Shenxu ^a   Da, Hu ^a   Cheng, Kang ^a   Zhou, Ri ^a   Tong, Chao ^a   Li, Xiujuan ^a   Bu, Qingting ^a   Li, Congye ^a   Han, Yaling ^c   Ren, Jun ^a,d   Cao, Feng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Digestive Endoscopy Center of Nanjing Military Command   (China)

^c SHENYANG NORTHERN HOSPITAL   (China)

^d UNIVERSITY OF WYOMING   (United States)

Author keywords

Adipose derived stromal cell; Aging; Angiogenesis; Inflammation; Molecular imaging; Peripheral arterial disease; Sarpogrelate

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; SARPOGRELATE; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ADIPOSE TISSUE CELL; AGED; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMORAL ARTERY; HINDLIMB; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEG ISCHEMIA; MALE; MOLECULAR IMAGING; MOUSE; MULTIPOTENT ADIPOSE DERIVED STROMAL CELL; NONHUMAN; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REOXYGENATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ADIPOSE TISSUE; AGING; ANGIOGENESIS INDUCING AGENTS; ANIMALS; DISEASE MODELS, ANIMAL; HINDLIMB; INFLAMMATION; ISCHEMIA; MALE; MICE; MICE, TRANSGENIC; NEOVASCULARIZATION, PHYSIOLOGIC; PLATELET AGGREGATION INHIBITORS; SIGNAL TRANSDUCTION; STROMAL CELLS; SUCCINATES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

MAMMALIA; MUS;

EID: 84872620559     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12014     Document Type: Article

References (31)

1. Ahmed ST, Ivashkiv LB (2000) Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways. J. Immunol. 165, 5227-5237.
2. Bartlett DB, Firth CM, Phillips AC, Moss P, Baylis D, Syddall H, Sayer AA, Cooper C, Lord JM (2012) The age-related increase in low grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. Aging Cell 11, 912-915.
3. Cao F, Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir SS, Wu JC (2006) In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation 113, 1005-1014.
4. Cao F, Sun D, Li C, Narsinh K, Zhao L, Li X, Feng X, Zhang J, Duan Y, Wang J, Liu D, Wang H (2009) Long-term myocardial functional improvement after autologous bone marrow mononuclear cells transplantation in patients with ST-segment elevation myocardial infarction: 4years follow-up. Eur. Heart J. 30, 1986-1994.
5. Criqui MH, Denenberg JO, Langer RD, Fronek A (1997) The epidemiology of peripheral arterial disease: importance of identifying the population at risk. Vasc. Med. 2, 221-226.
6. Erren M, Reinecke H, Junker R, Fobker M, Schulte H, Schurek JO, Kropf J, Kerber S, Breithardt G, Assmann G, Cullen P (1999) Systemic inflammatory parameters in patients with atherosclerosis of the coronary and peripheral arteries. Arterioscler. Thromb. Vasc. Biol. 19, 2355-2363.
7. Fan W, Sun D, Liu J, Liang D, Wang Y, Narsinh K, Li Y, Qin X, Liang J, Tian J, Cao F (2012) Adipose stromal cells amplify angiogenic signaling via the VEGF/mTOR/Akt pathway in a murine hindlimb ischemia model: a 3D multimodality imaging study. PLoS ONE 7, e45621.
8. Ge W, Ren J (2012) mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. J. Cell Mol. Med. 16, 616-626.
9. Gimble JM, Bunnell BA, Guilak F (2012) Human adipose-derived cells: an update on the transition to clinical translation. Regen Med. 7, 225-235.
10. Holladay C, Power K, Sefton M, O'Brien T, Gallagher WM, Pandit A (2011) Functionalized scaffold-mediated interleukin 10 gene delivery significantly improves survival rates of stem cells in vivo. Mol. Ther. 19, 969-978.
11. Imhof BA, Aurrand-Lions M (2006) Angiogenesis and inflammation face off. Nat. Med. 12, 171-172.
12. Ishii D, Schenk AD, Baba S, Fairchild RL (2010) Role of TNFalpha in early chemokine production and leukocyte infiltration into heart allografts. Am. J. Transplant. 10, 59-68.
13. Kidoya H, Naito H, Takakura N (2010) Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia. Blood 115, 3166-3174.
14. Kinnaird T, Stabile E, Zbinden S, Burnett MS, Epstein SE (2008) Cardiovascular risk factors impair native collateral development and may impair efficacy of therapeutic interventions. Cardiovasc. Res. 78, 257-264.
15. Laflamme MA, Murry CE (2011) Heart regeneration. Nature 473, 326-335.
16. Lakshmikanthan S, Sobczak M, Chun C, Henschel A, Dargatz J, Ramchandran R, Chrzanowska-Wodnicka M (2011) Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin alphavbeta. Blood 118, 2015-2026.
17. Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149, 274-293.
18. Liu Y, Wang L, Kikuiri T, Akiyama K, Chen C, Xu X, Yang R, Chen W, Wang S, Shi S (2011) Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-gamma and TNF-alpha. Nat. Med. 17, 1594-1601.
19. Mizuno H, Tobita M, Uysal AC (2012) Concise review: adipose-derived stem cells as a novel tool for future regenerative medicine. Stem Cells 30, 804-810.
20. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L (2006) VEGF receptor signalling - in control of vascular function. Nat. Rev. Mol. Cell Biol. 7, 359-371.
21. Rajesh KG, Suzuki R, Maeda H, Murio Y, Sasaguri S (2006) 5-HT2 receptor blocker sarpogrelate prevents downregulation of antiapoptotic protein Bcl-2 and protects the heart against ischemia-reperfusion injury. Life Sci. 79, 1749-1755.
22. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, Pell CL, Johnstone BH, Considine RV, March KL (2004) Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 109, 1292-1298.
23. Sheikh AY, Lin SA, Cao F, Cao Y, van der Bogt KE, Chu P, Chang CP, Contag CH, Robbins RC, Wu JC (2007) Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium. Stem Cells 25, 2677-2684.
24. Sun D, Narsinh K, Wang H, Li C, Li W, Zhang Z, Li J, Cao F (2012) Effect of autologous bone marrow mononuclear cells transplantation in diabetic patients with ST-segment elevation myocardial infarction. Int. J. Cardiol. doi: 10.1016/j.ijcard.2012.01.068.
25. Suzuki K, Murtuza B, Beauchamp JR, Brand NJ, Barton PJ, Varela-Carver A, Fukushima S, Coppen SR, Partridge TA, Yacoub MH (2004) Role of interleukin-1beta in acute inflammation and graft death after cell transplantation to the heart. Circulation 110, II219-II224.
26. Tanaka T, Fujita M, Nakae I, Tamaki S, Hasegawa K, Kihara Y, Nohara R, Sasayama S (1998) Improvement of exercise capacity by sarpogrelate as a result of augmented collateral circulation in patients with effort angina. J. Am. Coll. Cardiol. 32, 1982-1986.
27. Tendera M, Aboyans V, Bartelink ML, Baumgartner I, Clement D, Collet JP, Cremonesi A, De Carlo M, Erbel R, Fowkes FG, Heras M, Kownator S, Minar E, Ostergren J, Poldermans D, Riambau V, Roffi M, Rother J, Sievert H, van Sambeek M, Zeller T, Bax J, Auricchio A, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu B, Reiner Z, Sechtem U, Sirnes PA, Torbicki A, Vahanian A, Windecker S, Agewall S, Blinc A, Bulvas M, Cosentino F, De Backer T, Gottsater A, Gulba D, Guzik TJ, Jonsson B, Kesmarky G, Kitsiou A, Kuczmik W, Larsen ML, Madaric J, Mas JL, McMurray JJ, Micari A, Mosseri M, Muller C, Naylor R, Norrving B, Oto O, Pasierski T, Plouin PF, Ribichini F, Ricco JB, Ruilope L, Schmid JP, Schwehr U, Sol BG, Sprynger M, Tiefenbacher C, Tsioufis C, Van Damme H (2011) ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European Society of Cardiology (ESC). Eur. Heart J. 32, 2851-2906.
28. Wang JS, Liu X, Xue ZY, Alderman L, Tilan JU, Adenika R, Epstein SE, Burnett MS (2011) Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice. Chin. Med. J. (Engl). 124, 1075-1081.
29. West XZ, Malinin NL, Merkulova AA, Tischenko M, Kerr BA, Borden EC, Podrez EA, Salomon RG, Byzova TV (2010) Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature 467, 972-976.
30. Xie X, Cao F, Sheikh AY, Li Z, Connolly AJ, Pei X, Li RK, Robbins RC, Wu JC (2007) Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function. Cloning Stem Cells 9, 549-563.
31. Yao JS, Zhai W, Young WL, Yang GY (2006) Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9. Biochem. Biophys. Res. Commun. 342, 1396-1404.