Effect of synbiotic in constipated adult women - A randomized, double-blind, placebo-controlled study of clinical response

Clinical Nutrition

Volumn 32, Issue 1, 2013, Pages 27-33

  Waitzberg, Dan L ^a,b   Logullo, Luciana C ^b   Bittencourt, Amanda F ^b   Torrinhas, Raquel S ^a   Shiroma, Glaucia M ^b   Paulino, Natalia P ^b   Teixeira da Silva, Maria L ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b GANEP Nutrição Humana   (Brazil)

Author keywords

Bifidobacteria; Constipation; Fructooligosaccharides; Lactobacillus; Probiotic; Synbiotic

Indexed keywords

LACTOFOS; MALTODEXTRIN; PLACEBO; SYNBIOTIC AGENT; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BLOATING; CONSTIPATION; CONTROLLED STUDY; DEFECATION; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG RESPONSE; FEMALE; FLATULENCE; HUMAN; MAJOR CLINICAL STUDY; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; AGED; BIFIDOBACTERIUM; BRAZIL; CHRONIC DISEASE; CONSTIPATION; DEFECATION; DOUBLE-BLIND METHOD; FECES; FEMALE; GASTROINTESTINAL TRACT; HUMANS; LACTOBACILLUS; MIDDLE AGED; OLIGOSACCHARIDES; SEVERITY OF ILLNESS INDEX; SYNBIOTICS; TIME FACTORS; YOUNG ADULT;

EID: 84872614766     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2012.08.010     Document Type: Article

References (32)

1. Mugie S.M., Benninga M.A., Di Lorenzo C. Epidemiology of constipation in children and adults: a systematic review. Best Pract Res Clin Gastroenterol 2011, 25:3-18.
2. Rantis P.C., Vernava A.M., Daniel G.L., Longo W.E. Chronic constipation-is the work-up worth the cost?. Dis Colon Rectum 1997, 40:280-286.
3. Drossman D.A. Rome III: the new criteria. Chin J Dig Dis 2006, 7:181-185.
4. Gerritsen J., Smidt H., Rijkers G.T., de Vos W.M. Intestinal microbiota in human health and disease: the impact of probiotics. Genes Nutr 2011, 6:209-240.
5. Macfarlane S., Macfarlane G.T., Cummings J.H. Review article: prebiotics in the gastrointestinal tract. Aliment Pharmacol Ther 2006, 24:701-714.
6. Sanders M.E. Probiotics: considerations for human health. Nutr Rev. 2003, 61:91-99.
7. MacFarlane G.T., Cummings J.H. Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health?. Br Med J 1999, 318:999-1003.
8. Morelli L., Zonenschain D., Callegari M.L., Grossi E., Maisano F., Fusillo M. Assessment of a new synbiotic preparation in healthy volunteers: survival, persistence of probiotic strains and its effect on the indigenous flora. Nutr J 2003, 2:11.
9. Lewis S.J., Heaton K.W. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997, 32:920-924.
10. Agachan F., Chen T., Pfeifer J., Reissman P., Wexner S.D. A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum 1996, 39:681-685.
11. Brunner E., Langer F. Nonparametric analysis of ordered categorical data in designs with longitudinal observations and small sample sizes. Biometr J 2000, 42:663-675.
12. Lahtinen S.J., Forssten S., Aakko J., Granlund L., Rautonen N., Salminen S., et al. Probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM(®) modifies subpopulations of fecal lactobacilli and Clostridium difficile in the elderly. Age (Dordr) 2012, 34:133-143.
13. Roessler A., Forssten S.D., Glei M., Ouwehand A.C., Jahreis G. The effect of probiotics on faecal microbiota and genotoxic activity of faecal water in patients with atopic dermatitis: a randomized, placebo-controlled study. Clin Nutr 2012, 31:22-29.
14. Ringel-Kulka T., Palsson O.S., Maier D., Carroll I., Galanko J.A., Leyer G., et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol 2011, 45:518-525.
15. Waller P.A., Gopal P.K., Leyer G.J., Ouwehand A.C., Reifer C., Stewart M.E., et al. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functionalgastrointestinal symptoms in adults. Scand J Gastroenterol 2011, 46:1057-1064.
16. Tokunaga T. Novel physiological function of fructooligosaccharides. Biofactors 2004, 21:89-94.
17. Shah N.P. Probiotic bacteria: selective enumeration and survival in dairy foods. J Dairy Sci. 2000, 83:894-907.
18. Kailasapathy K., Chin J. Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp. Immunol Cell Biol. 2000, 78:80-88.
19. Khodadad A., Sabbaghian M. Role of synbiotics in the treatment of childhood constipation: a double-blind randomized placebo controlled trial. Iran J Pediatr 2010, 20:387-392.
20. Fateh R., Iravani S., Frootan M., Rasouli M.R., Saadat S. Synbiotic preparation in men suffering from functional constipation: a randomised controlled trial. Swiss Med Wkly 2011, 141:w13239.
21. Koebnick C., Wagner I., Leitzmann P., Stern U., Zunft H.J. Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Can J Gastroenterol. 2003, 17:655-659.
22. Möllenbrink M., Bruckschen E. Treatment of chronic constipation with physiologic Escherichia coli bacteria. Results of a clinical study of the effectiveness and tolerance of microbiological therapy with the E. coli Nissle 1917 strain (Mutaflor). Med Klin (Munich) 1994, 89:587-593.
23. Yang Y.X., He M., Hu G., Wei J., Pages P., Yang X.H., et al. Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women. World J Gastroenterol 2008, 14:6237-6243.
24. Yen C.H., Kuo Y.W., Tseng Y.H., Lee M.C., Chen H.L. Beneficial effects of fructo-oligosaccharides supplementation on fecal bifidobacteria and index of peroxidation status in constipated nursing-home residents-a placebo-controlled, diet-controlled trial. Nutrition 2011, 27:323-328.
25. Hughes C., Davoodi-Semiromi Y., Colee J.C., Culpepper T., Dahl W.J., Mai V., et al. Galactooligosaccharide supplementation reduces stress-induced gastrointestinal dysfunction and days of cold or flu: a randomized, double-blind, controlled trial in healthy university students. Am J Clin Nutr 2011, 93:1305-1311.
26. Waitzberg D.L., Pereira C.C.A., Logullo L., Jacintho T.M., Almeida D., Teixeira Da Silva M.L., et al. Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women. Nutr Hop 2012, 27:123-129.
27. Saulnier D.M., Gibson G.R., Kolida S. In vitro effects of selected synbiotics on the human faecal microbiota composition. FEMS Microbiol Ecol 2008, 66:516-527.
28. Fujimori S., Gudis K., Mitsui K., Seo T., Yonezawa M., Tanaka S., et al. A randomized controlled trial on the efficacy of synbiotic versus probiotic or prebiotic treatment to improve the quality of life in patients with ulcerative colitis. Nutrition 2009, 25:520-525.
29. Colecchia A., Vestito A., La Rocca A., Pasqui F., Nikiforaki A., Festi D. Effect of a symbiotic preparation on the clinical manifestations of irritable bowel syndrome, constipation-variant. Results of an open, uncontrolled multicenter study. Minerva Gastroenterol Dietol 2006, 52:349-358. Symbiotic Study Group.
30. Dughera L., Elia C., Navino M., Cisarò F. Effects of symbiotic preparations on constipated irritable bowel syndrome symptoms. Acta Biomed 2007, 78:111-116. ARMONIA Study Group.
31. Sousa F.F., Silva J.A. A métrica da dor (dormetria): problemas teóricos e metodológicos. Revista DOR 2005, 6:469-513.
32. Miwa H. Placebo effect in Parkinson's disease. Brain Nerve 2007, 59:139-146.