Sexual quality of life in Hodgkin Lymphoma: A longitudinal analysis by the German Hodgkin Study Group

British Journal of Cancer

Volumn 108, Issue 1, 2013, Pages 49-57

  Behringer, K ^a   Muller H ^a   Gorgen H ^a   Flechtner, H H ^b   Brillant, C ^a   Halbsguth, T V ^a   Thielen, I ^a   Eichenauer, D A ^a   Schober, T ^a   Nisters Backes, H ^a   Fuchs, M ^a   Engert, A ^a   Borchmann, P ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

ABVD; BEACOPP; fatigue; Health related quality of life (HRQoL); Hodgkin Lymphoma; sexual function

Indexed keywords

BLEOMYCIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; ETOPOSIDE; PREDNISONE; PROCARBAZINE; VINBLASTINE; VINCRISTINE;

ADULT; ADVANCED CANCER; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVOR; CONTROLLED STUDY; DISEASE SEVERITY; FATIGUE; FEMALE; FOLLOW UP; HODGKIN DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDIMENSIONAL FATIGUE INVENTORY; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; QUALITY OF LIFE; QUALITY OF LIFE QUESTIONNAIRE; QUESTIONNAIRE; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SEXUAL FUNCTION; SOCIAL STATUS;

ADULT; FATIGUE; FEMALE; HODGKIN DISEASE; HUMANS; MALE; MIDDLE AGED; QUALITY OF LIFE; SEX FACTORS; SEXUAL BEHAVIOR;

EID: 84872585004     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2012.550     Document Type: Article

References (41)

1. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5): 365-376.
2. Abrahamsen A, Loge J, Hannisdal E, Holte H, Kvaloy S (1998) Socio-medical situation for long-term survivors of Hodgkin's disease: a survey of 459 patients treated at one institution. Eur J Cancer 34(12): p1865-p1870.
3. Arden-Close E, Eiser C, Pacey A (2011) Sexual Functioning in male survivors of lymphoma: a systematic review. J Sex Med 8(7): 1833-1840.
4. Behringer K, Breuer K, Reineke T, May M, Nogova L, Klimm B, Schmitz T, Wildt L, Diehl V, Engert A (2005) Secondary amenorrhea after Hodgkin's lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: a report from the German Hodgkin's Lymphoma Study Group. J Clin Oncol 23(30): 7555-7564.
5. Bober SL, Recklitis CJ, Campbell EG, Park ER, Kutner JS, Najita JS, Diller L (2009) Caring for cancer survivors: a survey of primary care physicians. Cancer 115(18 Suppl): 4409-4418.
6. Borchmann P, Haverkamp H, Diehl V, Cerny T, Markova J, Ho AD, Eich HT, Mueller-Hermelink HK, Kanz L, Greil R, Rank A, Paulus U, Smardova L, Huber C, Dorken B, Nerl C, Krause SW, Mueller RP, Fuchs M, Engert A. Eight cycles of escalated-dose BEACOPP Compared with four cycles of escalated-dose BEACOPP followed by four cycles of baseline-dose BEACOPP with or without radiotherapy in patients with advanced-stage Hodgkin's Lymphoma: final analysis of the hd12 trial of the German Hodgkin Study Group. J Clin Oncol 29(32): 4234-4242.
7. Cocks K, King MT, Velikova G, Fayers PM, Brown JM (2008) Quality, interpretation and presentation of European Organisation for Research and Treatment of Cancer quality of life questionnaire core 30 data in randomised controlled trials. Eur J Cancer 44(13): 1793-1798.
8. De Bruin ML, Huisbrink J, Hauptmann M, Kuenen MA, Ouwens GM, van't Veer MB, Aleman BM, van Leeuwen FE (2008) Treatment-related risk factors for premature menopause following Hodgkin lymphoma. Blood 111(1): 101-108.
9. Eich HT, Diehl V, Gorgen H, Pabst T, Markova J, Debus J, Ho A, Dorken B, Rank A, Grosu AL, Wiegel T, Karstens JH, Greil R, Willich N, Schmidberger H, Dohner H, Borchmann P, Muller-Hermelink HK, Muller RP, Engert A (2010) Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial. J Clin Oncol 28(27): 4199-4206.
10. Engert A, Diehl V, Franklin J, Lohri A, Dorken B, Ludwig WD, Koch P, Hanel M, Pfreundschuh M, Wilhelm M, Trumper L, Aulitzky WE, Bentz M, Rummel M, Sezer O, Muller-Hermelink HK, Hasenclever D, Loffler M (2009) Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study. J Clin Oncol 27(27): 4548-4554.
11. Engert A, Plutschow A, Eich HT, Lohri A, Dorken B, Borchmann P, Berger B, Greil R, Willborn KC, Wilhelm M, Debus J, Eble MJ, Sokler M, Ho A, Rank A, Ganser A, Trumper L, Bokemeyer C, Kirchner H, Schubert J, Kral Z, Fuchs M, Muller-Hermelink HK, Mulle RP, Diehl V (2010) Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma. N Engl J Med 363(7): 640-652.
12. Fegg MJ, Gerl A, Vollmer TC, Gruber U, Jost C, Meiler S, Hiddemann W (2003) Subjective quality of life and sexual functioning after germ-cell tumour therapy. Br J Cancer 89(12): 2202-2206.
13. Flechtner H, Ruffer J, Henry-Amar M, Mellink W, Sieber M, Ferme C, Eghbali H, Josting A, Diehl V (1998) Quality of life assessment in Hodgkin's disease: a new comprehensive approach. First experiences from the EORTC/GELA and GHSG trials. EORTC Lymphoma Cooperative Group. Groupe D'Etude des Lymphomes de L'Adulte and German Hodgkin Study Group. Ann Oncol 9(Suppl 5): S147-S154.
14. Franchi-Rezgui P, Rousselot P, Espie M, Briere J, Pierre Marolleau J, Gisselbrecht C, Brice P (2003) Fertility in young women after chemotherapy with alkylating agents for Hodgkin and non-Hodgkin lymphomas. Hematol J 4(2): 116-120.
15. Greenfield DM, Walters SJ, Coleman RE, Hancock BW, Snowden JA, Shalet SM, DeRogatis LR, Ross RJ (2010) Quality of life, self-esteem, fatigue, and sexual function in young men after cancer: a controlled cross-sectional study. Cancer 116(6): 1592-1601.
16. Heutte N, Flechtner HH, Mounier N, Mellink WA, Meerwaldt JH, Eghbali H, van't Veer MB, Noordijk EM, Kluin-Nelemans JC, Lampka E, Thomas J, Lugtenburg PJ, Viterbo L, Carde P, Hagenbeek A, van der Maazen RW, Smit WG, Brice P, van Marwijk Kooy M, Baars JW, Poortmans P, Tirelli U, Leeksma OC, Tomsic R, Feugier P, Salles G, Gabarre J, Kersten MJ, Van Den Neste E, Creemers GJ, Gaillard I, Meijnders P, Tertian G, Reman O, Muller HP, Troncy J, Blanc M, Schroyens W, Voogt PJ, Wijermans P, Rieux C, Ferme C, Henry-Amar M (2009) Quality of life after successful treatment of early-stage Hodgkin's lymphoma: 10-year follow-up of the EORTC-GELA H8 randomised controlled trial. Lancet Oncol 10(12): 1160-1170.
17. Hordern AJ, Street AF (2007) Communicating about patient sexuality and intimacy after cancer: mismatched expectations and unmet needs. Med J Aust 186(5): 224-227.
18. Howell SJ, Radford JA, Adams JE, Smets EM, Warburton R, Shalet SM (2001) Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy. Clin Endocrinol (Oxf) 55(3): 315-324.
19. Howell SJ, Radford JA, Smets EM, Shalet SM (2000) Fatigue, sexual function and mood following treatment for haematological malignancy: the impact of mild Leydig cell dysfunction. Br J Cancer 82(4): 789-793.
20. Huyghe E, Sui D, Odensky E, Schover LR (2009) Needs assessment survey to justify establishing a reproductive health clinic at a comprehensive cancer center. J Sex Med 6(1): 149-163.
21. Kiserud CE, Fossa A, Bjoro T, Holte H, Cvancarova M, Fossa SD (2009) Gonadal function in male patients after treatment for malignant lymphomas, with emphasis on chemotherapy. Br J Cancer 100(3): 455-463.
22. Kiserud CE, Schover LR, Dahl AA, Fossa A, Bjoro T, Loge JH, Holte H, Yuan Y, Fossa SD (2009) Do male lymphoma survivors have impaired sexual function? J Clin Oncol 27(35): 6019-6026.
23. Klinkhammer-Schalke M, Koller M, Ehret C, Steinger B, Ernst B, Wyatt JC, Hofstadter F, Lorenz W (2008) Implementing a system of quality-of-life diagnosis and therapy for breast cancer patients: results of an exploratory trial as a prerequisite for a subsequent RCT. Br J Cancer 99(3): 415-422.
24. Kornblith A, Anderson J, Cella D, Tross S, Zuckerman E, Cherin E, Henderson E, Canellos G, Kosty M, Cooper M (1992a) Comparison of psychosocial adaptation and sexual function of survivors of advanced Hodgkin disease treated by MOPP, ABVD, or MOPP alternating with ABVD. Cancer 70(10): p2508-p2516.
25. Kornblith A, Anderson J, Cella D, Tross S, Zuckerman E, Cherin E, Henderson E, Weiss R, Cooper M, Silver R (1992b) Hodgkin disease survivors at increased risk for problems in psychosocial adaptation. The Cancer and Leukemia Group B. Cancer 70(8): p2214-p2224.
26. Mercadante S, Vitrano V, Catania V (2010) Sexual issues in early and late stage cancer: a review. Support Care Cancer 18(6): 659-665.
27. Muthén LK, Muthén BO (1998-2007) Mplus User's Guide. Fifth Edn. Muthén & Muthén: Los Angeles, CA.
28. Osoba D, Bezjak A, Brundage M, Zee B, Tu D, Pater J (2005) Analysis and interpretation of health-related quality-of-life data from clinical trials: basic approach of The National Cancer Institute of Canada Clinical Trials Group. Eur J Cancer 41(2): 280-287.
29. Osoba D, Rodrigues G, Myles J, Zee B, Pater J (1998) Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol 16(1): 139-144.
30. Park ER, Bober SL, Campbell EG, Recklitis CJ, Kutner JS, Diller L (2009) General internist communication about sexual function with cancer survivors. J Gen Intern Med 24(Suppl 2): S407-S411.
31. Quinn GP, Vadaparampil ST, Gwede CK, Miree C, King LM, Clayton HB, Wilson C, Munster P (2007) Discussion of fertility preservation with newly diagnosed patients: oncologists' views. J Cancer Surviv 1(2): 146-155.
32. Recklitis CJ, Sanchez Varela V, Ng A, Mauch P, Bober S (2010) Sexual functioning in long-term survivors of Hodgkin's lymphoma. Psychooncology 19(11): 1229-1233.
33. Ruffer JU, Flechtner H, Tralls P, Josting A, Sieber M, Lathan B, Diehl V (2003) Fatigue in long-term survivors of Hodgkin's lymphoma; a report from the German Hodgkin Lymphoma Study Group (GHSG). Eur J Cancer 39(15): 2179-2186.
34. Sadovsky R, Basson R, Krychman M, Morales AM, Schover L, Wang R, Incrocci L (2010) Cancer and sexual problems. J Sex Med 7(1 Pt 2): 349-373.
35. Schover LR (2005) Sexuality and fertility after cancer. Hematology Am Soc Hematol Educ Program 2005: 523-527.
36. Sieniawski M, Reineke T, Josting A, Nogova L, Behringer K, Halbsguth T, Fuchs M, Diehl V, Engert A (2008) Assessment of male fertility in patients with Hodgkin's lymphoma treated in the German Hodgkin Study Group (GHSG) clinical trials. Ann Oncol 19(10): 1795-1801.
37. van der Kaaij MA, Heutte N, Le Stang N, Raemaekers JM, Simons AH, Carde P, Noordijk EM, Ferme C, Thomas J, Eghbali H, Kluin-Nelemans HC, Henry-Amar M (2007) Gonadal function in males after chemotherapy for early-stage Hodgkin's lymphoma treated in four subsequent trials by the European Organisation for Research and Treatment of Cancer: EORTC Lymphoma Group and the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 25(19): 2825-2832.
38. van Tulder MW, Aaronson NK, Bruning PF (1994) The quality of life of long-term survivors of Hodgkin's disease. Ann Oncol 5(2): 153-158.
39. Webber K, Mok K, Bennett B, Lloyd AR, Friedlander M, Juraskova I, Goldstein D (2011) Ifiamin the mood, i enjoy it: an exploration of cancer-related fatigue and sexual functioning in women with breast cancer. Oncologist 16(9): 1333-1344.
40. Weissbach L, Bussar-Maatz R, Flechtner H, Pichlmeier U, Hartmann M, Keller L (2000) RPLND or primary chemotherapy in clinical stage IIA/B nonseminomatous germ cell tumors? Results of a prospective multicenter trial including quality of life assessment. Eur Urol 37(5): 582-594.
41. Zebrack BJ, Mills J, Weitzman TS (2007) Health and supportive care needs of young adult cancer patients and survivors. J Cancer Surviv 1(2): 137-145.