Angioimmunoblastic T-cell lymphoma partially obscured by an epstein-barr virus-negative clonal plasma cell proliferation

Journal of Clinical Oncology

Volumn 31, Issue 2, 2013, Pages

  Huppmann, Alison R ^a   Roullet, Michele R ^b   Raffeld, Mark ^a   Jaffe, Elaine S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; PREDNISONE; VINCRISTINE;

ADULT; ANGIOIMMUNOBLASTIC T CELL LYMPHOMA; ARTICLE; BONE MARROW BIOPSY; BREAST TUMOR; CASE REPORT; CELL PROLIFERATION; COMPUTER ASSISTED TOMOGRAPHY; COOMBS POSITIVE HEMOLYTIC ANEMIA; DRUG TOLERABILITY; EPSTEIN BARR VIRUS; FEMALE; HUMAN; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPH NODE BIOPSY; LYMPHADENOPATHY; MULTIPLE CYCLE TREATMENT; PLASMA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; THROMBOCYTOPENIA;

CELL PROLIFERATION; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOBLASTIC LYMPHADENOPATHY; LYMPHOMA, T-CELL; MIDDLE AGED; PLASMA CELLS;

EID: 84872583501     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2012.43.3797     Document Type: Article

References (16)

1. Abruzzo LV, Rosales CM, Medeiros LJ, et al: Epstein-Barr virus-positive B-cell lymphoproliferative disorders arising in immunodeficient patients previously treated with fludarabine for low-grade B-cell neoplasms. Am J Surg Pathol 26: 630-636, 2002
2. Attygalle AD, Kyriakou C, Dupuis J, et al: Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: Clinical correlation and insights into natural history and disease progression. Am J Surg Pathol 31:1077- 1088, 2007
3. Zettl A, Lee SS, Rudiger T, et al: Epstein-Barr virus-associated B-cell lymphoproliferative disorders in angloimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified. Am J Clin Pathol 117: 368-379, 2002
4. Willenbrock K, Brauninger A, Hansmann ML: Frequent occurrence of B-cell lymphomas in angioimmunoblastic T-cell lymphoma and proliferation of Epstein- Barr virus-infected cells in early cases. Br J Haematol 138: 733-739, 2007
5. Smith JL, Hodges E, Quin CT, et al: Frequent T and B cell oligoclones in histologically and immunophenotypically characterized angioimmunoblastic lymphadenopathy. Am J Pathol 156: 661-669, 2000
6. Tan BT, Warnke RA, Arber DA: The frequency of B- and T-cell gene rearrangements and Epstein-Barr virus in T-cell lymphomas: A comparison between angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified with and without associated B-cell proliferations. J Mol Diagn 8: 466-475; quiz 527, 2006
7. Zaki MA, Wada N, Kohara M, et al: Presence of B-cell clones in T-cell lymphoma. Eur J Haematol 86: 412-419, 2011
8. de Leval L, Rickman DS, Thielen C, et al: The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood 109: 4952-4963, 2007
9. Grogg KL, Attygalle AD, Macon WR, et al: Angioimmunoblastic T-cell lymphoma: A neoplasm of germinal-center T-helper cells? Blood 106: 1501-1502, 2005
10. Balague O, Martinez A, Colomo L, et al: Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: A phenomenon with distinctive clinicopathologic features Am J Surg Pathol 31: 1310-1322, 2007
11. Brauninger A, Spieker T, Willenbrock K, et al: Survival and clonal expansion of mutating "forbidden" (immunoglobulin receptor-deficient) Epstein-Barr virusinfected b cells in angioimmunoblastic t cell lymphoma. J Exp Med 194: 927-940, 2001
12. Lome-Maldonado C, Canioni D, Hermine O, et al: Angio-immunoblastic T cell lymphoma (AILD-TL) rich in large B cells and associated with Epstein-Barr virus infection: A different subtype of AILD-TL? Leukemia 16: 2134-2141, 2002
13. Niino D, Kawano R, Arakawa F, et al: No correlation between immunoglobulin heavy chain rearrangements and the prognosis of angioimmunoblastic T-cell lymphoma. Eur J Haematol 83: 159-160, 2009
14. Feller A, Griesser H, Schilling C, et al: Clonal gene rearrangement patterns correlate with immunophenotype and clinical parameters in patients with angioimmunoblastic lymphadenopathy. Am J Pathol 133: 549-556, 1988
15. Dunleavy K, Wilson WH, Jaffe ES: Angioimmunoblastic T cell lymphoma: Pathobiological insights and clinical implications. Curr Opin Hematol 14: 348-353, 2007
16. Delfau-Larue MH, de Leval L, Joly B, et al: Targeting intratumoral B-cells with rituximab in addition to CHOP in angioimmunoblastic T-cell lymphoma. A clinicobiological study of the GELA. Haematologica, 2012