Therapeutic radiation induces different changes in expression profiles of metallothionein (MT) mRNA, MT protein, Ki67 and minichromosome maintenance protein 3 in human rectal adenocarcinoma

Anticancer Research

Volumn 32, Issue 12, 2012, Pages 5291-5298

  Szelachowska, Jolanta ^a,b   Dziegiel, Piotr ^a,b   Tarkowski, Radoslaw ^a,b   Gomulkiewicz, Agnieszka ^a   Bebenek, Marek ^b   Halon, Agnieszka ^a   Fortuna, Krzysztof ^a   Wojnar, Andrzej ^b   Kornafel, Jan ^a,b   Matkowski, Rafal ^a,b  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b Dolnoslaskie Centrum Onkologii Wroclaw   (Poland)

Author keywords

Ki 67; MCM3; Metallothionein; Radiosensitivity; Radiotherapy; Rectal cancer

Indexed keywords

KI 67 ANTIGEN; MESSENGER RNA; METALLOTHIONEIN; MINICHROMOSOME MAINTENANCE PROTEIN 3;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECTOSCOPY; RECTUM CARCINOMA;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; METALLOTHIONEIN; MIDDLE AGED; NUCLEAR PROTEINS; PROTEIN ISOFORMS; REAL-TIME POLYMERASE CHAIN REACTION; RECTAL NEOPLASMS; RNA, MESSENGER;

EID: 84872578542     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Cherian MG, Jayasurya A and Bay BH: Metallothioneins in human tumors and potential roles in carcinogenesis. Mutat Res 533: 201-209, 2003.
2. Apostolova MD and Cherian MG: Nuclear localization of metallothionein during cell proliferation and differentiation. Cell Mol Biol 46: 347-356, 2000.
3. Cai L and Cherian MG: Adaptive response to ionizing radiation-induced chromosome aberrations in rabbit lymphocytes: Effect of pre-exposure to zinc, and copper salts. Mutat Res 369: 233-241, 1996.
4. Bouzourene H, Chaubert P, Gebhard S, Bosman FT and Coucke P: Role of metallothioneins in irradiated human rectal carcinoma. Cancer 95: 1003-1008, 2002.
5. Stennard FA, Holloway AF, Hamilton J and West AK: Characterisation of six additional human metallothionein genes. Biochim Biophys Acta 1218: 357-365, 1994.
6. Jin R, Huang J, Tan PH and Bay BH: Clinicopathological significance of metallothioneins in breast cancer. Pathol Oncol Res 10: 74-79, 2004.
7. Nielsen AE, Bohr A, Penkowa M: The balance between life and death of cells: Roles of metallothioneins. Biomark Insights 1: 99-111, 2007.
8. Hishikawa Y, Koji T, Dhar DK, Kinugasa S, Yamaguchi M and Nagasue N: Metallothionein expression correlates with metastatic and proliferative potential in squamous cell carcinoma of the oesophagus. Br J Cancer 81: 712-720, 1999.
9. Dziegiel P: Expression of metallothioneins in tumor cells. Pol J Pathol 55: 3-12, 2004.
10. Endo T, Yoshikawa M, Ebara M, Kato K, Sunaga M, Fukuda H, Hayasaka A, Kondo F, Sugiura N and Saisho H: Immunohistochemical metallothionein expression in hepatocellular carcinoma: Relation to tumor progression and chemoresistance to platinum agents. J Gastroenterol 39: 1196-1201, 2004.
11. Surowiak P, Materna V, Kaplenko I, Spaczyñski M, Dietel M, Lage H and Zabel M: Augmented expression of metallothionein and glutathione-S- transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients. Virchows Arch 447: 626-633, 2005.
12. Wülfing C, van Ahlen H, Eltze E, Piechota H, Hertle L and Schmid KW: Metallothionein in bladder cancer: Correlation of overexpression with poor outcome after chemotherapy. World J Urol 25: 199-205, 2007.
13. Cai L and Cherian MG: Zinc-metallothionein protects from DNA damage induced by radiation better than glutathione and copper- or cadmium- metallothioneins. Toxicol Lett 136: 193-198, 2003.
14. Cai L, Satoh M, Tohyama C and Cherian MG: Metallothionein in radiation exposure: Its induction and protective role. Toxicology 132: 85 98, 1999.
15. Surowiak P, Materna V, Maciejczyk A, Pudelko M, Markwitz E, Spaczynski M, Dietel M, Zabel M and Lage H: Nuclear metallothionein expression correlates with cisplatin resistance of ovarian cancer cells and poor clinical outcome. Virchows Arch 450: 279-285, 2007.
16. Smith DJ, Jaggi M, Zhang W, Galich A, Du C, Sterrett SP, Smith LM and Balaji KC: Metallothioneins and resistance to cisplatin and radiation in prostate cancer. Urology 67: 1341-1347, 2006.
17. Jin R, Chow VT, Tan PH, Dheen ST, Duan W and Bay BH: Metallothionein 2A expression is associated with cell proliferation in breast cancer. Carcinogenesis 23: 81-86, 2002.
18. Cardoso SV, Barbosa HM, Candellori IM, Loyola AM and Aguiar MC: Prognostic impact of metallothionein on oral squamous cell carcinoma. Virchows Arch 441: 174-178, 2002.
19. Dziegiel P, Forgacz J, Suder E, Surowiak P, Kornafel J and Zabel M: Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine. Histol Histopathol 18: 401-407, 2003.
20. Lim D, Jocelyn KM, Yip GW and Bay BH: Silencing the metallothionein-2A gene inhibits cell cycle progression from G- 1- to S-phase involving ATM and CDC25A signaling in breast cancer cells. Cancer Lett 276: 109-117, 2009.
21. Szelachowska J, Dziegiel P, Jelen-Krzeszewska J, Jelen M, Tarkowski R, Wlodarska I, Spytkowska B, Gisterek I, Matkowski R and Kornafel J: Prognostic significance of nuclear and cytoplasmic expression of metallothioneins as related to proliferative activity in squamous cell carcinomas of oral cavity. Histol Histopathol 23: 843-851, 2008.
22. Tai SK, Tan OJ, Chow VT, Jin R, Jones JL, Tan PH, Jayasurya A and Bay BH: Differential expression of metallothionein 1 and 2 isoforms in breast cancer lines with different invasive potential: Identification of a novel nonsilent metallothionein-1H mutant variant. Am J Pathol 163: 2009-2019, 2003.
23. Garrett SH, Sens MA, Shukla D, Flores L, Somji S, Todd JH and Sens DA: Metallothionein isoform 1 and 2 gene expression in the human prostate: Down-regulation of MT-1X in advanced prostate cancer. Prostate 43: 125-135, 2000.
24. Barnes NL, Ackland ML and Cornish EJ: Metallothionein isoform expression by breast cancer cells. Int J Biochem Cell Biol 32: 895-903, 2000.
25. Jin R, Bay BH, Chow VT and Tan PH: Metallothionein 1F mRNA expression correlates with histological grade in breast carcinoma. Breast Cancer Res Treat 66: 265-272, 2001.
26. Du HY, Li Y, Olivo M, Yip GW and Bay BH: Differential upregulation of metallothionein isoforms in well-differentiated nasopharyngeal cancer cells in vitro by photoactivated hypericin. Oncol Rep 16: 1397-1402, 2006.
27. Lu DD, Chen YC, Zhang XR, Cao XR, Jiang HY and Yao L: The relationship between metallothionein-1F (MT1F) gene and hepatocellular carcinoma. Yale J Biol Med 76: 55-62, 2003.
28. Laskey RA and Madine MA: A rotary pumping model for helicase function of MCM proteins at a distance from replication forks. EMBO Rep 4: 26-30, 2003.
29. Remmele W and Stegner HE: Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Der Pathologe 8: 138-140, 1987.
30. Haq F, Mahoney M and Koropatnick J: Signaling events for metallothionein induction. Mutat Res 533: 211-226, 2003.
31. Gomulkiewicz A, Podhorska-Okolow M, Szulc R, Smorag Z, Wojnar A, Zabel M and Dziegiel P: Correlation between metallothionein (MT) expression and selected factors in ductal breast cancers. Folia Histochem Cytobiol 48: 242-248, 2010.
32. Debucquoy A, Goethals L, Libbrecht L, Perneel C, Geboes K, Ectors N, McBride WH and Haustermans K: Molecular and clinicopathological markers in rectal cancer: A tissue microarray study. Int J Colorectal Dis 24: 129-138, 2009.
33. Debucquoy A, Libbrecht L, Roobrouck V, Goethals L, McBride W and Haustermans K: Morphological features and molecular markers in rectal cancer from 95 patients included in the European Organisation for Research and Treatment of Cancer 22921 trial: Prognostic value and effects of preoperative radio (chemo) therapy. Eur J Cancer 44: 791-797, 2008.
34. Adell G, Zhang H, Jansson A, Sun XF, Stål O and Nordenskjöld B: Decreased tumor cell proliferation as an indicator of the effect of preoperative radiotherapy of rectal cancer. Int J Radiat Oncol Biol Phys 50: 659-663, 2001.
35. Cortez D, Glick G and Elledge SJ: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci USA 101: 10078-10083, 2004.
36. Shechter D and Gautier J: MCM proteins and checkpoint kinases get together at the fork. Proc Natl Acad Sci USA 101: 10845-10846, 2004.