Hedgehog signalling is downregulated in celiac disease

Canadian Journal of Gastroenterology

Volumn 27, Issue 1, 2013, Pages

  Liang, Rui ^a,b,c   Hinds, Rupert ^b,d   Abud, Helen E ^e   Cheng, Wei ^a,b,c,f  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b MONASH MEDICAL CENTRE   (Australia)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d Faculty of Medicine   (Australia)

^e Faculty of Medicine Nursing and Health Sciences ^*  (Australia)

^f MONASH UNIVERSITY   (Australia)

Author keywords

BMP4; Celiac disease; Duodenum; Hedgehog signalling; PTCH1

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; COMPLEMENTARY DNA; MESSENGER RNA; SONIC HEDGEHOG PROTEIN;

ADOLESCENT; ARTICLE; CELIAC DISEASE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; DUODENUM BIOPSY; GASTROSCOPY; HUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SCHOOL CHILD; SIGNAL TRANSDUCTION;

ADOLESCENT; CASE-CONTROL STUDIES; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; DOWN-REGULATION; GASTROSCOPY; HEDGEHOG PROTEINS; HUMANS; INTESTINAL MUCOSA; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; VICTORIA;

EID: 84872577478     PISSN: 08357900     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Mao J, Kim BM, Rajurkar M, et al. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development 2010;137:1721-9.
2. Madison BB, Braunstein K, Kuizon E, et al. Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 2005;132:279-89.
3. Ramalho-Santos M, Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 2000;127:2763-72.
4. Sukegawa A, Narita T, Kameda T, et al. The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. Development 2000;127:1971-80.
5. Ming JE, Roessler E, Muenke M. Human developmental disorders and the Sonic hedgehog pathway. Mol Med Today 1998;4:343-9.
6. Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007;449:1003-7.
7. Shin K, Lee J, Guo N, et al. Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature 2011;472:110-4.
8. Kosinski C, Stange DE, Xu C, et al. Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Gastroenterology 2010;139:893-903.
9. Lees CW, Zacharias WJ, Tremelling M, et al. Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS Med 2008;5:e239.
10. Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432:324-31.
11. Straface G, Aprahamian T, Flex A, et al. Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration. J Cell Mol Med 2009;13:2424-35.
12. Miyaji T, Nakase T, Iwasaki M, et al. Expression and distribution of transcripts for sonic hedgehog in the early phase of fracture repair. Histochem Cell Biol 2003;119:233-7.
13. Kusano KF, Pola R, Murayama T, et al. Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling. Nat Med 2005;11:1197-204.
14. Asai J, Takenaka H, Kusano KF, et al. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 2006;113:2413-24.
15. Nielsen CM, Williams J, van den Brink GR, et al. Hh pathway expression in human gut tissues and in inflammatory gut diseases. Lab Invest 2004;84:1631-42.
16. Kang DH, Han ME, Song MH, et al. The role of hedgehog signaling during gastric regeneration. J Gastroenterol 2009;44:372-9.
17. Zacharias WJ, Li X, Madison BB, et al. Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria. Gastroenterology 2010;138:2368-77;77 e1-4.
18. van Dop WA, Heijmans J, Buller NV, et al. Loss of Indian hedgehog activates multiple aspects of a wound healing response in the mouse intestine. Gastroenterology 2010;139:1665-76:76;e1-10.